Rev-erbα and the circadian transcriptional regulation of metabolism

Diabetes, Obesity and Metabolism

Volumn 17, Issue S1, 2015, Pages 12-16

  Gerhart Hines, Z ^a   Lazar, M A ^b  

^a Capital Region   (Denmark)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Circadian rhythms; Metabolism; Physiology; Rev erb ; Transcription

Indexed keywords

NUCLEAR RECEPTOR NR1D1; TRANSCRIPTION FACTOR CLOCK;

BRAIN; BROWN ADIPOSE TISSUE; CIRCADIAN RHYTHM; HUMAN; INTESTINE FLORA; LIVER; METABOLIC REGULATION; NONHUMAN; PANCREAS; PROTEIN FUNCTION; REVIEW; SKELETAL MUSCLE; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; WHITE ADIPOSE TISSUE; BIOLOGICAL RHYTHM; GENETIC TRANSCRIPTION; METABOLISM; PHYSIOLOGY;

BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; CLOCK PROTEINS; HUMANS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; TRANSCRIPTION, GENETIC;

EID: 84940536313     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12510     Document Type: Review

References (59)

1. Bass J. Circadian topology of metabolism. Nature 2012; 491: 348-356.
2. Robinson I, Reddy AB. Molecular mechanisms of the circadian clockwork in mammals. FEBS Lett 2014; 588: 2477-2483.
3. Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science 2010; 330: 1349-1354.
4. Feng D, Lazar MA. Clocks, metabolism, and the epigenome. Mol Cell 2012; 47: 158-167.
5. Everett LJ, Lazar MA. Nuclear receptor Rev-erbα: up, down, and all around. Trends Endocrinol Metab 2014; 25: 586-592.
6. Bugge A, Feng D, Everett LJ et al. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes Dev 2012; 26: 657-667.
7. Cho H, Zhao X, Hatori M et al. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature 2012; 485: 123-127.
8. Jager J, O'Brien WT, Manlove J et al. Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Mol Endocrinol 2014; 28: 490-498.
9. Gerhart-Hines Z, Feng D, Emmett MJ et al. The nuclear receptor Rev-erbα controls circadian thermogenic plasticity. Nature 2013; 503: 410-413.
10. Raghuram S, Stayrook KR, Huang P et al. Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol 2007; 14: 1207-1213.
11. Yin L, Wu N, Curtin JC et al. Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science 2007; 318: 1786-1789.
12. Torra IP, Tsibulsky V, Delaunay F et al. Circadian and glucocorticoid regulation of Rev-erbalpha expression in liver. Endocrinology 2000; 141: 3799-3806.
13. Güler AD, Ecker JL, Lall GS et al. Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature 2008; 453: 102-105.
14. Provencio I, Jiang G, De Grip WJ, Hayes WP, Rollag MD. Melanopsin: an opsin in melanophores, brain, and eye. Proc Natl Acad Sci U S A 1998; 95: 340-345.
15. Moore RY. Organization and function of a central nervous system circadian oscillator: the suprachiasmatic hypothalamic nucleus. Fed Proc 1983; 42: 2783-2789.
16. Bartness TJ, Song CK, Demas GE. SCN efferents to peripheral tissues: implications for biological rhythms. J Biol Rhythms 2001; 16: 196-204.
17. Chung S, Lee EJ, Yun S et al. Impact of circadian nuclear receptor REV-ERBα on midbrain dopamine production and mood regulation. Cell 2014; 157: 858-868.
18. Banerjee S, Wang Y, Solt LA et al. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat Commun 2014; 5: 5759.
19. Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med 2013; 19: 1252-1263.
20. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277-359.
21. Redlin U, Nuesslein B, Schmidt I. Circadian changes of brown adipose tissue thermogenesis in juvenile rats. Am J Physiol 1992; 262: 504-508.
22. Yang Y, Shen Z, Tang Y, Wang N, Sun B. Simultaneous telemetric analyzing of the temporal relationship for the changes of the circadian rhythms of brown adipose tissue thermogenesis and core temperature in the rat. Zhongguo Ying Yong Sheng Li Xue Za Zhi (Chin J Appl Physiol) 2011; 27: 348-352.
23. Zvonic S, Ptitsyn AA, Conrad SA et al. Characterization of peripheral circadian clocks in adipose tissues. Diabetes 2006; 55: 962-970.
24. Van der Veen DR, Shao J, Chapman S, Leevy WM, Duffield GE. A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging. Obesity (Silver Spring Md) 2012; 20: 1527-1529.
25. Li S, Yu Q, Wang G-X, Lin JD. The biological clock is regulated by adrenergic signaling in brown fat but is dispensable for cold-Induced thermogenesis. PLoS One 2013; 8: e70109.
26. Nam D, Guo B, Chatterjee S, Chen M-H et al. The adipocyte clock controls brown adipogenesis via TGF-β and BMP signaling pathway. J Cell Sci 2015; 128: 1835-1847.
27. Chappuis S, Ripperger JA, Schnell A et al. Role of the circadian clock gene Per2 in adaptation to cold temperature. Mol Metab 2013; 2: 184-193.
28. Shostak A, Meyer-Kovac J, Oster H. Circadian regulation of lipid mobilization in white adipose tissues. Diabetes 2013; 62: 2195-2203.
29. Paschos GK, Ibrahim S, Song W-L et al. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med 2012; 18: 1768-1777.
30. Delezie J, Dumont S, Dardente H et al. The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism. FASEB J 2012; 26: 3321-3335.
31. Kelley DE, Goodpaster BH, Storlien L. Muscle triglyceride and insulin resistance. Annu Rev Nutr 2002; 22: 325-346.
32. Thiebaud D, Jacot E, Defronzo RA, Maeder E, Jequier E, Felber J-P. The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes 1982; 31: 957-963.
33. Dyar KA, Ciciliot S, Wright LE et al. Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock. Mol Metab 2014; 3: 29-41.
34. Woldt E, Sebti Y, Solt LA et al. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med 2013; 19: 1039-1046.
35. Liu C, Li S, Liu T, Borjigin J, Lin JD. Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 2007; 447: 477-481.
36. Rudic RD, McNamara P, Curtis A-M et al. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol 2004; 2: e377.
37. Lamia KA, Storch K-F, Weitz CJ. Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A 2008; 105: 15172-15177.
38. Kennaway DJ, Owens JA, Voultsios A, Boden MJ, Varcoe TJ. Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissues. Am J Physiol Regul Integr Comp Physiol 2007; 293: 1528-1537.
39. Kennaway DJ, Varcoe TJ, Voultsios A, Boden MJ. Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism. PLoS One 2013; 8: e65255.
40. Doi R, Oishi K, Ishida N. CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J Biol Chem 2010; 285: 22114-22121.
41. Zani F, Breasson L, Becattini B et al. PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression. Mol Metab 2013; 2: 292-305.
42. Lamia KA, Papp SJ, Yu RT et al. Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature 2011; 480: 552-557.
43. Zhang EE, Liu Y, Dentin R et al. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med 2010; 16: 1152-1156.
44. Feng D, Liu T, Sun Z et al. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 2011; 331: 1315-1319.
45. Sun Z, Miller RA, Patel RT, Chen J et al. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med 2012; 18: 934-942.
46. Fang B, Everett LJ, Jager J et al. Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. Cell 2014; 159: 1140-1152.
47. Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science 2005; 307: 1915-1920.
48. Sekirov I, Russell SL, Antunes LCM, Finlay BB. Gut microbiota in health and disease. Physiol Rev 2010; 90: 859-904.
49. Qin J, Li R, Raes J, Arumugam M et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59-65.
50. Mukherji A, Kobiita A, Ye T, Chambon P. Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell 2013; 153: 812-827.
51. Hatori M, Vollmers C, Zarrinpar A et al. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab 2012; 15: 848-860.
52. Zarrinpar A, Chaix A, Yooseph S, Panda S. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metab 2014; 20: 1006-1017.
53. Chaix A, Zarrinpar A, Miu P, Panda S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab 2014; 20: 991-1005.
54. Marcheva B, Ramsey KM, Buhr ED et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 2010; 466: 627-631.
55. Sadacca LA, Lamia KA, deLemos AS, Blum B, Weitz CJ. An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia 2011; 54: 120-124.
56. Lee J, Moulik M, Fang Z et al. Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol 2013; 33: 2327-2338.
57. Vieira E, Marroquí L, Batista TM et al. The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet. Endocrinology 2012; 153: 592-601.
58. Vieira E, Marroquí L, Figueroa ALC et al. Involvement of the clock gene rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells. PLoS One 2013; 8: e69939.
59. Solt LA, Wang Y, Banerjee S et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 2012; 485: 62-68.