Fish embryo toxicity of carbamazepine, diclofenac and metoprolol

Ecotoxicology and Environmental Safety

Volumn 73, Issue 8, 2010, Pages 1862-1866

  van den Brandhof, Evert Jan ^a   Montforts, Mark ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Carbamazepine; Danio rerio; Diclofenac; Ecotoxicity; Metoprolol

Indexed keywords

CARBAMAZEPINE; DICLOFENAC; METOPROLOL;

DRUG; ECOTOXICOLOGY; EMBRYO; FISH; HATCHING; MORTALITY; OTOLITH; TOXICITY;

ARTICLE; BRAIN MALFORMATION; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DRUG STRUCTURE; EMBRYO; EMBRYOTOXICITY; GASTRULATION; GROWTH RETARDATION; HATCHING; HEART BEAT; INNER EAR MALFORMATION; MORTALITY; NONHUMAN; OTOLITH; PIGMENTATION; SCOLIOSIS; SOMITE; TOXICITY TESTING; YOLK SAC; ZEBRA FISH;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIHYPERTENSIVE AGENTS; ANTIMANIC AGENTS; CARBAMAZEPINE; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; METOPROLOL; TIME FACTORS; TOXICITY TESTS; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

DANIO RERIO; RATTUS;

EID: 77957916105     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2010.08.031     Document Type: Article

References (22)

1. Cleuvers M. Initial risk assessment for three B-blockers found in the aquatic environment. Chemosphere 2005, 59:199-205.
2. Dzialowski E.M., Turner P.K., Brooks B.W. Physiological and reproductive effects of beta adrenergic receptor antagonists in Daphnia magna. Archives of Environmental Contamination and Toxicology 2006, 50(4):503-510.
3. Eimon P.M., Rubinstein A.L. The use of in vivo Zebrafish assays in drug toxicity screening. Expert Opinion on Drug Metabolism & Toxicology 2009, 5:393-401.
4. Embry M.R., Belanger S.E., Braunbeck T.A., Galay-Burgos M., Halder M., Hinton D.E., Léonard M.A., Lillicrap A., Norberg-King T., Whale G. The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research. Aquatic Toxicology 2010, 97:79-87.
5. Ensenbach U., Nagel R. Toxicity of binary chemical mixtures: effects on reproduction of zebrafish (Brachydanio rerio). Archives of Environmental Contamination and Toxicology 1997, 32:204-210.
6. Ferrari B., Paxéus N., Lo Giudice R., Pollio A., Garric J. Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac. Ecotoxicology and Environmental Safety 2003, 55:359-370.
7. Groth G., Schreeb K., Herdt V., Freundt K.J. Toxicity studies in fertilized zebrafish eggs treated with N-methlyamine, N,N-dimethlyamine, 2-aminoethanol, isopropylamine, aniline, N-methlyaniline, N,N-dimethlyaniline, quinone, chloroacetaldehyde, or cyclohexanol. Bulletin of Environmental Contamination and Toxicology 1993, 50:878-882.
8. Hallare A.V., Köhler H.R., Triebskorn R. Developmental toxicity and stress protein responses in Zebrafi{ligature}sh embryos after exposure to diclofenac and its solvent DMSO. Chemosphere 2004, 56:659-666.
9. Hamilton M.A., Russo R.C., Thurston R.V. Trimmed Spearman-Kärber method for estimating median lethal concentrations in toxicity bioassays. Environmental Science and Technology 1977, 11(7):714-719. (Correction (1978) 12(4): 417).
10. Hisoaka K.K., Battle H.I. The normal developmental stages of the zebrafish, Brachydanio rerio. Journal of Morphology 1958, 102:311-323.
11. Klug S., Thiel R., Schwabe R., Merker H-J., Neubert D. Toxicity of Β-blockers in a rat whole embryo culture: concentration-response relationships and tissue concentrations. Archives of Toxicology 1994, 58:84-88.
12. Laale H.W. The biology and use of zebrafish, Brachydanio rerio in fisheries research: a literature review. Journal of Fish Biology 1977, 10:121-173.
13. Lammer E., Carr G.J., Wendler K., Rawlings J.M., Belanger S.E., Braunbeck Th. Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test?. Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology 2009, 149:196-209.
14. Mons M.N., Van Genderen J., Van Dijk-Looijaard A.M. Inventory on the Presence of Pharmaceuticals in Dutch Water 2000, KIWA, Nieuwegein, The Netherlands.
15. OECD, 2006. OECD Guideline for the Testing of Chemicals. Draft Proposal for a New Guideline Fish Embryo Toxicity (FET) Test. OECD, Paris. Draft Guideline, May 30, 2006 (1st Version).
16. Piersma A., Verhoef A., Opperhuizen A., Klaassen R., Van Eijkeren J., Olling M. Embryotoxicity of carbamazepine in rat postimplantation embryo culture after in vitro exposure via three different routes. Reproductive Toxicology 1998, 12(2):161-168.
17. Ter Laak, T., Van der Aa, M., Houtman, C., Stoks, P., Van Wezel, A., 2010. Temporal and Spatial Trends of Pharmaceuticals in the Rhine. Nieuwegein, the Netherlands: RIWA-Rhine, B111670 (BTO).
18. Triebskorn R., Casper H., Heyd A., Eikemper R., Köhler H-R., Schwaiger J. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac, Part II. Cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology 2004, 68:151-166.
19. Triebskorn R., Casper H., Scheil V., Schwaiger J. Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in Rainbow trout (Oncorhynchus mykiss) and Common carp (Cyprinus carpio). Analytical and Bioanalytical Chemistry 2007, 387:1405-1416.
20. Van Vlaardingen, P.L.A., Verbruggen, E.M.J., 2007. Guidance for the derivation of environmental risk limits within the framework of the project. International and National Environmental Quality Standards for Substances in the Netherlands (INS), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Report No. 601501031, 117 pp.
21. Versteegh, J.F.M., Van der Aa, N.G.F.M., Dijkman, E., 2007. Pharmaceuticals in drinking water and drinking water sources. RIVM Report 703719016/2007. RIVM Bilthoven, the Netherlands [in Dutch].
22. Westerfield M. The Zebrafish Book 1998, University of Oregon Press, Eugene, OR, USA.