Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?

Trends in Immunology

Volumn 23, Issue 3, 2002, Pages 135-139

  Netea, Mihai G ^a   Van Deuren, Marcel ^a   Kullberg, Bart Jan ^a   Cavaillon, Jean Marc ^b   Van Der Meer, Jos W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; LIPID A; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; ESCHERICHIA COLI; IMMUNE SYSTEM; MOUSE; NONHUMAN; PORPHYROMONAS GINGIVALIS; PROTEIN EXPRESSION; REVIEW; RHODOBACTER SPHAEROIDES; SPECIES DIFFERENCE;

ANIMALS; CARBOHYDRATE CONFORMATION; CYTOKINES; DROSOPHILA PROTEINS; LIPID A; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MODELS, MOLECULAR; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 0036498687     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)02169-X     Document Type: Review

References (32)

1. Lipopolysaccharides of Gram-negative bacteria
2. Preparation of the specific polysaccharides of bacteria
3. Bacterial endotoxins: Chemical structure, biological activity and role in septicaemia
4. Lipid A, the endotoxic center of bacterial lipopolysaccharides: Relation of chemical structure to biological activity
5. Interleukin-1 induction by lipopolysaccharides: Structural requirements of the 3-deoxy-d-manno-2-octulosonic acid (KDO)
6. Lipopolysaccharide structure influences the macrophage response via CD14-independent and CD14-dependent pathways
7. Molecular requirement for interleukin-1 induction by lipopolysaccharide-stimulated human monocytes: Involvement of the heptosyl-2-keto 3-deoxyoctulosonate region
8. Cytokine induction by lipopolysaccharide (LPS) corresponds to the lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatum LPS
9. Signaling by Toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages
10. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo
11. Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways
12. Passive immunization against cachexin/tumor necrosis factor protects mice from lethal effect of endotoxin
13. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
14. Immune and inflammatory responses in TNF-α-deficient mice: A critical requirement for TNF-α in the formation of primary B-cell follicles, follicular dendritic-cell networks and germinal centers, and in the maturation of the humoral immune response
15. Lipopolysaccharide-induced cytokine cascade and lethality in lymphotoxin-α/tumor-necrosis-factor-α-deficient mice
16. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
17. Decreased sensitivity to tumour necrosis factor but normal T-cell development in TNF-receptor-2-deficient mice
18. Chemical structure, molecular conformation and bioactivity of endotoxins
19. Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion
20. The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity
21. Investigation into the fluidity of lipopolysaccharide and free lipid A membrane systems by Fourier-transform infrared spectroscopy and differential scanning calorimetry
22. Analysis of TLR4-mediated LPS signal transduction in macrophages by mutational modification of the receptor
23. Defective LPS signalling in C3H/HeJ and C57Bl/10ScCr mice: Mutations in TLR4 gene
24. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell-wall components
25. Extolling the diversity of bacterial endotoxins
26. Escherichia coli and Porphyromonas gingivalis lipopolysaccharide interactions with CD14: Implications for myeloid and nonmyeloid cell activation
27. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
28. Evidence of an accessory protein function for Toll-like receptor 1 in anti-bacterial responses
29. Toll-like receptor 4, but not Toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides
30. Structure and biosynthesis of lipid A of Escherichia coli
31. Structural characterization of the lipid A component of pathogenic Neisseria meningitidis
32. Nontoxic lipopolysaccharide from Rhodopseudomonas sphaeroides ATCC 17023