KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue

ACS Medicinal Chemistry Letters

Volumn 1, Issue 6, 2010, Pages 273-276

  Yamakoshi, Hiroyuki ^a   Kanoh, Naoki ^a   Kudo, Chieko ^a   Sato, Atsuko ^a   Ueda, Kazunori ^a   Muroi, Makoto ^b   Kon, Shunsuke ^a   Satake, Masanobu ^a   Ohori, Hisatsugu ^a   Ishioka, Chikashi ^a   Oshima, Yoshiteru ^a   Osada, Hiroyuki ^b   Chiba, Natsuko ^a   Shibata, Hiroyuki ^c   Iwabuchi, Yoshiharu ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c AKITA UNIVERSITY HOSPITAL   (Japan)

Author keywords

anticancer; bis(arylmethylidene) acetone; c Myc; curcumin analogue; KSRP FUBP2; target protein

Indexed keywords

ANTINEOPLASTIC AGENT; BINDING PROTEIN; CURCUMIN; GO Y 030; GO Y 086; GO Y 088; KH TYPE SPLICING REGULATORY PROTEIN; MYC PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN HEK293; CYTOTOXICITY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TARGETING; WESTERN BLOTTING;

EID: 77956537089     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml1000454     Document Type: Article

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22. Curcumin and its analogues including bis(arylmethylidene)acetones are considered multitarget compounds that exhibit various biological activities. Accordingly, KSRP/FUBP2 is assumed to be one of the targets of cytotoxic bis(arylmethylidene)acetones. Thus, we also intend to explore other targets of bis(arylmethylidene)acetones by other approaches. These efforts are now underway.