Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy

Diabetes

Volumn 61, Issue 8, 2012, Pages 2084-2092

  Li, Xuezheng ^a,b   Weng, Hongbo ^a,c   Xu, Cheng ^a   Reece, E Albert ^a   Yang, Peixin ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b YANBIAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CASPASE 3; CASPASE 8; COPPER ZINC SUPEROXIDE DISMUTASE; E TWENTY SIX LIKE TRANSCRIPTION FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; DIABETES MELLITUS; DIABETIC EMBRYOPATHY; EMBRYO; ENZYME ACTIVATION; FEMALE; GENE DELETION; GENE OVEREXPRESSION; HYPERGLYCEMIA; MALE; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TERATOGENICITY; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CASPASES; DIABETES MELLITUS; ENZYME ACTIVATION; FEMALE; FETAL DISEASES; GENE DELETION; HYPERGLYCEMIA; MAP KINASE KINASE 7; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NERVE TISSUE PROTEINS; NEURAL TUBE DEFECTS; OXIDATIVE STRESS; PREGNANCY; PREGNANCY COMPLICATIONS; SUPEROXIDE DISMUTASE;

EID: 84864392621     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1624     Document Type: Article

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