Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: Protection by nifedipine

Biochemical Pharmacology

Volumn 86, Issue 9, 2013, Pages 1338-1346

  Syeda, Khadija ^a   Mohammed, Abiy M ^a   Arora, Daleep K ^a   Kowluru, Anjaneyulu ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Caspase 3; Glucotoxicity; Nifedipine; Nuclear lamin B; Pancreatic islet cell

Indexed keywords

4 PHENYL BUTYRIC ACID; BUTYRIC ACID; CASPASE 3; GLUCOSE; LAMIN B; NIFEDIPINE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FRACTIONATION; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INTRACELLULAR SPACE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

4-PHENYLBUTYRIC ACID; C/EBP HOMOLOGOUS PROTEIN; CASPASE 3; CHOP; ENDOPLASMIC RETICULUM; ER; FARNESYL TRANSFERASE; FARNESYL TRANSFERASE INHIBITOR; FTASE; FTI; GLUCOTOXICITY; NIF; NIFEDIPINE; NUCLEAR LAMIN B; PANCREATIC ISLET Β-CELL; PBA; TG; THAPSIGARGIN;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CASPASE 3; CELLS, CULTURED; CYTOSOL; ENDOPLASMIC RETICULUM STRESS; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; LAMIN TYPE B; MALE; NIFEDIPINE; PHENYLBUTYRATES; RATS; RATS, SPRAGUE-DAWLEY; THAPSIGARGIN; TRANSCRIPTION FACTOR CHOP;

EID: 84886721856     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.023     Document Type: Article

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