-
1
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel, D.P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
2
-
-
70349320158
-
Causes and consequences of microRNA dysregulation in cancer
-
Croce, C.M. Causes and consequences of microRNA dysregulation in cancer. Nat. Rev. Genet. 10, 704-714 (2009).
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 704-714
-
-
Croce, C.M.1
-
3
-
-
84857079737
-
The microcosmos of cancer
-
Lujambio, A. & Lowe, S.W. The microcosmos of cancer. Nature 482, 347-355 (2012).
-
(2012)
Nature
, vol.482
, pp. 347-355
-
-
Lujambio, A.1
Lowe, S.W.2
-
4
-
-
20444460289
-
MicroRNA expression profiles classify human cancers
-
Lu, J. et al. MicroRNA expression profiles classify human cancers. Nature 435, 834-838 (2005).
-
(2005)
Nature
, vol.435
, pp. 834-838
-
-
Lu, J.1
-
5
-
-
33144490646
-
A microRNA expression signature of human solid tumors defines cancer gene targets
-
Volinia, S. et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. USA 103, 2257-2261 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2257-2261
-
-
Volinia, S.1
-
6
-
-
77956339881
-
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
-
Medina, P.P., Nolde, M. & Slack, F.J. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467, 86-90 (2010).
-
(2010)
Nature
, vol.467
, pp. 86-90
-
-
Medina, P.P.1
Nolde, M.2
Slack, F.J.3
-
7
-
-
77957361864
-
Targeting microRNAs in cancer: Rationale, strategies and challenges
-
Garzon, R., Marcucci, G. & Croce, C.M. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat. Rev. Drug Discov. 9, 775-789 (2010).
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 775-789
-
-
Garzon, R.1
Marcucci, G.2
Croce, C.M.3
-
8
-
-
77955167841
-
Signatures of RNA binding proteins globally coupled to effective microRNA target sites
-
Jacobsen, A., Wen, J., Marks, D.S. & Krogh, A. Signatures of RNA binding proteins globally coupled to effective microRNA target sites. Genome Res. 20, 1010-1019 (2010).
-
(2010)
Genome Res.
, vol.20
, pp. 1010-1019
-
-
Jacobsen, A.1
Wen, J.2
Marks, D.S.3
Krogh, A.4
-
9
-
-
84880291315
-
Evaluating cell lines as tumour models by comparison of genomic profiles
-
Domcke, S., Sinha, R., Levine, D.A., Sander, C. & Schultz, N. Evaluating cell lines as tumour models by comparison of genomic profiles. Nat. Commun. 4, 2126 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2126
-
-
Domcke, S.1
Sinha, R.2
Levine, D.A.3
Sander, C.4
Schultz, N.5
-
10
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
11
-
-
79959838081
-
Integrated genomic analyses of ovarian carcinoma
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474, 609-615 (2011).
-
(2011)
Nature
, vol.474
, pp. 609-615
-
-
-
12
-
-
49949116902
-
The impact of microRNAs on protein output
-
Baek, D. et al. The impact of microRNAs on protein output. Nature 455, 64-71 (2008).
-
(2008)
Nature
, vol.455
, pp. 64-71
-
-
Baek, D.1
-
13
-
-
49949117302
-
Widespread changes in protein synthesis induced by microRNAs
-
Selbach, M. et al. Widespread changes in protein synthesis induced by microRNAs. Nature 455, 58-63 (2008).
-
(2008)
Nature
, vol.455
, pp. 58-63
-
-
Selbach, M.1
-
14
-
-
36749005527
-
Using expression profiling data to identify human microRNA targets
-
Huang, J.C. et al. Using expression profiling data to identify human microRNA targets. Nat. Methods 4, 1045-1049 (2007).
-
(2007)
Nat. Methods
, vol.4
, pp. 1045-1049
-
-
Huang, J.C.1
-
15
-
-
84878517261
-
Joint analysis of miRNA and mRNA expression data
-
Muniategui, A., Pey, J., Planes, F.J. & Rubio, A. Joint analysis of miRNA and mRNA expression data. Brief. Bioinform. 14, 263-278 (2013).
-
(2013)
Brief. Bioinform.
, vol.14
, pp. 263-278
-
-
Muniategui, A.1
Pey, J.2
Planes, F.J.3
Rubio, A.4
-
16
-
-
84858987120
-
MiR-34a Repression in proneural malignant gliomas upregulates expression of its Target PDGFRA and promotes tumorigenesis
-
Silber, J. et al. miR-34a Repression in proneural malignant gliomas upregulates expression of its Target PDGFRA and promotes tumorigenesis. PLoS ONE 7, e33844 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Silber, J.1
-
17
-
-
84866248155
-
MicroRNA regulatory network inference identifies miR-34a as a novel regulator of TGF signaling in glioblastoma
-
Genovese, G. et al. microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-? signaling in glioblastoma. Cancer Discov. 2, 736-749 (2012).
-
(2012)
Cancer Discov.
, vol.2
, pp. 736-749
-
-
Genovese, G.1
-
18
-
-
84866104494
-
Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma
-
Setty, M. et al. Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma. Mol. Syst. Biol. 8, 605 (2012).
-
(2012)
Mol. Syst. Biol.
, vol.8
, pp. 605
-
-
Setty, M.1
-
19
-
-
84859090208
-
Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma
-
Creighton, C.J. et al. Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma. PLoS ONE 7, e34546 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Creighton, C.J.1
-
20
-
-
84873582060
-
Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer
-
Yang, D. et al. Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell 23, 186-199 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 186-199
-
-
Yang, D.1
-
21
-
-
34250805982
-
MicroRNA targeting specificity in mammals: Determinants beyond seed pairing
-
Grimson, A. et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell 27, 91-105 (2007).
-
(2007)
Mol. Cell
, vol.27
, pp. 91-105
-
-
Grimson, A.1
-
22
-
-
77955963884
-
Comprehensive modeling of microRNA targets predicts functional nonconserved and noncanonical sites
-
Betel, D., Koppal, A., Agius, P., Sander, C. & Leslie, C. Comprehensive modeling of microRNA targets predicts functional nonconserved and noncanonical sites. Genome Biol. 11, R90 (2010).
-
(2010)
Genome Biol.
, vol.11
-
-
Betel, D.1
Koppal, A.2
Agius, P.3
Sander, C.4
Leslie, C.5
-
23
-
-
84857355139
-
Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
-
Kim, K. et al. Identification of oncogenic microRNA-17-92/ZBTB4/ specificity protein axis in breast cancer. Oncogene 31, 1034-1044 (2012).
-
(2012)
Oncogene
, vol.31
, pp. 1034-1044
-
-
Kim, K.1
-
24
-
-
84866106532
-
Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters
-
Kim, K. et al. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Mol. Cancer Ther. 11, 1852-1862 (2012).
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 1852-1862
-
-
Kim, K.1
-
25
-
-
77956230322
-
The ZEB/miR-200 feedback loop a motor of cellular plasticity in development and cancer?
-
Brabletz, S. & Brabletz, T. The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer? EMBO Rep. 11, 670-677 (2010).
-
(2010)
EMBO Rep.
, vol.11
, pp. 670-677
-
-
Brabletz, S.1
Brabletz, T.2
-
26
-
-
78049232281
-
The Myc-miR-17 92 axis blunts TGF signaling and production of multiple TGF-dependent antiangiogenic factors
-
Dews, M. et al. The Myc-miR-17 92 axis blunts TGF signaling and production of multiple TGF-dependent antiangiogenic factors. Cancer Res. 70, 8233-8246 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 8233-8246
-
-
Dews, M.1
-
27
-
-
78649941638
-
The miR-17-92 microRNA cluster regulates multiple components of the TGF- pathway in neuroblastoma
-
Mestdagh, P. et al. The miR-17-92 microRNA cluster regulates multiple components of the TGF-? pathway in neuroblastoma. Mol. Cell 40, 762-773 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 762-773
-
-
Mestdagh, P.1
-
28
-
-
84866985855
-
Targeting the TGF' signalling pathway in disease
-
Akhurst, R.J. & Hata, A. Targeting the TGF? signalling pathway in disease. Nat. Rev. Drug Discov. 11, 790-811 (2012).
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 790-811
-
-
Akhurst, R.J.1
Hata, A.2
-
29
-
-
0035355473
-
The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway
-
Hocevar, B.A., Smine, A., Xu, X.X. & Howe, P.H. The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. EMBO J. 20, 2789-2801 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 2789-2801
-
-
Hocevar, B.A.1
Smine, A.2
Xu, X.X.3
Howe, P.H.4
-
30
-
-
77955295090
-
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter
-
Hannigan, A. et al. Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. J. Clin. Invest. 120, 2842-2857 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2842-2857
-
-
Hannigan, A.1
-
31
-
-
79955166265
-
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
-
Mermel, C.H. et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12, R41 (2011).
-
(2011)
Genome Biol.
, vol.12
-
-
Mermel, C.H.1
-
32
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani, M. et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009).
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
-
33
-
-
80052461558
-
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
-
Ito, S. et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333, 1300-1303 (2011).
-
(2011)
Science
, vol.333
, pp. 1300-1303
-
-
Ito, S.1
-
34
-
-
80052495940
-
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
-
He, Y.-F. et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333, 1303-1307 (2011).
-
(2011)
Science
, vol.333
, pp. 1303-1307
-
-
He, Y.-F.1
-
35
-
-
79959937861
-
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
-
Cortellino, S. et al. Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell 146, 67-79 (2011).
-
(2011)
Cell
, vol.146
, pp. 67-79
-
-
Cortellino, S.1
-
36
-
-
73949118737
-
MicroRNA 29b functions in acute myeloid leukemia
-
Garzon, R. et al. MicroRNA 29b functions in acute myeloid leukemia. Blood 114, 5331-5341 (2009).
-
(2009)
Blood
, vol.114
, pp. 5331-5341
-
-
Garzon, R.1
-
37
-
-
44449111693
-
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
-
Sengupta, S. et al. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc. Natl. Acad. Sci. USA 105, 5874-5878 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 5874-5878
-
-
Sengupta, S.1
-
38
-
-
81855228621
-
Molecular Basis for Interaction of let-7 MicroRNAs with Lin28
-
Nam, Y., Chen, C., Gregory, R.I., Chou, J.J. & Sliz, P. Molecular Basis for Interaction of let-7 MicroRNAs with Lin28. Cell 147, 1080-1091 (2011).
-
(2011)
Cell
, vol.147
, pp. 1080-1091
-
-
Nam, Y.1
Chen, C.2
Gregory, R.I.3
Chou, J.J.4
Sliz, P.5
-
39
-
-
0035872447
-
Identification and validation of P311 as a glioblastoma invasion gene using laser capture microdissection
-
Mariani, L. et al. Identification and validation of P311 as a glioblastoma invasion gene using laser capture microdissection. Cancer Res. 61, 4190-4196 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 4190-4196
-
-
Mariani, L.1
-
40
-
-
84872233600
-
The role of the TGF- family in wound healing, burns and scarring: A review
-
Penn, J.W., Grobbelaar, A.O. & Rolfe, K.J. The role of the TGF-? family in wound healing, burns and scarring: a review. Int. J. Burns Trauma 2, 18 (2012).
-
(2012)
Int. J. Burns Trauma
, vol.2
, pp. 18
-
-
Penn, J.W.1
Grobbelaar, A.O.2
Rolfe, K.J.3
-
41
-
-
80052933429
-
DNA demethylation dynamics
-
Bhutani, N., Burns, D.M. & Blau, H.M. DNA demethylation dynamics. Cell 146, 866-872 (2011).
-
(2011)
Cell
, vol.146
, pp. 866-872
-
-
Bhutani, N.1
Burns, D.M.2
Blau, H.M.3
-
42
-
-
84863621527
-
Cancer epigenetics: From mechanism to therapy
-
Dawson, M.A. & Kouzarides, T. Cancer epigenetics: from mechanism to therapy. Cell 150, 12-27 (2012).
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
43
-
-
84880947688
-
Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a
-
Zhang, P., Huang, B., Xu, X. & Sessa, W.C. Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a. Biochem. Biophys. Res. Commun. 437, 368-373 (2013).
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.437
, pp. 368-373
-
-
Zhang, P.1
Huang, B.2
Xu, X.3
Sessa, W.C.4
-
44
-
-
35649020283
-
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
-
Fabbri, M. et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. USA 104, 15805-15810 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 15805-15810
-
-
Fabbri, M.1
-
45
-
-
67650588646
-
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
-
Garzon, R. et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 113, 6411-6418 (2009).
-
(2009)
Blood
, vol.113
, pp. 6411-6418
-
-
Garzon, R.1
-
46
-
-
78951485885
-
Pre-processing and differential expression analysis of Agilent microRNA arrays using the AgiMicroRna Bioconductor library
-
López-Romero, P. Pre-processing and differential expression analysis of Agilent microRNA arrays using the AgiMicroRna Bioconductor library. BMC Genomics 12, 64 (2011).
-
(2011)
BMC Genomics
, vol.12
, pp. 64
-
-
López-Romero, P.1
-
47
-
-
77649115847
-
MiRMaid: A unified programming interface for microRNA data resources
-
Jacobsen, A., Krogh, A., Kauppinen, S. & Lindow, M. miRMaid: a unified programming interface for microRNA data resources. BMC Bioinformatics 11, 29 (2010).
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 29
-
-
Jacobsen, A.1
Krogh, A.2
Kauppinen, S.3
Lindow, M.4
-
48
-
-
84870330917
-
MiRT: A database of validated transcription start sites of human microRNAs
-
Bhattacharyya, M., Das, M. & Bandyopadhyay, S. miRT: a database of validated transcription start sites of human microRNAs. Genomics Proteomics Bioinformatics 10, 310-316 (2012).
-
(2012)
Genomics Proteomics Bioinformatics
, vol.10
, pp. 310-316
-
-
Bhattacharyya, M.1
Das, M.2
Bandyopadhyay, S.3
-
49
-
-
38149042783
-
Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
-
Frankel, L.B. et al. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J. Biol. Chem. 283, 1026-1033 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1026-1033
-
-
Frankel, L.B.1
|