Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: Preclinical findings

Neuropsychopharmacology

Volumn 37, Issue 8, 2012, Pages 1838-1847

  Panlilio, Leigh V ^a   Justinova, Zuzana ^a,b   Mascia, Paola ^a   Pistis, Marco ^c   Luchicchi, Antonio ^c   Lecca, Salvatore ^c   Barnes, Chanel ^a   Redhi, Godfrey H ^a   Adair, Jordan ^a,b   Heishman, Stephen J ^a   Yasar, Sevil ^d   Aliczki, Mano ^e   Haller, Jozsef ^e   Goldberg, Steven R ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

dopamine signaling; fibrate; nicotine; PPAR ; relapse; reward

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; CLOFIBRATE; DOPAMINE; NICOTINE;

ABSTINENCE; ANIMAL EXPERIMENT; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SELF ADMINISTRATION; FOOD INTAKE; INSTRUMENTAL CONDITIONING; MALE; NEUROCHEMISTRY; NEUROPROTECTION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REINFORCEMENT; REWARD; SIGNAL TRANSDUCTION; SMOKING CESSATION; SQUIRREL MONKEY;

ACTION POTENTIALS; ANIMALS; CLOFIBRATE; DISEASE MODELS, ANIMAL; DOPAMINE; DRUG EVALUATION, PRECLINICAL; HYPOLIPIDEMIC AGENTS; INDOLES; MALE; NEURONS; NICOTINE; NUCLEUS ACCUMBENS; PPAR ALPHA; RATS; RATS, SPRAGUE-DAWLEY; RECURRENCE; REWARD; SAIMIRI; SELF ADMINISTRATION; TOBACCO USE DISORDER; VENTRAL TEGMENTAL AREA;

EID: 84862319134     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.31     Document Type: Article

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