Occurrence of drugs in German sewage treatment plants and rivers

Water Research

Volumn 32, Issue 11, 1998, Pages 3245-3260

  Ternes, Thomas A ^a  

^a ESWE Institute for Water Research and Water Technology   (Germany)

Author keywords

2 sympathomimetics; Anticancer agents; Antiphlogistics; Betablockers; Carbamazepine; Diazepan; Drugs; Lipid regulating agents; Rivers and streams; Sewage treatment plant effluents

Indexed keywords

ANTICANCER AGENTS; ANTIPHLOGISTICS; LIPID REGULATING AGENTS;

DRUG PRODUCTS; EFFLUENTS; LIPIDS; METABOLITES; PHARMACOKINETICS; RIVER POLLUTION; WASTE UTILIZATION;

SEWAGE TREATMENT;

ANTICONVULSIVE AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BEZAFIBRATE; CARBAMAZEPINE; CLOFIBRIC ACID; DICLOFENAC; DRUG RESIDUE; FENOFIBRIC ACID; GEMFIBROZIL; IBUPROFEN; INDOMETACIN; METOPROLOL; NAPROXEN; PHENAZONE; PROPRANOLOL; SALICYLIC ACID;

POLLUTION INCIDENCE; RIVER WATER; SEWAGE TREATMENT; WATER POLLUTION;

ARTICLE; EFFLUENT; GERMANY; METABOLITE; PRIORITY JOURNAL; RIVER; SEWAGE TREATMENT PLANT; WASTE WATER MANAGEMENT; WATER CONTAMINATION;

GERMANY;

EID: 0032210734     PISSN: 00431354     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0043-1354(98)00099-2     Document Type: Article

References (39)

1. Abshagen U., Bablok W., Koch K., Schmidt H. A. E., Senn M., Stork H. Disposition pharmacokinetics of bezafibrate in man. European J. Clin. Pharmacol. 16:1979;31-38.
2. Aherne G. W., Briggs R. The relevance of the presence of certain synthetic steroids in the aquatic environment. J. Pharm. Pharmacol. 41:1989;735-736.
3. Balfour J. A., McTarish D., Heel R. C. A review of its pharmacodynamic and pharmacokinetic propertiesand therapeutic use in dyslipidaemia. Drugs. 40:1990;260-290.
4. Balmér K., Zhang Y., Lagerström P.-O., Persson B.-A. Determination of metoprolol and two major metabolites in plasma and urine by column liquid chromatography and fluorometric detection. J. Chrom. 417:1987;357-365.
5. Bendetta C., Sallustio B., Fairchild B. A. Biosynthesis, characterisation and direct high-performance liquid chormatographic analysis of gemfibrozil 1-o-β-acyl-glucuronide. J. Chrom. 665:1995;345-353.
6. Berthold G., Grieb H., Konarski C. U., Löns-Hana C., Meyer U., Von Pape W. P. and Toussaint B. (1993) Hydrogeologie in Hessen Handbuch Teil 3, Grundwasserbeschaffenheitsbericht 1993 Hessen. Hydrogeology in Hessian, Handbook, Part 3, Conditions of Ground Water Quality.
7. Fooken C., Gihr R., Häckle M. and Seel P (1997) Orientierende Messungen gefährlicher Stoffe -Landesweite Untersuchungen auf organische Spurenverunreiningungen in hessischern Fließgewässern, Abwässern und Klärschlamm 1991-1996. Orientated measurements of polluting compounds - nationwide investigations for organic trace pollutants in Hessian running waters, sewages and activated sludge 1991-1996. Umweltplanung, Arbeits- und Umweltschutz, 233 Schriftenreihe der Hessischen Landesanstalt für Umwelt, Wiesbaden.
8. Forth W., Henschler D., Rummel W. and Starke K. (1996) Allgemeine und spezielle Pharmakologie und Toxikologie. Wissenschaftsverlag Mannheim/Leipzig/Wien/ Zürich, 6. Auflage.
9. Frey H.-H and Janz D. (1985) Antiepileptic Drugs, Handbook of Experimental Pharmacology, Vol. 74. Springer Verlag Berlin, Heidelberg, New York, Tokyo.
10. Hardman J. G., Limbird L. E., Molinoff P. B., Ruddon R. W. and Gilman, A. G. (1996) Goodman and Gilman's The Pharmacological Basis of Therapeutics. MacGraw-Hill Health Professions Divisions, New York.
11. Hall J. E. and Medmenham W. (1992) Agricultural value of organic sludge and liquid agricultural waters In Treatment and use of sewage sludge and liquid agricultural wastes, eds., J. E. Hall, P. L. 'Hermite and P. J. Newmann, Review of COST 68/681 programme, 1972-1990.
12. Heberer T., Stan H.-J. Vorkommen von polaren organischen Kontaminanten im Berliner Trinkwasser. Occurrence of polar organic contaminants in Berlin drinking water. Vom Wasser. 86:1996;19-31.
13. Hignite C., Azarnoff D. L. Drugs and drug metabolites as environmental contaminants: Chlorophenoxyisobutyrate and salicylic acid in sewage water effluent. Life Sci. 20:1977;337-342.
14. 2-sympatomimetics in the aquatic environment. Vom Wasser. 87:1996;263-274.
15. Holm J. H., Rügge K., Bjerg P. L., Christensen T. H. Occurrence and distribution of pharmaceutical organic compounds in the ground water downgradient of a landfill (Grinsted, Denmark). Environ. Sci. Technol. 29:1995;1415-1420.
16. Landsdorp D., Vree T. B., Janssen T. J., Guelen P. J. Pharmacokinetics of retal Dilclofenac and its hydroxy metabolites in man. Int. J. Clin. Pharmacol. Ther. Toxicol. 28:1990;298-302.
17. Löscher W., Ungemach F. R. and Kroker R. (1994) Grundlagen der Pharmakotherapie bei Haus und Nutztieren. Basics of pharmacological therapy of domestic animals. Verlag Paul Parey, Berlin, Hamburg.
18. Mutschler E. (1996) Arzneimittelwirkungen, Lehrbuch der Pharmakologie und Toxikologie, Textbook of pharmacology and toxicology. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart.
19. Richardson M. L., Bowron J. M. The fate of pharmaceutical chemicals in the aquatic environment. J. Pharm. Pharmacol. 37:1985;1-12.
20. Rogers I. H., Birtwell I. K., Kruzynski G. M. Organic extractables in municipal wastewater Vancouver, British Columia. Water Poll. Res. J. Can. 21:1986;187-204.
21. Römbke J., Knacker Th. and Stahlschmidt-Allner P. (1996) Studie über Umweltprobleme im Zusammenhang mit Arzneimitteln. Study about enviromental problems in context with drugs. F+E Vorhabens Nr. 106 04 121, Umweltbundesamt, Berlin.
22. Rote Liste (1994) Arzneimittelverzeichnis des BPI. Drug register of BPI, ed., Bundesverband der pharmazeutischen Industrie e.V., ECV Editor Cantor Verlag für Medizin und Naturwissenschaften GmbH.
23. Rurainski R. D., Theiss H. J., Zimmermann W. Über das Vorkommen von natürlichen und synthetischen Östrogenen im Trinkwasser. Occurrence of natural and synthetic estrogenes in drinking water. Gwf-Wasser/Abwasser. 118:1977;287-291.
24. Schwabe U. and Paffrath D. (1995) Arzneiverordnungsreport ́95 Aktuelle Daten, Kosten, Trends und Kommentare. Drug prescribing report '95 Current data, costs, trends and comments, Gustav Fischer Verlag, Stuttgart, Jena.
25. Schwabe U. and Paffrath D. (1996) Arzneiverordnungsreport ́96 Aktuelle Daten, Kosten, Trends und Kommentare. Drug prescribing report '96 Current data, costs, trends and comments, Gustav Fischer Verlag, Stuttgart, Jena.
26. Shore L. S., Gurevitz M., Shemesh M. Estrogen as an environmental pollutant. Bull. Environ. Contam. Toxicol. 51:1993;361-366.
27. Stan H.-J., Linkerhäger M. Vorkommen von Clofibrinsäure im aquatischen System -Führt die therapeutische Anwendung zu einer Belastung von Oberflächen-, Grund- und Trinkwasser. Occurrence of clofibric acid in aquatic systems - Does the medical application cause a contamination of surface, ground and drinking water. Vom Wasser. 83:1994;57-68.
28. Steger-Hartmann Th., Kümmerer K., Schecker J. trace analysis of the antineoplastics ifosfamide and cyclophosphamide in ewage water by two-step solid-phase extraction and gas chromatography-mass spectrometry. J. Chrom. 726:1996;179-184.
29. Stumpf M., Ternes T. A., Haberer K., Seel P., Baumann W. Nachweis von Arzneimittelrückständen in Kläranlagen und Fließgewässern. Determination of drugs in sewage treatment plants and river water. Vom Wasser. 86:1996;291-303.
30. Stumpf M., Ternes T., Haberer K., Baumann W. Nachweis von natürlichen Östrogenen in Kläranlagen und Fließgewässern. Determination of natural estrogens in sewage treatement plants and river water. Vom Wasser. 87:1996;251-261.
31. Suflita J. M., Liang L., Saxena A. The anaerobic biodegradation of o-, m- and p-cresol by sulfate-reducing bacterial enrichment cultures obtained from a shallow anoxic aquifer. J. Industrial Microbiol. 4:1989;255-266.
32. Tabak H., Bloomhuff R. N., Bunch R. L. Steroid hormones as water pollutants II. Dev. Ind. Microbiol. 22:1981;497-519.
33. Tabak H., Bunch H. L. Steroid hormonesas water pollutants I. Dev. Ind. Microbiol. 11:1970;367-376.
34. 2-sympathomimetics in aqueous matrices using GC/MS and LC/MS/MS. Fres. J. Anal. Chem. (accepted).
35. Ternes T. A., Stumpf M., Schuppert B. and Haberer K. (1998) Determination of acidic drugs and antiseptics in sewage and river water. Vom Wasser (in press).
36. Todd P. A., Ward A. A review of ist pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia. Drugs. 36:1988;314-339.
37. Waggott A. (1981) Trace Organic Substances in the River Lee [Great Britain].Chem. Water Reuse, ed., W. J. Cooper, Vol. 2, pp. 55-99. Ann. Arbor Sci., Ann Arbor, MI.
38. Walle Th., Webb J. G., Bagwell E. E., Walle U. K., Daniell H. B., Gaffney Th. E. Stereoselective delivery and actions of beta receptor antagonists. Biochem. Pharmacol. 37:1988;115-124.
39. Watts C. D., Crathorne M., Fielding M. and Steel C. P. (1983) Identification of non-volatile organics in water using field desorption mass spectrometry and high performance liquid chromatography. In Analysis of organic micropollutants in water, ed., G. Angeletti et al. pp. 120-131. Reidel Publ. Corp., Dordrecht.