The novel metabotropic glutamate receptor 2 positive allosteric modulator, AZD8529, decreases nicotine self-administration and relapse in squirrel monkeys

Biological Psychiatry

Volumn 78, Issue 7, 2015, Pages 452-462

  Justinova, Zuzana ^a   Panlilio, Leigh V ^a   Secci, Maria E ^a   Redhi, Godfrey H ^a   Schindler, Charles W ^a   Cross, Alan J ^b   Mrzljak, Ladislav ^b   Medd, Amy ^b   Shaham, Yavin ^a   Goldberg, Steven R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Allosteric modulation; Glutamate; Nicotine; Relapse; Self administration; Smoking cessation

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; ADENOSINE A3 RECEPTOR; AZD 8529; DOPAMINE; DRUGS USED IN THE TREATMENT OF ADDICTION; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 6; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR 8; METABOTROPIC RECEPTOR AGONIST; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR AFFECTING AGENT; AZD8529; INDOLE DERIVATIVE; METABOTROPIC RECEPTOR; NICOTINE; NICOTINIC AGENT; OXADIAZOLE DERIVATIVE;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; BRAIN CORTEX; BRAIN SLICE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG BLOOD LEVEL; DRUG POTENTIATION; DRUG SELF ADMINISTRATION; DRUG WITHDRAWAL; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; MEDIAL PREFRONTAL CORTEX; MEMBRANE BINDING; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS SHELL; PRIORITY JOURNAL; RAT; RELAPSE; SQUIRREL MONKEY; TOBACCO DEPENDENCE; ANIMAL; BLOOD; BRAIN; CHO CELL LINE; CRICETULUS; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; DRUG SEEKING BEHAVIOR; FEEDING BEHAVIOR; GENETICS; HEK293 CELL LINE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TOBACCO USE DISORDER;

ANIMALS; BRAIN; CHO CELLS; CRICETULUS; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-SEEKING BEHAVIOR; EXCITATORY AMINO ACID AGENTS; FEEDING BEHAVIOR; HEK293 CELLS; HUMANS; INDOLES; MALE; NICOTINE; NICOTINIC AGONISTS; OXADIAZOLES; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SAIMIRI; SELF ADMINISTRATION; TOBACCO USE DISORDER;

EID: 84941026458     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.01.014     Document Type: Article

References (52)

1. U.S. Department of Health and Human Services How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General 2010 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health Atlanta, GA
2. I.P. Stolerman, and M.J. Jarvis The scientific case that nicotine is addictive Psychopharmacology (Berl) 117 1995 2 10 discussion 14-20
3. J.R. Hughes, E.N. Peters, and S. Naud Relapse to smoking after 1 year of abstinence: A meta-analysis Addict Behav 33 2008 1516 1520
4. D. Harmey, P.R. Griffin, and P.J. Kenny Development of novel pharmacotherapeutics for tobacco dependence: Progress and future directions Nicotine Tob Res 14 2012 1300 1318
5. J.E. Rose New findings on nicotine addiction and treatment Nebr Symp Motiv 55 2009 131 141
6. P.J. Kenny, and A. Markou The ups and downs of addiction: Role of metabotropic glutamate receptors Trends Pharmacol Sci 25 2004 265 272
7. M.E. Liechti, and A. Markou Role of the glutamatergic system in nicotine dependence: Implications for the discovery and development of new pharmacological smoking cessation therapies CNS Drugs 22 2008 705 724
8. D.D. Schoepp Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system J Pharmacol Exp Ther 299 2001 12 20
9. Z.X. Xi, D.A. Baker, H. Shen, D.S. Carson, and P.W. Kalivas Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens J Pharmacol Exp Ther 300 2002 162 171
10. Y. Tamaru, S. Nomura, N. Mizuno, and R. Shigemoto Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic sites Neuroscience 106 2001 481 503
11. J.A. Monn, M.J. Valli, S.M. Massey, M.M. Hansen, T.J. Kress, J.P. Wepsiec, and et al. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors J Med Chem 42 1999 1027 1040
12. M.A. Baptista, R. Martin-Fardon, and F. Weiss Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: Comparison between cocaine and a potent conventional reinforcer J Neurosci 24 2004 4723 4727
13. J.M. Bossert, S.Y. Liu, L. Lu, and Y. Shaham A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking J Neurosci 24 2004 10726 10730
14. J.M. Bossert, R.F. Busch, and S.M. Gray The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking Neuroreport 16 2005 1013 1016
15. J. Peters, and P.W. Kalivas The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats Psychopharmacology 186 2006 143 149
16. Z.A. Rodd, D.L. McKinzie, R.L. Bell, V.K. McQueen, J.M. Murphy, D.D. Schoepp, and et al. The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats Behav Brain Res 171 2006 207 215
17. L. Lu, J.L. Uejima, S.M. Gray, J.M. Bossert, and Y. Shaham Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving Biol Psychiatry 61 2007 591 598
18. P.R. Kufahl, L.R. Watterson, N.E. Nemirovsky, L.E. Hood, A. Villa, C. Halstengard, and et al. Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration Neuropharmacology 66 2013 290 301
19. A.S. Adewale, D.M. Platt, and R.D. Spealman Pharmacological stimulation of group II metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys J Pharmacol Exp Ther 318 2006 922 931
20. M.E. Liechti, L. Lhuillier, K. Kaupmann, and A. Markou Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence J Neurosci 27 2007 9077 9085
21. R.P. Dhanya, S. Sidique, D.J. Sheffler, H.H. Nickols, A. Herath, L. Yang, and et al. Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats J Med Chem 54 2011 342 353
22. P.J. Conn, C.W. Lindsley, and C.K. Jones Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia Trends Pharmacol Sci 30 2009 25 31
23. M.J. Marino, and P.J. Conn Glutamate-based therapeutic approaches: Allosteric modulators of metabotropic glutamate receptors Curr Opin Pharmacol 6 2006 98 102
24. D.J. Sheffler, A.B. Pinkerton, R. Dahl, A. Markou, and N.D. Cosford Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators ACS Chem Neurosci 2 2011 382 393
25. H. Schaffhauser, B.A. Rowe, S. Morales, L.E. Chavez-Noriega, R. Yin, C. Jachec, and et al. Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2 Mol Pharmacol 64 2003 798 810
26. R. Galici, C.K. Jones, K. Hemstapat, Y. Nong, N.G. Echemendia, L.C. Williams, and et al. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice J Pharmacol Exp Ther 318 2006 173 185
27. X. Jin, S. Semenova, L. Yang, R. Ardecky, D.J. Sheffler, R. Dahl, and et al. The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats Neuropsychopharmacology 35 2010 2021 2036
28. P. Mascia, M. Pistis, Z. Justinova, L.V. Panlilio, A. Luchicchi, S. Lecca, and et al. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors Biol Psychiatry 69 2011 633 641
29. L.V. Panlilio, Z. Justinova, P. Mascia, M. Pistis, A. Luchicchi, S. Lecca, and et al. Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: Preclinical findings Neuropsychopharmacology 37 2012 1838 1847
30. A.J. Cross AZD8529 - an mGluR2 positive allosteric modulator for the treatment of schizophrenia Neuropsychopharmacology 38 2013 S25
31. Y. Shaham, U. Shalev, L. Lu, H. De Wit, and J. Stewart The reinstatement model of drug relapse: History, methodology and major findings Psychopharmacology 168 2003 3 20
32. S.R. Goldberg Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey J Pharmacol Exp Ther 186 1973 18 30
33. P. Raboisson, A. Breitholtz-Emanuelsson, H. Dahllof, L. Edwards, W.L. Heaton, M. Isaac, and et al. Discovery and characterization of AZD9272 and AZD6538 - two novel mGluR5 negative allosteric modulators selected for clinical development Bioorg Med Chem Lett 22 2012 6974 6979
34. E. Rosemond, M. Wang, Y. Yao, L. Storjohann, T. Stormann, E.C. Johnson, and et al. Molecular basis for the differential agonist affinities of group III metabotropic glutamate receptors Mol Pharmacol 66 2004 834 842
35. C. Levinthal, L. Barkdull, P. Jacobsen, L. Storjihann, B.C. Van Wagenen, T.M. Stormann, and et al. Modulation of group III metabotropic glutamate receptors by hydrogen ions Pharmacology 83 2009 88 94
36. M. Solinas, M. Scherma, L. Fattore, J. Stroik, C. Wertheim, G. Tanda, and et al. Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse J Neurosci 27 2007 5615 5620
37. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 5th ed. 2005 Elsevier Academic Press Burlington, MA
38. D. Caprioli, M. Venniro, T. Zeric, X. Li, N.J. Marchant, S. Adhikary, and et al. Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence Biol Psychiatry 78 2015 463 473
39. R.A. Wise Neurobiology of addiction Curr Opin Neurobiol 6 1996 243 251
40. S.R. Goldberg Stimuli associated with drug injections as events that control behavior Pharmacol Rev 27 1976 325 340
41. A.R. Caggiula, E.C. Donny, A.R. White, N. Chaudhri, S. Booth, M.A. Gharib, and et al. Cue dependency of nicotine self-administration and smoking Pharmacol Biochem Behav 70 2001 515 530
42. N. Chaudhri, A.R. Caggiula, E.C. Donny, M.I. Palmatier, X. Liu, and A.F. Sved Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement Psychopharmacology (Berl) 184 2006 353 366
43. E.C. Donny, A.R. Caggiula, M.T. Weaver, M.E. Levin, and A.F. Sved The reinforcement-enhancing effects of nicotine: Implications for the relationship between smoking, eating and weight Physiol Behav 104 2011 143 148
44. H. de Wit, and J. Stewart Reinstatement of cocaine-reinforced responding in the rat Psychopharmacology 75 1981 134 143
45. S. Shiffman, J.A. Paty, M. Gnys, J.A. Kassel, and M. Hickcox First lapses to smoking: Within-subjects analysis of real-time reports J Consult Clin Psychol 64 1996 366 379
46. N. Herd, R. Borland, and A. Hyland Predictors of smoking relapse by duration of abstinence: Findings from the International Tobacco Control (ITC) Four Country Survey Addiction 104 2009 2088 2099
47. G. Bedi, K.L. Preston, D.H. Epstein, S.J. Heishman, G.F. Marrone, Y. Shaham, and et al. Incubation of cue-induced cigarette craving during abstinence in human smokers Biol Psychiatry 69 2011 708 711
48. D. Kandel, K. Chen, L.A. Warner, R.C. Kessler, and B. Grant Prevalence and demographic correlates of symptoms of last year dependence on alcohol, nicotine, marijuana and cocaine in the U.S. population Drug Alcohol Depend 44 1997 11 29
49. J. Istvan, and J.D. Matarazzo Tobacco, alcohol, and caffeine use: A review of their interrelationships Psychol Bull 95 1984 301 326
50. A. Agrawal, K.J. Verweij, N.A. Gillespie, A.C. Heath, C.N. Lessov-Schlaggar, N.G. Martin, and et al. The genetics of addiction - a translational perspective Transl Psychiatry 2 2012 e140
51. J.C. Anthony, L.A. Warner, and R.C. Kessler Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: Basic findings from the National Comorbidity Survey Drug Alcohol Depend 2 1994 244 268
52. Substance Abuse and Mental Health Services Administration Results from the 2012 National Survey on Drug Use and Health: Summary of National Findings Administration 2013 Substance Abuse and Mental Health Services Rockville, MD