Mechanism and developmental changes in iron transport across the blood-brain barrier

Developmental Neuroscience

Volumn 24, Issue 2-3, 2002, Pages 106-113

  Morgan, Evan H ^a   Moos, Torben ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b NONE

Author keywords

Blood brain barrier; Iron transport; Postnatal development; Transferrin receptor

Indexed keywords

IRON; TRANSFERRIN;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BONE MARROW; CONTROLLED STUDY; DEVELOPMENT; ENDOCYTOSIS; FEMUR; IRON TRANSPORT; MALE; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT;

AGE FACTORS; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BONE MARROW; BRAIN; BRAIN CHEMISTRY; ENDOTHELIUM, VASCULAR; FEMUR; INJECTIONS, INTRAVENOUS; IRON; MALE; RABBITS; RATS; RATS, WISTAR; TRANSFERRIN;

EID: 0036967837     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065699     Document Type: Article

References (30)

1. Dobbing J, Sands J: Vulnerability of the developing brain. IX. The effects of nutritional growth retardation on the timing of the brain growth spurt. Biol Neonate 1971;19:363-378.
2. Dobbing J, Sands J: Comparative aspects of the brain growth spurt. Early Hum Dev 1979;3: 79-83.
3. Taylor EM, Morgan EH: Developmental changes in transferrin and iron uptake by the brain in the rat. Dev Brain Res 1990;55:35-42.
4. Crowe A, Morgan EH: Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res 1992;592:8-16.
5. Jefferies WA, Brandon MR, Hunt SV, Williams AF, Gatter KC, Mason DY: Transferrin receptors on endothelium of brain capillaries. Nature 1984;312:162-163.
6. Fishman JB, Rubin JB, Handrahan JV, Connor JR, Fine RE: Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res 1987;18:299-304.
7. Pardridge WM, Eisenberg J, Yang J: Human blood-brain barrier transferrin receptor. Metabolism 1987;36:892-895.
8. Bickel U, Yoshikawa T, Pardridge WM: Delivery of peptides and proteins through the blood-brain barrier. Adv Drug Deliv Rev 2001;46: 247-279.
9. Moos T, Morgan EH: Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid. J Neurosci Res 1998;54:486-494.
10. Moos T, Morgan EH: Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol 2000;20:77-95.
11. Qian ZM, Shen X: Brain iron transport and neurodegeneration. Trends Mol Med 2001;7: 103-108.
12. International Committee for Standardization in Hematology: Proposed recommendations for measurement of serum iron in human blood. J Clin Pathol 1971;24:334-335.
13. Kaldor I: Studies on intermediary iron metabolism. V. The measurement of non-haemoglobin tissue iron. Aust J Exp Biol Med Sci 1954;32: 795-800.
14. Strahan ME, Crowe A, Morgan EH: Iron uptake in relation to transferrin degradation in brain and other tissues of rats. Am J Physiol 1992;263:R924-R929.
15. Zhang Y, Pardridge WM: Rapid transferrin efflux from brain to blood across the blood-brain barrier. J Neurochem 2001;76:1597-1600.
16. Morgan EH: Transferrin, biochemistry, physiology and clinical significance. Mol Aspects Med 1981;4:1-123.
17. Kailis SG, Morgan EH: Transferrin and iron uptake by rabbit bone marrow cells in vitro. Br J Haematol 1974;28:37-52.
18. Skarlatos S, Yoshikawa T, Pardridge WN: Transport of transferrin through the rat blood-brain barrier. Brain Res 1995;683:164-171.
19. Broadwell RD, Baker-Cairns B, Friden PM, Oliver C, Villegas JC: Transcytosis of protein through the mammalian cerebral epithelium and endothelium. Exp Neurol 1996;142:47-65.
20. Roberts R, Sandra A, Siek GC, Fine RE: Studies on the mechanism of iron transport across the blood-brain barrier. Ann Neurol 1992;32: 543-550.
21. Roberts R, Fine RE, Sandra A: Receptor-mediated endocytosis of transferrin at the blood-brain barrier. J Cell Sci 1993;104:521-532.
22. Bradbury M: The Concept of a Blood-Brain Barrier. Chichester, Wiley, 1979.
23. Moos,T: Developmental profile of non-heme iron distribution in the rat brain during ontogenesis. Dev Brain Res 1995;87:203-213.
24. Hill JM, Switzer RC: The regional distribution and cellular localization of iron in the rat brain. Neuroscience 1984;11:595-603.
25. Moos T, Morgan EH: Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat. J Neurochem 2001;79:119-129.
26. Morgan EH: Iron metabolism and transport; in Zakin D, Boyer TD (eds): Hepatology: A Textbook of Liver Disease. Philadelphia, Saunders, 1996, vol 1, pp 526-554.
27. Altman J: DNA metabolism and cell proliferation; in Lajtha A (ed): Handbook of Neurochemistry. New York, Plenum, 1969, vol 2, pp 137-182.
28. Robertson PL, du Bois M, Bowman PD, Goldstein GW: Angiogenesis in developing rat brain: An in vivo and in vitro study. Dev Brain Res 1985;23:219-223.
29. Taylor EM, Crowe A, Morgan EH: Transferrin and iron uptake by the brain: Effects of altered iron status. J Neurochem 1991;57:1584-1592.
30. 125I]transferrin injected into the ventricular system of the rat. Brain Res 1998;790: 115-128.