Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors

Journal of Biological Chemistry

Volumn 290, Issue 31, 2015, Pages 19208-19217

  Ibeawuchi, Stella Rita C ^a   Agbor, Larry N ^a   Quelle, Frederick W ^a   Sigmund, Curt D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SIGNALING; SUBSTRATES;

CELL TYPES; PROTEIN TURNOVERS; UBIQUITIN LIGASES; UBIQUITINATION;

PROTEINS;

ADAPTOR PROTEIN; PROTEIN RBX1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CARRIER PROTEIN; CUL3 PROTEIN, HUMAN; CULLIN; PROTEIN BINDING; RBX1 PROTEIN, HUMAN; RHOA PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; CULLIN3 GENE; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENE MUTATION; HEK293 CELL LINE; HYPERTENSION; MOLECULAR PATHOLOGY; NEDDYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; UBIQUITINATION; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PROTEIN MULTIMERIZATION;

CARRIER PROTEINS; CULLIN PROTEINS; GENE EXPRESSION; HEK293 CELLS; HUMANS; HYPERTENSION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RHOA GTP-BINDING PROTEIN; UBIQUITINATION;

EID: 84940536795     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.645358     Document Type: Article

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