Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna - A multigenerational study

Chemosphere

Volumn 79, Issue 1, 2010, Pages 60-66

  Dietrich, Sabine ^a   Ploessl, Florian ^a   Bracher, Franz ^a   Laforsch, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Chronic toxicity; Cladoceran; Drugs; Mixture toxicity; Multiple generations

Indexed keywords

AMIDES; AQUATIC ECOSYSTEMS; CELL PROLIFERATION; MIXTURES; TOXICITY;

CHRONIC TOXICITY; CLADOCERAN; DRUGS; MIXTURE TOXICITY; MULTIPLE GENERATIONS;

AQUATIC ORGANISMS;

CARBAMAZEPINE; DICLOFENAC; ETHINYLESTRADIOL; METOPROLOL;

ACCLIMATION; AQUATIC ECOSYSTEM; AQUATIC ORGANISM; DRUG; LIFE HISTORY; MORPHOLOGY; TOXICITY;

ANIMAL EXPERIMENT; ARTICLE; BODY HEIGHT; CONTROLLED STUDY; DAPHNIA; DRUG DETERMINATION; DRUG MIXTURE; ECOTOXICITY; FEMALE; LIFE HISTORY; LIFESPAN; NEWBORN; NONHUMAN; PROGENY; REPRODUCTIVE TOXICITY;

DAPHNIA MAGNA; DAPHNIIDAE;

EID: 77249152166     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2009.12.069     Document Type: Article

References (36)

1. Adler P., Steger-Hartmann T., and Kalbfus W. Vorkommen natürlicher und synthetischer östrogener Steroide in Wässern des süd- und mitteldeutschen Raumes. Acta Hydrochim. Hydrobiol. 29 (2001) 227-241
2. Borgmann U., Bennie D.T., Ball A.L., and Palabrica V. Effect of a mixture of seven pharmaceuticals on Hyalella azteca over multiple generations. Chemosphere 66 (2007) 1278-1283
3. Brennan S.J., Brougham C.A., Roche J.J., and Fogarty A.M. Multi-generational effects of four selected environmental oestrogens on Daphnia magna. Chemosphere 64 (2006) 49-55
4. Cleuvers M. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol. Lett. 142 (2003) 185-194
5. Cleuvers M. Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid. Ecotoxicol. Environ. Safe. 59 (2004) 309-315
6. Clubbs R.L., and Brooks B.W. Daphnia magna responses to a vertebrate estrogen receptor agonist and an antagonist: a multigenerational study. Ecotoxicol. Environ. Safe. 67 (2007) 385-398
7. Daughton C.G., and Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ. Health Persp. 107 (1999) 907-938
8. Dietrich, S., Dammel, S., Ploessl, F., Bracher, F., Laforsch, C., in press. Effects of a pharmaceutical mixture at environmentally relevant concentrations on the amphipod Gammarus fossarum. Mar. Freshwater Res.
9. Dzialowski E.M., Turner P.K., and Brooks B.W. Physiological and reproductive effects of beta adrenergic receptor antagonists in Daphnia magna. Arch. Environ. Con. Tox. 50 (2006) 503-510
10. Ebert D. The trade-off between offspring size and number in Daphnia magna - the influence of genetic, environmental and maternal effects. Arch. Hydrobiol. 4 (1993) 453-473
11. Fent K., Weston A.A., and Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 76 (2006) 122-159
12. Ferrari B., Paxéus N., Lo Giudice R., Pollio A., and Garric J. Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac. Ecotoxicol. Environ. Safe. 55 (2003) 359-370
13. Flaherty C.M., and Dodson S.I. Effects of pharmaceuticals on Daphnia survival, growth, and reproduction. Chemosphere 61 (2005) 200-207
14. Goto T., and Hiromi J. Toxicity of 17 alpha-ethynylestradiol and norethindrone, constituents of an oral contraceptive pill to the swimming and reproduction of cladoceran Daphnia magna, with special reference to their synergetic effect. Mar. Pollut. Bull. 47 (2003) 139-142
15. Haap T., Triebskorn R., and Köhler H.R. Acute effects of diclofenac and DMSO to Daphnia magna: immobilisation and hsp70-induction. Chemosphere 73 (2008) 353-359
16. Halling-Sørensen B., Nielsen S.N., Lanzky P.F., Ingerslev F., Holten Lützhøft H.C., and Jørgensen S.E. Occurrence, fate and effects of pharmaceutical substances in the environment - a review. Chemosphere 36 (1998) 357-394
17. Heberer T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 131 (2002) 5-17
18. Heckmann L.H., Callaghan A., Hooper H.L., Connon R., Hutchinson T.H., Maund S.J., and Sibly R.M. Chronic toxicity of ibuprofen to Daphnia magna: effects on life history traits and population dynamics. Toxicol. Lett. 172 (2007) 137-145
19. Huggett D.B., Brooks B.W., Peterson B., Foran C.M., and Schlenk C. Toxicity of select beta adrenergic receptor-blocking pharmaceuticals (B-blockers) on aquatic organisms. Arch. Environ. Con. Tox. 43 (2002) 229-235
20. Klerks P.L., and Weis J.S. Genetic adaptation to heavy-metals in aquatic organisms - a review. Environ. Pollut. 45 (1987) 173-205
21. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., and Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 36 (2002) 1202-1211
22. Kreuzinger N., Clara M., Strenn B., and Vogel B. Investigation on the behaviour of selected pharmaceuticals in the groundwater after infiltration of treated wastewater. Water Sci. Technol. 50 (2004) 221-228
23. Kwok K.W.H., Grist E.P.M., and Leung K.M.Y. Acclimation effect and fitness cost of copper resistance in the marine copepod Tigriopus japonicus. Ecotoxicol. Environ. Safe. 72 (2009) 358-364
24. Ladewig V., Jungmann D., Köhler H.R., Schirling M., Triebskorn R., and Nagel R. Population structure and dynamics of Gammarus fossarum (Amphipoda) upstream and downstream from effluents of sewage treatment plants. Arch. Environ. Con. Tox. 50 (2006) 370-383
25. Laforsch C., Beccara L., and Tollrian R. Inducible defenses: the relevance of chemical alarm cues in Daphnia. Limnol. Oceanogr. 51 (2006) 1466-1472
26. Lürling M., Sargant E., and Roessink I. Life-history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine. Environ. Toxicol. 21 (2006) 172-180
27. Marcial H.S., and Hagiwara A. Multigenerational effects of 17 beta-estradiol and nonylphenol on euryhaline cladoceran Diaphanosoma celebensis. Fish. Sci. 73 (2007) 324-330
28. Rohweder, U., 2003. Arzneimittel in der Umwelt, Auswertung der Untersuchungsergebnisse. Bund/Länderausschuss für Chemikaliensicherheit (BLAC), Bericht an die 61. Umweltministerkonferenz, Hamburg.
29. Schnell S., Bols N.C., Barata C., and Porte C. Single and combined toxicity of pharmaceuticals and personal care products (PPCPs) on the rainbow trout liver cell line RTL-W1. Aquat. Toxicol. 93 (2009) 244-252
30. Schwarzenbach R.P., Escher B.I., Fenner K., Hofstetter T.B., Johnson C.A., von Gunten U., and Wehrli B. The challenge of micropollutants in aquatic systems. Science 313 (2006) 1072-1077
31. Segner H., Caroll K., Fenske M., Janssen C.R., Maack G., Pascoe D., Schäfers C., Vandenbergh G.F., Watts M., and Wenzel A. Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project. Ecotoxicol. Environ. Safe. 54 (2003) 302-314
32. Sengl, M., Schüssler, W., 2004. Arzneimittel in der Umwelt. Bayerisches Landesamt für Wasserwirtschaft, Schlußbericht, München.
33. Tanaka Y., and Nakanishi J. Chronic effects of p-nonylphenol on survival and reproduction of Daphnia galeata: multigenerational life table experiment. Environ. Toxicol. 17 (2002) 487-492
34. Ternes T.A. Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32 (1998) 3245-3260
35. Vandenbergh G.F., Adriaens D., Verslycke T., and Janssen C.R. Effects of 17α-ethinylestradiol on sexual development of the amphipod Hyalella azteca. Ecotoxicol. Environ. Safe. 54 (2003) 216-222
36. Xie L.T., and Klerks P.L. Fitness cost of resistance to cadmium in the least killifish (Heterandria formosa). Environ. Toxicol. Chem. 23 (2004) 1499-1503