Maternal hyperglycemia activates an ASK1-FoxO3a-Caspase 8 pathway that leads to embryonic neural tube defects

Science Signaling

Volumn 6, Issue 290, 2013, Pages

  Yang, Peixin ^a   Li, Xuezheng ^a   Xu, Cheng ^a   Eckert, Richard L ^a   Reece, E Albert ^a   Zielke, Horst Ronald ^a   Wang, Fang ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 8; THIOREDOXIN; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE DELETION; GENETIC ASSOCIATION; HYPERGLYCEMIA; MALE; MATERNAL DIABETES MELLITUS; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; POPULATION ABUNDANCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASE 8; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; HUMANS; HYPERGLYCEMIA; IMMUNOBLOTTING; MALE; MAP KINASE KINASE KINASE 5; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURAL TUBE DEFECTS; OXIDATIVE STRESS; PREGNANCY; PREGNANCY COMPLICATIONS; PROTEIN BINDING; SIGNAL TRANSDUCTION; THIOREDOXINS; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN;

EID: 84884126091     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2004020     Document Type: Article

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