Hmga2 regulates self-renewal of retinal progenitors

Development (Cambridge)

Volumn 141, Issue 21, 2014, Pages 4087-4097

  Parameswaran, Sowmya ^a   Xia, Xiaohuan ^a   Hegde, Ganapati ^a   Ahmad, Iqbal ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Epigenetic; Hmga2; Progenitors; Rat; Retina; Self renewal; Stem cells

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; HIGH MOBILITY GROUP A2 PROTEIN; PIGMENT EPITHELIUM DERIVED FACTOR; STEM CELL FACTOR;

ANIMAL CELL; ARTICLE; CELL CLONING; CELL COUNT; CELL DENSITY; CELL DIFFERENTIATION; CELL DIVISION; CELL INTERACTION; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; ENDOTHELIUM CELL; EPIGENETICS; HISTOGENESIS; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PROMOTER REGION; RAT; RETINA CELL; RETINA DEVELOPMENT; RETINA PROGENITOR CELL; STEM CELL; STEM CELL NICHE; ANIMAL; CELL CULTURE; CELL CYCLE; CYTOLOGY; FEMALE; GENETICS; METABOLISM; PHYSIOLOGY; PREGNANCY; RETINA; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HMGA2 PROTEIN; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RETINA; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84908032748     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.107326     Document Type: Article

References (46)

1. Agathocleous, M. and Harris, W. A. (2009). From progenitors to differentiated cells in the vertebrate retina. Annu. Rev. Cell Dev. Biol. 25, 45-69.
2. Ahmad, I., Dooley, C. M., Thoreson, W. B., Rogers, J. A. and Afiat, S. (1999). In vitro analysis of a mammalian retinal progenitor that gives rise to neurons and glia. Brain Res. 831, 1-10.
3. Ahmad, I., Das, A. V., James, J., Bhattacharya, S. and Zhao, X. (2004). Neural stem cells in the mammalian eye: types and regulation. Semin. Cell Dev. Biol. 15, 53-62.
4. Andreu-Agulló, C., Morante-Redolat, J. M., Delgado A. C. and Fariñas, I. (2009). Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat. Neurosci. 12, 1514-1523.
5. Bhattacharya, S., Jackson, J. D., Das, A. V., Thoreson, W. B., Kuszynski, C., James, J., Joshi, S. and Ahmad, I. (2003). Direct identification and enrichment of retinal stem cells/progenitors by Hoechst dye efflux assay. Invest. Ophthalmol. Vis. Sci. 44, 2764-2773.
6. Butler, J. M., Nolan, D. J., Vertes, E. L., Varnum-Finney, B., Kobayashi, H., Hooper, A. T., Seandel, M., Shido, K., White, I. A., Kobayashi, M. et al. (2010). Endothelial cells are essential for the self-renewal and repopulation of Notchdependent hematopoietic stem cells. Cell Stem Cell 6, 251-264.
7. Cayouette, M. and Raff, M. (2003). The orientation of cell division influences cellfate choice in the developing mammalian retina. Development 130, 2329-2339.
8. Cepko, C. L. (1999). The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr. Opin. Neurobiol. 9, 37-46.
9. Chatoo, W., Abdouh, M., Duparc, R.-H. and Bernier, G. (2010). Bmi1 distinguishes immature retinal progenitor/stem cells from the main progenitor cell population and is required for normal retinal development. Stem Cells 28, 1412-1423.
10. Cho, S.-H. and Cepko, C. L. (2006). Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Development 133, 3167-3177.
11. Copley, M. R., Babovic, S., Benz, C., Knapp, D. J. H. F., Beer, P. A., Kent, D. G., Wohrer, S., Treloar, D. Q., Day, C., Rowe, K. et al. (2013). The Lin28b-let-7- Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat. Cell Biol. 15, 916-925.
12. Das, A. V., Mallya, K. B., Zhao, X., Ahmad, F., Bhattacharya, S., Thoreson, W. B., Hegde, G. V. and Ahmad, I. (2006). Neural stem cell properties of Muller glia in the mammalian retina: regulation by Notch and Wnt signaling. Dev. Biol. 299, 283-302.
13. Das, A. V., James, J., Bhattacharya, S., Imbalzano, A. N., Bhattacharya, S., Antony, M. L., Hegde, G., Zhao, X., Mallya, K., Ahmad, F., Knudsen, E. and Ahmad, I. (2007). SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling. J. Biol. Chem. 282, 35187-35201.
14. Del Debbio, C. B., Balasubramanian, S., Parameswaran, S., Chaudhuri, A., Qiu, F. and Ahmad, I. (2010). Notch and Wnt signaling mediated rod photoreceptor regeneration by Mü ller cells in adult mammalian retina. PLoS One 5, e12425.
15. De Marzo, A., Aruta, C. and Marigo, V. (2010). PEDF promotes retinal neurosphere formation and expansion in vitro. Adv. Exp. Med. Biol. 664, 621-630.
16. Ferrón, S. R., Andreu-Agulló, C., Mira, H., Sanchez, P., Marques-Torrejon, M. A. and Fariñas, I. (2007). A combined ex/in vivo assay to detect effects of exogenously added factors in neural stem cells. Nat. Protoc. 2, 849-859.
17. Gomes, F. L. A. F., Zhang, G., Carbonell, F., Correa, J. A., Harris, W. A., Simons, B. D. and Cayouette, M. (2011). Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions. Development 138, 227-235.
18. Hatakeyama, J., Tomita, K., Inoue, T. and Kageyama, R. (2001). Roles of homeobox and bHLH genes in specification of a retinal cell type. Development 28, 1313-1322.
19. Imura, T., Tane, K., Toyoda, N. and Fushiki, S. (2008). Endothelial cell-derived one morphogenetic proteins regulate glial differentiation of cortical progenitors. ur. J. Neurosci. 27, 1596-1606.
20. Jensen, A. M. and Raff, M. C. (1997). Continuous observation of multipotential etinal progenitor cells in clonal density culture. Dev. Biol. 188, 267-279.
21. Kidder, B. L., Palmer, S. and Knott, J. G. (2009). SWI/SNF-Brg1 regulates selfrenewal nd occupies core pluripotency-related genes in embryonic stem cells. tem Cells 27, 317-328.
22. Lee, Y. S. and Dutta, A. (2007). The tumor suppressor microRNA let-7 represses he HMGA2 oncogene. Genes Dev. 21, 1025-1030.
23. Livesey, F. J. and Cepko, C. L. (2001). Vertebrate neural cell-fate determination: essons from the retina. Nat. Rev. Neurosci. 2, 109-118.
24. Morrison, S. J. and Spradling, A. C. (2008). Stem cells and niches: mechanisms hat promote stem cell maintenance throughout life. Cell 132, 598-611.
25. Nishino, J., Kim, I., Chada, K. and Morrison, S. J. (2008). Hmga2 promotes neural tem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell 135, 227-239.
26. Noro, B., Licheri, B., Sgarra, R., Rustighi, A., Tessari, M. A., Chau, K.-Y., Ono, S. J., Giancotti, V. and Manfioletti, G. (2003). Molecular dissection of the architectural transcription factor HMGA2. Biochemistry 42, 4569-4577.
27. Palmer, T. D., Willhoite, A. R. and Gage, F. H. (2000). Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425, 479-494.
28. Pan, G., Li, J., Zhou, Y., Zheng, H. and Pei, D. (2006). A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J. 20, 1730-1732.
29. Parameswaran, S., Balasubramanian, S., Babai, N., Qiu, F., Eudy, J. D., Thoreson, W. B. and Ahmad, I. (2010). Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors: therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration. Stem Cells 28, 695-703.
30. Parameswaran, S., Balasubramanian, S., Babai, N., DelDebbio, C. B., Harms, D. W., Gurumurthy, C. B., Rao, M. S., Sharp, J. G. and Ahmad, I. (2012). Nucleic acid and non-nucleic acid-based reprogramming of adult limbal progenitors to pluripotency. PLoS One 7, e46734.
31. Ramírez-Castillejo, C., Sánchez-Sánchez, F., Andreu-Agulló, C., Ferrón, S. R., Aroca-Aguilar, J. D., Sánchez, P., Mira, H., Escribano, J. and Fariñas, I. (2006). Pigment epithelium-derived factor is a niche signal for neural stem cell renewal. Nat. Neurosci. 9, 331-339.
32. Rapaport, D. H., Wong, L. L., Wood, E. D., Yasumura, D. and LaVail, M. M.(2004). Timing and topography of cell genesis in the rat retina. J. Comp. Neurol. 474, 304-324.
33. Reich, M., Liefeld, T., Gould, J., Lerner, J., Tamayo, P. and Mesirov, J. P. (2006). GenePattern 2.0. Nat. Genet. 38, 500-501.
34. Robinson, S. (1991). Neuroanatomy of the visual pathways and their development. In Vision and Visual Dysfunction, Vol. 3 (ed. B. Dreber and S. R. Robinson), pp. 59-128. London: MacMillan.
35. Saint-Geniez, M. and D’Amore, P. A. (2004). Development and pathology of the hyaloid, choroidal and retinal vasculature. Int. J. Dev. Biol. 48, 1045-1058.
36. Shen, Q., Goderie, S. K., Jin, L., Karanth, N., Sun, Y., Abramova, N., Vincent, P., Pumiglia, K. and Temple, S. (2004). Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304, 1338-1340.
37. Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S.-M., Goderie, S.K., Roysam, B. and Temple, S. (2008). Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3, 289-300.
38. Shenghui, H., Nakada, D. and Morrison, S. J. (2009). Mechanisms of stem cell self-renewal. Annu. Rev. Cell Dev. Biol. 25, 377-406.
39. Sonoda, S., Sreekumar, P. G., Kase, S., Spee, C., Ryan, S. J., Kannan, R. and Hinton, D. R. (2009). Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging 2, 28-42.
40. Temple, S. (2001). The development of neural stem cells. Nature 414, 112-117.
41. Tombran-Tink, J., Chader, G. G. and Johnson, L. V. (1991). PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp. Eye Res. 53, 411-414.
42. Wang, Y., Dakubo, G. D., Thurig, S., Mazerolle, C. J. and Wallace, V. A. (2005). Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina. Development 132, 5103-5113.
43. Wang, L., Schulz, T. C., Sherrer, E. S., Dauphin, D. S., Shin, S., Nelson, A. M., Ware, C. B., Zhan, M., Song, C.-Z., Chen, X. et al. (2007). Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood 110, 4111-4119.
44. Weiss, S., Dunne, C., Hewson, J., Wohl, C., Wheatley, M., Peterson, A. C. and Reynolds, B. A. (1996). Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J. Neurosci. 16, 7599-7609.
45. Yang, X.-J. (2004). Roles of cell-extrinsic growth factors in vertebrate eye pattern formation and retinogenesis. Semin. Cell Dev. Biol. 15, 91-103.
46. Yin, T. and Li, L. (2006). The stem cell niches in bone. J. Clin. Invest. 116, 1195-1201.