메뉴 건너뛰기




Volumn 11, Issue 9, 2015, Pages 536-544

Is early-life iron exposure critical in neurodegeneration?

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; IRON; LACTOFERRIN; TRANSFERRIN; TRANSFERRIN RECEPTOR 2;

EID: 84941022712     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2015.100     Document Type: Review
Times cited : (83)

References (147)
  • 1
    • 0035153971 scopus 로고    scopus 로고
    • Iron biology in immune function, muscle metabolism and neuronal functioning
    • Beard, J. L. Iron biology in immune function, muscle metabolism and neuronal functioning. J. Nutr. 131, 568S-579S (2001
    • (2001) J. Nutr , vol.131 , pp. 568S-579S
    • Beard, J.L.1
  • 2
    • 0030667658 scopus 로고    scopus 로고
    • The Lactobacillus anomaly: Total iron abstinence
    • Weinberg, E. D. The Lactobacillus anomaly: total iron abstinence. Perspect. Biol. Med. 40, 578-583 (1997
    • (1997) Perspect. Biol. Med , vol.40 , pp. 578-583
    • Weinberg, E.D.1
  • 3
    • 84875478975 scopus 로고    scopus 로고
    • A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen Borrelia burgdorferi
    • Aguirre, J. D. et al. A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi. J. Biol. Chem. 288, 8468-8478 (2013
    • (2013) J. Biol. Chem , vol.288 , pp. 8468-8478
    • Aguirre, J.D.1
  • 5
    • 0038670759 scopus 로고    scopus 로고
    • Iron deficiency alters brain development and functioning
    • Beard, J. Iron deficiency alters brain development and functioning. J. Nutr. 133, 1468S-1472S (2003
    • (2003) J. Nutr , vol.133 , pp. 1468S-1472S
    • Beard, J.1
  • 6
    • 59649126243 scopus 로고    scopus 로고
    • Iron supplementation of breastfed infants from an early age
    • Ziegler, E. E., Nelson, S. E. & Jeter, J. M. Iron supplementation of breastfed infants from an early age. Am. J. Clin. Nutr. 89, 525-532 (2009
    • (2009) Am. J. Clin. Nutr , vol.89 , pp. 525-532
    • Ziegler, E.E.1    Nelson, S.E.2    Jeter, J.M.3
  • 7
    • 33750841283 scopus 로고    scopus 로고
    • Iron deficiency and brain development
    • Lozoff, B. & Georgieff, M. K. Iron deficiency and brain development. Semin. Pediatr. Neurol. 13, 158-165 (2006
    • (2006) Semin. Pediatr. Neurol , vol.13 , pp. 158-165
    • Lozoff, B.1    Georgieff, M.K.2
  • 8
    • 77955494166 scopus 로고    scopus 로고
    • Iron deficiency anemia and cognitive function in infancy
    • Carter, R. C. et al. Iron deficiency anemia and cognitive function in infancy. Pediatrics 126, e427-e434 (2010
    • (2010) Pediatrics , vol.126 , pp. e427-e434
    • Carter, R.C.1
  • 9
    • 51849108672 scopus 로고    scopus 로고
    • World Health Organization World Health Organization Institutional Repository for Information Sharing [online]
    • World Health Organization. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. World Health Organization Institutional Repository for Information Sharing [online], http://whqlibdoc.who.int/publications/2008/9789241596657-eng.pdf (2008).
    • (2008) Worldwide Prevalence of Anaemia 1993-2005: WHO Global Database on Anaemia
  • 10
    • 34547652466 scopus 로고    scopus 로고
    • Nutritional iron deficiency
    • Zimmermann, M. B. & Hurrell, R. F. Nutritional iron deficiency. Lancet 370, 511-520 (2007
    • (2007) Lancet , vol.370 , pp. 511-520
    • Zimmermann, M.B.1    Hurrell, R.F.2
  • 11
    • 84881167995 scopus 로고    scopus 로고
    • World Health Organization World Health Organization Institutional Repository for Information Sharing [online].
    • Horta, B., Victora, C. & World Health Organization. Long-term effects of breastfeeding: A systematic review. World Health Organization Institutional Repository for Information Sharing [online]. http://apps.who.int/iris/bitstream/10665/79198/1/9789241505307-eng.pdf?ua=1 (2013
    • (2013) Long-term effects of breastfeeding: A systematic review
    • Horta, B.1    Victora, C.2
  • 12
    • 84865099731 scopus 로고    scopus 로고
    • Prevalence of breastfeeding in industrialized countries
    • Ibanez, G. et al. Prevalence of breastfeeding in industrialized countries. Rev. Epidemiol. Sante Publique 60, 305-320 (2012
    • (2012) Rev. Epidemiol. Sante Publique , vol.60 , pp. 305-320
    • Ibanez, G.1
  • 13
    • 2542430275 scopus 로고    scopus 로고
    • Factors influencing decision to breastfeed
    • Kong, S. K. & Lee, D. T. Factors influencing decision to breastfeed. J. Adv. Nurs. 46, 369-379 (2004
    • (2004) J. Adv. Nurs , vol.46 , pp. 369-379
    • Kong, S.K.1    Lee, D.T.2
  • 14
    • 84903867773 scopus 로고    scopus 로고
    • Historic records on the commercial production of infant formula
    • Obladen, M. Historic records on the commercial production of infant formula. Neonatology 106, 173-180 (2014
    • (2014) Neonatology , vol.106 , pp. 173-180
    • Obladen, M.1
  • 15
    • 84878874714 scopus 로고    scopus 로고
    • Non-compliance with the International Code of Marketing of Breast Milk Substitutes is not confined to the infant formula industry
    • Forsyth, S. Non-compliance with the International Code of Marketing of Breast Milk Substitutes is not confined to the infant formula industry. J. Public Health (Oxf.) 35, 185-190 (2013
    • (2013) J. Public Health (Oxf) , vol.35 , pp. 185-190
    • Forsyth, S.1
  • 16
    • 0033524117 scopus 로고    scopus 로고
    • Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: A randomised trial
    • Lucas, A. et al. Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: A randomised trial. Lancet 354, 1948-1954 (1999
    • (1999) Lancet , vol.354 , pp. 1948-1954
    • Lucas, A.1
  • 17
    • 0017829040 scopus 로고
    • Need for iron supplementation in infants on prolonged breast feeding
    • Saarinen, U. M. Need for iron supplementation in infants on prolonged breast feeding. J. Pediatr. 93, 177-180 (1978
    • (1978) J. Pediatr , vol.93 , pp. 177-180
    • Saarinen, U.M.1
  • 18
    • 0021367038 scopus 로고
    • Exclusive breast-feeding for 9 months: Risk of iron deficiency
    • Siimes, M. A., Salmenperä, L. & Perheentupa, J. Exclusive breast-feeding for 9 months: risk of iron deficiency. J. Pediatr. 104, 196-199 (1984
    • (1984) J. Pediatr , vol.104 , pp. 196-199
    • Siimes, M.A.1    Salmenperä, L.2    Perheentupa, J.3
  • 19
    • 0014444640 scopus 로고
    • Iron balance and requirements in infancy
    • Lowe, C. U. et al. Iron balance and requirements in infancy. Pediatrics 43, 134-142 (1969
    • (1969) Pediatrics , vol.43 , pp. 134-142
    • Lowe, C.U.1
  • 20
    • 0017139455 scopus 로고
    • Iron sufficiency in breast-fed infants and the availability of iron from human milk
    • McMillan, J. A., Landaw, S. A. & Oski, F. A. Iron sufficiency in breast-fed infants and the availability of iron from human milk. Pediatrics 58, 686-691 (1976
    • (1976) Pediatrics , vol.58 , pp. 686-691
    • McMillan, J.A.1    Landaw, S.A.2    Oski, F.A.3
  • 21
    • 0024817434 scopus 로고
    • American Academy of Pediatrics Committee on Nutrition: Iron-fortified infant formulas
    • [No authors listed] American Academy of Pediatrics Committee on Nutrition: Iron-fortified infant formulas. Pediatrics 84, 1114-1115 (1989
    • (1989) Pediatrics , vol.84 , pp. 1114-1115
  • 22
    • 0033020074 scopus 로고    scopus 로고
    • No authors listed Iron fortification of infant formulas American Academy of Pediatrics. Committee on Nutrition
    • [No authors listed] Iron fortification of infant formulas. American Academy of Pediatrics. Committee on Nutrition. Pediatrics 104, 119-123 (1999
    • (1999) Pediatrics , vol.104 , pp. 119-123
  • 23
    • 78049422747 scopus 로고    scopus 로고
    • Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age)
    • Committee on Nutrition American Academy of Pediatrics
    • Baker, R. D., Greer, F. R. & Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics 126, 1040-1050 (2010
    • (2010) Pediatrics , vol.126 , pp. 1040-1050
    • Baker, R.D.1    Greer, F.R.2
  • 24
    • 27644489939 scopus 로고    scopus 로고
    • Global standard for the composition of infant formula: Recommendations of an ESPGHAN coordinated international expert group
    • Koletzko, B. et al. Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group. J. Pediatr. Gastroenterol. Nutr. 41, 584-599 (2005
    • (2005) J. Pediatr. Gastroenterol. Nutr , vol.41 , pp. 584-599
    • Koletzko, B.1
  • 25
    • 84893692714 scopus 로고    scopus 로고
    • Iron requirements of infants and toddlers
    • Domellöf, M. et al. Iron requirements of infants and toddlers. J. Pediatr. Gastroenterol. Nutr. 58, 119-129 (2014
    • (2014) J. Pediatr. Gastroenterol. Nutr , vol.58 , pp. 119-129
    • Domellöf, M.1
  • 26
    • 77649339705 scopus 로고    scopus 로고
    • Upper levels of nutrients in infant formulas: Comparison of analytical data with the revised Codex infant formula standard
    • MacLean, W. C. Jr et al. Upper levels of nutrients in infant formulas: comparison of analytical data with the revised Codex infant formula standard. J. Food Comp. Anal. 23, 44-53 (2010
    • (2010) J. Food Comp. Anal , vol.23 , pp. 44-53
    • MacLean, W.C.1
  • 27
    • 0034146585 scopus 로고    scopus 로고
    • Clinical safety of iron-fortified formulas
    • Singhal, A. et al. Clinical safety of iron-fortified formulas. Pediatrics 105, E38 (2000
    • (2000) Pediatrics , vol.105 , pp. E38
    • Singhal, A.1
  • 28
    • 17444394519 scopus 로고    scopus 로고
    • Effect of iron supplementation on mental and motor development in children: Systematic review of randomised controlled trials
    • Sachdev, H., Gera, T. & Nestel, P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr. 8, 117-132 (2005
    • (2005) Public Health Nutr , vol.8 , pp. 117-132
    • Sachdev, H.1    Gera, T.2    Nestel, P.3
  • 29
    • 0344276474 scopus 로고    scopus 로고
    • A double-masked, randomized control trial of iron supplementation in early infancy in healthy term breast-fed infants
    • Friel, J. K. et al. A double-masked, randomized control trial of iron supplementation in early infancy in healthy term breast-fed infants. J. Pediatr. 143, 582-586 (2003
    • (2003) J. Pediatr , vol.143 , pp. 582-586
    • Friel, J.K.1
  • 30
    • 77957721818 scopus 로고    scopus 로고
    • Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants
    • Berglund, S., Westrup, B. & Domellöf, M. Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants. Pediatrics 126, e874-e883 (2010
    • (2010) Pediatrics , vol.126 , pp. e874-e883
    • Berglund, S.1    Westrup, B.2    Domellöf, M.3
  • 31
    • 84863229124 scopus 로고    scopus 로고
    • Iron-fortified vs low-iron infant formula: Developmental outcome at 10 years
    • Lozoff, B., Castillo, M., Clark, K. M. & Smith, J. B. Iron-fortified vs low-iron infant formula: developmental outcome at 10 years. Arch. Pediatr. Adolesc. Med. 166, 208-215 (2012
    • (2012) Arch. Pediatr. Adolesc. Med , vol.166 , pp. 208-215
    • Lozoff, B.1    Castillo, M.2    Clark, K.M.3    Smith, J.B.4
  • 32
    • 79953312856 scopus 로고    scopus 로고
    • Recommendations on iron questioned
    • Hernell, O. & Lönnerdal, B. Recommendations on iron questioned. Pediatrics 127, e1099-e1101 (2011
    • (2011) Pediatrics , vol.127 , pp. e1099-e1101
    • Hernell, O.1    Lönnerdal, B.2
  • 33
    • 79953298985 scopus 로고    scopus 로고
    • Exclusively breastfed infants: Iron recommendations are premature
    • Furman, L. M. Exclusively breastfed infants: iron recommendations are premature. Pediatrics 127, e1098-e1099 (2011
    • (2011) Pediatrics , vol.127 , pp. e1098-e1099
    • Furman, L.M.1
  • 34
    • 79953329183 scopus 로고    scopus 로고
    • Concerns with early universal iron supplementation of breastfeeding infants
    • AAP Section on Breastfeeding et al.
    • AAP Section on Breastfeeding et al. Concerns with early universal iron supplementation of breastfeeding infants. Pediatrics 127, e1097 (2011
    • (2011) Pediatrics , vol.127 , pp. e1097
  • 35
    • 6444228979 scopus 로고    scopus 로고
    • Multielemental distribution patterns in premature human milk whey and pre-term formula milk whey by size exclusion chromatography coupled to inductively coupled plasma mass spectrometry with octopole reaction cell
    • De La Flor St Remy, R. R., Sánchez, M. L., Sastre, J. B. & Sanz-Medel, A. Multielemental distribution patterns in premature human milk whey and pre-term formula milk whey by size exclusion chromatography coupled to inductively coupled plasma mass spectrometry with octopole reaction cell. J. Anal. At. Spectrom. 19, 1104-1110 (2004
    • (2004) J. Anal. At. Spectrom , vol.19 , pp. 1104-1110
    • De La Flor St Remy, R.R.1    Sánchez, M.L.2    Sastre, J.B.3    Sanz-Medel, A.4
  • 37
    • 84874618740 scopus 로고    scopus 로고
    • Bioactive proteins in breast milk
    • Lönnerdal, B. Bioactive proteins in breast milk. J. Paediatr. Child Health 49 (Suppl. 1), 1-7 (2013
    • (2013) J. Paediatr. Child Health , vol.49
    • Lönnerdal, B.1
  • 38
    • 84896887668 scopus 로고    scopus 로고
    • Infant formula and infant nutrition: Bioactive proteins of human milk and implications for composition of infant formulas
    • Lönnerdal, B. Infant formula and infant nutrition: bioactive proteins of human milk and implications for composition of infant formulas. Am. J. Clin. Nutr. 99, 712S-717S (2014
    • (2014) Am. J. Clin. Nutr , vol.99 , pp. 712S-717S
    • Lönnerdal, B.1
  • 39
    • 2642534875 scopus 로고    scopus 로고
    • Iron zinc, and copper concentrations in breast milk are independent of maternal mineral status
    • Domellöf, M., Lönnerdal, B., Dewey, K. G., Cohen, R. J. & Hernell, O. Iron, zinc, and copper concentrations in breast milk are independent of maternal mineral status. Am. J. Clin. Nutr. 79, 111-115 (2004
    • (2004) Am. J. Clin. Nutr , vol.79 , pp. 111-115
    • Domellöf, M.1    Lönnerdal, B.2    Dewey, K.G.3    Cohen, R.J.4    Hernell, O.5
  • 40
    • 84896855646 scopus 로고    scopus 로고
    • Longitudinal changes in lactoferrin concentrations in human milk: A global systematic review
    • Rai, D. et al. Longitudinal changes in lactoferrin concentrations in human milk: A global systematic review. Crit. Rev. Food Sci. Nutr. 54, 1539-1547 (2014
    • (2014) Crit. Rev. Food Sci. Nutr , vol.54 , pp. 1539-1547
    • Rai, D.1
  • 43
    • 0022508546 scopus 로고
    • Absorption of fortification iron from milk formulas in infants
    • Stekel, A. et al. Absorption of fortification iron from milk formulas in infants. Am. J. Clin. Nutr. 43, 917-922 (1986
    • (1986) Am. J. Clin. Nutr , vol.43 , pp. 917-922
    • Stekel, A.1
  • 44
    • 0031019037 scopus 로고    scopus 로고
    • Absorption of calcium, zinc, and iron from breast milk by five- to seven month old infants
    • Abrams, S. A., Wen, J. & Stuff, J. E. Absorption of calcium, zinc, and iron from breast milk by five- to seven month old infants. Pediatr. Res. 41, 384-390 (1997
    • (1997) Pediatr. Res , vol.41 , pp. 384-390
    • Abrams, S.A.1    Wen, J.2    Stuff, J.E.3
  • 45
    • 2942633772 scopus 로고    scopus 로고
    • The mortality risk of elevated serum transferrin saturation and consumption of dietary iron
    • Mainous, A. G. 3rd, Wells, B., Carek, P. J., Gill, J. M. & Geesey, M. E. The mortality risk of elevated serum transferrin saturation and consumption of dietary iron. Ann. Fam. Med. 2, 139-144 (2004
    • (2004) Ann. Fam. Med , vol.2 , pp. 139-144
    • Mainous, A.G.1    Wells, B.2    Carek, P.J.3    Gill, J.M.4    Geesey, M.E.5
  • 46
    • 84873933182 scopus 로고    scopus 로고
    • Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation
    • Acikyol, B. et al. Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation. Neuroscience 235, 119-128 (2013
    • (2013) Neuroscience , vol.235 , pp. 119-128
    • Acikyol, B.1
  • 47
    • 79955492902 scopus 로고    scopus 로고
    • HFE gene variants affect iron in the brain
    • Nandar, W. & Connor, J. R. HFE gene variants affect iron in the brain. J. Nutr. 141, 29S-739S (2011
    • (2011) J. Nutr , vol.141 , pp. 29S-739S
    • Nandar, W.1    Connor, J.R.2
  • 48
    • 0029959921 scopus 로고    scopus 로고
    • Neurobehavioral dysfunctions associated with dietary iron overload
    • Sobotka, T. J. et al. Neurobehavioral dysfunctions associated with dietary iron overload. Physiol. Behav. 59, 213-219 (1996)
    • (1996) Physiol. Behav , vol.59 , pp. 213-219
    • Sobotka, T.J.1
  • 50
    • 0342948905 scopus 로고    scopus 로고
    • Variations in dietary iron alter brain iron metabolism in developing rats
    • Piñero, D. J., Li, N. Q., Connor, J. R. & Beard, J. L. Variations in dietary iron alter brain iron metabolism in developing rats. J. Nutr. 130, 254-263 (2000
    • (2000) J. Nutr , vol.130 , pp. 254-263
    • Piñero, D.J.1    Li, N.Q.2    Connor, J.R.3    Beard, J.L.4
  • 51
    • 77952293098 scopus 로고    scopus 로고
    • mRNA expression of proteins involved in iron homeostasis in brain regions is altered by age and by iron overloading in the neonatal period
    • Dornelles, A. S. et al. mRNA expression of proteins involved in iron homeostasis in brain regions is altered by age and by iron overloading in the neonatal period. Neurochem. Res. 35, 564-571 (2010
    • (2010) Neurochem. Res , vol.35 , pp. 564-571
    • Dornelles, A.S.1
  • 52
    • 79958107465 scopus 로고    scopus 로고
    • Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats
    • Miwa, C. P. et al. Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats. Neurotox. Res. 19, 527-535 (2011
    • (2011) Neurotox. Res , vol.19 , pp. 527-535
    • Miwa, C.P.1
  • 53
    • 80052639339 scopus 로고    scopus 로고
    • Early post-natal iron administration induces astroglial response in the brain of adult and aged rats
    • Fernandez, L. L. et al. Early post-natal iron administration induces astroglial response in the brain of adult and aged rats. Neurotox. Res. 20, 193-199 (2011
    • (2011) Neurotox. Res , vol.20 , pp. 193-199
    • Fernandez, L.L.1
  • 54
    • 0017655551 scopus 로고
    • Iron absorption in infants: High bioavailability of breast milk iron as indicated by the extrinsic tag method of iron absorption and by the concentration of serum ferritin
    • Saarinen, U. M., Siimes, M. A. & Dallman, P. R. Iron absorption in infants: high bioavailability of breast milk iron as indicated by the extrinsic tag method of iron absorption and by the concentration of serum ferritin. J. Pediatr. 91, 36-39 (1977
    • (1977) J. Pediatr , vol.91 , pp. 36-39
    • Saarinen, U.M.1    Siimes, M.A.2    Dallman, P.R.3
  • 55
    • 33644851945 scopus 로고    scopus 로고
    • Absorption of iron from recombinant human lactoferrin in young US women
    • Lönnerdal, B. & Bryant, A. Absorption of iron from recombinant human lactoferrin in young US women. Am. J. Clin. Nutr. 83, 305-309 (2006
    • (2006) Am. J. Clin. Nutr , vol.83 , pp. 305-309
    • Lönnerdal, B.1    Bryant, A.2
  • 56
    • 84872056251 scopus 로고    scopus 로고
    • Iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of the frontal cortex and hippocampus in adult rats
    • Rao, R. et al. Iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of the frontal cortex and hippocampus in adult rats. Pediatr. Res. 73, 31-37 (2013
    • (2013) Pediatr. Res , vol.73 , pp. 31-37
    • Rao, R.1
  • 57
    • 84869121627 scopus 로고    scopus 로고
    • Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats
    • Unger, E. L. et al. Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats. J. Nutr. 142, 2040-2049 (2012
    • (2012) J. Nutr , vol.142 , pp. 2040-2049
    • Unger, E.L.1
  • 58
    • 84872255665 scopus 로고    scopus 로고
    • Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas
    • Lugonja, N. et al. Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas. Nutrition 29, 431-435 (2013
    • (2013) Nutrition , vol.29 , pp. 431-435
    • Lugonja, N.1
  • 60
    • 84922814574 scopus 로고    scopus 로고
    • R2.mapping for brain iron: Associations with cognition in normal aging
    • Ghadery, C. et al. R2.mapping for brain iron: Associations with cognition in normal aging. Neurobiol. Aging 36, 925-932 (2015
    • (2015) Neurobiol. Aging , vol.36 , pp. 925-932
    • Ghadery, C.1
  • 61
    • 78649663704 scopus 로고    scopus 로고
    • Differential effects of age and history of hypertension on regional brain volumes and iron
    • Rodrigue, K. M., Haacke, E. M. & Raz, N. Differential effects of age and history of hypertension on regional brain volumes and iron. Neuroimage 54, 750-759 (2011
    • (2011) Neuroimage , vol.54 , pp. 750-759
    • Rodrigue, K.M.1    Haacke, E.M.2    Raz, N.3
  • 62
    • 84899898647 scopus 로고    scopus 로고
    • Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging
    • Callaghan, M. F. et al. Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging. Neurobiol. Aging 35, 1862-1872 (2014
    • (2014) Neurobiol. Aging , vol.35 , pp. 1862-1872
    • Callaghan, M.F.1
  • 63
    • 84907999177 scopus 로고    scopus 로고
    • The role of iron in brain ageing and neurodegenerative disorders
    • Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R. & Zecca, L. The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol. 13, 1045-1060 (2014
    • (2014) Lancet Neurol , vol.13 , pp. 1045-1060
    • Ward, R.J.1    Zucca, F.A.2    Duyn, J.H.3    Crichton, R.R.4    Zecca, L.5
  • 64
    • 34247564692 scopus 로고    scopus 로고
    • Role of iron in neurodegenerative disorders
    • Berg, D. & Youdim, M. B. Role of iron in neurodegenerative disorders. Top. Magn. Reson. Imaging 17, 5-17 (2006
    • (2006) Top. Magn. Reson. Imaging , vol.17 , pp. 5-17
    • Berg, D.1    Youdim, M.B.2
  • 65
    • 0034776216 scopus 로고    scopus 로고
    • Brain iron pathways and their relevance to Parkinsons disease
    • Berg, D. et al. Brain iron pathways and their relevance to Parkinsons disease. J. Neurochem. 79, 225-236 (2001
    • (2001) J. Neurochem , Issue.79 , pp. 225-236
    • Berg, D.1
  • 66
    • 84906417439 scopus 로고
    • On the occurrence of abnormal deposits of iron in the brain in parkinsonism with special reference to its localisation
    • Lhermitte, J., Kraus, W. M. & McAlpine, D. On the occurrence of abnormal deposits of iron in the brain in parkinsonism with special reference to its localisation. J. Neurol. Psychopathol. 5, 195-208 (1924
    • (1924) J. Neurol. Psychopathol , vol.5 , pp. 195-208
    • Lhermitte, J.1    Kraus, W.M.2    McAlpine, D.3
  • 67
    • 12944305793 scopus 로고    scopus 로고
    • Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
    • Sulzer, D. et al. Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc. Natl Acad. Sci. USA 97, 11869-11874 (2000
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 11869-11874
    • Sulzer, D.1
  • 68
    • 0035662768 scopus 로고    scopus 로고
    • Substantia nigra neuromelanin: Structure, synthesis, and molecular behaviour
    • Zecca, L. et al. Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour. Mol. Pathol. 54, 414-418 (2001
    • (2001) Mol. Pathol , vol.54 , pp. 414-418
    • Zecca, L.1
  • 69
    • 58149127699 scopus 로고    scopus 로고
    • Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X ray microspectroscopy
    • Bohic, S. et al. Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X ray microspectroscopy. Anal. Chem. 80, 9557-9566 (2008
    • (2008) Anal. Chem , vol.80 , pp. 9557-9566
    • Bohic, S.1
  • 70
    • 84856708923 scopus 로고    scopus 로고
    • Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
    • Lei, P. et al. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat. Med. 18, 291-295 (2012
    • (2012) Nat. Med , vol.18 , pp. 291-295
    • Lei, P.1
  • 71
    • 84878398613 scopus 로고    scopus 로고
    • Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
    • Ayton, S. et al. Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease. Ann. Neurol. 73, 554-559 (2013
    • (2013) Ann. Neurol , vol.73 , pp. 554-559
    • Ayton, S.1
  • 72
    • 78650695967 scopus 로고    scopus 로고
    • Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinsons disease
    • Jin, L. et al. Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinsons disease. Brain 134, 50-58 (2011
    • (2011) Brain , vol.134 , pp. 50-58
    • Jin, L.1
  • 73
    • 84855409709 scopus 로고    scopus 로고
    • DJ 1 modulates the expression of Cu/Zn-superoxide dismutase 1 through the Erk1/2 Elk1 pathway in neuroprotection
    • Wang, Z. et al. DJ 1 modulates the expression of Cu/Zn-superoxide dismutase 1 through the Erk1/2 Elk1 pathway in neuroprotection. Ann. Neurol. 70, 591-599 (2011
    • (2011) Ann. Neurol , vol.70 , pp. 591-599
    • Wang, Z.1
  • 74
    • 84880805523 scopus 로고    scopus 로고
    • Iron metabolism in the CNS: Implications for neurodegenerative diseases
    • Rouault, T. A. Iron metabolism in the CNS: implications for neurodegenerative diseases. Nat. Rev. Neurosci. 14, 551-564 (2013
    • (2013) Nat. Rev. Neurosci , vol.14 , pp. 551-564
    • Rouault, T.A.1
  • 76
    • 0030885482 scopus 로고    scopus 로고
    • Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
    • Smith, M. A., Harris, P. L., Sayre, L. M. & Perry, G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl Acad. Sci. USA 94, 9866-9868 (1997
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 9866-9868
    • Smith, M.A.1    Harris, P.L.2    Sayre, L.M.3    Perry, G.4
  • 77
    • 79959395494 scopus 로고    scopus 로고
    • Iron zinc and copper in the Alzheimers disease brain: A quantitative meta-Analysis Some insight on the influence of citation bias on scientific opinion
    • Schrag, M., Mueller, C., Oyoyo, U., Smith, M. A. & Kirsch, W. M. Iron, zinc and copper in the Alzheimers disease brain: A quantitative meta-Analysis. Some insight on the influence of citation bias on scientific opinion. Prog. Neurobiol. 94, 296-306 (2011
    • (2011) Prog. Neurobiol , vol.94 , pp. 296-306
    • Schrag, M.1    Mueller, C.2    Oyoyo, U.3    Smith, M.A.4    Kirsch, W.M.5
  • 78
    • 77956647381 scopus 로고    scopus 로고
    • Iron-export ferroxidase activity of β-Amyloid precursor protein is inhibited by zinc in Alzheimers disease
    • Duce, J. A. et al. Iron-export ferroxidase activity of â-Amyloid precursor protein is inhibited by zinc in Alzheimers disease. Cell 142, 857-867 (2010
    • (2010) Cell , vol.142 , pp. 857-867
    • Duce, J.A.1
  • 79
    • 75149152568 scopus 로고    scopus 로고
    • Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment
    • Smith, M. A. et al. Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J. Alzheimers Dis. 19, 363-372 (2010
    • (2010) J. Alzheimers Dis , vol.19 , pp. 363-372
    • Smith, M.A.1
  • 80
    • 83055194393 scopus 로고    scopus 로고
    • High field magnetic resonance microscopy of the human hippocampus in Alzheimers disease: Quantitative imaging and correlation with iron
    • Antharam, V. et al. High field magnetic resonance microscopy of the human hippocampus in Alzheimers disease: quantitative imaging and correlation with iron. Neuroimage 59, 1249-1260 (2012
    • (2012) Neuroimage , vol.59 , pp. 1249-1260
    • Antharam, V.1
  • 81
    • 84883168593 scopus 로고    scopus 로고
    • Increased iron levels and decreased tissue integrity in hippocampus of Alzheimers disease detected in vivo with magnetic resonance imaging
    • Raven, E. P., Lu, P. H., Tishler, T. A., Heydari, P. & Bartzokis, G. Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer disease detected in vivo with magnetic resonance imaging. J. Alzheimers Dis. 37, 127-136 (2013
    • (2013) J. Alzheimers Dis , vol.37 , pp. 127-136
    • Raven, E.P.1    Lu, P.H.2    Tishler, T.A.3    Heydari, P.4    Bartzokis, G.5
  • 82
    • 84892915145 scopus 로고    scopus 로고
    • Iron and neurodegeneration in the multiple sclerosis brain
    • Hametner, S. et al. Iron and neurodegeneration in the multiple sclerosis brain. Ann. Neurol. 74, 848-861 (2013
    • (2013) Ann. Neurol , vol.74 , pp. 848-861
    • Hametner, S.1
  • 83
    • 84908897414 scopus 로고    scopus 로고
    • An anemia of Alzheimers disease
    • Faux, N. G. et al. An anemia of Alzheimers disease. Mol. Psychiatr. 19, 1227-1234 (2014
    • (2014) Mol. Psychiatr , vol.19 , pp. 1227-1234
    • Faux, N.G.1
  • 84
    • 84879529900 scopus 로고    scopus 로고
    • Serum iron levels and the risk of Parkinson disease: A Mendelian randomization study
    • Pichler, I. et al. Serum iron levels and the risk of parkinson disease: A Mendelian randomization study. PLoS Med. 10, e1001462 (2013
    • (2013) PLoS Med , vol.10 , pp. e1001462
    • Pichler, I.1
  • 85
    • 84904757635 scopus 로고    scopus 로고
    • HFE gene variants, iron, and lipids: A novel connection in Alzheimers disease
    • Ali-Rahmani, F., Schengrund, C. L. & Connor, J. R. HFE gene variants, iron, and lipids: A novel connection in Alzheimers disease. Front. Pharmacol. 5, 165 (2014
    • (2014) Front. Pharmacol , vol.5 , Issue.165
    • Ali-Rahmani, F.1    Schengrund, C.L.2    Connor, J.R.3
  • 86
    • 33745919520 scopus 로고    scopus 로고
    • Epidemiology of Parkinsons disease
    • De Lau, L. M. & Breteler, M. M. Epidemiology of Parkinsons disease. Lancet Neurol. 5, 525-535 (2006
    • (2006) Lancet Neurol , vol.5 , pp. 525-535
    • De Lau, L.M.1    Breteler, M.M.2
  • 87
    • 1642358352 scopus 로고    scopus 로고
    • Alzheimers disease: The two-hit hypothesis
    • Zhu, X., Raina, A. K., Perry, G. & Smith, M. A. Alzheimers disease: the two-hit hypothesis. Lancet Neurol. 3, 219-226 (2004
    • (2004) Lancet Neurol , vol.3 , pp. 219-226
    • Zhu, X.1    Raina, A.K.2    Perry, G.3    Smith, M.A.4
  • 88
    • 2942729775 scopus 로고    scopus 로고
    • Metals in our minds: Therapeutic implications for neurodegenerative disorders
    • Doraiswamy, P. M. & Finefrock, A. E. Metals in our minds: therapeutic implications for neurodegenerative disorders. Lancet Neurol. 3, 431-434 (2004
    • (2004) Lancet Neurol , vol.3 , pp. 431-434
    • Doraiswamy, P.M.1    Finefrock, A.E.2
  • 89
    • 84897930725 scopus 로고    scopus 로고
    • Targeting chelatable iron as a therapeutic modality in Parkinsons disease
    • Devos, D. et al. Targeting chelatable iron as a therapeutic modality in Parkinsons disease. Antioxid. Redox Signal. 21, 195-210 (2014
    • (2014) Antioxid. Redox Signal , vol.21 , pp. 195-210
    • Devos, D.1
  • 90
    • 0242684415 scopus 로고    scopus 로고
    • Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinsons disease
    • Kaur, D. et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinsons disease. Neuron 37, 899-909 (2003
    • (2003) Neuron , vol.37 , pp. 899-909
    • Kaur, D.1
  • 91
    • 34247116462 scopus 로고    scopus 로고
    • Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age
    • Kaur, D. et al. Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age. Neurobiol. Aging 28, 907-913 (2007
    • (2007) Neurobiol. Aging , vol.28 , pp. 907-913
    • Kaur, D.1
  • 92
    • 77149134320 scopus 로고    scopus 로고
    • Effects of increased iron intake during the neonatal period on the brain of adult AβPP/PS1 transgenic mice
    • Fernandez, L. L. et al. Effects of increased iron intake during the neonatal period on the brain of adult AβPP/PS1 transgenic mice. J. Alzheimers Dis. 19, 1069-1080 (2010
    • (2010) J. Alzheimers Dis , vol.19 , pp. 1069-1080
    • Fernandez, L.L.1
  • 93
    • 84903818809 scopus 로고    scopus 로고
    • Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimers disease
    • Becerril-Ortega, J., Bordji, K., Frret, T., Rush, T. & Buisson, A. Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer disease. Neurobiol. Aging 35, 2288-2301 (2014
    • (2014) Neurobiol. Aging , vol.35 , pp. 2288-2301
    • Becerril-Ortega, J.1    Bordji, K.2    Frret, T.3    Rush, T.4    Buisson, A.5
  • 94
    • 0030752629 scopus 로고    scopus 로고
    • Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats
    • Erikson, K. M., Pinero, D. J., Connor, J. R. & Beard, J. L. Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J. Nutr. 127, 2030-2038 (1997
    • (1997) J. Nutr , vol.127 , pp. 2030-2038
    • Erikson, K.M.1    Pinero, D.J.2    Connor, J.R.3    Beard, J.L.4
  • 95
    • 0038454676 scopus 로고    scopus 로고
    • Parkinsons disease risks associated with dietary iron, manganese, and other nutrient intakes
    • Powers, K. M. et al. Parkinsons disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 60, 1761-1766 (2003
    • (2003) Neurology , vol.60 , pp. 1761-1766
    • Powers, K.M.1
  • 96
    • 67449123256 scopus 로고    scopus 로고
    • Brain iron homeostasis and neurodegenerative disease
    • Benarroch, E. E. Brain iron homeostasis and neurodegenerative disease. Neurology 72, 1436-1440 (2009
    • (2009) Neurology , vol.72 , pp. 1436-1440
    • Benarroch, E.E.1
  • 97
    • 0026662411 scopus 로고
    • Brain iron homeostasis
    • Morris, C. M. et al. Brain iron homeostasis. J. Inorg. Biochem. 47, 257-265 (1992
    • (1992) J. Inorg. Biochem , vol.47 , pp. 257-265
    • Morris, C.M.1
  • 98
    • 3042793602 scopus 로고    scopus 로고
    • The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
    • Zecca, L. et al. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc. Natl Acad. Sci. USA 101, 9843-9848 (2004
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 9843-9848
    • Zecca, L.1
  • 99
    • 84900302515 scopus 로고    scopus 로고
    • An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
    • Hare, D. J. et al. An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta. Chem. Sci. 5, 2160-2169 (2014
    • (2014) Chem. Sci , vol.5 , pp. 2160-2169
    • Hare, D.J.1
  • 100
    • 66849115653 scopus 로고    scopus 로고
    • Body iron excretion by healthy men and women
    • Hunt, J. R., Zito, C. A. & Johnson, L. K. Body iron excretion by healthy men and women. Am. J. Clin. Nutr. 89, 1792-1798 (2009
    • (2009) Am. J. Clin. Nutr , vol.89 , pp. 1792-1798
    • Hunt, J.R.1    Zito, C.A.2    Johnson, L.K.3
  • 101
    • 84875382226 scopus 로고    scopus 로고
    • Teeth as a biomarker of past chemical exposure
    • Arora, M. & Austin, C. Teeth as a biomarker of past chemical exposure. Curr. Opin. Pediatr. 25, 261-267 (2013
    • (2013) Curr. Opin. Pediatr , vol.25 , pp. 261-267
    • Arora, M.1    Austin, C.2
  • 102
    • 79955076184 scopus 로고    scopus 로고
    • Elemental bio-imaging of trace elements in teeth using laser ablation-inductively coupled plasma-mass spectrometry
    • Hare, D., Austin, C., Doble, P. & Arora, M. Elemental bio-imaging of trace elements in teeth using laser ablation-inductively coupled plasma-mass spectrometry. J. Dent. 39, 397-403 (2011
    • (2011) J. Dent , vol.39 , pp. 397-403
    • Hare, D.1    Austin, C.2    Doble, P.3    Arora, M.4
  • 103
    • 84885164900 scopus 로고    scopus 로고
    • Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community
    • Gunier, R. B. et al. Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community. Environ. Sci. Technol. 47, 11249-11257 (2013
    • (2013) Environ. Sci. Technol , vol.47 , pp. 11249-11257
    • Gunier, R.B.1
  • 104
    • 79851508993 scopus 로고    scopus 로고
    • Spatial distribution of manganese in enamel and coronal dentine of human primary teeth
    • Arora, M., Hare, D., Austin, C., Smith, D. R. & Doble, P. Spatial distribution of manganese in enamel and coronal dentine of human primary teeth. Sci. Total Environ. 409, 1315-1319 (2011
    • (2011) Sci. Total Environ , vol.409 , pp. 1315-1319
    • Arora, M.1    Hare, D.2    Austin, C.3    Smith, D.R.4    Doble, P.5
  • 105
    • 84879001461 scopus 로고    scopus 로고
    • Barium distributions in teeth reveal early-life dietary transitions in primates
    • Austin, C. et al. Barium distributions in teeth reveal early-life dietary transitions in primates. Nature 498, 216-219 (2013
    • (2013) Nature , vol.498 , pp. 216-219
    • Austin, C.1
  • 107
    • 0018571144 scopus 로고
    • Iron concentration in teeth of patients with and without beta-thalassaemia major
    • Garfunkel, A., Kantzuker, M., Gedalia, I. & Chevion, M. Iron concentration in teeth of patients with and without beta-thalassaemia major. Arch. Oral Biol. 24, 829-831 (1979
    • (1979) Arch. Oral Biol , vol.24 , pp. 829-831
    • Garfunkel, A.1    Kantzuker, M.2    Gedalia, I.3    Chevion, M.4
  • 110
    • 0345422771 scopus 로고    scopus 로고
    • Speciation of iron in breast milk and infant formulas whey by size exclusion chromatography-high performance liquid chromatography and electrothermal atomic absorption spectrometry
    • Bermejo, P. et al. Speciation of iron in breast milk and infant formulas whey by size exclusion chromatography-high performance liquid chromatography and electrothermal atomic absorption spectrometry. Talanta 50, 1211-1222 (2000
    • (2000) Talanta , vol.50 , pp. 1211-1222
    • Bermejo, P.1
  • 111
    • 84874874800 scopus 로고    scopus 로고
    • Metals and trace element concentrations in breast milk of first time healthy mothers: A biological monitoring study
    • Björklund, K. L. et al. Metals and trace element concentrations in breast milk of first time healthy mothers: A biological monitoring study. Environ. Health 11, 92 (2012
    • (2012) Environ. Health , vol.11 , Issue.92
    • Björklund, K.L.1
  • 113
    • 0033839224 scopus 로고    scopus 로고
    • Concentrations of selected trace elements in human milk and in infant formulas determined by magnetic sector field inductively coupled plasma-mass spectrometry
    • Krachler, M., Prohaska, T., Koellensperger, G., Rossipal, E. & Stingeder, G. Concentrations of selected trace elements in human milk and in infant formulas determined by magnetic sector field inductively coupled plasma-mass spectrometry. Biol. Trace Elem. Res. 76, 97-112 (2000
    • (2000) Biol. Trace Elem. Res , vol.76 , pp. 97-112
    • Krachler, M.1    Prohaska, T.2    Koellensperger, G.3    Rossipal, E.4    Stingeder, G.5
  • 114
    • 24944554518 scopus 로고    scopus 로고
    • And essential trace elements in human milk from Greek lactating women: Association with dietary habits and other factors
    • Leotsinidis, M., Alexopoulos, A. & Kostopoulou-Farri, E. Toxic and essential trace elements in human milk from Greek lactating women: Association with dietary habits and other factors. Chemosphere 61, 238-247 (2005
    • (2005) Chemosphere , vol.61 , pp. 238-247
    • Leotsinidis, M.1    Alexopoulos, A.2    Toxic, K.E.3
  • 115
    • 84896143323 scopus 로고    scopus 로고
    • Calcium magnesium, iron, zinc and copper, compositions of human milk from populations with cereal and enset based diets
    • Maru, M., Birhanu, T. & Tessema, D. A. Calcium, magnesium, iron, zinc and copper, compositions of human milk from populations with cereal and ensetbased diets. Ethiop. J. Health Sci. 23, 90-97 (2013
    • (2013) Ethiop. J. Health Sci , vol.23 , pp. 90-97
    • Maru, M.1    Birhanu, T.2    Tessema, D.A.3
  • 116
    • 84875767359 scopus 로고    scopus 로고
    • Iron supplementation in pregnancy and breastfeeding and iron, copper and zinc status of lactating women from a human milk bank
    • Mello-Neto, J. et al. Iron supplementation in pregnancy and breastfeeding and iron, copper and zinc status of lactating women from a human milk bank. J. Trop. Pediatr. 59, 140-144 (2013
    • (2013) J. Trop. Pediatr , vol.59 , pp. 140-144
    • Mello-Neto, J.1
  • 117
    • 77954705616 scopus 로고    scopus 로고
    • Iron concentrations in breast milk and selected maternal factors of human milk bank donors
    • Mello-Neto, J. et al. Iron concentrations in breast milk and selected maternal factors of human milk bank donors. J. Hum. Lact. 26, 175-179 (2010
    • (2010) J. Hum. Lact , vol.26 , pp. 175-179
    • Mello-Neto, J.1
  • 118
    • 0004133273 scopus 로고
    • World Health Organization & International Atomic Energy Agency World Health Organization Institutional Repository for Information Sharing [online]
    • World Health Organization & International Atomic Energy Agency. Minor and trace elements in breast milk: report of a joint WHO/IAEA collaborative study. World Health Organization Institutional Repository for Information Sharing [online], http://apps.who.int/iris/bitstream/10665/39678/1/9241561211.pdf?ua=1 (1989
    • (1989) Minor and Trace Elements in Breast Milk: Report of A Joint WHO/IAEA Collaborative Study
  • 119
    • 0031980653 scopus 로고    scopus 로고
    • Copper iron, zinc, and manganese in dietary supplements, infant formulas, and ready to eat breakfast cereals
    • Suppl
    • Johnson, M. A., Smith, M. M. & Edmonds, J. T. Copper, iron, zinc, and manganese in dietary supplements, infant formulas, and ready to eat breakfast cereals. Am. J. Clin. Nutr. 67 (5 Suppl.), 1035S-1040S (1998
    • (1998) Am. J. Clin. Nutr , vol.67 , Issue.5 , pp. 1035S-1040S
    • Johnson, M.A.1    Smith, M.M.2    Edmonds, J.T.3
  • 120
    • 79952534891 scopus 로고    scopus 로고
    • High concentrations of essential and toxic elements in infant formula and infant foods-A matter of concern
    • Ljung, K., Palm, B., Grandr, M. & Vahter, M. High concentrations of essential and toxic elements in infant formula and infant foods-A matter of concern. Food Chem. 127, 943-951 (2011
    • (2011) Food Chem , vol.127 , pp. 943-951
    • Ljung, K.1    Palm, B.2    Grandr, M.3    Vahter, M.4
  • 121
    • 0017703210 scopus 로고
    • Iron absorption from infant milk formula and the optimal level of iron supplementation
    • Saarinen, U. M. & Siimes, M. A. Iron absorption from infant milk formula and the optimal level of iron supplementation. Acta Paediatr. Scand. 66, 719-722 (1977
    • (1977) Acta Paediatr. Scand , vol.66 , pp. 719-722
    • Saarinen, U.M.1    Siimes, M.A.2
  • 122
    • 0031950296 scopus 로고    scopus 로고
    • Prevention of iron-deficiency anemia: Comparison of high- and low-iron formulas in term healthy infants after six months of life
    • Walter, T., Pino, P., Pizarro, F. & Lozoff, B. Prevention of iron-deficiency anemia: comparison of high- and low-iron formulas in term healthy infants after six months of life. J. Pediatr. 132, 635-640 (1998
    • (1998) J. Pediatr , vol.132 , pp. 635-640
    • Walter, T.1    Pino, P.2    Pizarro, F.3    Lozoff, B.4
  • 123
    • 79954705723 scopus 로고    scopus 로고
    • Fenton reaction-controversy concerning the chemistry
    • Chemizmu, K. & Fentona, R. Fenton reaction-controversy concerning the chemistry. Ecol. Chem. Eng. S. 16, 347-358 (2009
    • (2009) Ecol. Chem. Eng. S. , vol.16 , pp. 347-358
    • Chemizmu, K.1    Fentona, R.2
  • 124
    • 33846568415 scopus 로고    scopus 로고
    • Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
    • Bartzokis, G. et al. Brain ferritin iron may influence age- and gender-related risks of neurodegeneration. Neurobiol. Aging 28, 414-423 (2007
    • (2007) Neurobiol. Aging , vol.28 , pp. 414-423
    • Bartzokis, G.1
  • 125
    • 0033793044 scopus 로고    scopus 로고
    • Heme oxygenase 1: Role in brain aging and neurodegeneration
    • Schipper, H. M. Heme oxygenase 1: role in brain aging and neurodegeneration. Exp. Gerontol. 35, 821-830 (2000
    • (2000) Exp. Gerontol , vol.35 , pp. 821-830
    • Schipper, H.M.1
  • 126
    • 3042658542 scopus 로고    scopus 로고
    • Brain iron deposition and the free radical-mitochondrial theory of ageing
    • Schipper, H. M. Brain iron deposition and the free radical-mitochondrial theory of ageing. Ageing Res. Rev. 3, 265-301 (2004
    • (2004) Ageing Res. Rev , vol.3 , pp. 265-301
    • Schipper, H.M.1
  • 127
    • 84904819994 scopus 로고    scopus 로고
    • Imbalance of iron influx and efflux causes brain iron accumulation over time in the healthy adult rat
    • Chen, J. H., Singh, N., Tay, H. & Walczyk, T. Imbalance of iron influx and efflux causes brain iron accumulation over time in the healthy adult rat. Metallomics 6, 1417-1426 (2014
    • (2014) Metallomics , vol.6 , pp. 1417-1426
    • Chen, J.H.1    Singh, N.2    Tay, H.3    Walczyk, T.4
  • 128
    • 0036800144 scopus 로고    scopus 로고
    • Strategy and tactics in the evolution of iron acquisition
    • Kaplan, J. Strategy and tactics in the evolution of iron acquisition. Semin. Hematol. 39, 219-226 (2002
    • (2002) Semin. Hematol , vol.39 , pp. 219-226
    • Kaplan, J.1
  • 129
    • 85027948814 scopus 로고    scopus 로고
    • Too much of a good thing: Evolutionary perspectives on infant formula fortification in the United States and its effects on infant health
    • Quinn, E. A. Too much of a good thing: evolutionary perspectives on infant formula fortification in the United States and its effects on infant health. Am. J. Hum. Biol. 26, 10-17 (2014
    • (2014) Am. J. Hum. Biol , vol.26 , pp. 10-17
    • Quinn, E.A.1
  • 130
    • 84857915777 scopus 로고    scopus 로고
    • Iron in evolution
    • Williams, R. J. Iron in evolution. FEBS Lett. 586, 479-484 (2012
    • (2012) FEBS Lett , vol.586 , pp. 479-484
    • Williams, R.J.1
  • 131
    • 84894029844 scopus 로고    scopus 로고
    • Neurobehavioural effects of developmental toxicity
    • Grandjean, P. & Landrigan, P. J. Neurobehavioural effects of developmental toxicity. Lancet Neurol. 13, 330-338 (2014
    • (2014) Lancet Neurol , vol.13 , pp. 330-338
    • Grandjean, P.1    Landrigan, P.J.2
  • 132
    • 84899441484 scopus 로고    scopus 로고
    • Novel insights into the development and maintenance of the blood-brain barrier
    • Engelhardt, B. & Liebner, S. Novel insights into the development and maintenance of the blood-brain barrier. Cell Tissue Res. 355, 687-699 (2014
    • (2014) Cell Tissue Res , vol.355 , pp. 687-699
    • Engelhardt, B.1    Liebner, S.2
  • 134
    • 0026756352 scopus 로고
    • The development of ion regulation at the blood-brain barrier
    • Jones, H. C., Keep, R. F. & Butt, A. M. The development of ion regulation at the blood-brain barrier. Prog. Brain Res. 91, 123-131 (1992
    • (1992) Prog. Brain Res , vol.91 , pp. 123-131
    • Jones, H.C.1    Keep, R.F.2    Butt, A.M.3
  • 135
    • 0028326826 scopus 로고
    • Studies of the ultrastructure and permeability of the blood-brain barrier in the developing corpus callosum in postnatal rat brain using electron dense tracers
    • Xu, J. & Ling, E. A. Studies of the ultrastructure and permeability of the blood-brain barrier in the developing corpus callosum in postnatal rat brain using electron dense tracers. J. Anat. 184, 227-237 (1994
    • (1994) J. Anat , vol.184 , pp. 227-237
    • Xu, J.1    Ling, E.A.2
  • 136
    • 0036967837 scopus 로고    scopus 로고
    • Mechanism and developmental changes in iron transport across the blood-brain barrier
    • Morgan, E. H. & Moos, T. Mechanism and developmental changes in iron transport across the blood-brain barrier. Dev. Neurosci. 24, 106-113 (2002
    • (2002) Dev. Neurosci , vol.24 , pp. 106-113
    • Morgan, E.H.1    Moos, T.2
  • 137
    • 0025354340 scopus 로고
    • Developmental changes in transferrin and iron uptake by the brain in the rat
    • Taylor, E. M. & Morgan, E. H. Developmental changes in transferrin and iron uptake by the brain in the rat. Brain Res. Dev. Brain. Res. 55, 35-42 (1990
    • (1990) Brain Res. Dev. Brain. Res , vol.55 , pp. 35-42
    • Taylor, E.M.1    Morgan, E.H.2
  • 138
    • 4444231917 scopus 로고    scopus 로고
    • Effect of blood transfusions on oxidative stress in preterm infants
    • Dani, C. et al. Effect of blood transfusions on oxidative stress in preterm infants. Arch. Dis. Child Fetal Neonatal Ed. 89, F408-F411 (2004
    • (2004) Arch. Dis. Child Fetal Neonatal E.d. , vol.89 , pp. F408-F411
    • Dani, C.1
  • 139
    • 84961292015 scopus 로고    scopus 로고
    • Iron transport across the blood-brain barrier: Development, neurovascular regulation and cerebral amyloid angiopathy
    • McCarthy, R. C. & Kosman, D. J. Iron transport across the blood-brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy. Cell Mol. Life Sci. 72, 709-727 (2015
    • (2015) Cell Mol. Life Sci , vol.72 , pp. 709-727
    • McCarthy, R.C.1    Kosman, D.J.2
  • 140
    • 10744219518 scopus 로고    scopus 로고
    • Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier
    • Wu, L. J. et al. Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res. 1001, 108-117 (2004
    • (2004) Brain Res , vol.1001 , pp. 108-117
    • Wu, L.J.1
  • 141
    • 33750738079 scopus 로고    scopus 로고
    • Ferroportin in the postnatal rat brain: Implications for axonal transport and neuronal export of iron
    • Moos, T. & Rosengren Nielsen, T. Ferroportin in the postnatal rat brain: implications for axonal transport and neuronal export of iron. Semin. Pediatr. Neurol. 13, 149-157 (2006
    • (2006) Semin. Pediatr. Neurol , vol.13 , pp. 149-157
    • Moos, T.1    Rosengren Nielsen, T.2
  • 142
    • 84920646171 scopus 로고    scopus 로고
    • A novel model for brain iron uptake: Introducing the concept of regulation
    • Simpson, I. A. et al. A novel model for brain iron uptake: introducing the concept of regulation. J. Cereb. Blood Flow Metab. 35, 48-57 (2015
    • (2015) J. Cereb. Blood Flow Metab , vol.35 , pp. 48-57
    • Simpson, I.A.1
  • 143
    • 0030739637 scopus 로고    scopus 로고
    • Transport of iron in the blood-brain-cerebrospinal fluid system
    • Bradbury, M. W. Transport of iron in the blood-brain-cerebrospinal fluid system. J. Neurochem. 69, 443-454 (1997
    • (1997) J. Neurochem , Issue.69 , pp. 443-454
    • Bradbury, M.W.1
  • 144
    • 0032549868 scopus 로고    scopus 로고
    • Kinetics and distribution of [59Fe-125I]transferrin injected into the ventricular system of the rat
    • Moos, T. & Morgan, E. H. Kinetics and distribution of [59Fe-125I]transferrin injected into the ventricular system of the rat. Brain Res. 790, 115-128 (1998
    • (1998) Brain Res , vol.790 , pp. 115-128
    • Moos, T.1    Morgan, E.H.2
  • 145
    • 84878828821 scopus 로고    scopus 로고
    • Stable iron isotope tracing reveals significant brain iron uptake in adult rats
    • Chen, J. H., Shahnavas, S., Singh, N., Ong, W. Y. & Walczyk, T. Stable iron isotope tracing reveals significant brain iron uptake in adult rats. Metallomics 5, 167-173 (2013
    • (2013) Metallomics , vol.5 , pp. 167-173
    • Chen, J.H.1    Shahnavas, S.2    Singh, N.3    Ong, W.Y.4    Walczyk, T.5
  • 146
    • 0037160028 scopus 로고    scopus 로고
    • Overexpression of Alzheimers disease amyloid-β opposes the age-dependent elevations of brain copper and iron
    • Maynard, C. J. et al. Overexpression of Alzheimers disease amyloid-β opposes the age-dependent elevations of brain copper and iron. J. Biol. Chem. 277, 44670-44676 (2002
    • (2002) J. Biol. Chem , vol.277 , pp. 44670-44676
    • Maynard, C.J.1
  • 147
    • 84855461629 scopus 로고    scopus 로고
    • MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping
    • Bilgic, B., Pfefferbaum, A., Rohlfing, T., Sullivan, E. V. & Adalsteinsson, E. MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping. Neuroimage 59, 2625-2635 (2012
    • (2012) Neuroimage , vol.59 , pp. 2625-2635
    • Bilgic, B.1    Pfefferbaum, A.2    Rohlfing, T.3    Sullivan, E.V.4    Adalsteinsson, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.