ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development

American Journal of Physiology - Endocrinology and Metabolism

Volumn 309, Issue 5, 2015, Pages E487-E499

  Wang, Fang ^a   Wu, Yanqing ^a   Quon, Michael J ^a   Li, Xuezheng ^a   Yang, Peixin ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Apoptosis signal regulating kinase 1; Endoplasmic reticulum stress; Heart defects; Maternal diabetes

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; BONE MORPHOGENETIC PROTEIN 4; CASPASE; CYCLIN D1; CYCLIN D3; JANUS KINASE 1; JANUS KINASE 2; PROTEIN P21; PROTEIN P27; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSCRIPTION FACTOR GATA 5; TRANSCRIPTION FACTOR NKX2.5; BMP4 PROTEIN, MOUSE; CCND1 PROTEIN, MOUSE; CCND3 PROTEIN, MOUSE; CDKN1A PROTEIN, MOUSE; CDKN1B PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GATA5 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; MAP3K5 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE 9; NKX2-5 PROTEIN, MOUSE; SMAD1 PROTEIN, MOUSE; SMAD5 PROTEIN, MOUSE; SMAD9 PROTEIN, MOUSE; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTERIAL TRUNK; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENE DELETION; HEART DEVELOPMENT; HEART VENTRICLE SEPTUM DEFECT; MATERNAL DIABETES MELLITUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TERATOGENICITY; ANIMAL; EMBRYOLOGY; GENETICS; HEART; HEART DEFECTS, CONGENITAL; HEART SEPTAL DEFECTS, VENTRICULAR; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; PREGNANCY; PREGNANCY DIABETES MELLITUS; SIGNAL TRANSDUCTION; TERATOGENESIS; TRUNCUS ARTERIOSUS, PERSISTENT;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEIN 4; CELL PROLIFERATION; CYCLIN D1; CYCLIN D3; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENDOPLASMIC RETICULUM STRESS; FEMALE; GATA5 TRANSCRIPTION FACTOR; HEART; HEART DEFECTS, CONGENITAL; HEART SEPTAL DEFECTS, VENTRICULAR; HOMEODOMAIN PROTEINS; MAP KINASE KINASE KINASE 5; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; PHOSPHORYLATION; PREGNANCY; PREGNANCY IN DIABETICS; SIGNAL TRANSDUCTION; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TERATOGENESIS; TRANSCRIPTION FACTORS; TRUNCUS ARTERIOSUS, PERSISTENT;

EID: 84940874034     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00121.2015     Document Type: Article

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