Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

Pediatric Nephrology

Volumn 25, Issue 4, 2010, Pages 633-642

  Bohensky, Jolene ^a   Leshinsky, Serge ^a   Srinivas, Vickram ^a   Shapiro, Irving M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

AMPK; Autophagy; Chondrocyte; HIF 1; MTOR

Indexed keywords

CASPASE 8; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 2; HYPOXIA INDUCIBLE FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BID; PROTEIN KINASE B; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AUTOPHAGY; CARTILAGE CELL; CELL CULTURE; CELL LINE; CELL STIMULATION; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REPRESSION; GENE SILENCING; GROWTH PLATE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; CALCIUM; CELL LINE; CELL SURVIVAL; CHONDROCYTES; ENZYME INHIBITORS; GENE SILENCING; GROWTH PLATE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; THAPSIGARGIN;

EID: 77951259001     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-009-1310-y     Document Type: Conference Paper

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