Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells

Apoptosis

Volumn 19, Issue 12, 2014, Pages 1691-1701

  Khadija, Syeda ^a,b   Veluthakal, Rajakrishnan ^a,b   Sidarala, Vaibhav ^a,b   Kowluru, Anjaneyulu ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Caspase 3; Caspase 6; Diabetes; Glucotoxicity; Lamin A; Pancreatic islet

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 6; GLUCOSE; LAMIN A; CASPASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEGRADATION; GLUCOSE BLOOD LEVEL; GLUCOTOXICITY; HUMAN; HUMAN CELL; INS 1 CELL LINE; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; ZUCKER DIABETIC FATTY RAT; ANIMAL; CELL CULTURE; CELL SURVIVAL; METABOLISM; PANCREAS ISLET; PROTEIN DEGRADATION; SPRAGUE DAWLEY RAT; ZUCKER RAT;

ANIMALS; CASPASE 3; CASPASE 6; CASPASE INHIBITORS; CELL SURVIVAL; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LAMIN TYPE A; MALE; PROTEOLYSIS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER;

EID: 84941053233     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-1038-4     Document Type: Article

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