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Volumn 138, Issue , 2015, Pages 281-291

Occurrence, ecotoxicological effects and risk assessment of antihypertensive pharmaceutical residues in the aquatic environment - A review

Author keywords

Angiotensin II receptor antagonists; Angiotensin converting enzyme inhibitors; Aquatic ecotoxicology; Beta blockers; Calcium channel blockers; Emerging contaminants

Indexed keywords

METABOLITES;

EID: 84940904228     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2015.06.024     Document Type: Review
Times cited : (207)

References (81)
  • 1
    • 84880863368 scopus 로고    scopus 로고
    • Occurrence and distribution of pharmaceutically active and endocrine disrupting compounds in Singapore's marine environment: Influence of hydrodynamics and physical-chemical properties
    • Bayen S., Zhang H., Desai M.M., Ooi S.K., Kelly B.C. Occurrence and distribution of pharmaceutically active and endocrine disrupting compounds in Singapore's marine environment: Influence of hydrodynamics and physical-chemical properties. Environ. Pollut. 2013, 182:1-8. 10.1016/j.envpol.2013.06.028.
    • (2013) Environ. Pollut. , vol.182 , pp. 1-8
    • Bayen, S.1    Zhang, H.2    Desai, M.M.3    Ooi, S.K.4    Kelly, B.C.5
  • 2
    • 84907861175 scopus 로고    scopus 로고
    • Behavior of sartans (antihypertensive drugs) in wastewater treatment plants, their occurrence and risk for the aquatic environment
    • Bayer A., Asner R., Schüssler W., Kopf W., Wei K., Sengl M., Letzel M. Behavior of sartans (antihypertensive drugs) in wastewater treatment plants, their occurrence and risk for the aquatic environment. Environ. Sci. Pollut. Res. 2014, 21:10830-10839. 10.1007/s11356-014-3060-z.
    • (2014) Environ. Sci. Pollut. Res. , vol.21 , pp. 10830-10839
    • Bayer, A.1    Asner, R.2    Schüssler, W.3    Kopf, W.4    Wei, K.5    Sengl, M.6    Letzel, M.7
  • 3
    • 20444435797 scopus 로고    scopus 로고
    • Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Höje River in Sweden
    • Bendz D., Paxéus N.A., Ginn T.R., Loge F.J. Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Höje River in Sweden. J. Hazard. Mater. 2005, 122:195-204. 10.1016/j.jhazmat.2005.03.012.
    • (2005) J. Hazard. Mater. , vol.122 , pp. 195-204
    • Bendz, D.1    Paxéus, N.A.2    Ginn, T.R.3    Loge, F.J.4
  • 4
    • 84906095702 scopus 로고    scopus 로고
    • Biodegradability and transformation of human pharmaceutical active ingredients in environmentally relevant test systems
    • Berkner S., Thierbach C. Biodegradability and transformation of human pharmaceutical active ingredients in environmentally relevant test systems. Environ. Sci. Pollut. Res. 2014, 21:9461-9467. 10.1007/s11356-013-1868-6.
    • (2014) Environ. Sci. Pollut. Res. , vol.21 , pp. 9461-9467
    • Berkner, S.1    Thierbach, C.2
  • 6
    • 84907320121 scopus 로고    scopus 로고
    • Exploiting monitoring data in environmental exposure modeling and risk assessment of pharmaceuticals
    • Boxall A.B.A., Keller V.D.J., Straub J.O., Monteiro S.C., Fussell R., Williams R.J. Exploiting monitoring data in environmental exposure modeling and risk assessment of pharmaceuticals. Environ. Int. 2014, 73:176-185. 10.1016/j.envint.2014.07.018.
    • (2014) Environ. Int. , vol.73 , pp. 176-185
    • Boxall, A.B.A.1    Keller, V.D.J.2    Straub, J.O.3    Monteiro, S.C.4    Fussell, R.5    Williams, R.J.6
  • 7
    • 84902663647 scopus 로고    scopus 로고
    • As Bases Farmacológicas da Terapêutica de Goodman e Gilman. 12. ed. AMGH, Porto Alegre.
    • Brunton, L.L., Chabner, B.A., Knollmann, B.C., 2012. As Bases Farmacológicas da Terapêutica de Goodman e Gilman. 12. ed. AMGH, Porto Alegre. 2112 p. ISBN: 9788580551167.
    • (2012) , pp. 2112
    • Brunton, L.L.1    Chabner, B.A.2    Knollmann, B.C.3
  • 8
    • 33646853060 scopus 로고    scopus 로고
    • Are pharmaceuticals potent environmental pollutants? Part I: environmental risk assessments of selected active pharmaceutical ingredients
    • Carlsson C., Johansson A.K., Alvan G., Bergman K., Kühler T. Are pharmaceuticals potent environmental pollutants? Part I: environmental risk assessments of selected active pharmaceutical ingredients. Sci. Total Environ. 2006, 364:67-87. 10.1016/j.scitotenv.2005.06.035.
    • (2006) Sci. Total Environ. , vol.364 , pp. 67-87
    • Carlsson, C.1    Johansson, A.K.2    Alvan, G.3    Bergman, K.4    Kühler, T.5
  • 9
    • 73449088388 scopus 로고    scopus 로고
    • Pharmaceutical metabolites in the environment: analytical challenges and ecological risks
    • Celiz M.D., Tso J., Aga D.S. Pharmaceutical metabolites in the environment: analytical challenges and ecological risks. Environ. Toxicol. Chem. 2009, 28:2473-2484. 10.1897/09-173.1.
    • (2009) Environ. Toxicol. Chem. , vol.28 , pp. 2473-2484
    • Celiz, M.D.1    Tso, J.2    Aga, D.S.3
  • 10
    • 84878654447 scopus 로고    scopus 로고
    • Emerging contaminants in Belgian marine waters: Single toxicant and mixture risks of pharmaceuticals
    • Claessens M., Vanhaecke L., Wille K., Janssens C.R. Emerging contaminants in Belgian marine waters: Single toxicant and mixture risks of pharmaceuticals. Mar. Pollut. Bull. 2013, 71:41-50. 10.1016/j.marpolbul.2013.03.039.
    • (2013) Mar. Pollut. Bull. , vol.71 , pp. 41-50
    • Claessens, M.1    Vanhaecke, L.2    Wille, K.3    Janssens, C.R.4
  • 11
    • 0037447779 scopus 로고    scopus 로고
    • Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects
    • Cleuvers M. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol. Lett. 2003, 142:185-194. 10.1016/S0378-4274(03)00068-7.
    • (2003) Toxicol. Lett. , vol.142 , pp. 185-194
    • Cleuvers, M.1
  • 12
    • 13844267823 scopus 로고    scopus 로고
    • Initial risk assessment for three β-blockers found in the aquatic environment
    • Cleuvers M. Initial risk assessment for three β-blockers found in the aquatic environment. Chemosphere 2005, 59:199-205. 10.1016/j.chemosphere.2004.11.090.
    • (2005) Chemosphere , vol.59 , pp. 199-205
    • Cleuvers, M.1
  • 13
    • 84902171134 scopus 로고    scopus 로고
    • Ecotoxicological evaluation of selected pharmaceuticals to Vibrio fischeri and Daphnia magna before and after photooxidation process
    • Czech B., JośKo I., Oleszczuk P. Ecotoxicological evaluation of selected pharmaceuticals to Vibrio fischeri and Daphnia magna before and after photooxidation process. Ecotox. Environ. Safe. 2014, 104:247-253. 10.1016/j.ecoenv.2014.03.024.
    • (2014) Ecotox. Environ. Safe. , vol.104 , pp. 247-253
    • Czech, B.1    JośKo, I.2    Oleszczuk, P.3
  • 14
    • 77249152166 scopus 로고    scopus 로고
    • Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna - a multigenerational study
    • Dietrich S., Ploessl F., Bracher F., Laforsch C. Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna - a multigenerational study. Chemosphere 2010, 79:60-66. 10.1016/j.chemosphere.2009.12.069.
    • (2010) Chemosphere , vol.79 , pp. 60-66
    • Dietrich, S.1    Ploessl, F.2    Bracher, F.3    Laforsch, C.4
  • 15
    • 33845331772 scopus 로고    scopus 로고
    • Comparative ecotoxicological hazard assessment of beta-blockers and their human metabolites using a mode-of-action-based test battery and a QSAR approach
    • Escher B.I., Bramaz N., Richter M., Lienert J. Comparative ecotoxicological hazard assessment of beta-blockers and their human metabolites using a mode-of-action-based test battery and a QSAR approach. Environ. Sci. Technol. 2006, 40:7402-7408. 10.1021/es052572v.
    • (2006) Environ. Sci. Technol. , vol.40 , pp. 7402-7408
    • Escher, B.I.1    Bramaz, N.2    Richter, M.3    Lienert, J.4
  • 16
    • 84940904764 scopus 로고    scopus 로고
    • Technical Guidance Document on Risk Assessment in Support of Commission Directive 93/67/EEC on Risk Assessment For New Notified Substances, Commission Regulation (EC) No 1488/94 on Risk Assessment For Existing Substances, Directive 98/8/EC of the European Parliament And Of The Council Concerning The Placing Of Biocidal Products On The Market-Part II.
    • European Commission, 2003. Technical Guidance Document on Risk Assessment in Support of Commission Directive 93/67/EEC on Risk Assessment For New Notified Substances, Commission Regulation (EC) No 1488/94 on Risk Assessment For Existing Substances, Directive 98/8/EC of the European Parliament And Of The Council Concerning The Placing Of Biocidal Products On The Market-Part II, 328 pp.
    • (2003) , pp. 328
  • 17
    • 84940922426 scopus 로고
    • Council Directive On The Approximation Of Laws, Regulations And Administrative Provisions Relating To The Classification, Packing and Labeling Of Dangerous Substances (67/548/EEC). Annex VI: General Classification And Labeling Requirements For Dangerous Substances And Preparations.
    • European Communities, 1967. Council Directive On The Approximation Of Laws, Regulations And Administrative Provisions Relating To The Classification, Packing and Labeling Of Dangerous Substances (67/548/EEC). Annex VI: General Classification And Labeling Requirements For Dangerous Substances And Preparations.
    • (1967)
  • 18
    • 80555126765 scopus 로고    scopus 로고
    • Transformation products of pharmaceuticals in surface waters and wastewater formed during photolysis and advanced oxidation processes - degradation, elucidation of byproducts and assessment of their biological potency
    • Fatta-Kassinos D., Vasquez M.I., Kümmerer K. Transformation products of pharmaceuticals in surface waters and wastewater formed during photolysis and advanced oxidation processes - degradation, elucidation of byproducts and assessment of their biological potency. Chemosphere 2011, 85:693-709. 10.1016/j.chemosphere.2011.06.082.
    • (2011) Chemosphere , vol.85 , pp. 693-709
    • Fatta-Kassinos, D.1    Vasquez, M.I.2    Kümmerer, K.3
  • 19
    • 84928824771 scopus 로고    scopus 로고
    • Sublethal effects of the beta-blocker sotalol at environmentally relevant concentrations on the New Zealand mudsnail Potamopyrgus antipodarum
    • Feiner M., Laforsch C., Letzel T., Geist J. Sublethal effects of the beta-blocker sotalol at environmentally relevant concentrations on the New Zealand mudsnail Potamopyrgus antipodarum. Environ. Toxicol. Chem. 2014, 33:2510-2515. 10.1002/etc.2699.
    • (2014) Environ. Toxicol. Chem. , vol.33 , pp. 2510-2515
    • Feiner, M.1    Laforsch, C.2    Letzel, T.3    Geist, J.4
  • 20
    • 2442603489 scopus 로고    scopus 로고
    • Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?
    • Ferrari B., Mons R., Vollat B., Fraysse B., Paxéus N., Giudice R.L., Pollio A., Garric J. Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?. Environ. Toxicol. Chem. 2004, 23:1344-1354. 10.1897/03-246.
    • (2004) Environ. Toxicol. Chem. , vol.23 , pp. 1344-1354
    • Ferrari, B.1    Mons, R.2    Vollat, B.3    Fraysse, B.4    Paxéus, N.5    Giudice, R.L.6    Pollio, A.7    Garric, J.8
  • 21
    • 84940952740 scopus 로고    scopus 로고
    • Results From The Swedish National Screening Programme 2010-Subreport 3. Pharmaceuticals. Swedish Environmental Research Institute.
    • Fick, J., Lindberg, R.H., Kaj, L., Brorström-Lundén, E., 2011. Results From The Swedish National Screening Programme 2010-Subreport 3. Pharmaceuticals. Swedish Environmental Research Institute.
    • (2011)
    • Fick, J.1    Lindberg, R.H.2    Kaj, L.3    Brorström-Lundén, E.4
  • 22
    • 78649577545 scopus 로고    scopus 로고
    • The β-blocker propranolol affects cAMP dependent signaling and induces the stress response in Mediterranean mussels, Mytilus galloprovincialis
    • Franzellitti S., Buratti S., Valbonesi P., Capuzzo A., Fabbri E. The β-blocker propranolol affects cAMP dependent signaling and induces the stress response in Mediterranean mussels, Mytilus galloprovincialis. Aquat. Toxicol. 2011, 101:299-308. 10.1016/j.aquatox.2010.11.001.
    • (2011) Aquat. Toxicol. , vol.101 , pp. 299-308
    • Franzellitti, S.1    Buratti, S.2    Valbonesi, P.3    Capuzzo, A.4    Fabbri, E.5
  • 23
    • 84880027136 scopus 로고    scopus 로고
    • The mode of action (MoA) approach reveals interactive effects of environmental pharmaceuticals on Mytilus galloprovincialis
    • Franzellitti S., Buratti S., Valbonesi P., Fabbri E. The mode of action (MoA) approach reveals interactive effects of environmental pharmaceuticals on Mytilus galloprovincialis. Aquat. Toxicol. 2013, 140-141:249-256. 10.1016/j.aquatox.2013.06.005.
    • (2013) Aquat. Toxicol. , pp. 249-256
    • Franzellitti, S.1    Buratti, S.2    Valbonesi, P.3    Fabbri, E.4
  • 24
    • 26844504986 scopus 로고    scopus 로고
    • Prediction and experimental validation of acute toxicity of β-blockers in Ceriodaphnia dubia
    • Fraysse B., Garric J. Prediction and experimental validation of acute toxicity of β-blockers in Ceriodaphnia dubia. Environ. Toxicol. Chem. 2005, 24:2470-2476. 10.1897/04-541R.1.
    • (2005) Environ. Toxicol. Chem. , vol.24 , pp. 2470-2476
    • Fraysse, B.1    Garric, J.2
  • 25
    • 85031873813 scopus 로고    scopus 로고
    • Uso De Genéricos Contra Hipertensão Cresce 190%. (accessed 02.02.15).
    • Frias, M.C. 2013. Uso De Genéricos Contra Hipertensão Cresce 190%. (accessed 02.02.15). http://www1.folha.uol.com.br/colunas/mercadoaberto/2013/08/1323813-uso-de-genericos-contra-hipertensao-cresce-190.shtml.
    • (2013)
    • Frias, M.C.1
  • 26
    • 84930570906 scopus 로고    scopus 로고
    • Ecotoxicological evaluation of propranolol hydrochloride and losartan potassium to Lemna minor L. (1753) individually and in binary mixtures
    • Godoy A.A., Kummrow F., Pamplin P.A.Z. Ecotoxicological evaluation of propranolol hydrochloride and losartan potassium to Lemna minor L. (1753) individually and in binary mixtures. Ecotoxicology 2015, 10.1007/s10646-015-1455-3.
    • (2015) Ecotoxicology
    • Godoy, A.A.1    Kummrow, F.2    Pamplin, P.A.Z.3
  • 27
    • 51249095222 scopus 로고    scopus 로고
    • Environmental assessment of Norwegian priority pharmaceuticals based on the EMEA guideline
    • Grung M., Källqvist T., Sakshaug S., Skurtveit S., Thomas K.V. Environmental assessment of Norwegian priority pharmaceuticals based on the EMEA guideline. Ecotox. Environ. Safe. 2008, 71:328-340. 10.1016/j.ecoenv.2007.10.015.
    • (2008) Ecotox. Environ. Safe. , vol.71 , pp. 328-340
    • Grung, M.1    Källqvist, T.2    Sakshaug, S.3    Skurtveit, S.4    Thomas, K.V.5
  • 28
    • 84867836770 scopus 로고    scopus 로고
    • Trends in antihypertensive medication use and blood pressure control among United States adults with hypertension: The National Health And Nutrition Examination Survey, 2001 to 2010
    • Gu Q., Burt V.L., Dillon C.F., Yoon S. Trends in antihypertensive medication use and blood pressure control among United States adults with hypertension: The National Health And Nutrition Examination Survey, 2001 to 2010. Circulation 2012, 126:2105-2114. 10.1161/CIRCULATIONAHA.112.096156.
    • (2012) Circulation , vol.126 , pp. 2105-2114
    • Gu, Q.1    Burt, V.L.2    Dillon, C.F.3    Yoon, S.4
  • 29
    • 84872471449 scopus 로고    scopus 로고
    • Effects of short-term exposure to environmentally relevant concentrations of different pharmaceutical mixtures on the immune response of the pond snail Lymnaea stagnalis
    • Gust M., Fortier M., Garric J., Fournier M., Gagné F. Effects of short-term exposure to environmentally relevant concentrations of different pharmaceutical mixtures on the immune response of the pond snail Lymnaea stagnalis. Sci. Total Environ. 2013, 445-446:210-218. 10.1016/j.scitotenv.2012.12.057.
    • (2013) Sci. Total Environ. , pp. 210-218
    • Gust, M.1    Fortier, M.2    Garric, J.3    Fournier, M.4    Gagné, F.5
  • 30
    • 3843140460 scopus 로고    scopus 로고
    • Analysis by liquid chromatography-electrospray ionization tandem mass spectrometry and acute toxicity evaluation for β-blockers and lipid-regulating agents in wastewater samples
    • Hernando M.D., Petrović M., Fernández-Alba A.R., Barceló D. Analysis by liquid chromatography-electrospray ionization tandem mass spectrometry and acute toxicity evaluation for β-blockers and lipid-regulating agents in wastewater samples. J. Chromatogr. A 2004, 1046:133-140. 10.1016/j.chroma.2004.06.102.
    • (2004) J. Chromatogr. A , vol.1046 , pp. 133-140
    • Hernando, M.D.1    Petrović, M.2    Fernández-Alba, A.R.3    Barceló, D.4
  • 31
    • 0036330058 scopus 로고    scopus 로고
    • Toxicity of select beta adrenergic receptor-blocking pharmaceuticals (B-Blockers) on aquatic organisms
    • Huggett D.B., Brooks B.W., Peterson B., Foran C.M., Schlenk D. Toxicity of select beta adrenergic receptor-blocking pharmaceuticals (B-Blockers) on aquatic organisms. Arch. Environ. Contam. Toxicol. 2002, 43:229-235. 10.1007/s00244-002-1182-7.
    • (2002) Arch. Environ. Contam. Toxicol. , vol.43 , pp. 229-235
    • Huggett, D.B.1    Brooks, B.W.2    Peterson, B.3    Foran, C.M.4    Schlenk, D.5
  • 32
    • 21644480813 scopus 로고    scopus 로고
    • Toxic and genotoxic evaluation of six antibiotics on non-target organisms
    • Isidori M., Lavorgna M., Nardelli A., Pascarella L., Parrella A. Toxic and genotoxic evaluation of six antibiotics on non-target organisms. Sci. Total Environ. 2005, 346:87-98. 10.1016/j.scitotenv.2004.11.017.
    • (2005) Sci. Total Environ. , vol.346 , pp. 87-98
    • Isidori, M.1    Lavorgna, M.2    Nardelli, A.3    Pascarella, L.4    Parrella, A.5
  • 33
    • 58549120162 scopus 로고    scopus 로고
    • The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters
    • Kasprzyk-Hordern B., Dinsdale R.M., Guwy A.J. The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Wat. Res. 2009, 43:363-380. 10.1016/j.watres.2008.10.047.
    • (2009) Wat. Res. , vol.43 , pp. 363-380
    • Kasprzyk-Hordern, B.1    Dinsdale, R.M.2    Guwy, A.J.3
  • 34
    • 33847279987 scopus 로고    scopus 로고
    • Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea
    • Kim Y., Choi K., Jung J., Park S., Kim P.G., Park J. Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ. Int. 2007, 33:370-375. 10.1016/j.envint.2006.11.017.
    • (2007) Environ. Int. , vol.33 , pp. 370-375
    • Kim, Y.1    Choi, K.2    Jung, J.3    Park, S.4    Kim, P.G.5    Park, J.6
  • 35
    • 66149177052 scopus 로고    scopus 로고
    • Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)
    • Kim J.W., Ishibashi H., Yamauchi R., Ichikawa N., Takao Y., Hirano M., Koga M., Arizono K. Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes). J. Toxicol. Sci. 2009, 34:227-232. 10.2131/jts.34.227.
    • (2009) J. Toxicol. Sci. , vol.34 , pp. 227-232
    • Kim, J.W.1    Ishibashi, H.2    Yamauchi, R.3    Ichikawa, N.4    Takao, Y.5    Hirano, M.6    Koga, M.7    Arizono, K.8
  • 36
    • 84873933711 scopus 로고    scopus 로고
    • Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary
    • Klosterhaus S.L., Grace R., Hamilton M.C., Yee D. Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary. Environ. Int. 2013, 54:92-99. 10.1016/j.envint.2013.01.009.
    • (2013) Environ. Int. , vol.54 , pp. 92-99
    • Klosterhaus, S.L.1    Grace, R.2    Hamilton, M.C.3    Yee, D.4
  • 37
    • 84885125793 scopus 로고    scopus 로고
    • Concentrations of prioritized pharmaceuticals in effluents from 50 large wastewater treatment plants in the US and implications for risk estimation
    • Kostich M.S., Batt A.L., Lazorchak J.M. Concentrations of prioritized pharmaceuticals in effluents from 50 large wastewater treatment plants in the US and implications for risk estimation. Environ. Pollut. 2014, 184:354-359. 10.1016/j.envpol.2013.09.013.
    • (2014) Environ. Pollut. , vol.184 , pp. 354-359
    • Kostich, M.S.1    Batt, A.L.2    Lazorchak, J.M.3
  • 39
    • 34548354864 scopus 로고    scopus 로고
    • Effluent from drug manufactures contains extremely high levels of pharmaceuticals
    • Larsson D.G.K., de Pedro C., Paxeus N. Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J. Hazard. Mater. 2007, 148:751-755. 10.1016/j.jhazmat.2007.07.008.
    • (2007) J. Hazard. Mater. , vol.148 , pp. 751-755
    • Larsson, D.G.K.1    de Pedro, C.2    Paxeus, N.3
  • 40
    • 80052590373 scopus 로고    scopus 로고
    • Toxicity evaluation of verapamil and tramadol based on toxicity assay and expression patterns of Dhb, Vtg, Arnt, CYP4 and CYP314 in Daphnia magna
    • Le T.H., Lim E.S., Lee S.K., Park J.S., Kim Y.H., Min J. Toxicity evaluation of verapamil and tramadol based on toxicity assay and expression patterns of Dhb, Vtg, Arnt, CYP4 and CYP314 in Daphnia magna. Environ. Toxicol. 2011, 26:515-523. 10.1002/tox.20665.
    • (2011) Environ. Toxicol. , vol.26 , pp. 515-523
    • Le, T.H.1    Lim, E.S.2    Lee, S.K.3    Park, J.S.4    Kim, Y.H.5    Min, J.6
  • 41
    • 77955056990 scopus 로고    scopus 로고
    • Ecotoxicological effects of short-term exposure to a human pharmaceutical verapamil in juvenile rainbow trout (Oncorhynchus mykiss)
    • Li Z.H., Li P., Randak T. Ecotoxicological effects of short-term exposure to a human pharmaceutical verapamil in juvenile rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Phys. C 2010, 152:385-391. 10.1016/j.cbpc.2010.06.007.
    • (2010) Comp. Biochem. Phys. C , vol.152 , pp. 385-391
    • Li, Z.H.1    Li, P.2    Randak, T.3
  • 42
    • 77956055569 scopus 로고    scopus 로고
    • Advanced monitoring of pharmaceuticals and estrogens in the Llobregat River basin (Spain) by liquid chromatography-triple quadrupole-tandem mass spectrometry in combination with ultra-performance liquid chromatography-time of flight-mass spectrometry
    • López-Roldán R., de Alda M.L., Gros M., Petrovic M., Martín-Alonso J., Braceló D. Advanced monitoring of pharmaceuticals and estrogens in the Llobregat River basin (Spain) by liquid chromatography-triple quadrupole-tandem mass spectrometry in combination with ultra-performance liquid chromatography-time of flight-mass spectrometry. Chemosphere 2010, 80:1337-1344. 10.1016/j.chemosphere.2010.06.042.
    • (2010) Chemosphere , vol.80 , pp. 1337-1344
    • López-Roldán, R.1    de Alda, M.L.2    Gros, M.3    Petrovic, M.4    Martín-Alonso, J.5    Braceló, D.6
  • 43
    • 78650028791 scopus 로고    scopus 로고
    • Fully automated determination of 74 pharmaceuticals in environmental and waste waters by online solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry
    • López-Serna R., Pérez S., Ginebreda A., Petrović M., Barceló D. Fully automated determination of 74 pharmaceuticals in environmental and waste waters by online solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Talanta 2010, 83:410-424. 10.1016/j.talanta.2010.09.046.
    • (2010) Talanta , vol.83 , pp. 410-424
    • López-Serna, R.1    Pérez, S.2    Ginebreda, A.3    Petrović, M.4    Barceló, D.5
  • 44
    • 82455171922 scopus 로고    scopus 로고
    • Development of a fast instrumental method for the analysis of pharmaceuticals in environmental and wastewaters based on ultra-high performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS)
    • López-Serna R., Petrović M., Barceló D. Development of a fast instrumental method for the analysis of pharmaceuticals in environmental and wastewaters based on ultra-high performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS). Chemosphere 2011, 85:1390-1399. 10.1016/j.chemosphere.2011.07.071.
    • (2011) Chemosphere , vol.85 , pp. 1390-1399
    • López-Serna, R.1    Petrović, M.2    Barceló, D.3
  • 45
    • 84872143487 scopus 로고    scopus 로고
    • Occurrence of 95 pharmaceuticals and transformation products in urban groundwaters underlying the metropolis of Barcelona, Spain
    • López-Serna R., Jurado A., Vázquez-Suñé E., Carrera J., Petrović M., Barceló D. Occurrence of 95 pharmaceuticals and transformation products in urban groundwaters underlying the metropolis of Barcelona, Spain. Environ. Pollut. 2013, 174:305-315. 10.1016/j.envpol.2012.11.022.
    • (2013) Environ. Pollut. , vol.174 , pp. 305-315
    • López-Serna, R.1    Jurado, A.2    Vázquez-Suñé, E.3    Carrera, J.4    Petrović, M.5    Barceló, D.6
  • 46
    • 84858725544 scopus 로고    scopus 로고
    • The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): evaluation of impacts on fish liver, by histopathology, stereology, vitellogenin and CYP1A immunohistochemistry, after sub-acute exposures of the zebrafish model
    • Madureira T.V., Rocha M.J., Cruzeiro C., Rodrigues I., Monteiro R.A.F., Rocha E. The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): evaluation of impacts on fish liver, by histopathology, stereology, vitellogenin and CYP1A immunohistochemistry, after sub-acute exposures of the zebrafish model. Environ. Toxicol. Phar. 2012, 34:34-45. 10.1016/j.etap.2012.02.007.
    • (2012) Environ. Toxicol. Phar. , vol.34 , pp. 34-45
    • Madureira, T.V.1    Rocha, M.J.2    Cruzeiro, C.3    Rodrigues, I.4    Monteiro, R.A.F.5    Rocha, E.6
  • 50
    • 33847648087 scopus 로고    scopus 로고
    • Elimination of β-blockers in sewage treatment plants
    • Maurer M., Escher B.I., Richle P., Schaffner C., Alder A.C. Elimination of β-blockers in sewage treatment plants. Wat. Res. 2007, 41:1614-1622. 10.1016/j.watres.2007.01.004.
    • (2007) Wat. Res. , vol.41 , pp. 1614-1622
    • Maurer, M.1    Escher, B.I.2    Richle, P.3    Schaffner, C.4    Alder, A.C.5
  • 52
    • 29344475424 scopus 로고    scopus 로고
    • Toxicity of selected pharmaceuticals to the anostracan crustacean Thamnocephalus platyurus - comparison of sublethal and lethal effect levels with the 1h Rapidtoxkit and the 24h Thamnotoxkit microbiotests
    • Nalecz-Jawecki G., Persoone G. Toxicity of selected pharmaceuticals to the anostracan crustacean Thamnocephalus platyurus - comparison of sublethal and lethal effect levels with the 1h Rapidtoxkit and the 24h Thamnotoxkit microbiotests. Environ. Sci. Pollut. R. 2006, 13:22-27. 10.1065/espr2006.01.005.
    • (2006) Environ. Sci. Pollut. R. , vol.13 , pp. 22-27
    • Nalecz-Jawecki, G.1    Persoone, G.2
  • 53
    • 27644586646 scopus 로고    scopus 로고
    • Influence of water hardness on the toxicity of selected pharmaceuticals and metals to the protozoa Spirostomum ambiguum and Tetrahymena termophila
    • Nalecz-Jawecki G., Sawicki J. Influence of water hardness on the toxicity of selected pharmaceuticals and metals to the protozoa Spirostomum ambiguum and Tetrahymena termophila. Fresen. Environ. Bull. 2005, 14:873-877.
    • (2005) Fresen. Environ. Bull. , vol.14 , pp. 873-877
    • Nalecz-Jawecki, G.1    Sawicki, J.2
  • 54
    • 84886087860 scopus 로고    scopus 로고
    • Occurrence and fate of the angiotensin II receptor antagonist transformation product valsartan acid in the water cycle - a comparative study with selected b-blockers and the persistent anthropogenic wastewater indicators carbamazepine and acesulfame
    • Nödler K., Hillebrand O., Idzik K., Strathmann M., Schiperski F., Zirlewagen J., Licha T. Occurrence and fate of the angiotensin II receptor antagonist transformation product valsartan acid in the water cycle - a comparative study with selected b-blockers and the persistent anthropogenic wastewater indicators carbamazepine and acesulfame. Wat. Res. 2013, 47:6650-6659. 10.1016/j.watres.2013.08.034.
    • (2013) Wat. Res. , vol.47 , pp. 6650-6659
    • Nödler, K.1    Hillebrand, O.2    Idzik, K.3    Strathmann, M.4    Schiperski, F.5    Zirlewagen, J.6    Licha, T.7
  • 55
    • 84905722086 scopus 로고    scopus 로고
    • Polar organic micropollutants in the coastal environment of different marine systems
    • Nödler K., Voutsa D., Licha T. Polar organic micropollutants in the coastal environment of different marine systems. Mar. Pollut. Bull. 2014, 85:50-59. 10.1016/j.marpolbul.2014.06.024.
    • (2014) Mar. Pollut. Bull. , vol.85 , pp. 50-59
    • Nödler, K.1    Voutsa, D.2    Licha, T.3
  • 56
    • 84896047789 scopus 로고    scopus 로고
    • Combined effects of pharmaceuticals, personal care products, biocides and organic contaminants on the growth of Skeletonema pseudocostatum
    • Petersen K., Heiaas H.H., Tollefsen K.E. Combined effects of pharmaceuticals, personal care products, biocides and organic contaminants on the growth of Skeletonema pseudocostatum. Aquat. Toxicol. 2014, 150:45-54. 10.1016/j.aquatox.2014.02.013.
    • (2014) Aquat. Toxicol. , vol.150 , pp. 45-54
    • Petersen, K.1    Heiaas, H.H.2    Tollefsen, K.E.3
  • 57
    • 54049103910 scopus 로고    scopus 로고
    • Photolysis of β-blockers in environmental waters
    • Piram A., Salvador A., Verne C., Herbreteau B., Faure R. Photolysis of β-blockers in environmental waters. Chemosphere 2008, 73:1265-1271. 10.1016/j.chemosphere.2008.07.018.
    • (2008) Chemosphere , vol.73 , pp. 1265-1271
    • Piram, A.1    Salvador, A.2    Verne, C.3    Herbreteau, B.4    Faure, R.5
  • 58
    • 35649024253 scopus 로고    scopus 로고
    • Gene expression profiles in zebrafish (Danio rerio) liver cells exposed to a mixture of pharmaceuticals at environmentally relevant concentrations
    • Pomati F., Cotsapas C.J., Castiglioni S., Zuccato E., Calamari D. Gene expression profiles in zebrafish (Danio rerio) liver cells exposed to a mixture of pharmaceuticals at environmentally relevant concentrations. Chemosphere 2007, 70:65-73. 10.1016/j.chemosphere.2007.07.048.
    • (2007) Chemosphere , vol.70 , pp. 65-73
    • Pomati, F.1    Cotsapas, C.J.2    Castiglioni, S.3    Zuccato, E.4    Calamari, D.5
  • 59
    • 85031878317 scopus 로고    scopus 로고
    • Saiba Quais São Os Genéricos Mais Vendidos No País. (accessed 02.02.15).
    • PróGenéricos - Associação Brasileira Das Indústrias De Medicamentos Genéricos, 2013. Saiba Quais São Os Genéricos Mais Vendidos No País. (accessed 02.02.15). http://www.progenericos.org.br/index.php/noticias/325-saiba-quais-sao-os-genericos-mais-vendidos-no-pais.
    • (2013)
  • 60
    • 33846890689 scopus 로고    scopus 로고
    • Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor
    • Radjenovic J., Petrovic M., Barceló D. Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Anal. Bioanal. Chem. 2007, 387:1365-1377. 10.1007/s00216-006-0883-6.
    • (2007) Anal. Bioanal. Chem. , vol.387 , pp. 1365-1377
    • Radjenovic, J.1    Petrovic, M.2    Barceló, D.3
  • 61
    • 84862829035 scopus 로고    scopus 로고
    • P-glycoprotein (P-gp) in the monogonont rotifer, Brachionus koreanus: molecular characterization and expression in response to pharmaceuticals
    • Rhee J.S., Jeong C.B., Kim B.M., Lee J.S. P-glycoprotein (P-gp) in the monogonont rotifer, Brachionus koreanus: molecular characterization and expression in response to pharmaceuticals. Aquat. Toxicol. 2012, 114-115:104-118. 10.1016/j.aquatox.2012.02.009.
    • (2012) Aquat. Toxicol. , pp. 104-118
    • Rhee, J.S.1    Jeong, C.B.2    Kim, B.M.3    Lee, J.S.4
  • 62
    • 32644485467 scopus 로고    scopus 로고
    • The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment
    • Roberts P.H., Thomas K.V. The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment. Sci. Total Environ. 2006, 356:143-153. 10.1016/j.scitotenv.2005.04.031.
    • (2006) Sci. Total Environ. , vol.356 , pp. 143-153
    • Roberts, P.H.1    Thomas, K.V.2
  • 66
    • 84878908692 scopus 로고    scopus 로고
    • Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals
    • Santos L.H.M.L.M., Gros M., Rodriguez-Mozaz S., Delerue-Matos C., Pena A., Barceló D., Montenegro M.C.B.S.M. Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals. Sci. Total Environ. 2013, 461-462:302-316. 10.1016/j.scitotenv.2013.04.077.
    • (2013) Sci. Total Environ. , pp. 302-316
    • Santos, L.H.M.L.M.1    Gros, M.2    Rodriguez-Mozaz, S.3    Delerue-Matos, C.4    Pena, A.5    Barceló, D.6    Montenegro, M.C.B.S.M.7
  • 67
    • 84894649558 scopus 로고    scopus 로고
    • A review of what is an emerging contaminant
    • Sauvé S., Desroirers M. A review of what is an emerging contaminant. Chem. Cent. J. 2014, 8:15. 10.1186/1752-153X-8-15.
    • (2014) Chem. Cent. J. , vol.8 , pp. 15
    • Sauvé, S.1    Desroirers, M.2
  • 69
    • 84878459123 scopus 로고    scopus 로고
    • Toxic effects, bioconcentration and depuration of verapamil in the early life stages of common carp (Cyprinus carpio L.)
    • Steinbach C., Fedorova G., Prokes M., Grabicova K., Machova J., Grabic R., Valentova O., Kroupova H.K. Toxic effects, bioconcentration and depuration of verapamil in the early life stages of common carp (Cyprinus carpio L.). Sci. Total Environ. 2013, 461-462:198-206. 10.1016/j.scitotenv.2013.05.002.
    • (2013) Sci. Total Environ. , pp. 198-206
    • Steinbach, C.1    Fedorova, G.2    Prokes, M.3    Grabicova, K.4    Machova, J.5    Grabic, R.6    Valentova, O.7    Kroupova, H.K.8
  • 70
    • 84911975827 scopus 로고    scopus 로고
    • Toxicity and enantiospecific differences of two β-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio)
    • Sun L., Xin L., Peng Z., Jin R., Jin Y., Qian H., Fu Z. Toxicity and enantiospecific differences of two β-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio). Environ. Toxicol. 2014, 29:1367-1378. 10.1002/tox.21867.
    • (2014) Environ. Toxicol. , vol.29 , pp. 1367-1378
    • Sun, L.1    Xin, L.2    Peng, Z.3    Jin, R.4    Jin, Y.5    Qian, H.6    Fu, Z.7
  • 71
    • 84921636466 scopus 로고    scopus 로고
    • Human pharmaceutical products in the environment-the "problem" in perspective
    • Taylor D., Senac T. Human pharmaceutical products in the environment-the "problem" in perspective. Chemosphere 2014, 115:95-99. 10.1016/j.chemosphere.2014.01.011.
    • (2014) Chemosphere , vol.115 , pp. 95-99
    • Taylor, D.1    Senac, T.2
  • 72
    • 0032210734 scopus 로고    scopus 로고
    • Occurrence of drugs in German sewage treatment plants and rivers
    • Ternes T.A. Occurrence of drugs in German sewage treatment plants and rivers. Wat. Res. 1998, 32:3245-3260. 10.1016/S0043-1354(98)00099-2.
    • (1998) Wat. Res. , vol.32 , pp. 3245-3260
    • Ternes, T.A.1
  • 73
    • 77957916105 scopus 로고    scopus 로고
    • Fish embryo toxicity of carbamazepine, diclofenac and metoprolol
    • van den Brandhof E.J., Montforts M. Fish embryo toxicity of carbamazepine, diclofenac and metoprolol. Ecotox. Environ. Safe. 2010, 73:1862-1866. 10.1016/j.ecoenv.2010.08.031.
    • (2010) Ecotox. Environ. Safe. , vol.73 , pp. 1862-1866
    • van den Brandhof, E.J.1    Montforts, M.2
  • 74
    • 78650853934 scopus 로고    scopus 로고
    • Effects of a complex mixture of therapeutic drugs on unicellular algae Pseudokirchneriella subcapitata
    • Vannini C., Domingo G., Marsoni M., De Mattia F., Labra M., Castiglioni S., Bracale M. Effects of a complex mixture of therapeutic drugs on unicellular algae Pseudokirchneriella subcapitata. Aquat. Toxicol. 2011, 101:459-465. 10.1016/j.aquatox.2010.10.011.
    • (2011) Aquat. Toxicol. , vol.101 , pp. 459-465
    • Vannini, C.1    Domingo, G.2    Marsoni, M.3    De Mattia, F.4    Labra, M.5    Castiglioni, S.6    Bracale, M.7
  • 75
    • 84904739776 scopus 로고    scopus 로고
    • Environmental side effects of pharmaceutical cocktails: what we know and what we should know
    • Vasquez M.I., Lambrianides A., Schneider M., Kümmerer K., Fatta-Kassinos D. Environmental side effects of pharmaceutical cocktails: what we know and what we should know. J. Hazard. Mater. 2014, 279:169-189. 10.1016/j.jhazmat.2014.06.069.
    • (2014) J. Hazard. Mater. , vol.279 , pp. 169-189
    • Vasquez, M.I.1    Lambrianides, A.2    Schneider, M.3    Kümmerer, K.4    Fatta-Kassinos, D.5
  • 76
    • 84861332141 scopus 로고    scopus 로고
    • Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment
    • Verlicchi P., Aukidy M.A., Galletti A., Petrovic M., Barceló D. Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. Sci. Total Environ. 2012, 430:109-118. 10.1016/j.scitotenv.2012.04.055.
    • (2012) Sci. Total Environ. , vol.430 , pp. 109-118
    • Verlicchi, P.1    Aukidy, M.A.2    Galletti, A.3    Petrovic, M.4    Barceló, D.5
  • 77
    • 84886952477 scopus 로고    scopus 로고
    • Molecular docking: a potential tool to aid ecotoxicity testing in environmental risk assessment of pharmaceuticals
    • Walker S., McEldowney S. Molecular docking: a potential tool to aid ecotoxicity testing in environmental risk assessment of pharmaceuticals. Chemosphere 2013, 93:2568-2577. 10.1016/j.chemosphere.2013.09.074.
    • (2013) Chemosphere , vol.93 , pp. 2568-2577
    • Walker, S.1    McEldowney, S.2
  • 78
    • 84867487460 scopus 로고    scopus 로고
    • Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater
    • Wilde M.L., Kümmerer K., Martins A.F. Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater. J. Braz. Chem. Soc. 2012, 23:1732-1740. 10.1590/S0103-50532012005000035.
    • (2012) J. Braz. Chem. Soc. , vol.23 , pp. 1732-1740
    • Wilde, M.L.1    Kümmerer, K.2    Martins, A.F.3
  • 80
    • 84921951328 scopus 로고    scopus 로고
    • Organic pollutants removal in wastewater by heterogeneous photocatalytic ozonation
    • Xiao J., Xie Y., Cao H. Organic pollutants removal in wastewater by heterogeneous photocatalytic ozonation. Chemosphere 2015, 121:1-17. 10.1016/j.chemosphere.2014.10.072.
    • (2015) Chemosphere , vol.121 , pp. 1-17
    • Xiao, J.1    Xie, Y.2    Cao, H.3
  • 81
    • 84930572903 scopus 로고    scopus 로고
    • Avaliação dos efeitos biológicos adversos dos fármacos anti-hipertensivos Losartan e Valsartan em ouriço-do-mar Lytechinus variegatus (ECHINODERMATA, ECHINOIDEA)
    • Yamamoto N.S., Pereira C.D.S., Cortez F.S., Pusceddu F.H., Santos A.R., Toma W., Guimarães L.L. Avaliação dos efeitos biológicos adversos dos fármacos anti-hipertensivos Losartan e Valsartan em ouriço-do-mar Lytechinus variegatus (ECHINODERMATA, ECHINOIDEA). UNISANTA BioScience 2014, 3:27-32.
    • (2014) UNISANTA BioScience , vol.3 , pp. 27-32
    • Yamamoto, N.S.1    Pereira, C.D.S.2    Cortez, F.S.3    Pusceddu, F.H.4    Santos, A.R.5    Toma, W.6    Guimarães, L.L.7


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