Toxicity and enantiospecific differences of two β-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio)

Environmental Toxicology

Volumn 29, Issue 12, 2014, Pages 1367-1378

  Sun, Liwei ^a   Xin, Lihua ^a   Peng, Zuhua ^a   Jin, Rong ^a   Jin, Yuanxiang ^a   Qian, Haifeng ^a   Fu, Zhengwei ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Acute toxicity; Adrenergic receptor; Chiral; Embryonic developmental toxicity; Gene transcription

Indexed keywords

AQUATIC ORGANISMS; CELL DEATH; DETOXIFICATION; ENANTIOSELECTIVITY; HEART; PHYSIOLOGICAL MODELS; RISK ASSESSMENT; TRANSCRIPTION;

ACUTE TOXICITY; ADRENERGIC RECEPTORS; CHIRAL; DEVELOPMENTAL TOXICITY; GENE TRANSCRIPTIONS;

TOXICITY;

METOPROLOL; PROPRANOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ASSAY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ECOTOXICITY; EMBRYO; EMBRYOTOXICITY; ENANTIOSELECTIVITY; GENE TARGETING; GENETIC TRANSCRIPTION; HATCHING; HEART RATE; LARVA; LC50; NONHUMAN; TOXICITY TESTING; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; CHEMISTRY; DRUG EFFECTS; EMBRYOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; STEREOISOMERISM;

DANIO RERIO;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; EMBRYO, NONMAMMALIAN; LARVA; METOPROLOL; PROPRANOLOL; STEREOISOMERISM; TRANSCRIPTION, GENETIC; ZEBRAFISH;

EID: 84911975827     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21867     Document Type: Article

References (43)

1. Ali I, Aboul-Enein H. 2004. Chiral Pollutants: Distribution, Toxicity, and Analysis by Chromatography and Capillary Electrophoresis. Chichester, UK: Wiley.
2. Ashton D, Hilton M, Thomas KV. 2004. Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom. Sci Total Environ 333:167-184.
3. Barrett A, Cullum V. 1968. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol 34:43-55.
4. Benotti MJ, Trenholm RA, Vanderford BJ, Holady JC, Stanford BD, Snyder SA. 2009. Pharmaceuticals and endocrine disrupting compounds in US drinking water. Environ Sci Technol 43:597-603.
5. Calabrese EJ. 2001. Adrenergic receptors: Biphasic dose responses. Crit Rev Toxicol 31:523-538.
6. Cleuvers M. 2005. Initial risk assessment for three β-blockers found in the aquatic environment. Chemosphere 59:199-205.
7. Contardo-Jara V, Pflugmacher S, Nutzmann G, Kloas W, Wiegand C. 2010. The β-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha. Environ Pollut 158:2059-2066.
8. Daughton CG. 2003. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy. Environ Health Perspect 111:757-774.
9. Deng J, Yu LQ, Liu CS, Yu K, Shi XJ, Yeung LWY, Lam PKS, Wu RSS, Zhou BS. 2009. Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquat Toxicol 93:29-36.
10. Dugan SG, Chen X, Nickerson JG, Montpetit CJ, Moon TW. 2008. Regulation of the black bullhead hepatic beta-adrenoceptors. Comp Biochem Physiol B 149:265-274.
11. Dzialowski E, Turner P, Brooks B. 2006. Physiological and reproductive effects of beta adrenergic receptor antagonists in Daphnia magna. Arch Environ Contam Toxicol 50:503-510.
12. Eimon PM, Ashkenazi A. 2010. The zebrafish as a model organism for the study of apoptosis. Apoptosis 15:331-349.
13. Fent K, Weston AA, Caminada D. 2006. Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122-159.
14. Filby AL, Thorpe KL, Maack G, Tyler CR. 2007. Gene expression profiles revealing the mechanisms of anti-androgen-and estrogen-induced feminization in fish. Aquat Toxicol 81:219-231.
15. Franzellitti S, Buratti S, Valbonesi P, Capuzzo A, Fabbri E. 2011. The beta-blocker propranolol affects cAMP-dependent signaling and induces the stress response in Mediterranean mussels, Mytilus galloprovincialis. Aquat Toxicol 101:299-308.
16. Fraysse B, Garric J. 2005. Prediction and experimental validation of acute toxicity of beta-blocks in Ceriodaphnia dubia. Environ Toxicol Chem 24:2470-2476.
17. Fraysse B, Mons R, Garric J. 2006. Development of a zebrafish 4-day toxicity of embryo-larval bioassay to assess chemicals. Ecotoxicol Environ Safe 63:253-267.
18. Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP. 2009. Chronic effects assessment and plasma concentrations of the beta-blocker propranolol in fathead minnows (Pimephales promelas). Aquat Toxicol 95:195-202.
19. Gomez MJ, Petrovic M, Fernandez-Alba AR, Barcelo D. 2006. Determination of pharmaceuticals of various therapeutic classes by solid-phase extraction and liquid chromatography-tandem mass spectrometry analysis in hospital effluent wastewaters. J Chromatogr A 1114:224-233.
20. Gonzalez P, Dominique Y, Massabuau JC, Boudou A, Bourdineaud JP. 2005. Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle, and brain of the zebrafish (Danio rerio). Environ Sci Technol 39:3972-3980.
21. Huggett DB, Brooks BW, Peterson B, Foran CM, Schlenk D. 2002. Toxicity of select beta adrenergic receptor-blocking pharmaceuticals (β-blockers) on aquatic organisms. Arch Environ Contam Toxicol 43:229-235.
22. Huggett DB, Khan IA, Foran CM, Schlenk D. 2003. Determination of beta-adrenergic receptor blocking pharmaceuticals in United States wastewater effluent. Environ Pollut 121:199-205.
23. Jin YX, Zhang XX, Shu LJ, Chen LF, Sun LW, Qian HF, Liu WP, Fu ZW. 2010. Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere 78:846-852.
24. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance. Environ Sci Technol 36:1202-1211.
25. Larsson DGJ, Fredriksson S, Sandblom E, Paxeus N, Axelsson M. 2006. Is heart rate in fish a sensitive indicator to evaluate acute effects of β-blockers in surface water? Environ Toxicol Pharmacol 22:338-340.
26. Liu QT, Williams TD, Cumming RI, Holm G, Hetheridge MJ, Murray-Smith R. 2009. Comparative aquatic toxicity of propranolol and its photodegraded mixtures: Algae and rotifer screening. Environ Toxicol Chem 28:2622-2631.
27. -ΔΔCt method. Methods 25:402-408.
28. Livingstone DR. 2001. Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. Mar Pollut Bull 42:656-666.
29. Massarsky A, Trudeau VL, Moon TW. 2011. β-blockers as endocrine disruptors: The potential effects of human β-blockers on aquatic organisms. J Exp Zool A 315:251-265.
30. Mehvar R, Brocks DR. 2001. Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans. J Pharm Pharm Sci 4:185-200.
31. OECD 1998. Fish, short-term toxicity test on embryo and sac-fry stage. OECD Guideline for Testing of Chemicals. Paris: OECD.
32. Owen SF, Giltrow E, Huggett DB, Hutchinson TH, Saye J, Winter MJ, Sumpter JP. 2007. Comparative physiology, pharmacology and toxicology of β-blockers: Mammals versus fish. Aquat Toxicol 82:145-162.
33. Owen SF, Huggett DB, Hutchinson TH, Hetheridge MJ, Kinter LB, Ericson JF, Sumpter JP. 2009. Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry. Aquat Toxicol 93:217-224.
34. Pearson A, Gaffney T, Walle T, Privitera P. 1989. A stereoselective central hypotensive action of atenolol. J Pharmacol Exp Ther 250:759-763.
35. Pham-Huy C, Radenen B, Sahui-Gnassi A, Claude JR. 1995. High-performance liquid chromatographic determination of (S)- and (R)-propanolol in human plasma and urine with a chiral β-cyclodextrin bonded phase. J Chromatogr B 665:125-132.
36. Santos LHMLM, Araujo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro MCBSM. 2010. Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater 175:45-95.
37. Sole M, Shaw JP, Frickers PE, Readman JW, Hutchinson TH. 2010. Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen. Anal Bioanal Chem 396:649-656.
38. Stanley JK, Ramirez AJ, Mottaleb M, Chambliss CK, Brooks BW. 2006. Enantiospecific toxicity of the beta-blocker propranolol to Daphnia magna and Pimephales promelas. Environ Toxicol Chem 25:1780-1786.
39. Ternes TA, 1998. Occurrence of drugs in German sewage treatment plants and rivers. Water Res 32:3245-3260.
40. Valavanidis A, Vlahogianni T, Dassenakis M, Scoullos M. 2006. Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants. Ecotoxicol Environ Safe 64:178-189.
41. Viarengo A, Lowe D, Bolognesi C, Fabbri E, Koehler A. 2007. The use of biomarkers in biomonitoring: A 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms. Comp Biochem Physiol C 46:281-300.
42. Wang ZP, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang LQ, Oka T, Sakamoto C, Kuroyanagi J, Tanaka T. 2009. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene 446:18-27.
43. Westerfield M. 1993. The zebrafish book: A guide for the laboratory use of zebrafish Danio (Brachydanio) rerio. University of Oregon Press, Eugene.