Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy

Cell Metabolism

Volumn 20, Issue 4, 2014, Pages 626-638

  Dubinsky, Amy N ^a   Dastidar, Somasish Ghosh ^a   Hsu, Cynthia L ^a   Zahra, Rabaab ^a,l   Djakovic, Stevan N ^a,m   Duarte, Sonia ^g   Esau, Christine C ⁱ   Spencer, Brian ^b   Ashe, Travis D ^a   Fischer, Kimberlee M ⁱ   Mackenna, Deidre A ⁱ   Sopher, Bryce L ^j   Masliah, Eliezer ^b   Gaasterland, Terry ^e,f   Chau, B Nelson ⁱ   Pereira De Almeida, Luis ^g,h   Morrison, Bradley E ^a   La Spada, Albert R ^{a,b,c,d,e,f,k}  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f University of California San Diego   (United States)

^g UNIVERSITY OF COIMBRA   (Portugal)

^h UNIVERSITY OF COIMBRA   (Portugal)

ⁱ REGULUS THERAPEUTICS   (United States)

^j UNIVERSITY OF WASHINGTON   (United States)

^k RADY CHILDREN'S HOSPITAL   (United States)

^l QUAID I AZAM UNIVERSITY   (Pakistan)

^m GENENTECH INC   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICRORNA; MICRORNA LET 7; TRANSCRIPTOME; UNCLASSIFIED DRUG; MAP4K3 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MULTIPROTEIN COMPLEX; PROTEIN SERINE THREONINE KINASE; RRAGD PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BINDING SITE; BRAIN; CONTROLLED STUDY; ENERGY METABOLISM; FAST MUSCLE; GENE ACTIVATION; GENE CONTROL; GENE FUNCTION; GENE TARGETING; HUMAN; IN VIVO STUDY; LIPOGENESIS; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN AGGREGATION; PROTEIN HOMEOSTASIS; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENETICS; HEK293 CELL LINE; METABOLISM; RNA INTERFERENCE; SEQUENCE ALIGNMENT; SKELETAL MUSCLE; TRANSGENIC MOUSE;

ADIPOSE TISSUE, WHITE; AMINO ACIDS; ANIMALS; AUTOPHAGY; BASE SEQUENCE; BRAIN; CELLS, CULTURED; HEK293 CELLS; HUMANS; INSULIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRORNAS; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; MUSCLE, SKELETAL; NEURONS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84907967415     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.09.001     Document Type: Article

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