Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 50, 2012, Pages E3395-E3404

  Zong, Yang ^a   Huang, Jiaoti ^b   Sankarasharma, Devipriya ^b   Morikawa, Teppei ^c   Fukayama, Masashi ^c   Epstein, Jonathan I ^d   Chada, Kiran K ^b   Witte, Owen N ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d JOHNS HOPKINS HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; ANDROGEN RECEPTOR; BETA CATENIN; CELL ADHESION MOLECULE; CYCLINE; CYTOKERATIN 5; CYTOKERATIN 8; DICKKOPF RELATED PROTEIN 1; FRIZZLED PROTEIN; HIGH MOBILITY GROUP A2 PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; PEPTIDES AND PROTEINS; RED FLUORESCENT PROTEIN; SECRETED FRIZZLED RELATED PROTEIN 2; STEM CELL ANTIGEN 1; UNCLASSIFIED DRUG; WNT PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CULTURE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; EPIGENETICS; EPITHELIUM CELL; FLOW CYTOMETRY; HISTOLOGY; HYPERPLASIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; MESENCHYME CELL; MOUSE; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; UPREGULATION; UROGENITAL SINUS; WNT SIGNALING PATHWAY; ADENOCARCINOMA; ANIMAL; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; METABOLISM; NEOPLASM; PATHOLOGY; PRENATAL DEVELOPMENT; PROSTATE; PROSTATE TUMOR; TRANSGENIC MOUSE; UROGENITAL SYSTEM;

ADENOCARCINOMA; ANIMALS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HMGA2 PROTEIN; MALE; MICE; MICE, TRANSGENIC; NEOPLASMS, HORMONE-DEPENDENT; PARACRINE COMMUNICATION; PROSTATE; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; STROMAL CELLS; TUMOR MICROENVIRONMENT; UROGENITAL SYSTEM; WNT SIGNALING PATHWAY;

EID: 84874440778     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217982109     Document Type: Article

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