Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 35, 2015, Pages 7731-7742

  Li, Yan ^a,c   Zhang, Li Ping ^b   Dai, Fang ^a   Yan, Wen Jing ^a   Wang, Hai Bo ^a   Tu, Zhi Shan ^a   Zhou, Bo ^a  

^a LANZHOU UNIVERSITY   (China)

^b GANSU PROVINCIAL HOSPITAL   (China)

^c SHAOXING UNIVERSITY   (China)

Author keywords

cell cycle; curcumin; reactive oxygen species; redox modulation; thioredoxin reductase

Indexed keywords

CYTOLOGY; CYTOTOXICITY; ENZYME ACTIVITY;

CELL CYCLE; CURCUMIN; CYTOTOXIC MECHANISMS; DESTABILIZING EFFECT; G2/M CELL CYCLE ARREST; INHIBITORY ACTIVITY; REACTIVE OXYGEN SPECIES; THIOREDOXIN REDUCTASE;

CELLS;

ANTINEOPLASTIC AGENT; CDKN1A PROTEIN, HUMAN; CURCUMIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TP53 PROTEIN, HUMAN;

ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; G2 PHASE CELL CYCLE CHECKPOINT; GENETICS; HUMAN; LUNG NEOPLASMS; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CURCUMIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; LUNG NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84941093823     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b02011     Document Type: Article

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