-
1
-
-
72549115018
-
Dicer1 functions as a haploinsufficient tumor suppressor
-
Kumar MS, Pester RE, Chen CY, Lane K, Chin C, et al. (2009) Dicer1 functions as a haploinsufficient tumor suppressor. Genes & development 23: 2700–2704.
-
(2009)
Genes & development
, vol.23
, pp. 2700-2704
-
-
Kumar, M.S.1
Pester, R.E.2
Chen, C.Y.3
Lane, K.4
Chin, C.5
-
2
-
-
77949541928
-
Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo
-
Lambertz I, Nittner D, Mestdagh P, Denecker G, Vandesompele J, et al. (2010) Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell death and differentiation 17: 633–641. doi: 10.1038/cdd.2009.202 20019750
-
(2010)
Cell death and differentiation
, vol.17
, pp. 633-641
-
-
Lambertz, I.1
Nittner, D.2
Mestdagh, P.3
Denecker, G.4
Vandesompele, J.5
-
3
-
-
50549095181
-
let-7 microRNAs in development, stem cells and cancer
-
Bussing I, Slack FJ, Grosshans H, (2008) let-7 microRNAs in development, stem cells and cancer. Trends Mol Med 14: 400–409. doi: 10.1016/j.molmed.2008.07.001 18674967
-
(2008)
Trends Mol Med
, vol.14
, pp. 400-409
-
-
Bussing, I.1
Slack, F.J.2
Grosshans, H.3
-
4
-
-
34247565615
-
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
-
Lee YS, Dutta A, (2007) The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev 21: 1025–1030. 17437991
-
(2007)
Genes Dev
, vol.21
, pp. 1025-1030
-
-
Lee, Y.S.1
Dutta, A.2
-
5
-
-
41649096450
-
Identification of let-7-regulated oncofetal genes
-
Boyerinas B, Park SM, Shomron N, Hedegaard MM, Vinther J, et al. (2008) Identification of let-7-regulated oncofetal genes. Cancer Res 68: 2587–2591. doi: 10.1158/0008-5472.CAN-08-0264 18413726
-
(2008)
Cancer Res
, vol.68
, pp. 2587-2591
-
-
Boyerinas, B.1
Park, S.M.2
Shomron, N.3
Hedegaard, M.M.4
Vinther, J.5
-
6
-
-
84876926693
-
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts
-
Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, et al. (2013) Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes Dev 27: 941–954. doi: 10.1101/gad.215376.113 23630078
-
(2013)
Genes Dev
, vol.27
, pp. 941-954
-
-
Gurtan, A.M.1
Ravi, A.2
Rahl, P.B.3
Bosson, A.D.4
JnBaptiste, C.K.5
-
7
-
-
52049124806
-
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28
-
Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, et al. (2008) Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem 283: 21310–21314. doi: 10.1074/jbc.C800108200 18550544
-
(2008)
J Biol Chem
, vol.283
, pp. 21310-21314
-
-
Piskounova, E.1
Viswanathan, S.R.2
Janas, M.3
LaPierre, R.J.4
Daley, G.Q.5
-
8
-
-
40849108663
-
Selective blockade of microRNA processing by Lin28
-
Viswanathan SR, Daley GQ, Gregory RI, (2008) Selective blockade of microRNA processing by Lin28. Science 320: 97–100. doi: 10.1126/science.1154040 18292307
-
(2008)
Science
, vol.320
, pp. 97-100
-
-
Viswanathan, S.R.1
Daley, G.Q.2
Gregory, R.I.3
-
9
-
-
81855183636
-
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms
-
Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, et al. (2011) Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell 147: 1066–1079. doi: 10.1016/j.cell.2011.10.039 22118463
-
(2011)
Cell
, vol.147
, pp. 1066-1079
-
-
Piskounova, E.1
Polytarchou, C.2
Thornton, J.E.3
LaPierre, R.J.4
Pothoulakis, C.5
-
10
-
-
68749102148
-
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
-
Heo I, Joo C, Kim YK, Ha M, Yoon MJ, et al. (2009) TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138: 696–708. doi: 10.1016/j.cell.2009.08.002 19703396
-
(2009)
Cell
, vol.138
, pp. 696-708
-
-
Heo, I.1
Joo, C.2
Kim, Y.K.3
Ha, M.4
Yoon, M.J.5
-
11
-
-
84912070093
-
Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation
-
Choudhury NR, Nowak JS, Zuo J, Rappsilber J, Spoel SH, et al. (2014) Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation. Cell Rep 9: 1265–1272. 25457611
-
(2014)
Cell Rep
, vol.9
, pp. 1265-1272
-
-
Choudhury, N.R.1
Nowak, J.S.2
Zuo, J.3
Rappsilber, J.4
Spoel, S.H.5
-
12
-
-
84862776516
-
High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer
-
Hamano R, Miyata H, Yamasaki M, Sugimura K, Tanaka K, et al. (2012) High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer. British journal of cancer 106: 1415–1423. doi: 10.1038/bjc.2012.90 22433967
-
(2012)
British journal of cancer
, vol.106
, pp. 1415-1423
-
-
Hamano, R.1
Miyata, H.2
Yamasaki, M.3
Sugimura, K.4
Tanaka, K.5
-
13
-
-
84907937174
-
Lin28B is a novel prognostic marker in gastric adenocarcinoma
-
Hu Q, Peng J, Liu W, He X, Cui L, et al. (2014) Lin28B is a novel prognostic marker in gastric adenocarcinoma. Int J Clin Exp Pathol 7: 5083–5092. 25197381
-
(2014)
Int J Clin Exp Pathol
, vol.7
, pp. 5083-5092
-
-
Hu, Q.1
Peng, J.2
Liu, W.3
He, X.4
Cui, L.5
-
14
-
-
84896703287
-
Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma
-
Cheng SW, Tsai HW, Lin YJ, Cheng PN, Chang YC, et al. (2013) Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma. PLoS One 8: e80053. doi: 10.1371/journal.pone.0080053 24244607
-
(2013)
PLoS One
, vol.8
, pp. 80053
-
-
Cheng, S.W.1
Tsai, H.W.2
Lin, Y.J.3
Cheng, P.N.4
Chang, Y.C.5
-
15
-
-
79958799436
-
LIN28B promotes colon cancer progression and metastasis
-
King CE, Cuatrecasas M, Castells A, Sepulveda AR, Lee JS, et al. (2011) LIN28B promotes colon cancer progression and metastasis. Cancer research 71: 4260–4268. doi: 10.1158/0008-5472.CAN-10-4637 21512136
-
(2011)
Cancer research
, vol.71
, pp. 4260-4268
-
-
King, C.E.1
Cuatrecasas, M.2
Castells, A.3
Sepulveda, A.R.4
Lee, J.S.5
-
16
-
-
70350778443
-
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
-
Iliopoulos D, Hirsch HA, Struhl K, (2009) An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139: 693–706. doi: 10.1016/j.cell.2009.10.014 19878981
-
(2009)
Cell
, vol.139
, pp. 693-706
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Struhl, K.3
-
17
-
-
67649881121
-
Lin28 promotes transformation and is associated with advanced human malignancies
-
Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, et al. (2009) Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 41: 843–848. doi: 10.1038/ng.392 19483683
-
(2009)
Nat Genet
, vol.41
, pp. 843-848
-
-
Viswanathan, S.R.1
Powers, J.T.2
Einhorn, W.3
Hoshida, Y.4
Ng, T.L.5
-
18
-
-
84885896439
-
LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
-
Madison BB, Liu Q, Zhong X, Hahn CM, Lin N, et al. (2013) LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev 27: 2233–2245. doi: 10.1101/gad.224659.113 24142874
-
(2013)
Genes Dev
, vol.27
, pp. 2233-2245
-
-
Madison, B.B.1
Liu, Q.2
Zhong, X.3
Hahn, C.M.4
Lin, N.5
-
19
-
-
84883315995
-
Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism
-
Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, et al. (2013) Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells 31: 1563–1573. doi: 10.1002/stem.1423 23666760
-
(2013)
Stem Cells
, vol.31
, pp. 1563-1573
-
-
Shinoda, G.1
Shyh-Chang, N.2
Soysa, T.Y.3
Zhu, H.4
Seligson, M.T.5
-
20
-
-
84887499256
-
Analysis of microRNA-target interactions across diverse cancer types
-
Jacobsen A, Silber J, Harinath G, Huse JT, Schultz N, et al. (2013) Analysis of microRNA-target interactions across diverse cancer types. Nat Struct Mol Biol 20: 1325–1332. doi: 10.1038/nsmb.2678 24096364
-
(2013)
Nat Struct Mol Biol
, vol.20
, pp. 1325-1332
-
-
Jacobsen, A.1
Silber, J.2
Harinath, G.3
Huse, J.T.4
Schultz, N.5
-
21
-
-
80053481600
-
The Lin28/let-7 axis regulates glucose metabolism
-
Zhu H, Shyh-Chang N, Segre AV, Shinoda G, Shah SP, et al. (2011) The Lin28/let-7 axis regulates glucose metabolism. Cell 147: 81–94. doi: 10.1016/j.cell.2011.08.033 21962509
-
(2011)
Cell
, vol.147
, pp. 81-94
-
-
Zhu, H.1
Shyh-Chang, N.2
Segre, A.V.3
Shinoda, G.4
Shah, S.P.5
-
22
-
-
84907967415
-
Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy
-
Dubinsky AN, Dastidar SG, Hsu CL, Zahra R, Djakovic SN, et al. (2014) Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy. Cell Metab 20: 626–638. doi: 10.1016/j.cmet.2014.09.001 25295787
-
(2014)
Cell Metab
, vol.20
, pp. 626-638
-
-
Dubinsky, A.N.1
Dastidar, S.G.2
Hsu, C.L.3
Zahra, R.4
Djakovic, S.N.5
-
23
-
-
84891818924
-
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data
-
Li JH, Liu S, Zhou H, Qu LH, Yang JH, (2014) starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res 42: D92–97. doi: 10.1093/nar/gkt1248 24297251
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 92-97
-
-
Li, J.H.1
Liu, S.2
Zhou, H.3
Qu, L.H.4
Yang, J.H.5
-
24
-
-
84899644869
-
IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development
-
Jonson L, Christiansen J, Hansen TV, Vikesa J, Yamamoto Y, et al. (2014) IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development. Cell Rep 7: 539–551. doi: 10.1016/j.celrep.2014.03.015 24703842
-
(2014)
Cell Rep
, vol.7
, pp. 539-551
-
-
Jonson, L.1
Christiansen, J.2
Hansen, T.V.3
Vikesa, J.4
Yamamoto, Y.5
-
25
-
-
84881460310
-
The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
-
Copley MR, Babovic S, Benz C, Knapp DJ, Beer PA, et al. (2013) The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat Cell Biol 15: 916–925. doi: 10.1038/ncb2783 23811688
-
(2013)
Nat Cell Biol
, vol.15
, pp. 916-925
-
-
Copley, M.R.1
Babovic, S.2
Benz, C.3
Knapp, D.J.4
Beer, P.A.5
-
26
-
-
53749098061
-
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression
-
Nishino J, Kim I, Chada K, Morrison SJ, (2008) Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell 135: 227–239. doi: 10.1016/j.cell.2008.09.017 18957199
-
(2008)
Cell
, vol.135
, pp. 227-239
-
-
Nishino, J.1
Kim, I.2
Chada, K.3
Morrison, S.J.4
-
27
-
-
84887368980
-
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties
-
Nishino J, Kim S, Zhu Y, Zhu H, Morrison SJ, (2013) A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife 2: e00924. doi: 10.7554/eLife.00924 24192035
-
(2013)
Elife
, vol.2
, pp. 00924
-
-
Nishino, J.1
Kim, S.2
Zhu, Y.3
Zhu, H.4
Morrison, S.J.5
-
28
-
-
36849023466
-
Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2
-
Park SM, Shell S, Radjabi AR, Schickel R, Feig C, et al. (2007) Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle 6: 2585–2590. 17957144
-
(2007)
Cell Cycle
, vol.6
, pp. 2585-2590
-
-
Park, S.M.1
Shell, S.2
Radjabi, A.R.3
Schickel, R.4
Feig, C.5
-
29
-
-
84908032748
-
Hmga2 regulates self-renewal of retinal progenitors
-
Parameswaran S, Xia X, Hegde G, Ahmad I, (2014) Hmga2 regulates self-renewal of retinal progenitors. Development 141: 4087–4097. doi: 10.1242/dev.107326 25336737
-
(2014)
Development
, vol.141
, pp. 4087-4097
-
-
Parameswaran, S.1
Xia, X.2
Hegde, G.3
Ahmad, I.4
-
30
-
-
80053585752
-
LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms
-
King CE, Wang L, Winograd R, Madison BB, Mongroo PS, et al. (2011) LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms. Oncogene 30: 4185–4193. doi: 10.1038/onc.2011.131 21625210
-
(2011)
Oncogene
, vol.30
, pp. 4185-4193
-
-
King, C.E.1
Wang, L.2
Winograd, R.3
Madison, B.B.4
Mongroo, P.S.5
-
31
-
-
84879047304
-
Distinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer
-
Schubert M, Spahn M, Kneitz S, Scholz CJ, Joniau S, et al. (2013) Distinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer. PLoS One 8: e65064. doi: 10.1371/journal.pone.0065064 23798998
-
(2013)
PLoS One
, vol.8
, pp. 65064
-
-
Schubert, M.1
Spahn, M.2
Kneitz, S.3
Scholz, C.J.4
Joniau, S.5
-
32
-
-
84922324392
-
miR-98 delays skeletal muscle differentiation by down-regulating E2F5
-
Kropp J, Degerny C, Morozova N, Pontis J, Harel-Bellan A, et al. (2015) miR-98 delays skeletal muscle differentiation by down-regulating E2F5. Biochem J 466: 85–93. doi: 10.1042/BJ20141175 25422988
-
(2015)
Biochem J
, vol.466
, pp. 85-93
-
-
Kropp, J.1
Degerny, C.2
Morozova, N.3
Pontis, J.4
Harel-Bellan, A.5
-
33
-
-
84924422753
-
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids
-
Matano M, Date S, Shimokawa M, Takano A, Fujii M, et al. (2015) Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nat Med 21: 256–262. doi: 10.1038/nm.3802 25706875
-
(2015)
Nat Med
, vol.21
, pp. 256-262
-
-
Matano, M.1
Date, S.2
Shimokawa, M.3
Takano, A.4
Fujii, M.5
-
34
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, et al. (2009) Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459: 262–265. doi: 10.1038/nature07935 19329995
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
Vries, R.G.2
Snippert, H.J.3
van de Wetering, M.4
Barker, N.5
-
35
-
-
84885137302
-
Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser
-
Cline MS, Craft B, Swatloski T, Goldman M, Ma S, et al. (2013) Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser. Sci Rep 3: 2652. doi: 10.1038/srep02652 24084870
-
(2013)
Sci Rep
, vol.3
, pp. 2652
-
-
Cline, M.S.1
Craft, B.2
Swatloski, T.3
Goldman, M.4
Ma, S.5
-
36
-
-
79955681163
-
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
-
Merlos-Suarez A, Barriga FM, Jung P, Iglesias M, Cespedes MV, et al. (2011) The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell 8: 511–524. doi: 10.1016/j.stem.2011.02.020 21419747
-
(2011)
Cell Stem Cell
, vol.8
, pp. 511-524
-
-
Merlos-Suarez, A.1
Barriga, F.M.2
Jung, P.3
Iglesias, M.4
Cespedes, M.V.5
-
37
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas N, (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330–337. doi: 10.1038/nature11252 22810696
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
Cancer Genome Atlas, N.1
-
38
-
-
77951496399
-
Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro
-
Gracz AD, Ramalingam S, Magness ST, Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol 298: G590–600. doi: 10.1152/ajpgi.00470.2009 20185687
-
Am J Physiol Gastrointest Liver Physiol
, vol.298
, pp. 590-600
-
-
Gracz, A.D.1
Ramalingam, S.2
Magness, S.T.3
-
39
-
-
83255193921
-
Interconversion between intestinal stem cell populations in distinct niches
-
Takeda N, Jain R, LeBoeuf MR, Wang Q, Lu MM, et al. (2011) Interconversion between intestinal stem cell populations in distinct niches. Science 334: 1420–1424. doi: 10.1126/science.1213214 22075725
-
(2011)
Science
, vol.334
, pp. 1420-1424
-
-
Takeda, N.1
Jain, R.2
LeBoeuf, M.R.3
Wang, Q.4
Lu, M.M.5
-
40
-
-
84874730918
-
Intestinal label-retaining cells are secretory precursors expressing Lgr5
-
Buczacki SJ, Zecchini HI, Nicholson AM, Russell R, Vermeulen L, et al. (2013) Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 495: 65–69. doi: 10.1038/nature11965 23446353
-
(2013)
Nature
, vol.495
, pp. 65-69
-
-
Buczacki, S.J.1
Zecchini, H.I.2
Nicholson, A.M.3
Russell, R.4
Vermeulen, L.5
-
41
-
-
84880558928
-
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay
-
Wang F, Scoville D, He XC, Mahe MM, Box A, et al. (2013) Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology 145: 383–395 e381–321. doi: 10.1053/j.gastro.2013.04.050 23644405
-
(2013)
Gastroenterology
, vol.145
, pp. 383-395
-
-
Wang, F.1
Scoville, D.2
He, X.C.3
Mahe, M.M.4
Box, A.5
-
42
-
-
84894623720
-
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
-
Yin X, Farin HF, van Es JH, Clevers H, Langer R, et al. (2014) Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nat Methods 11: 106–112. doi: 10.1038/nmeth.2737 24292484
-
(2014)
Nat Methods
, vol.11
, pp. 106-112
-
-
Yin, X.1
Farin, H.F.2
van Es, J.H.3
Clevers, H.4
Langer, R.5
-
43
-
-
84876998128
-
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
-
Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, et al. (2013) ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep 3: 1128–1139. doi: 10.1016/j.celrep.2013.02.031 23545496
-
(2013)
Cell Rep
, vol.3
, pp. 1128-1139
-
-
Heijmans, J.1
van Lidth de Jeude, J.F.2
Koo, B.K.3
Rosekrans, S.L.4
Wielenga, M.C.5
-
44
-
-
84924244580
-
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
-
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, et al. (2015) Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat Med 21: 62–70. doi: 10.1038/nm.3750 25419707
-
(2015)
Nat Med
, vol.21
, pp. 62-70
-
-
Davis, H.1
Irshad, S.2
Bansal, M.3
Rafferty, H.4
Boitsova, T.5
-
45
-
-
84903443257
-
A conditional system to specifically link disruption of protein-coding function with reporter expression in mice
-
Chiou SH, Kim-Kiselak C, Risca VI, Heimann MK, Chuang CH, et al. (2014) A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. Cell Rep 7: 2078–2086. doi: 10.1016/j.celrep.2014.05.031 24931605
-
(2014)
Cell Rep
, vol.7
, pp. 2078-2086
-
-
Chiou, S.H.1
Kim-Kiselak, C.2
Risca, V.I.3
Heimann, M.K.4
Chuang, C.H.5
-
46
-
-
34548012848
-
The let-7 microRNA represses cell proliferation pathways in human cells
-
Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, et al. (2007) The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 67: 7713–7722. 17699775
-
(2007)
Cancer Res
, vol.67
, pp. 7713-7722
-
-
Johnson, C.D.1
Esquela-Kerscher, A.2
Stefani, G.3
Byrom, M.4
Kelnar, K.5
-
47
-
-
36849078711
-
let-7 regulates self renewal and tumorigenicity of breast cancer cells
-
Yu F, Yao H, Zhu P, Zhang X, Pan Q, et al. (2007) let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131: 1109–1123. 18083101
-
(2007)
Cell
, vol.131
, pp. 1109-1123
-
-
Yu, F.1
Yao, H.2
Zhu, P.3
Zhang, X.4
Pan, Q.5
-
48
-
-
35449003175
-
MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells
-
Sampson VB, Rong NH, Han J, Yang Q, Aris V, et al. (2007) MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res 67: 9762–9770. 17942906
-
(2007)
Cancer Res
, vol.67
, pp. 9762-9770
-
-
Sampson, V.B.1
Rong, N.H.2
Han, J.3
Yang, Q.4
Aris, V.5
-
49
-
-
41649114199
-
Suppression of non-small cell lung tumor development by the let-7 microRNA family
-
Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, et al. (2008) Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A 105: 3903–3908. doi: 10.1073/pnas.0712321105 18308936
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 3903-3908
-
-
Kumar, M.S.1
Erkeland, S.J.2
Pester, R.E.3
Chen, C.Y.4
Ebert, M.S.5
-
50
-
-
34547463506
-
Let-7 expression defines two differentiation stages of cancer
-
Shell S, Park SM, Radjabi AR, Schickel R, Kistner EO, et al. (2007) Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci U S A 104: 11400–11405. 17600087
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 11400-11405
-
-
Shell, S.1
Park, S.M.2
Radjabi, A.R.3
Schickel, R.4
Kistner, E.O.5
-
51
-
-
42049083140
-
Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma
-
Peng Y, Laser J, Shi G, Mittal K, Melamed J, et al. (2008) Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma. Mol Cancer Res 6: 663–673. doi: 10.1158/1541-7786.MCR-07-0370 18403645
-
(2008)
Mol Cancer Res
, vol.6
, pp. 663-673
-
-
Peng, Y.1
Laser, J.2
Shi, G.3
Mittal, K.4
Melamed, J.5
-
52
-
-
84940767468
-
Nuclear Localization Signal-enhanced Polyurethane-Short Branch Polyethylenimine-mediated Delivery of Let-7a Inhibited Cancer Stem-like Properties by Targeting the 3'UTR of HMGA2 in Anaplastic Astrocytoma
-
Yang MY, Chen MT, Huang PI, Wang CY, Chang YC, et al. (2014) Nuclear Localization Signal-enhanced Polyurethane-Short Branch Polyethylenimine-mediated Delivery of Let-7a Inhibited Cancer Stem-like Properties by Targeting the 3'UTR of HMGA2 in Anaplastic Astrocytoma. Cell Transplant.
-
(2014)
Cell Transplant
-
-
Yang, M.Y.1
Chen, M.T.2
Huang, P.I.3
Wang, C.Y.4
Chang, Y.C.5
-
53
-
-
42249103794
-
Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family
-
Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K, et al. (2008) Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. Clin Cancer Res 14: 2334–2340. doi: 10.1158/1078-0432.CCR-07-4667 18413822
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2334-2340
-
-
Motoyama, K.1
Inoue, H.2
Nakamura, Y.3
Uetake, H.4
Sugihara, K.5
-
54
-
-
84863985549
-
Genome-wide analysis of HMGA2 transcription factor binding sites by ChIP on chip in gastric carcinoma cells
-
Zha L, Wang Z, Tang W, Zhang N, Liao G, et al. (2012) Genome-wide analysis of HMGA2 transcription factor binding sites by ChIP on chip in gastric carcinoma cells. Mol Cell Biochem 364: 243–251. doi: 10.1007/s11010-012-1224-z 22246783
-
(2012)
Mol Cell Biochem
, vol.364
, pp. 243-251
-
-
Zha, L.1
Wang, Z.2
Tang, W.3
Zhang, N.4
Liao, G.5
-
55
-
-
84870856707
-
An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis
-
Li Z, Gilbert JA, Zhang Y, Zhang M, Qiu Q, et al. (2012) An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. Dev Cell 23: 1176–1188. doi: 10.1016/j.devcel.2012.10.019 23177649
-
(2012)
Dev Cell
, vol.23
, pp. 1176-1188
-
-
Li, Z.1
Gilbert, J.A.2
Zhang, Y.3
Zhang, M.4
Qiu, Q.5
-
56
-
-
34248233108
-
HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB
-
Cleynen I, Brants JR, Peeters K, Deckers R, Debiec-Rychter M, et al. (2007) HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB. Mol Cancer Res 5: 363–372. 17426251
-
(2007)
Mol Cancer Res
, vol.5
, pp. 363-372
-
-
Cleynen, I.1
Brants, J.R.2
Peeters, K.3
Deckers, R.4
Debiec-Rychter, M.5
-
57
-
-
3042547563
-
Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2
-
Brants JR, Ayoubi TA, Chada K, Marchal K, Van de Ven WJ, et al. (2004) Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett 569: 277–283. 15225648
-
(2004)
FEBS Lett
, vol.569
, pp. 277-283
-
-
Brants, J.R.1
Ayoubi, T.A.2
Chada, K.3
Marchal, K.4
Van de Ven, W.J.5
-
58
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003–1007. 17934449
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
van Es, J.H.2
Kuipers, J.3
Kujala, P.4
van den Born, M.5
-
59
-
-
78751644734
-
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
-
Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, et al. (2011) Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469: 415–418. doi: 10.1038/nature09637 21113151
-
(2011)
Nature
, vol.469
, pp. 415-418
-
-
Sato, T.1
van Es, J.H.2
Snippert, H.J.3
Stange, D.E.4
Vries, R.G.5
-
60
-
-
84874440778
-
Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling
-
Zong Y, Huang J, Sankarasharma D, Morikawa T, Fukayama M, et al. (2012) Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling. Proc Natl Acad Sci U S A 109: E3395–3404. doi: 10.1073/pnas.1217982109 23184966
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 3395-3404
-
-
Zong, Y.1
Huang, J.2
Sankarasharma, D.3
Morikawa, T.4
Fukayama, M.5
-
61
-
-
84929590704
-
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans
-
Tu HC, Schwitalla S, Qian Z, LaPier GS, Yermalovich A, et al. (2015) LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev 29: 1074–1086. doi: 10.1101/gad.256693.114 25956904
-
(2015)
Genes Dev
, vol.29
, pp. 1074-1086
-
-
Tu, H.C.1
Schwitalla, S.2
Qian, Z.3
LaPier, G.S.4
Yermalovich, A.5
-
62
-
-
84873283904
-
WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer
-
Wend P, Runke S, Wend K, Anchondo B, Yesayan M, et al. (2013) WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. EMBO Mol Med 5: 264–279. doi: 10.1002/emmm.201201320 23307470
-
(2013)
EMBO Mol Med
, vol.5
, pp. 264-279
-
-
Wend, P.1
Runke, S.2
Wend, K.3
Anchondo, B.4
Yesayan, M.5
-
63
-
-
79954578408
-
Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers
-
Wang X, Liu X, Li AY, Chen L, Lai L, et al. (2011) Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers. Clin Cancer Res 17: 2570–2580. doi: 10.1158/1078-0432.CCR-10-2542 21252160
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2570-2580
-
-
Wang, X.1
Liu, X.2
Li, A.Y.3
Chen, L.4
Lai, L.5
-
64
-
-
33845894956
-
PDGF signaling specificity is mediated through multiple immediate early genes
-
Schmahl J, Raymond CS, Soriano P, (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat Genet 39: 52–60. 17143286
-
(2007)
Nat Genet
, vol.39
, pp. 52-60
-
-
Schmahl, J.1
Raymond, C.S.2
Soriano, P.3
-
65
-
-
84856055494
-
HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells
-
Belton A, Gabrovsky A, Bae YK, Reeves R, Iacobuzio-Donahue C, et al. (2012) HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells. PLoS One 7: e30034. doi: 10.1371/journal.pone.0030034 22276142
-
(2012)
PLoS One
, vol.7
, pp. 30034
-
-
Belton, A.1
Gabrovsky, A.2
Bae, Y.K.3
Reeves, R.4
Iacobuzio-Donahue, C.5
-
66
-
-
84885905136
-
IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts
-
Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, et al. (2013) IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis 34: 2647–2654. doi: 10.1093/carcin/bgt217 23764754
-
(2013)
Carcinogenesis
, vol.34
, pp. 2647-2654
-
-
Hamilton, K.E.1
Noubissi, F.K.2
Katti, P.S.3
Hahn, C.M.4
Davey, S.R.5
-
67
-
-
0037370137
-
Pathology of mouse models of intestinal cancer: consensus report and recommendations
-
Boivin GP, Washington K, Yang K, Ward JM, Pretlow TP, et al. (2003) Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology 124: 762–777. 12612914
-
(2003)
Gastroenterology
, vol.124
, pp. 762-777
-
-
Boivin, G.P.1
Washington, K.2
Yang, K.3
Ward, J.M.4
Pretlow, T.P.5
-
68
-
-
84856490464
-
Controlled gene expression in primary Lgr5 organoid cultures
-
Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, et al. (2012) Controlled gene expression in primary Lgr5 organoid cultures. Nat Methods 9: 81–83.
-
(2012)
Nat Methods
, vol.9
, pp. 81-83
-
-
Koo, B.K.1
Stange, D.E.2
Sato, T.3
Karthaus, W.4
Farin, H.F.5
-
69
-
-
84866002291
-
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
-
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, et al. (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2: 401–404. doi: 10.1158/2159-8290.CD-12-0095 22588877
-
(2012)
Cancer Discov
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
Gross, B.E.4
Sumer, S.O.5
-
70
-
-
84875740314
-
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
-
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, et al. (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6: pl1. doi: 10.1126/scisignal.2004088 23550210
-
(2013)
Sci Signal
, vol.6
, pp. 11
-
-
Gao, J.1
Aksoy, B.A.2
Dogrusoz, U.3
Dresdner, G.4
Gross, B.5
|