Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84

Journal of Biochemistry

Volumn 157, Issue 5, 2015, Pages 311-320

  Nikaido, Yoshiaki ^a   Koyama, Yuuta ^a   Yoshikawa, Yasushi ^b   Furuya, Toshio ^b   Takeda, Shigeki ^a  

^a GUNMA UNIVERSITY   (Japan)

^b PharmaDesign Inc   (Japan)

Author keywords

diindolylmethane; free fatty acid receptor; G protein coupled receptor; G protein coupled receptor G fusion proteins; positive allosteric modulator

Indexed keywords

3,3' DIINDOLYLMETHANE; BETA 2 ADRENERGIC RECEPTOR; DECANOIC ACID; DECYLAMINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 84; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MEMBRANE PROTEIN; TRANSMEMBRANE HELIX III; TRANSMEMBRANE HELIX IV; TRANSMEMBRANE HELIX V; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; GPR84 PROTEIN, HUMAN; LIGAND; PROTEIN BINDING;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GTPGAMMAS BINDING ASSAY; HUMAN; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; MUTATION; SITE DIRECTED MUTAGENESIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM;

ALLOSTERIC REGULATION; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MUTATION; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

EID: 84941115304     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvu075     Document Type: Article

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