-
1
-
-
0037223971
-
The evolution of signalling pathways in animal development
-
Pires-daSilva, A. & Sommer, R. J. The evolution of signalling pathways in animal development. Nature Rev. Genet. 4, 39-49 (2003).
-
(2003)
Nature Rev. Genet
, vol.4
, pp. 39-49
-
-
Pires-daSilva, A.1
Sommer, R.J.2
-
2
-
-
17944394278
-
Signaling receptome: A genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction
-
Ben-Shlomo, I., Hsu, S. Y., Rauch, R., Kowalski, H. W. & Hsueh, A. J. W. Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction. Sci. STKE 2003, re9 (2003).
-
(2003)
Sci. STKE
, vol.2003
-
-
Ben-Shlomo, I.1
Hsu, S.Y.2
Rauch, R.3
Kowalski, H.W.4
Hsueh, A.J.W.5
-
3
-
-
0033179767
-
Conserved genetic programs in insect and mammalian brain development
-
Hirth, F. & Reichert, H. Conserved genetic programs in insect and mammalian brain development. Bioessays 21, 677-684(1999).
-
(1999)
Bioessays
, vol.21
, pp. 677-684
-
-
Hirth, F.1
Reichert, H.2
-
4
-
-
48249094942
-
Molecular analysis of sleep: Wake cycles in Drosophila
-
Sehgal, A. et al. Molecular analysis of sleep: wake cycles in Drosophila. Cold Spring Harb. Symp. Quant. Biol. 72, 557-564 (2007).
-
(2007)
Cold Spring Harb. Symp. Quant. Biol
, vol.72
, pp. 557-564
-
-
Sehgal, A.1
-
5
-
-
0034927971
-
Molecular biology and anatomy of Drosophila olfactory associative learning
-
Roman, G. & Davis, R. L. Molecular biology and anatomy of Drosophila olfactory associative learning. Bioessays 23, 571-581 (2001).
-
(2001)
Bioessays
, vol.23
, pp. 571-581
-
-
Roman, G.1
Davis, R.L.2
-
6
-
-
39149129675
-
Fly fighting: Octopamine modulates aggression
-
Dierick, H. A. Fly fighting: octopamine modulates aggression. Curr. Biol. 18, R161-R163 (2008).
-
(2008)
Curr. Biol
, vol.18
-
-
Dierick, H.A.1
-
7
-
-
0036081081
-
Homophila: Human disease gene cognates in Drosophila
-
Chien, S., Reiter, L. T., Bier, E. & Gribskov, M. Homophila: human disease gene cognates in Drosophila. Nucleic Acids Res. 30, 149-151 (2002).
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 149-151
-
-
Chien, S.1
Reiter, L.T.2
Bier, E.3
Gribskov, M.4
-
8
-
-
0015529008
-
Mapping of behaviour in Drosophila mosaics
-
Hotta, Y. & Benzer, S. Mapping of behaviour in Drosophila mosaics. Nature 240, 527-535 (1972).
-
(1972)
Nature
, vol.240
, pp. 527-535
-
-
Hotta, Y.1
Benzer, S.2
-
9
-
-
59449096097
-
A Tribute to Seymour Benzer, 1921-2007
-
Bonini, N. M. A Tribute to Seymour Benzer, 1921-2007. Genetics 180, 1265-1273 (2008).
-
(2008)
Genetics
, vol.180
, pp. 1265-1273
-
-
Bonini, N.M.1
-
10
-
-
0031282443
-
Spongecake and eggroll: Two hereditary diseases in Drosophila resemble patterns of human brain degeneration
-
Min, K. T. & Benzer, S. Spongecake and eggroll: two hereditary diseases in Drosophila resemble patterns of human brain degeneration. Curr. Biol. 7, 885-888(1997).
-
(1997)
Curr. Biol
, vol.7
, pp. 885-888
-
-
Min, K.T.1
Benzer, S.2
-
11
-
-
0033581027
-
Preventing neurodegeneration in the Drosophila mutant bubblegum
-
Min, K. T. & Benzer, S. Preventing neurodegeneration in the Drosophila mutant bubblegum. Science 284, 1985-1988(1999).
-
(1999)
Science
, vol.284
, pp. 1985-1988
-
-
Min, K.T.1
Benzer, S.2
-
12
-
-
0018352065
-
Isolation of anatomical brain mutants of Drosophila by histological means
-
Heisenberg, M. & Bohl, K. Isolation of anatomical brain mutants of Drosophila by histological means. Z. Naturforsch. B 34, 143-147 (1979).
-
(1979)
Z. Naturforsch. B
, vol.34
, pp. 143-147
-
-
Heisenberg, M.1
Bohl, K.2
-
13
-
-
0036021395
-
Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila
-
Palladino, M. J., Hadley, T. J. & Ganetzky, B. Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila. Genetics 161, 1197-1208 (2002).
-
(2002)
Genetics
, vol.161
, pp. 1197-1208
-
-
Palladino, M.J.1
Hadley, T.J.2
Ganetzky, B.3
-
14
-
-
33746384132
-
Metabolic disruption in Drosophila bang-sensitive seizure mutants
-
Fergestad, T., Bostwick, B. & Ganetzky, B. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Genetics 173, 1357-1364(2006).
-
(2006)
Genetics
, vol.173
, pp. 1357-1364
-
-
Fergestad, T.1
Bostwick, B.2
Ganetzky, B.3
-
15
-
-
54449094069
-
A functional misexpression screen uncovers a role for enabled in progressive neurodegeneration
-
Rezaval, C. et al. A functional misexpression screen uncovers a role for enabled in progressive neurodegeneration. PLoSONE 3, e3332 (2008).
-
(2008)
PLoSONE
, vol.3
-
-
Rezaval, C.1
-
16
-
-
0030864464
-
The swiss cheese mutant causes glial hyperwrappingand brain degeneration in Drosophila
-
Kretzschmar, D., Hasan, G., Sharma, S., Heisenberg, M. & Benzer, S. The swiss cheese mutant causes glial hyperwrappingand brain degeneration in Drosophila. J. Neurosci. 17, 7425-7432 (1997).
-
(1997)
J. Neurosci
, vol.17
, pp. 7425-7432
-
-
Kretzschmar, D.1
Hasan, G.2
Sharma, S.3
Heisenberg, M.4
Benzer, S.5
-
17
-
-
0032524552
-
Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man
-
Lush, M. J., Li, Y., Read, D. J., Willis, A. C. & Glynn, P. Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man. Biochem. J. 332, 1 -4 (1998).
-
(1998)
Biochem. J
, vol.332
, pp. 1-4
-
-
Lush, M.J.1
Li, Y.2
Read, D.J.3
Willis, A.C.4
Glynn, P.5
-
18
-
-
24344508083
-
Neuropathy target esterase and phospholipid deacylation
-
Glynn, P. Neuropathy target esterase and phospholipid deacylation. Biochim. Biophys. Acta 1736, 87-93(2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1736
, pp. 87-93
-
-
Glynn, P.1
-
19
-
-
15244351250
-
Loss of Swiss cheese/ neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila
-
Muhlig-Versen, M. et al. Loss of Swiss cheese/ neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila. J. Neurosci. 25, 2865-2873 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 2865-2873
-
-
Muhlig-Versen, M.1
-
20
-
-
58149161907
-
Swiss cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3
-
Bettencourt da Cruz, A., Wentzell, J. & Kretzschmar, D. Swiss cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3. J. Neurosci. 28, 10885-10892 (2008).
-
(2008)
J. Neurosci
, vol.28
, pp. 10885-10892
-
-
Bettencourt da Cruz, A.1
Wentzell, J.2
Kretzschmar, D.3
-
21
-
-
1842687240
-
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration
-
Akassoglou, K. et al. Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc. NatlAcad. Sci. USA 101, 5075-5080 (2004).
-
(2004)
Proc. NatlAcad. Sci. USA
, vol.101
, pp. 5075-5080
-
-
Akassoglou, K.1
-
22
-
-
41149133870
-
Neuropathy target esterase gene mutations cause motor neuron disease
-
Rainier, S. et al. Neuropathy target esterase gene mutations cause motor neuron disease. Am. J. Hum. Genet. 82, 780-785 (2008).
-
(2008)
Am. J. Hum. Genet
, vol.82
, pp. 780-785
-
-
Rainier, S.1
-
24
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark, I. E. et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441, 11 62-1166 (2006).
-
(2006)
Nature
, vol.441
, Issue.11
, pp. 62-1166
-
-
Clark, I.E.1
-
25
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park, J. et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441, 1157-1161 (2006).
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
-
26
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink 1 is rescued by Parkin
-
Yang, Y. et al. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink 1 is rescued by Parkin. Proc. NatlAcad. Sci. USA 103, 10793-10798(2006).
-
(2006)
Proc. NatlAcad. Sci. USA
, vol.103
, pp. 10793-10798
-
-
Yang, Y.1
-
27
-
-
36049038504
-
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by Parkin
-
Exner, N. et al. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by Parkin. J. Neurosci. 27, 12413-12418 (2007).
-
(2007)
J. Neurosci
, vol.27
, pp. 12413-12418
-
-
Exner, N.1
-
28
-
-
39449088321
-
The PINK 1 /Parkin pathway regulates mitochondrial morphology
-
Poole, A. C. et al. The PINK 1 /Parkin pathway regulates mitochondrial morphology. Proc. NatlAcad. Sci. USA 105, 1638-1643(2008).
-
(2008)
Proc. NatlAcad. Sci. USA
, vol.105
, pp. 1638-1643
-
-
Poole, A.C.1
-
29
-
-
55749090654
-
The Parkinson's disease genes pink 1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng, H., Dodson, M. W., Huang, H. & Guo, M. The Parkinson's disease genes pink 1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. NatlAcad. Sci. USA 105, 14503-14508(2008).
-
(2008)
Proc. NatlAcad. Sci. USA
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
30
-
-
34547601410
-
Mitochondrial fusion protects against neurodegeneration in the cerebellum
-
Chen, H., McCaffery, J. M. & Chan, D. C. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130, 548-562 (2007).
-
(2007)
Cell
, vol.130
, pp. 548-562
-
-
Chen, H.1
McCaffery, J.M.2
Chan, D.C.3
-
31
-
-
0036247596
-
The role of chaperones in polyglutamine disease
-
Opal, P. & Zoghbi, H. Y. The role of chaperones in polyglutamine disease. Trends Mol. Med. 8, 232-236 (2002).
-
(2002)
Trends Mol. Med
, vol.8
, pp. 232-236
-
-
Opal, P.1
Zoghbi, H.Y.2
-
32
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B. & Kroemer, G. Autophagy in the pathogenesis of disease. Cell 132, 27-42 (2008).
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
33
-
-
40849084018
-
Neuropathology in Drosophila mutants with increased seizure susceptibility
-
Fergestad, T. et al. Neuropathology in Drosophila mutants with increased seizure susceptibility. Genetics 178, 947-956(2008).
-
(2008)
Genetics
, vol.178
, pp. 947-956
-
-
Fergestad, T.1
-
34
-
-
50949084838
-
Phosphatidylserine and phosphatidylethanolamine in mammalian cells: Two metabolically related aminophospholipids
-
Vance, J. E. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. J. Lipid Res. 49, 1377-1387(2008).
-
(2008)
J. Lipid Res
, vol.49
, pp. 1377-1387
-
-
Vance, J.E.1
-
35
-
-
33749836234
-
Phosphoinositides in cell regulation and membrane dynamics
-
Di Paolo, G. & De Camilli, P. Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657(2006).
-
(2006)
Nature
, vol.443
, pp. 651-657
-
-
Di Paolo, G.1
De Camilli, P.2
-
36
-
-
45749083772
-
De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system
-
Bosveld, F. et al. De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system. Hum. Mol. Genet. 17, 2058-2069 (2008).
-
(2008)
Hum. Mol. Genet
, vol.17
, pp. 2058-2069
-
-
Bosveld, F.1
-
37
-
-
4444323965
-
Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects
-
Rubio-Gozalbo, M. E., Bakker, J. A., Waterham, H. R. & Wanders, R. J. Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects. Mol. Aspects Med. 25, 521-532 (2004).
-
(2004)
Mol. Aspects Med
, vol.25
, pp. 521-532
-
-
Rubio-Gozalbo, M.E.1
Bakker, J.A.2
Waterham, H.R.3
Wanders, R.J.4
-
38
-
-
27744602604
-
Cholesterol in Alzheimer's disease
-
Shobab, L. A., Hsiung, G.-Y. R. & Feldman, H. H. Cholesterol in Alzheimer's disease. Lancet Neurol. 4, 841-852(2005).
-
(2005)
Lancet Neurol
, vol.4
, pp. 841-852
-
-
Shobab, L.A.1
Hsiung, G.-Y.R.2
Feldman, H.H.3
-
39
-
-
0037011118
-
The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and Appl processing
-
Tschape, J. A. et al. The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and Appl processing. EMBO J. 21, 6367-6376 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 6367-6376
-
-
Tschape, J.A.1
-
40
-
-
33847080728
-
AMP-activated protein kinase in metabolic control and insulin signaling
-
Towler, M. C. & Hardie, D. G. AMP-activated protein kinase in metabolic control and insulin signaling. Circ. Res. 100,328-341 (2007).
-
(2007)
Circ. Res
, vol.100
, pp. 328-341
-
-
Towler, M.C.1
Hardie, D.G.2
-
41
-
-
35848935828
-
Greased hedgehogs: New links between hedgehog signaling and cholesterol metabolism
-
Breitling, R. Greased hedgehogs: new links between hedgehog signaling and cholesterol metabolism. Bioessays 29, 1085-1094 (2007).
-
(2007)
Bioessays
, vol.29
, pp. 1085-1094
-
-
Breitling, R.1
-
42
-
-
0037710127
-
Cholesterol homeostasis and function in neurons of the central nervous system
-
Pfrieger, F. W. Cholesterol homeostasis and function in neurons of the central nervous system. Cell. Mol. Life Sci. 60, 1158-1171 (2003).
-
(2003)
Cell. Mol. Life Sci
, vol.60
, pp. 1158-1171
-
-
Pfrieger, F.W.1
-
43
-
-
0032745853
-
The dare gene: Steroid hormone production, olfactory behavior, and neural degeneration in Drosophila
-
Freeman, M. R., Dobritsa, A., Gaines, P., Segraves, W. A. & Carlson, J. R. The dare gene: steroid hormone production, olfactory behavior, and neural degeneration in Drosophila. Development 126, 4591-4602(1999).
-
(1999)
Development
, vol.126
, pp. 4591-4602
-
-
Freeman, M.R.1
Dobritsa, A.2
Gaines, P.3
Segraves, W.A.4
Carlson, J.R.5
-
45
-
-
3142774112
-
Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone
-
Griffin, L. D., Gong, W., Verot, L. & Mellon, S. H. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Nature Med. 10, 704-711 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 704-711
-
-
Griffin, L.D.1
Gong, W.2
Verot, L.3
Mellon, S.H.4
-
46
-
-
46749133868
-
Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration
-
Spasic, M. R., Callaerts, P. & Norga, K. K. Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration. J. Neurosci. 28, 6419-6429 (2008).
-
(2008)
J. Neurosci
, vol.28
, pp. 6419-6429
-
-
Spasic, M.R.1
Callaerts, P.2
Norga, K.K.3
-
47
-
-
0347359224
-
Localized effects of cAMP mediated by distinct routes of protein kinase A
-
Tasken, K. &Aandahl, E. M. Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol. Rev. 84, 137-167 (2004).
-
(2004)
Physiol. Rev
, vol.84
, pp. 137-167
-
-
Tasken, K.1
Aandahl, E.M.2
-
48
-
-
33644793597
-
Axonal regeneration in adult CNS neurons - signaling molecules and pathways
-
Teng, F. Y. & Tang, B. L. Axonal regeneration in adult CNS neurons - signaling molecules and pathways. J. Neurochem. 96, 1501-1508 (2006).
-
(2006)
J. Neurochem
, vol.96
, pp. 1501-1508
-
-
Teng, F.Y.1
Tang, B.L.2
-
49
-
-
56049091236
-
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
-
Kim, Y. et al. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 377, 975-980 (2008).
-
(2008)
Biochem. Biophys. Res. Commun
, vol.377
, pp. 975-980
-
-
Kim, Y.1
-
50
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra, D.,Tanaka, A., Suen, D.-F. &Youle, R. J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. CellBiol. 183, 795-803 (2008).
-
(2008)
J. CellBiol
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.-F.3
Youle, R.J.4
-
51
-
-
33751267701
-
-
Moore, D. J. Parkin: a multifaceted ubiquitin ligase. Biochem. Soc. Trans. 34, 749-753 (2006).
-
Moore, D. J. Parkin: a multifaceted ubiquitin ligase. Biochem. Soc. Trans. 34, 749-753 (2006).
-
-
-
-
52
-
-
33846471122
-
Proteasome-independent functions of ubiquitin in endocytosis and signaling
-
Mukhopadhyay, D. & Riezman, H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 315, 201-205 (2007).
-
(2007)
Science
, vol.315
, pp. 201-205
-
-
Mukhopadhyay, D.1
Riezman, H.2
-
53
-
-
35748935851
-
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
-
Plun-Favreau, H. et al. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nature CellBiol. 9, 1243-1252 (2007).
-
(2007)
Nature CellBiol
, vol.9
, pp. 1243-1252
-
-
Plun-Favreau, H.1
-
54
-
-
39449115415
-
The mitochondrial serine protease HtrA2/Omi: An overview
-
Vande Walle, L., Lamkanfi, M. & Vandenabeele, P. The mitochondrial serine protease HtrA2/Omi: an overview. Cell Death Differ. 15, 453-460 (2008).
-
(2008)
Cell Death Differ
, vol.15
, pp. 453-460
-
-
Vande Walle, L.1
Lamkanfi, M.2
Vandenabeele, P.3
-
55
-
-
34447323097
-
Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease
-
Challa, M. et al. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBOJ. 26, 3144-3156 (2007).
-
(2007)
EMBOJ
, vol.26
, pp. 3144-3156
-
-
Challa, M.1
-
56
-
-
34047135028
-
Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila
-
Igaki, T. et al. Evolution of mitochondrial cell death pathway: proapoptotic role of HtrA2/Omi in Drosophila. Biochem. Biophys. Res. Commun. 356, 993-997 (2007).
-
(2007)
Biochem. Biophys. Res. Commun
, vol.356
, pp. 993-997
-
-
Igaki, T.1
-
57
-
-
0027987061
-
Presynaptic dysfunction in Drosophila csp mutants
-
Umbach, J. A. et al. Presynaptic dysfunction in Drosophila csp mutants. Neuron 13, 899-907 (1994).
-
(1994)
Neuron
, vol.13
, pp. 899-907
-
-
Umbach, J.A.1
-
58
-
-
0028281387
-
Paralysis and early death in cysteine string protein mutants of Drosophila
-
Zinsmaier, K. E., Eberle, K. K., Buchner, E., Walter, N. & Benzer, S. Paralysis and early death in cysteine string protein mutants of Drosophila. Science 263, 977-980(1994).
-
(1994)
Science
, vol.263
, pp. 977-980
-
-
Zinsmaier, K.E.1
Eberle, K.K.2
Buchner, E.3
Walter, N.4
Benzer, S.5
-
59
-
-
14644415031
-
Thesynaptic vesicle protein CSP alpha prevents presynaptic degeneration
-
Fernandez-Chacon, R. et al. Thesynaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron 42, 237-251 (2004).
-
(2004)
Neuron
, vol.42
, pp. 237-251
-
-
Fernandez-Chacon, R.1
-
60
-
-
27544507306
-
a-Synuclein cooperates with CSPa in preventing neurodegeneration
-
Chandra, S., Gallardo, G., Fernandez-Chacon, R., Schluter, O. M. & Sudhof, T. C. a-Synuclein cooperates with CSPa in preventing neurodegeneration. Cell 123, 383-396 (2005).
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernandez-Chacon, R.3
Schluter, O.M.4
Sudhof, T.C.5
-
61
-
-
33749240943
-
Mechanisms of Parkinson's disease linked to pathological a-synuclein: New targets for drug discovery
-
Lee, V. M. & Trojanowski, J. Q. Mechanisms of Parkinson's disease linked to pathological a-synuclein: new targets for drug discovery. Neuron 52, 33-38 (2006).
-
(2006)
Neuron
, vol.52
, pp. 33-38
-
-
Lee, V.M.1
Trojanowski, J.Q.2
-
62
-
-
0018889608
-
Acetylcholinesterase mutants in Drosophila and their effects on the structure and function of the central nervous system
-
Greenspan, R. J., Finn, J. A. Jr & Hall, J. C. Acetylcholinesterase mutants in Drosophila and their effects on the structure and function of the central nervous system. J. Comp. Neurol. 189, 741-774(1980).
-
(1980)
J. Comp. Neurol
, vol.189
, pp. 741-774
-
-
Greenspan, R.J.1
Finn Jr, J.A.2
Hall, J.C.3
-
63
-
-
0019105940
-
Behavioral and biochemical defects in temperature-sensitive acetylcholinesterase mutants of Drosophila melanogaster
-
Hall, J. C., Alahiotis, S. N., Strumpf, D. A. & White, K. Behavioral and biochemical defects in temperature-sensitive acetylcholinesterase mutants of Drosophila melanogaster. Genetics 96, 939-965(1980).
-
(1980)
Genetics
, vol.96
, pp. 939-965
-
-
Hall, J.C.1
Alahiotis, S.N.2
Strumpf, D.A.3
White, K.4
-
64
-
-
1842816630
-
Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain
-
Rival, T. et al. Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain. Curr. Biol. 14, 599-605 (2004).
-
(2004)
Curr. Biol
, vol.14
, pp. 599-605
-
-
Rival, T.1
-
65
-
-
0037442821
-
Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants
-
Palladino, M. J., Bower, J. E., Kreber, R. & Ganetzky, B. Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants. J. Neurosci. 23, 1276-1286 (2003).
-
(2003)
J. Neurosci
, vol.23
, pp. 1276-1286
-
-
Palladino, M.J.1
Bower, J.E.2
Kreber, R.3
Ganetzky, B.4
-
66
-
-
0037168108
-
Unrestricted synaptic growth in spinster - a late endosomal protein implicated in TGF-β-mediated synaptic growth regulation
-
Sweeney, S. T. & Davis, G. W. Unrestricted synaptic growth in spinster - a late endosomal protein implicated in TGF-β-mediated synaptic growth regulation. Neuron 36, 403-41 6 (2002).
-
(2002)
Neuron
, vol.36
, Issue.403-441
, pp. 6
-
-
Sweeney, S.T.1
Davis, G.W.2
-
67
-
-
22244450095
-
Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer
-
Dermaut, B. et al. Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer. J. CellBiol. 170, 127-139 (2005).
-
(2005)
J. CellBiol
, vol.170
, pp. 127-139
-
-
Dermaut, B.1
-
68
-
-
32544439499
-
Mitochondrial encephalomyopathy in Drosophila
-
Celotto, A. M. et al. Mitochondrial encephalomyopathy in Drosophila. J. Neurosci. 26, 810-820(2006).
-
(2006)
J. Neurosci
, vol.26
, pp. 810-820
-
-
Celotto, A.M.1
-
69
-
-
0034604506
-
Roleof adenine nucleotide translocator 1 in mtDNA maintenance
-
Kaukonen, J. et al. Roleof adenine nucleotide translocator 1 in mtDNA maintenance. Science 289, 782-785 (2000).
-
(2000)
Science
, vol.289
, pp. 782-785
-
-
Kaukonen, J.1
-
70
-
-
23844558266
-
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
-
Wallace, D. C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39, 359-407 (2005).
-
(2005)
Annu. Rev. Genet
, vol.39
, pp. 359-407
-
-
Wallace, D.C.1
-
71
-
-
34547127902
-
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP 1
-
e 172
-
Pridgeon, J. W., Olzmann, J. A., Chin, L.-S. & Li, L. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP 1. PLoS Biol. 5, e 172 (2007).
-
(2007)
PLoS Biol
, vol.5
-
-
Pridgeon, J.W.1
Olzmann, J.A.2
Chin, L.-S.3
Li, L.4
-
72
-
-
0034329742
-
Apoptosis in neurodegenerative disorders
-
Mattson, M. P. Apoptosis in neurodegenerative disorders. Nature Rev. Mol. Cell Biol. 1,120-129 (2000).
-
(2000)
Nature Rev. Mol. Cell Biol
, vol.1
, pp. 120-129
-
-
Mattson, M.P.1
-
73
-
-
61649088435
-
PINK1-associated parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
-
Gandhi, S. et al. PINK1-associated parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol. Cell 33, 627-638 (2009).
-
(2009)
Mol. Cell
, vol.33
, pp. 627-638
-
-
Gandhi, S.1
-
74
-
-
32044462033
-
Glial cell biology in Drosophila and vertebrates
-
Freeman, M. R. & Doherty, J. Glial cell biology in Drosophila and vertebrates. Trends Neurosci. 29, 82-90 (2006).
-
(2006)
Trends Neurosci
, vol.29
, pp. 82-90
-
-
Freeman, M.R.1
Doherty, J.2
-
75
-
-
0028916322
-
Defective glia induce neuronal apoptosis in the repo visual system of Drosophila
-
Xiong, W. C. & Montell, C. Defective glia induce neuronal apoptosis in the repo visual system of Drosophila. Neuron 14, 581-590 (1995).
-
(1995)
Neuron
, vol.14
, pp. 581-590
-
-
Xiong, W.C.1
Montell, C.2
-
76
-
-
0027241846
-
Defective glia in the Drosophila brain degeneration mutant drop-dead
-
Buchanan, R. L. & Benzer, S. Defective glia in the Drosophila brain degeneration mutant drop-dead. Neuron 10,839-850(1993).
-
(1993)
Neuron
, vol.10
, pp. 839-850
-
-
Buchanan, R.L.1
Benzer, S.2
-
77
-
-
48549102737
-
Neuronal loss of Drosophila NPCla causes cholesterol aggregation and age-progressive neurodegeneration
-
Phillips, S. E., Woodruff, E. A. 3rd, Liang, P., Patten, M. & Broadie, K. Neuronal loss of Drosophila NPCla causes cholesterol aggregation and age-progressive neurodegeneration. J. Neurosci. 28, 6569-6582 (2008).
-
(2008)
J. Neurosci
, vol.28
, pp. 6569-6582
-
-
Phillips, S.E.1
Woodruff 3rd, E.A.2
Liang, P.3
Patten, M.4
Broadie, K.5
-
78
-
-
0034682706
-
-
Palladino, M. J., Keegan, L. P., O'Connell, M. A. & Reenan, R. A. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell 102, 437-449 (2000).
-
Palladino, M. J., Keegan, L. P., O'Connell, M. A. & Reenan, R. A. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell 102, 437-449 (2000).
-
-
-
-
79
-
-
3242733807
-
Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila
-
McGuire, S. E., Mao, Z. & Davis, R. L. Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila. Sci. STKE 2004, p1 6 (2004).
-
(2004)
Sci. STKE
, vol.2004
-
-
McGuire, S.E.1
Mao, Z.2
Davis, R.L.3
-
80
-
-
47749087494
-
Tools for neuroanatomy and neurogenetics in Drosophila
-
Pfeiffer, B. D. et al. Tools for neuroanatomy and neurogenetics in Drosophila. Proc. NatlAcad. Sci. USA 105, 9715-9720(2008).
-
(2008)
Proc. NatlAcad. Sci. USA
, vol.105
, pp. 9715-9720
-
-
Pfeiffer, B.D.1
-
81
-
-
0033103536
-
Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
-
Lee, T. & Luo, L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22, 451-461 (1999).
-
(1999)
Neuron
, vol.22
, pp. 451-461
-
-
Lee, T.1
Luo, L.2
-
82
-
-
34250890832
-
-
Wang, T. & Montell, C. Phototransduction and retinal degeneration in Drosophila. PflugersArch. 454, 821-847(2007).
-
Wang, T. & Montell, C. Phototransduction and retinal degeneration in Drosophila. PflugersArch. 454, 821-847(2007).
-
-
-
-
83
-
-
0345192349
-
A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype
-
Stowers, R. S. & Schwarz, T. L. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics 152, 1631-1639(1999).
-
(1999)
Genetics
, vol.152
, pp. 1631-1639
-
-
Stowers, R.S.1
Schwarz, T.L.2
-
85
-
-
40149101562
-
-
Lessing, D. & Bonini, N. M. Polyglutamine genes interact to modulate the severity and progression of neuro-degeneration in Drosophila. PLoSBiol. 6, e29 (2008).
-
Lessing, D. & Bonini, N. M. Polyglutamine genes interact to modulate the severity and progression of neuro-degeneration in Drosophila. PLoSBiol. 6, e29 (2008).
-
-
-
-
86
-
-
0032568802
-
Regulation of Armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
-
Ahmed, Y., Hayashi, S., Levine, A. & Wieschaus, E. Regulation of Armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell 93, 1171-1182 (1998).
-
(1998)
Cell
, vol.93
, pp. 1171-1182
-
-
Ahmed, Y.1
Hayashi, S.2
Levine, A.3
Wieschaus, E.4
-
87
-
-
33845477523
-
Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity
-
Zhai, R. G. et al. Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol. 4, e4 16 (2006).
-
(2006)
PLoS Biol
, vol.4
-
-
Zhai, R.G.1
-
88
-
-
33646543714
-
Normal mitochondrial dynamics requires Rhomboid-7 and affects Drosophila lifespan and neuronal function
-
McQuibban, G. A., Lee, J. R., Zheng, L., Juusola, M. & Freeman, M. Normal mitochondrial dynamics requires Rhomboid-7 and affects Drosophila lifespan and neuronal function. Curr. Biol. 16, 982-989 (2006).
-
(2006)
Curr. Biol
, vol.16
, pp. 982-989
-
-
McQuibban, G.A.1
Lee, J.R.2
Zheng, L.3
Juusola, M.4
Freeman, M.5
-
89
-
-
50649095537
-
Reactive oxygen species act remotely to cause synapse loss in a Drosophila model of developmental mitochondrial encephalopathy
-
Mast, J. D., Tomalty, K. M., Vogel, H. & Clandinin, T. R. Reactive oxygen species act remotely to cause synapse loss in a Drosophila model of developmental mitochondrial encephalopathy. Development 135, 2669-2679 (2008).
-
(2008)
Development
, vol.135
, pp. 2669-2679
-
-
Mast, J.D.1
Tomalty, K.M.2
Vogel, H.3
Clandinin, T.R.4
-
90
-
-
0029050058
-
Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: Neuropathology and a model of dimer dysequilibrium
-
Phillips, J. P. et al. Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium. Proc. NatlAcad. Sci. USA 92, 8574-8578 (1995).
-
(1995)
Proc. NatlAcad. Sci. USA
, vol.92
, pp. 8574-8578
-
-
Phillips, J.P.1
-
91
-
-
43249103898
-
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of ataxia telangiectasia
-
Rimkus, S. A. et al. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of ataxia telangiectasia. Genes Dev. 22, 1205-1220(2008).
-
(2008)
Genes Dev
, vol.22
, pp. 1205-1220
-
-
Rimkus, S.A.1
-
92
-
-
33750818947
-
Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration
-
Muraro, N. I. & Moffat, K. G. Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. J. Neurobiol. 66, 1338-1353 (2006).
-
(2006)
J. Neurobiol
, vol.66
, pp. 1338-1353
-
-
Muraro, N.I.1
Moffat, K.G.2
-
93
-
-
1542569542
-
Techniques to dissect cellular and subcellular function in the Drosophila nervous system
-
Matthies, H. J. G. & Broadie, K. Techniques to dissect cellular and subcellular function in the Drosophila nervous system. Methods Cell Biol. 71, 195-265(2003).
-
(2003)
Methods Cell Biol
, vol.71
, pp. 195-265
-
-
Matthies, H.J.G.1
Broadie, K.2
-
94
-
-
0027959760
-
Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na, K-ATPase
-
Magyar, J. P. et al. Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na, K-ATPase. J. Cell Biol. 127, 835-845(1994).
-
(1994)
J. Cell Biol
, vol.127
, pp. 835-845
-
-
Magyar, J.P.1
-
95
-
-
17544391947
-
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
-
Watase, K. et al. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur. J. Neurosci. 10, 976-988 (1998).
-
(1998)
Eur. J. Neurosci
, vol.10
, pp. 976-988
-
-
Watase, K.1
-
96
-
-
29444459269
-
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse
-
Aoyama, K. et al. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nature Neurosci. 9, 119-126(2006).
-
(2006)
Nature Neurosci
, vol.9
, pp. 119-126
-
-
Aoyama, K.1
-
97
-
-
0028108924
-
The Drosophila easily shocked gene: A mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis
-
Pavlidis, P., Ramaswami, M. &Tanouye, M. A. The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis. Cell 79, 23-33 (1994).
-
(1994)
Cell
, vol.79
, pp. 23-33
-
-
Pavlidis, P.1
Ramaswami, M.2
Tanouye, M.A.3
-
98
-
-
18244384190
-
Disruption of the MAP 1 B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila
-
Bettencourt da Cruz, A. et al. Disruption of the MAP 1 B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila. Mol. Biol. Cell 16, 2433-2442 (2005).
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 2433-2442
-
-
Bettencourt da Cruz, A.1
-
99
-
-
34250716562
-
Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila
-
Liu, W. et al. Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. Genetics 176, 937-946 (2007).
-
(2007)
Genetics
, vol.176
, pp. 937-946
-
-
Liu, W.1
-
100
-
-
15544380902
-
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
-
Greene, J. C., Whitworth, A. J., Andrews, L. A., Parker, T. J. & Pallanck, L. J. Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Hum. Mol. Genet. 14, 799-811 (2005).
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 799-811
-
-
Greene, J.C.1
Whitworth, A.J.2
Andrews, L.A.3
Parker, T.J.4
Pallanck, L.J.5
-
101
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
Greene, J. C. et al. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc. NatlAcad. Sci. USA 100, 4078-4083 (2003).
-
(2003)
Proc. NatlAcad. Sci. USA
, vol.100
, pp. 4078-4083
-
-
Greene, J.C.1
-
102
-
-
0141906285
-
-
eds Horowski, R. et al, Springer, Wien
-
Tschape, J. A., Bettencourt da Cruz, A. & Kretzschmar, D. in Advances in Neurodegeneration (eds Horowski, R. et al.) 51 -62 (Springer, Wien, 2003).
-
(2003)
Advances in Neurodegeneration
, pp. 51-62
-
-
Tschape, J.A.1
Bettencourt da Cruz, A.2
Kretzschmar, D.3
|