α-Synuclein knockout mice have cognitive impairments

Behavioural Brain Research

Volumn 231, Issue 1, 2012, Pages 226-230

  Kokhan, V S ^a   Afanasyeva, M A ^a   Van'kin, G I ^a  

^a INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

Author keywords

Synuclein; Knockout mice; Learning; Memory

Indexed keywords

ALPHA SYNUCLEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; EXPERIMENTAL TEST; KNOCKOUT MOUSE; LEARNING; LONG TERM MEMORY; MALE; MAZE TEST; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; SPATIAL MEMORY; WORKING MEMORY;

ALPHA-SYNUCLEIN; ANIMALS; AVOIDANCE LEARNING; BRAIN; COGNITION; MAZE LEARNING; MICE; MICE, KNOCKOUT; NEURONS;

EID: 84859905739     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.03.026     Document Type: Article

References (42)

1. Aarsland D., Bronnick K., Williams-Gray C., Weintraub D., Marder K., Kulisevsky J., et al. Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. Neurology 2010, 75:1062-1069.
2. Abeliovich A., Schmitz Y., Farinas I., Choi-Lundberg D., Ho W.H., Castillo P.E., et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 2000, 25:239-252.
3. Al-Wandi A., Ninkina N., Millership S., Williamson S.J., Jones P.A., Buchman V.L. Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiology of Aging 2010, 31:796-804.
4. Amrein I., Lipp H.P. Adult hippocampal neurogenesis of mammals: evolution and life history. Biology Letters 2009, 5:141-144.
5. Blumenfeld-Katzir T., Pasternak O., Dagan M., Assaf Y. Diffusion MRI of structural brain plasticity induced by a learning and memory task. PLoS One 2011, 6:e20678.
6. Bonaventure P., Aluisio L., Shoblock J., Boggs J.D., Fraser I.C., Lord B., et al. Pharmacological blockade of serotonin 5-HT receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission. PLoS One 2011, 6:e20210.
7. Brown R.G., Lacomblez L., Landwehrmeyer B.G., Bak T., Uttner I., Dubois B., et al. Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain: A Journal of Neurology 2010, 133:2382-2393.
8. Buccafusco J.J. Methods of Behavioral Analysis in Neuroscience 2009, CRC Press, Boca Raton. 2nd ed.
9. Chen P.E., Specht C.G., Morris R.G., Schoepfer R. Spatial learning is unimpaired in mice containing a deletion of the alpha-synuclein locus. The European Journal of Neuroscience 2002, 16:154-158.
10. Cheng F., Vivacqua G., Yu S. The role of alpha-synuclein in neurotransmission and synaptic plasticity. Journal of Chemical Neuroanatomy 2010, 42:242-248.
11. Cheng F., Vivacqua G., Yu S. The role of alpha-synuclein in neurotransmission and synaptic plasticity. Journal of Chemical Neuroanatomy 2011, 42:242-248.
12. Clayton D.F., George J.M. Synucleins in synaptic plasticity and neurodegenerative disorders. Journal of Neuroscience Research 1999, 58:120-129.
13. Cools R. Dopaminergic control of the striatum for high-level cognition. Current Opinion in Neurobiology 2011, 21:402-407.
14. Dityatev A., El-Husseini A. Molecular Mechanisms of Synaptogenesis 2006, Springer, New York, NY.
15. Dossena S., Imeri L., Mangieri M., Garofoli A., Ferrari L., Senatore A., et al. Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model. Neuron 2008, 60:598-609.
16. Elrod K., Buccafusco J.J. An evaluation of the mechanism of scopolamine-induced impairment in two passive avoidance protocols. Pharmacology, Biochemistry, and Behavior 1988, 29:15-21.
17. Getova D.P., Doncheva N.D. Effects of ketamine on memory and nociception in rats. Folia Medica 2011, 53:53-59.
18. Green R.J., Stanton M.E. Differential ontogeny of working memory and reference memory in the rat. Behavioral Neuroscience 1989, 103:98-105.
19. Gureviciene I., Gurevicius K., Tanila H. Role of alpha-synuclein in synaptic glutamate release. Neurobiology of Disease 2007, 28:83-89.
20. Hacioglu G., Agar A., Ozkaya G., Yargicoglu P., Gumuslu S. The effect of different hypertension models on active avoidance learning. Brain and Cognition 2003, 52:216-222.
21. Katonai R.E., Szekely A., Sasvari-Szekely M. Effect of dopaminergic and serotonergic gene variants on cognitive performance. Official Journal of the Hungarian Association of Psychopharmacology 2011, 13:81-86.
22. Klinkenberg I., Blokland A. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neuroscience and Biobehavioral Reviews 2010, 34:1307-1350.
23. Lavedan C. The synuclein family. Genome Research 1998, 8:871-880.
24. Mahowald M.W., Bornemann M.A., Schenck C.H. When and where do synucleinopathies begin. Neurology 2010, 75:488-489.
25. Matzel L.D., Babiarz J., Townsend D.A., Grossman H.C., Grumet M. Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity. Genes, Brain, and Behavior 2008, 7:470-480.
26. Molodtsova G.F. Metabolism and receptor binding of serotonin in brain structures during performance of a conditioned passive avoidance response. Neuroscience and Behavioral Physiology 2005, 35:685-692.
27. Netzer W.J., Powell C., Nong Y., Blundell J., Wong L., Duff K., et al. Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. PLoS One 2010, 5:e10943.
28. Norris E.H., Giasson B.I., Lee V.M. Alpha-synuclein: normal function and role in neurodegenerative diseases. Current Topics in Developmental Biology 2004, 60:17-54.
29. Oaks A.W., Sidhu A. Synuclein modulation of monoamine transporters. FEBS Letters 2011, 585:1001-1006.
30. Pelkonen A., Yavich L. Neuromuscular pathology in mice lacking alpha-synuclein. Neuroscience Letters 2011, 487:350-353.
31. Pena-Oliver Y., Buchman V.L., Stephens D.N. Lack of involvement of alpha-synuclein in unconditioned anxiety in mice. Behavioural Brain Research 2010, 209:234-240.
32. Robertson D.C., Schmidt O., Ninkina N., Jones P.A., Sharkey J., Buchman V.L. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. Journal of Neurochemistry 2004, 89:1126-1136.
33. Robinson O.J., Cools R., Crockett M.J., Sahakian B.J. Mood state moderates the role of serotonin in cognitive biases. Journal of Psychopharmacology (Oxford, England) 2010, 24:573-583.
34. Senior S.L., Ninkina N., Deacon R., Bannerman D., Buchman V.L., Cragg S.J., et al. Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. The European Journal of Neuroscience 2008, 27:947-957.
35. Shors T.J., Miesegaes G., Beylin A., Zhao M., Rydel T., Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature 2001, 410:372-376.
36. Sidhu A., Wersinger C., Moussa C.E., Vernier P. The role of alpha-synuclein in both neuroprotection and neurodegeneration. Annals of the New York Academy of Sciences 2004, 1035:250-270.
37. Simon A.M., Schiapparelli L., Salazar-Colocho P., Cuadrado-Tejedor M., Escribano L., Lopez de Maturana R., et al. Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels. Neurobiology of Disease 2009, 33:369-378.
38. Souza J.M., Giasson B.I., Lee V.M., Ischiropoulos H. Chaperone-like activity of synucleins. FEBS Letters 2000, 474:116-119.
39. Specht C.G., Schoepfer R. Deletion of multimerin-1 in alpha-synuclein-deficient mice. Genomics 2004, 83:1176-1178.
40. Varanese S., Perfetti B., Ghilardi M.F., Di Rocco A. Apathy, but not depression, reflects inefficient cognitive strategies in Parkinson's disease. PLoS One 2011, 6:e17846.
41. Vignisse J., Steinbusch H.W., Bolkunov A., Nunes J., Santos A.I., Grandfils C., et al. Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2011, 35:510-522.
42. Yu J., Warnke J., Lyubchenko Y.L. Nanoprobing of alpha-synuclein misfolding and aggregation with atomic force microscopy. Nanomedicine: Nanotechnology, Biology, and Medicine 2011, 7:146-152.