메뉴 건너뛰기




Volumn 40, Issue 23, 2006, Pages 7402-7408

Comparative ecotoxicological hazard assessment of beta-blockers and their human metabolites using a mode-of-action-based test battery and a QSAR approach

Author keywords

[No Author keywords available]

Indexed keywords

ENVIRONMENTAL ENGINEERING; HEALTH HAZARDS; METABOLITES; TOXIC MATERIALS; TOXICITY; YEAST;

EID: 33845331772     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es052572v     Document Type: Article
Times cited : (170)

References (48)
  • 2
    • 0033383635 scopus 로고    scopus 로고
    • Pharmaceuticals and personal care products in the environment: Agents of subtle change?
    • Daughton, C.; Ternes, T. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ. Health Perspect. 1999, 107, Supp. 6, 907-937.
    • (1999) Environ. Health Perspect. , vol.107 , Issue.SUPPL. 6 , pp. 907-937
    • Daughton, C.1    Ternes, T.2
  • 3
    • 0032210734 scopus 로고    scopus 로고
    • Occurrence of drugs in German sewage treatment plants and rivers
    • Ternes, T. A. Occurrence of drugs in German sewage treatment plants and rivers. Chemosphere 1998, 32, 3245-3260.
    • (1998) Chemosphere , vol.32 , pp. 3245-3260
    • Ternes, T.A.1
  • 4
    • 0037085574 scopus 로고    scopus 로고
    • Pharmaceuticals, hormones and other organic contaminants in U.S. streams, 1999-2000: A national reconnaissance
    • Kolpin, D. W.; Furlong, E. T.; Meyer, M. T.; Thurman, E. M.; Zaugg, S. D. Pharmaceuticals, hormones and other organic contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 2002, 36, 1201-1211.
    • (2002) Environ. Sci. Technol. , vol.36 , pp. 1201-1211
    • Kolpin, D.W.1    Furlong, E.T.2    Meyer, M.T.3    Thurman, E.M.4    Zaugg, S.D.5
  • 5
    • 0242432410 scopus 로고    scopus 로고
    • Strategic survey of therapeutic drugs in the rivers Po and Lambro in northern Italy
    • Calamari, D.; Zuccato, E.; Castiglioni, S.; Bagnati, R.; Fanelli, R. Strategic survey of therapeutic drugs in the rivers Po and Lambro in northern Italy. Environ. Sci. Technol. 2003, 37, 1241-1248.
    • (2003) Environ. Sci. Technol. , vol.37 , pp. 1241-1248
    • Calamari, D.1    Zuccato, E.2    Castiglioni, S.3    Bagnati, R.4    Fanelli, R.5
  • 6
    • 5444262575 scopus 로고    scopus 로고
    • Removal of selected nonsteroidal antiinflammatory drugs (NSAIDs), gemfibrozil, carbamazepine, beta-blockers, trimethoprim and triclosan in conventional wastewater treatment plants in five EU countries and their discharge to the aquatic environment
    • Paxeus, N. Removal of selected nonsteroidal antiinflammatory drugs (NSAIDs), gemfibrozil, carbamazepine, beta-blockers, trimethoprim and triclosan in conventional wastewater treatment plants in five EU countries and their discharge to the aquatic environment. Water Sci. Technol. 2004, 50, 253-260.
    • (2004) Water Sci. Technol. , vol.50 , pp. 253-260
    • Paxeus, N.1
  • 7
    • 0038187641 scopus 로고    scopus 로고
    • Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy
    • Daughton, C. G. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy. Environ. Health Perspect. 2003, 111, 757-774.
    • (2003) Environ. Health Perspect. , vol.111 , pp. 757-774
    • Daughton, C.G.1
  • 8
    • 0037512363 scopus 로고    scopus 로고
    • Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. II. Drug disposal, waste reduction, and future directions
    • Daughton, C. G. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. II. Drug disposal, waste reduction, and future directions. Environ. Health Perspect. 2003, 111, 775-785.
    • (2003) Environ. Health Perspect. , vol.111 , pp. 775-785
    • Daughton, C.G.1
  • 12
    • 2442603489 scopus 로고    scopus 로고
    • Environmental risk assessment of six human pharmaceuticals: Are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?
    • Ferrari, B.; Mons, R.; Vollat, B.; Fraysse, B.; Paxeus, N.; Lo Giudice, R.; Pollio, A.; Garric, J. Environmental risk assessment of six human pharmaceuticals: Are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment? Environ. Toxicol. Chem./SETAC2004, 23, 1344-1354.
    • (2004) Environ. Toxicol. Chem./SETAC , vol.23 , pp. 1344-1354
    • Ferrari, B.1    Mons, R.2    Vollat, B.3    Fraysse, B.4    Paxeus, N.5    Lo Giudice, R.6    Pollio, A.7    Garric, J.8
  • 13
    • 3042569762 scopus 로고    scopus 로고
    • Environmental risk assessment of medicinal products for human use according to the European Commission recommendations
    • Huschek, G.; Hansen, P. D.; Maurer, H. H.; Krengel, D.; Kayser, A. Environmental risk assessment of medicinal products for human use according to the European Commission recommendations. Environ. Toxicol. 2004, 226-240.
    • (2004) Environ. Toxicol. , pp. 226-240
    • Huschek, G.1    Hansen, P.D.2    Maurer, H.H.3    Krengel, D.4    Kayser, A.5
  • 14
    • 0032452075 scopus 로고    scopus 로고
    • Pharmacological properties of beta-adrenoreceptor blocking drugs
    • Borchard, U. Pharmacological properties of beta-adrenoreceptor blocking drugs. J. Clinical Basic Cardiology 1998, 1, 5-9.
    • (1998) J. Clinical Basic Cardiology , vol.1 , pp. 5-9
    • Borchard, U.1
  • 15
    • 0036330058 scopus 로고    scopus 로고
    • Toxicity of select beta adrenergic receptor-blocking pharmaceuticals (β-blockers) on aquatic organisms
    • Huggett, D. B.; Brooks, B. W.; Peterson, B.; Foran, C. M.; Schlenk, D. Toxicity of select beta adrenergic receptor-blocking pharmaceuticals (β-blockers) on aquatic organisms. Archives Environ. Contamin. Toxicol. 2002, 43, 229-235.
    • (2002) Archives Environ. Contamin. Toxicol. , vol.43 , pp. 229-235
    • Huggett, D.B.1    Brooks, B.W.2    Peterson, B.3    Foran, C.M.4    Schlenk, D.5
  • 17
    • 0037052834 scopus 로고    scopus 로고
    • Environmental risk assessment of pharmaceutical drug substances - Conceptual considerations
    • Länge, R.; Dietrich, D. Environmental risk assessment of pharmaceutical drug substances - conceptual considerations. Toxicol. Lett. 2002, 131, 97-104.
    • (2002) Toxicol. Lett. , vol.131 , pp. 97-104
    • Länge, R.1    Dietrich, D.2
  • 18
    • 0037052833 scopus 로고    scopus 로고
    • Pharmacodynamic activity of drugs and ecotoxicology - Can the two be connected?
    • Seiler, J. P., Pharmacodynamic activity of drugs and ecotoxicology - can the two be connected? Toxicol. Lett. 2002, 131, 105-115.
    • (2002) Toxicol. Lett. , vol.131 , pp. 105-115
    • Seiler, J.P.1
  • 19
    • 18344391885 scopus 로고    scopus 로고
    • PPCP's in the Environment: Future research-beginning with the end always in mind
    • Kümmerer, K., Ed.; Springer: New York
    • Daughton, C. G. PPCP's in the Environment: future research-beginning with the end always in mind. In Pharmaceuticals in the Environment; Kümmerer, K., Ed.; Springer: New York, 2004; pp 463-495.
    • (2004) Pharmaceuticals in the Environment , pp. 463-495
    • Daughton, C.G.1
  • 21
    • 0037107331 scopus 로고    scopus 로고
    • Modes of action in ecotoxicology: Their role in body burdens, species sensitivity, QSARs, and mixture effects
    • Escher, B. I.; Hermens, J. L. M., Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects. Environ. Sci. Technol. 2002, 36, 4201-4217.
    • (2002) Environ. Sci. Technol. , vol.36 , pp. 4201-4217
    • Escher, B.I.1    Hermens, J.L.M.2
  • 22
    • 18344384131 scopus 로고    scopus 로고
    • In-vitro assessment of modes of toxic action of pharmaceuticals in aquatic life
    • Escher, B. I.; Bramaz, N.; Eggen, R. I. L.; Richter, M., In-vitro assessment of modes of toxic action of pharmaceuticals in aquatic life. Environ. Sci. Technol. 2005, 39, 3090-3100.
    • (2005) Environ. Sci. Technol. , vol.39 , pp. 3090-3100
    • Escher, B.I.1    Bramaz, N.2    Eggen, R.I.L.3    Richter, M.4
  • 24
    • 0004047129 scopus 로고
    • Churchill Livingstone: New York
    • Therapeutic Drugs; Churchill Livingstone: New York, 1991.
    • (1991) Therapeutic Drugs
  • 25
    • 0004300307 scopus 로고    scopus 로고
    • Baselt, R. C., Cravey, R. H., Dollery, C., Boobis, A. R., Burley, D., Davies, D. M., Davies, D. S., Harrison, P. I., Orme, M. L. E., Park, B. K., Goldberg, L. I., Eds; Chemical Toxicology Institute: Foster City, CA
    • Disposition of Toxic Drugs and Chemicals in Man, fourth edition; Baselt, R. C., Cravey, R. H., Dollery, C., Boobis, A. R., Burley, D., Davies, D. M., Davies, D. S., Harrison, P. I., Orme, M. L. E., Park, B. K., Goldberg, L. I., Eds; Chemical Toxicology Institute: Foster City, CA, 2000.
    • (2000) Disposition of Toxic Drugs and Chemicals in Man, Fourth Edition
  • 26
    • 0034664261 scopus 로고    scopus 로고
    • Evaluation of liposome-water partitioning of organic acids and bases: I. Development of sorption model
    • Escher, B. I.; Schwarzenbach, R. P.; Westall, J. W. C. Evaluation of liposome-water partitioning of organic acids and bases: I. Development of sorption model. Environ. Sci. Technol. 2000, 34, 3954-3961.
    • (2000) Environ. Sci. Technol. , vol.34 , pp. 3954-3961
    • Escher, B.I.1    Schwarzenbach, R.P.2    Westall, J.W.C.3
  • 29
    • 0030066424 scopus 로고    scopus 로고
    • Estrogenic activity of surfactants and some of their degradation products assessed during a recombinant yeast estrogen screen
    • Routledge, E.; Sumpter, J., Estrogenic activity of surfactants and some of their degradation products assessed during a recombinant yeast estrogen screen. Environ. Toxicol. Chem. 1996, 15, 241-248.
    • (1996) Environ. Toxicol. Chem. , vol.15 , pp. 241-248
    • Routledge, E.1    Sumpter, J.2
  • 30
    • 0031656115 scopus 로고    scopus 로고
    • Several environmental estrogenic compounds are also anti-androgens
    • Sohoni, P.; Sumpter, J. P., Several environmental estrogenic compounds are also anti-androgens. J. Endocrinol. 1998, 158, 327-339.
    • (1998) J. Endocrinol. , vol.158 , pp. 327-339
    • Sohoni, P.1    Sumpter, J.P.2
  • 32
    • 0026785215 scopus 로고
    • Classifying environmental pollutants. 1: Structure-activity relationships for prediction of aquatic toxicity
    • Verhaar, H. J. M.; van Leeuwen, C. J.; Hermens, J. L. M. Classifying environmental pollutants. 1: Structure-activity relationships for prediction of aquatic toxicity. Chemosphere 1992, 25, 471-491.
    • (1992) Chemosphere , vol.25 , pp. 471-491
    • Verhaar, H.J.M.1    Van Leeuwen, C.J.2    Hermens, J.L.M.3
  • 33
    • 0017160403 scopus 로고
    • Clinical pharmacokinetics of β-adrenoreceptor blocking drugs
    • Johnsson, G.; Regardh, C. G. Clinical pharmacokinetics of β-adrenoreceptor blocking drugs. Clin. Pharmacokin. 1976, 1, 233-263.
    • (1976) Clin. Pharmacokin. , vol.1 , pp. 233-263
    • Johnsson, G.1    Regardh, C.G.2
  • 34
    • 0036096744 scopus 로고    scopus 로고
    • Mechanistic studies on baseline toxicity and uncoupling as a basis for modeling internal lethal concentrations in aquatic organisms
    • Escher, B.; Schwarzenbach, R. P. Mechanistic studies on baseline toxicity and uncoupling as a basis for modeling internal lethal concentrations in aquatic organisms. Aquat. Sci. 2002, 64, 20-35.
    • (2002) Aquat. Sci. , vol.64 , pp. 20-35
    • Escher, B.1    Schwarzenbach, R.P.2
  • 37
    • 29644437023 scopus 로고    scopus 로고
    • Chemical Speciation of Organics and of Metals at Biological Interfaces
    • Van Leeuwen, H. P., Köster, W., Eds.; John Wiley & Sons: Chichester
    • Escher, B. I.; Sigg, L. Chemical Speciation of Organics and of Metals at Biological Interfaces. In Physicochemical Kinetics and Transport at Biointerfaces; Van Leeuwen, H. P., Köster, W., Eds.; John Wiley & Sons: Chichester, 2004; Vol. 9, pp 205-271.
    • (2004) Physicochemical Kinetics and Transport at Biointerfaces , vol.9 , pp. 205-271
    • Escher, B.I.1    Sigg, L.2
  • 40
    • 0002511981 scopus 로고    scopus 로고
    • Liposome/water partitioning: Theory, techniques, and applications
    • Testa, B., Waterbeemd, V., Folkers, G., Guy, R., Eds.; Verlag Helvetica Chimica Acta: Zürich, Switzerland
    • Krämer, S. Liposome/water partitioning: theory, techniques, and applications. In Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies; Testa, B., Waterbeemd, V., Folkers, G., Guy, R., Eds.; Verlag Helvetica Chimica Acta: Zürich, Switzerland, 2001; pp 401-428.
    • (2001) Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies , pp. 401-428
    • Krämer, S.1
  • 41
    • 0036558059 scopus 로고    scopus 로고
    • Baseline toxicity (narcosis) of organic chemicals determined by membrane potential measurements in energy-transducing membranes
    • Escher, B. I.; Eggen, R.; Vye, E.; Schreiber, U.; Wisner, B.; Schwarzenbach, R. P. Baseline toxicity (narcosis) of organic chemicals determined by membrane potential measurements in energy-transducing membranes. Environ. Sci. Technol. 2002, 36, 1971-1979.
    • (2002) Environ. Sci. Technol. , vol.36 , pp. 1971-1979
    • Escher, B.I.1    Eggen, R.2    Vye, E.3    Schreiber, U.4    Wisner, B.5    Schwarzenbach, R.P.6
  • 42
    • 0031899034 scopus 로고    scopus 로고
    • Quantitative Structure-Activity Relationships of chemicals acting by nonpolar narcosis - Theoretical considerations
    • Zhao, Y. T.; Cronin, M. T.; Dearden, J. C. Quantitative Structure-Activity Relationships of chemicals acting by nonpolar narcosis - theoretical considerations. Quant. Struct.-Act. Relat. 1998, 17, 131-138.
    • (1998) Quant. Struct.-Act. Relat. , vol.17 , pp. 131-138
    • Zhao, Y.T.1    Cronin, M.T.2    Dearden, J.C.3
  • 43
    • 0021891433 scopus 로고
    • Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens
    • Oda, J.; Nakamura, S. I.; Oki, I.; Kato, T.; Shinagawa, H. Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens. Mutat. Res. 1985, 147, 219-229.
    • (1985) Mutat. Res. , vol.147 , pp. 219-229
    • Oda, J.1    Nakamura, S.I.2    Oki, I.3    Kato, T.4    Shinagawa, H.5
  • 44
    • 13844267823 scopus 로고    scopus 로고
    • Initial risk assessment for three beta-blockers found in the aquatic environment
    • Cleuvers, M. Initial risk assessment for three beta-blockers found in the aquatic environment. Chemosphere 2005, 59, 199-205.
    • (2005) Chemosphere , vol.59 , pp. 199-205
    • Cleuvers, M.1
  • 45
    • 0028290593 scopus 로고
    • Partitioning coefficients in vitro: Artificial membranes as standardized distribution model
    • Pauletti, G. M.; Wunderli-Allenspach, H. Partitioning coefficients in vitro: artificial membranes as standardized distribution model. Eur. J. Pharm. Sci. 1994, 1, 273-282.
    • (1994) Eur. J. Pharm. Sci. , vol.1 , pp. 273-282
    • Pauletti, G.M.1    Wunderli-Allenspach, H.2
  • 46
    • 0023179169 scopus 로고
    • Thermodynamics of partitioning of beta-blockers in the n-octanol-buffer and liposome systems
    • Betageri, G. V.; Rogers, J. A. Thermodynamics of partitioning of beta-blockers in the n-octanol-buffer and liposome systems. Int. J. Pharm. 1987, 36, 165-173.
    • (1987) Int. J. Pharm. , vol.36 , pp. 165-173
    • Betageri, G.V.1    Rogers, J.A.2
  • 47
    • 0033013540 scopus 로고    scopus 로고
    • Drug liposome partitioning as a tool for the prediction of human passive intestinal absorption
    • Balon, K.; Riebesehl, B. U.; Muller, B. W. Drug liposome partitioning as a tool for the prediction of human passive intestinal absorption. Pharm. Res. 1999, 16, 882-888.
    • (1999) Pharm. Res. , vol.16 , pp. 882-888
    • Balon, K.1    Riebesehl, B.U.2    Muller, B.W.3
  • 48
    • 0000102522 scopus 로고    scopus 로고
    • Derivation and application of relative potency estimates based on in-vitro bioassays
    • Villeneuve, D.; Blankenship, A.; Giesy, J. Derivation and application of relative potency estimates based on in-vitro bioassays. Environ. Toxicol. Chem./SETAC 2000, 19, 2835-2843.
    • (2000) Environ. Toxicol. Chem./SETAC , vol.19 , pp. 2835-2843
    • Villeneuve, D.1    Blankenship, A.2    Giesy, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.