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Volumn 22, Issue , 2014, Pages 303-330

Transgenic rodent models to study alpha-synuclein pathogenesis, with a focus on cognitive deficits

Author keywords

Behavior; Dementia; Mouse; Parkinson s disease; Rat

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; DOPAMINE TRANSPORTER; TRANSCRIPTION FACTOR PITX3; VIRUS VECTOR;

EID: 84941123145     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2014_355     Document Type: Article
Times cited : (35)

References (99)
  • 1
    • 77950813474 scopus 로고    scopus 로고
    • The epidemiology of dementia associated with parkinson's disease
    • Aarsland D, Kurz MW (2010) The epidemiology of dementia associated with parkinson's disease. Brain Pathol 20:633-639
    • (2010) Brain Pathol , vol.20 , pp. 633-639
    • Aarsland, D.1    Kurz, M.W.2
  • 5
    • 84984575714 scopus 로고    scopus 로고
    • Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult mice
    • Botton PH, Costa MS, Ardais AP, Mioranzza S, Souza DO, da Rocha JBT, Porciúncula LO (2010) Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult mice. Behav Brain Res 214:254-259
    • (2010) Behav Brain Res , vol.214 , pp. 254-259
    • Botton, P.H.1    Costa, M.S.2    Ardais, A.P.3    Mioranzza, S.4    Souza, D.O.5    da Rocha, J.B.T.6    Porciúncula, L.O.7
  • 6
    • 0036392590 scopus 로고    scopus 로고
    • Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)
    • Braak H, Del Tredici K, Bratzke H, Hamm-Clement J, Sandmann-Keil D, Rüb U (2002) Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). J Neurol 249:1-5
    • (2002) J Neurol , vol.249 , pp. 1-5
    • Braak, H.1    Del Tredici, K.2    Bratzke, H.3    Hamm-Clement, J.4    Sandmann-Keil, D.5    Rüb, U.6
  • 8
    • 33750440804 scopus 로고    scopus 로고
    • Cognitive decline correlates with neuropathological stage in Parkinson's disease
    • Braak H, Rüb U, Del Tredici K (2006) Cognitive decline correlates with neuropathological stage in Parkinson's disease. J Neurol Sci 248:255-258
    • (2006) J Neurol Sci , vol.248 , pp. 255-258
    • Braak, H.1    Rüb, U.2    Del Tredici, K.3
  • 10
    • 0036458810 scopus 로고    scopus 로고
    • Spatial learning is unimpaired in mice containing a deletion of the alpha-synuclein locus
    • Chen PE, Specht CG, Morris RGM, Schoepfer R (2002) Spatial learning is unimpaired in mice containing a deletion of the alpha-synuclein locus. Eur J Neurosci 16:154-158
    • (2002) Eur J Neurosci , vol.16 , pp. 154-158
    • Chen, P.E.1    Specht, C.G.2    Morris, R.G.M.3    Schoepfer, R.4
  • 11
    • 81255210997 scopus 로고    scopus 로고
    • Modelling of Parkinson's disease in mice
    • Chesselet M-F, Richter F (2011) Modelling of Parkinson's disease in mice. Lancet Neurol 10:1108-1118
    • (2011) Lancet Neurol , vol.10 , pp. 1108-1118
    • Chesselet, M.-F.1    Richter, F.2
  • 12
    • 77953068390 scopus 로고    scopus 로고
    • Synergistic Interactions between Aβ, Tau, and α-Synuclein: Acceleration of Neuropathology and Cognitive Decline
    • Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM (2010) Synergistic Interactions between Aβ, Tau, and α-Synuclein: Acceleration of Neuropathology and Cognitive Decline. J Neurosci 30:7281-7289
    • (2010) J Neurosci , vol.30 , pp. 7281-7289
    • Clinton, L.K.1    Blurton-Jones, M.2    Myczek, K.3    Trojanowski, J.Q.4    LaFerla, F.M.5
  • 15
    • 84860603741 scopus 로고    scopus 로고
    • Animal models of multiple system atrophy
    • Fernagut PO, Tison F (2012) Animal models of multiple system atrophy. Neuroscience 211:77-82
    • (2012) Neuroscience , vol.211 , pp. 77-82
    • Fernagut, P.O.1    Tison, F.2
  • 19
    • 26044454647 scopus 로고    scopus 로고
    • How to diagnose dementia with Lewy bodies: State of the art
    • Geser F, Wenning GK, Poewe W, McKeith I (2005) How to diagnose dementia with Lewy bodies: State of the art. Mov Disord 20:S11-S20
    • (2005) Mov Disord , vol.20 , pp. S11-S20
    • Geser, F.1    Wenning, G.K.2    Poewe, W.3    McKeith, I.4
  • 20
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T Human α-Synuclein
    • Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VMY (2002) Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T Human α-Synuclein. Neuron 34:521-533
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.Y.6
  • 22
    • 84877987961 scopus 로고    scopus 로고
    • Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors
    • Hall H, Jewett M, Landeck N, Nilsson N, Schagerlöf U, Leanza G, Kirik D (2013) Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors. PLoS ONE 8:e64844
    • (2013) PLoS ONE , vol.8
    • Hall, H.1    Jewett, M.2    Landeck, N.3    Nilsson, N.4    Schagerlöf, U.5    Leanza, G.6    Kirik, D.7
  • 23
    • 79960842310 scopus 로고    scopus 로고
    • Neuropathology underlying clinical variability in patients with synucleinopathies
    • Halliday G, Holton J, Revesz T, Dickson D (2011) Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol 122:187-204
    • (2011) Acta Neuropathol , vol.122 , pp. 187-204
    • Halliday, G.1    Holton, J.2    Revesz, T.3    Dickson, D.4
  • 25
    • 84878149242 scopus 로고    scopus 로고
    • A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP
    • Hansen C, Björklund T, Petit GH, Lundblad M, Murmu RP, Brundin P, Li J-Y (2013) A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP. Neurobiology of Disease. 56:145-155
    • (2013) Neurobiology of Disease , vol.56 , pp. 145-155
    • Hansen, C.1    Björklund, T.2    Petit, G.H.3    Lundblad, M.4    Murmu, R.P.5    Brundin, P.6    Li, J.-Y.7
  • 29
    • 33750367778 scopus 로고    scopus 로고
    • Subtypes of mild cognitive impairment in parkinson's disease: Progression to dementia
    • Janvin CC, Larsen JP, Aarsland D, Hugdahl K (2006) Subtypes of mild cognitive impairment in parkinson's disease: Progression to dementia. Mov Disord 21:1343-1349
    • (2006) Mov Disord , vol.21 , pp. 1343-1349
    • Janvin, C.C.1    Larsen, J.P.2    Aarsland, D.3    Hugdahl, K.4
  • 30
    • 36949031267 scopus 로고    scopus 로고
    • alpha-Synucleinopathy models and human neuropathology: Similarities and differences
    • Kahle PJ (2008) alpha-Synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol 115:87-95
    • (2008) Acta Neuropathol , vol.115 , pp. 87-95
    • Kahle, P.J.1
  • 32
    • 75949111774 scopus 로고    scopus 로고
    • Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy
    • Kao AW, Racine CA, Quitania LC, Kramer JH, Christine CW, Miller BL (2009) Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. Alzheimer Dis Assoc Disord 23(365-370):3. doi:10. 1097/WAD.1090b1013e3181b5065d
    • (2009) Alzheimer Dis Assoc Disord , vol.23 , Issue.365-370 , pp. 3
    • Kao, A.W.1    Racine, C.A.2    Quitania, L.C.3    Kramer, J.H.4    Christine, C.W.5    Miller, B.L.6
  • 33
    • 38349019621 scopus 로고    scopus 로고
    • Risk and protective haplotypes of the alpha-synuclein gene associated with Parkinson's disease differentially affect cognitive sequence learning
    • Kéri S, Nagy H, Myers CE, Benedek G, Shohamy D, Gluck MA (2008) Risk and protective haplotypes of the alpha-synuclein gene associated with Parkinson's disease differentially affect cognitive sequence learning. Genes Brain Behav 7:31-36
    • (2008) Genes Brain Behav , vol.7 , pp. 31-36
    • Kéri, S.1    Nagy, H.2    Myers, C.E.3    Benedek, G.4    Shohamy, D.5    Gluck, M.A.6
  • 36
    • 0036202813 scopus 로고    scopus 로고
    • Dopaminergic cell loss induced by human A30P a-synuclein gene transfer to the rat substantia nigra
    • Klein RL, King MA, Hamby ME, Meyer EM (2002) Dopaminergic cell loss induced by human A30P a-synuclein gene transfer to the rat substantia nigra. Hum Gene Ther 13:605-612
    • (2002) Hum Gene Ther , vol.13 , pp. 605-612
    • Klein, R.L.1    King, M.A.2    Hamby, M.E.3    Meyer, E.M.4
  • 37
  • 39
    • 77952478217 scopus 로고    scopus 로고
    • Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated Î ±-synuclein gene mutations precede central nervous system changes
    • Kuo Y-M, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL (2010) Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated Î ±-synuclein gene mutations precede central nervous system changes. Hum Mol Genet 19:1633-1650
    • (2010) Hum Mol Genet , vol.19 , pp. 1633-1650
    • Kuo, Y.-M.1    Li, Z.2    Jiao, Y.3    Gaborit, N.4    Pani, A.K.5    Orrison, B.M.6    Bruneau, B.G.7    Giasson, B.I.8    Smeyne, R.J.9    Gershon, M.D.10    Nussbaum, R.L.11
  • 41
    • 73849152772 scopus 로고    scopus 로고
    • Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice
    • Li B, Arime Y, Hall FS, Uhl GR, Sora I (2010) Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice. Eur J Pharmacol 628:104-107
    • (2010) Eur J Pharmacol , vol.628 , pp. 104-107
    • Li, B.1    Arime, Y.2    Hall, F.S.3    Uhl, G.R.4    Sora, I.5
  • 42
    • 79960069979 scopus 로고    scopus 로고
    • α-syn suppression reverses synaptic and memory defects in a mouse model of dementia with lewy bodies
    • Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, Lee VMY (2011) α-syn suppression reverses synaptic and memory defects in a mouse model of dementia with lewy bodies. J Neurosci 31:10076-10087
    • (2011) J Neurosci , vol.31 , pp. 10076-10087
    • Lim, Y.1    Kehm, V.M.2    Lee, E.B.3    Soper, J.H.4    Li, C.5    Trojanowski, J.Q.6    Lee, V.M.Y.7
  • 44
    • 0036679197 scopus 로고    scopus 로고
    • α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
    • Lo Bianco C, Ridet JL, Schneider BL, Déglon N, Aebischer P (2002) α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci 99:10813-10818
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 10813-10818
    • Lo Bianco, C.1    Ridet, J.L.2    Schneider, B.L.3    Déglon, N.4    Aebischer, P.5
  • 45
    • 77957245642 scopus 로고    scopus 로고
    • Genetic mouse models of Parkinson's disease: The state of the art
    • (Elsevier, Chapter 4)
    • Magen I, Chesselet M-F (2010) Genetic mouse models of Parkinson's disease: the state of the art. Prog Brain Res 184:53-87 (Elsevier, Chapter 4)
    • (2010) Prog Brain Res , vol.184 , pp. 53-87
    • Magen, I.1    Chesselet, M.-F.2
  • 46
    • 84858173709 scopus 로고    scopus 로고
    • Mouse models of cognitive deficits due to alpha-synuclein pathology
    • Magen I, Chesselet M-F (2011) Mouse models of cognitive deficits due to alpha-synuclein pathology. J Parkinson's Dis 1:217-227
    • (2011) J Parkinson's Dis , vol.1 , pp. 217-227
    • Magen, I.1    Chesselet, M.-F.2
  • 48
    • 33747441863 scopus 로고    scopus 로고
    • Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression
    • Maingay M, Romero-Ramos M, Carta M, Kirik D (2006) Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression. Neurobiol Dis 23:522-532
    • (2006) Neurobiol Dis , vol.23 , pp. 522-532
    • Maingay, M.1    Romero-Ramos, M.2    Carta, M.3    Kirik, D.4
  • 49
    • 84893769413 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice
    • Martin LJ, Semenkow S, Hanaford A, Wong M (2014) The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice. Neurobiol Aging 35:1132-1152
    • (2014) Neurobiol Aging , vol.35 , pp. 1132-1152
    • Martin, L.J.1    Semenkow, S.2    Hanaford, A.3    Wong, M.4
  • 51
    • 0035834076 scopus 로고    scopus 로고
    • β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    • Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L (2001) β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci 98:12245-12250
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 12245-12250
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Sagara, Y.4    Mallory, M.5    Hashimoto, M.6    Mucke, L.7
  • 54
    • 84899949452 scopus 로고    scopus 로고
    • Clinical presentation and differential diagnosis of dementia with Lewy bodies: A review
    • n/a-n/a
    • Morra LF, Donovick PJ (2013) Clinical presentation and differential diagnosis of dementia with Lewy bodies: a review. Int J Geriatr Psychiatry n/a-n/a
    • (2013) Int J Geriatr Psychiatry
    • Morra, L.F.1    Donovick, P.J.2
  • 57
    • 84875638056 scopus 로고    scopus 로고
    • Age-dependent effects of A53T alphasynuclein on behavior and dopaminergic function
    • Oaks AW, Frankfurt M, Finkelstein DI, Sidhu A (2013) Age-dependent effects of A53T alphasynuclein on behavior and dopaminergic function. PLoS ONE 8:e60378
    • (2013) PLoS ONE , vol.8
    • Oaks, A.W.1    Frankfurt, M.2    Finkelstein, D.I.3    Sidhu, A.4
  • 59
    • 84860806544 scopus 로고    scopus 로고
    • Cognitive impairment and dementia in Parkinson's disease
    • Pagonabarraga J, Kulisevsky J (2012) Cognitive impairment and dementia in Parkinson's disease. Neurobiol Dis 46:590-596
    • (2012) Neurobiol Dis , vol.46 , pp. 590-596
    • Pagonabarraga, J.1    Kulisevsky, J.2
  • 68
    • 2642553802 scopus 로고    scopus 로고
    • Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of γ-synuclein, α-synuclein and double α/γ-synuclein null mutant mice
    • Robertson DC, Schmidt O, Ninkina N, Jones PA, Sharkey J, Buchman VL (2004) Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of γ-synuclein, α-synuclein and double α/γ-synuclein null mutant mice. J Neurochem 89:1126-1136
    • (2004) J Neurochem , vol.89 , pp. 1126-1136
    • Robertson, D.C.1    Schmidt, O.2    Ninkina, N.3    Jones, P.A.4    Sharkey, J.5    Buchman, V.L.6
  • 69
    • 0036605566 scopus 로고    scopus 로고
    • Differential neuropathological alterations in transgenic mice expressing α-synuclein from the platelet-derived growth factor and Thy-1 promoters
    • Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, Masliah E (2002) Differential neuropathological alterations in transgenic mice expressing α-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 68:568-578
    • (2002) J Neurosci Res , vol.68 , pp. 568-578
    • Rockenstein, E.1    Mallory, M.2    Hashimoto, M.3    Song, D.4    Shults, C.W.5    Lang, I.6    Masliah, E.7
  • 72
    • 84880232532 scopus 로고    scopus 로고
    • Neuronal Expression of Familial Parkinson's Disease A53T α-Synuclein Causes Early Motor Impairment, Reduced Anxiety and Potential Sleep Disturbances in Mice
    • Rothman SM, Griffioen KJ, Vranis N, Ladenheim B, Cong W-N, Cadet J-L, Haran J, Martin B, Mattson MP (2013) Neuronal Expression of Familial Parkinson's Disease A53T α-Synuclein Causes Early Motor Impairment, Reduced Anxiety and Potential Sleep Disturbances in Mice. J Parkinson's Dis 3:215-229
    • (2013) J Parkinson's Dis , vol.3 , pp. 215-229
    • Rothman, S.M.1    Griffioen, K.J.2    Vranis, N.3    Ladenheim, B.4    Cong, W.-N.5    Cadet, J.-L.6    Haran, J.7    Martin, B.8    Mattson, M.P.9
  • 74
    • 64649106275 scopus 로고    scopus 로고
    • Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice
    • Schell H, Hasegawa T, Neumann M, Kahle PJ (2009) Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice. Neuroscience 160:796-804
    • (2009) Neuroscience , vol.160 , pp. 796-804
    • Schell, H.1    Hasegawa, T.2    Neumann, M.3    Kahle, P.J.4
  • 75
    • 84870261823 scopus 로고    scopus 로고
    • Impaired c-fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic mice
    • Schell H, Boden C, Chagas AM, Kahle PJ (2012) Impaired c-fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic mice. PLoS ONE 7:e50245
    • (2012) PLoS ONE , vol.7
    • Schell, H.1    Boden, C.2    Chagas, A.M.3    Kahle, P.J.4
  • 76
    • 40549093026 scopus 로고    scopus 로고
    • Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
    • Senior SL, Ninkina N, Deacon R, Bannerman D, Buchman VL, Cragg SJ, Wade-Martins R (2008) Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur J Neurosci 27:947-957
    • (2008) Eur J Neurosci , vol.27 , pp. 947-957
    • Senior, S.L.1    Ninkina, N.2    Deacon, R.3    Bannerman, D.4    Buchman, V.L.5    Cragg, S.J.6    Wade-Martins, R.7
  • 77
    • 11444261071 scopus 로고    scopus 로고
    • Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of α-synuclein
    • Siegmund A, Langnaese K, Wotjak CT (2005) Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of α-synuclein. Behav Brain Res 157:291-298
    • (2005) Behav Brain Res , vol.157 , pp. 291-298
    • Siegmund, A.1    Langnaese, K.2    Wotjak, C.T.3
  • 79
    • 80054116713 scopus 로고    scopus 로고
    • Initial neuropsychological impairments in patients with the E46 K mutation of the α-synuclein gene (PARK 1)
    • Somme JH, Gomez-Esteban JC, Molano A, Tijero B, Lezcano E, Zarranz JJ (2011) Initial neuropsychological impairments in patients with the E46 K mutation of the α-synuclein gene (PARK 1). J Neurol Sci 310:86-89
    • (2011) J Neurol Sci , vol.310 , pp. 86-89
    • Somme, J.H.1    Gomez-Esteban, J.C.2    Molano, A.3    Tijero, B.4    Lezcano, E.5    Zarranz, J.J.6
  • 80
    • 2642552972 scopus 로고    scopus 로고
    • Deletion of multimerin-1 in α-synuclein-deficient mice
    • Specht CG, Schoepfer R (2004) Deletion of multimerin-1 in α-synuclein-deficient mice. Genomics 83:1176-1178
    • (2004) Genomics , vol.83 , pp. 1176-1178
    • Specht, C.G.1    Schoepfer, R.2
  • 81
    • 0032568534 scopus 로고    scopus 로고
    • α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci 95:6469-6473
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 82
    • 0035097503 scopus 로고    scopus 로고
    • Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation
    • Spira PJ, Sharpe DM, Halliday G, Cavanagh J, Nicholson GA (2001) Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation. Ann Neurol 49:313-319
    • (2001) Ann Neurol , vol.49 , pp. 313-319
    • Spira, P.J.1    Sharpe, D.M.2    Halliday, G.3    Cavanagh, J.4    Nicholson, G.A.5
  • 84
    • 80054111618 scopus 로고    scopus 로고
    • Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice
    • Szegő ÉM, Gerhardt E, Outeiro TF, Kermer P (2011) Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice. J Neurol Sci 310:90-95
    • (2011) J Neurol Sci , vol.310 , pp. 90-95
    • Szegő, É.M.1    Gerhardt, E.2    Outeiro, T.F.3    Kermer, P.4
  • 89
    • 38849094086 scopus 로고    scopus 로고
    • Dopamine receptor agonists reverse behavioral abnormalities of α-synuclein transgenic mouse, a new model of Parkinson's disease
    • Wakamatsu M, Iwata S, Funakoshi T, Yoshimoto M (2008b) Dopamine receptor agonists reverse behavioral abnormalities of α-synuclein transgenic mouse, a new model of Parkinson's disease. J Neurosci Res 86:640-646
    • (2008) J Neurosci Res , vol.86 , pp. 640-646
    • Wakamatsu, M.1    Iwata, S.2    Funakoshi, T.3    Yoshimoto, M.4
  • 90
    • 77950809857 scopus 로고    scopus 로고
    • Profile of cognitive impairment in Parkinson's disease
    • Watson GS, Leverenz JB (2010) Profile of cognitive impairment in Parkinson's disease. Brain Pathol 20:640-645
    • (2010) Brain Pathol , vol.20 , pp. 640-645
    • Watson, G.S.1    Leverenz, J.B.2
  • 93
    • 5444249974 scopus 로고    scopus 로고
    • Overexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase-9: Resemblance to pathogenetic changes in Parkinson's disease
    • Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H (2004) Overexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease. J Neurochem 91:451-461
    • (2004) J Neurochem , vol.91 , pp. 451-461
    • Yamada, M.1    Iwatsubo, T.2    Mizuno, Y.3    Mochizuki, H.4
  • 94
    • 26444445118 scopus 로고    scopus 로고
    • Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the α-synuclein gene
    • Yamaguchi K, Cochran E, Murrell J, Polymeropoulos M, Shannon K, Crowther RA, Goedert M, Ghetti B (2005) Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the α-synuclein gene. Acta Neuropathol 110:298-305
    • (2005) Acta Neuropathol , vol.110 , pp. 298-305
    • Yamaguchi, K.1    Cochran, E.2    Murrell, J.3    Polymeropoulos, M.4    Shannon, K.5    Crowther, R.A.6    Goedert, M.7    Ghetti, B.8
  • 97
    • 70349958198 scopus 로고    scopus 로고
    • Ginsenoside Rh2 Ameliorates Scopolamine-Induced Learning Deficit in Mice
    • Yang J-H, Han S-J, Ryu JH, Jang I-S, Kim D-H (2009) Ginsenoside Rh2 Ameliorates Scopolamine-Induced Learning Deficit in Mice. Biol Pharm Bull 32:1710-1715
    • (2009) Biol Pharm Bull , vol.32 , pp. 1710-1715
    • Yang, J.-H.1    Han, S.-J.2    Ryu, J.H.3    Jang, I.-S.4    Kim, D.-H.5
  • 98
    • 84882681039 scopus 로고    scopus 로고
    • Mild cognitive impairment in Parkinson's disease
    • Yarnall AJ, Rochester L, Burn DJ (2013) Mild cognitive impairment in Parkinson's disease. Age Ageing 42:567-576
    • (2013) Age Ageing , vol.42 , pp. 567-576
    • Yarnall, A.J.1    Rochester, L.2    Burn, D.J.3
  • 99
    • 44349123056 scopus 로고    scopus 로고
    • Transgenic mice overexpressing tyrosine-to-cysteine mutant human α-synuclein: A progressive nurodegenerative model of diffuse Lewy body disease
    • Zhou W, Milder JB, Freed CR (2008) Transgenic mice overexpressing tyrosine-to-cysteine mutant human α-synuclein: a progressive nurodegenerative model of diffuse Lewy body disease. J Biol Chem 283:9863-9870
    • (2008) J Biol Chem , vol.283 , pp. 9863-9870
    • Zhou, W.1    Milder, J.B.2    Freed, C.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.