Role of the circadian clock gene Per2 in adaptation to cold temperature

Molecular Metabolism

Volumn 2, Issue 3, 2013, Pages 184-193

  Chappuis, Sylvie ^a   Ripperger, Jürgen Alexander ^a   Schnell, Anna ^a   Rando, Gianpaolo ^b   Jud, Corinne ^a,d   Wahli, Walter ^b,c   Albrecht, Urs ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Brown adipose tissue; Humidity; Season

Indexed keywords

FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 3; HEAT SHOCK TRANSCRIPTION FACTOR 1; PER2 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RETINOID X RECEPTOR ALPHA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ADAPTIVE BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CHROMATIN IMMUNOPRECIPITATION; CIRCADIAN RHYTHM; COLD ACCLIMATIZATION; COLD EXPOSURE; COLD SENSITIVITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HUMIDITY; LIPOLYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PER2 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN AGGREGATION; PROTEIN BINDING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SKIN TEMPERATURE; TEMPERATURE; THERMOGENESIS; TRIACYLGLYCEROL BLOOD LEVEL; UCP1 GENE;

MAMMALIA; MUS;

EID: 84883254227     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2013.05.002     Document Type: Article

References (35)

1. Romanovsky A.A. Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. American Journal of Physiology-Regulatory, Integrative, and Comparative Physiology 2007, 292:R37-46.
2. Refinetti R. The circadian rhythm of body temperature. Frontiers in Bioscience 2010, 15:564-594.
3. VanderLeest H.T., Houben T., Michel S., Deboer T., Albus H., Vansteensel M.J., et al. Seasonal encoding by the circadian pacemaker of the SCN. Current Biology 2007, 17:468-473.
4. Hanon E.A., Lincoln G.A., Fustin J.M., Dardente H., Masson-Pevet M., Morgan P.J., et al. Ancestral TSH mechanism signals summer in a photoperiodic mammal. Current Biology 2008, 18:1147-1152.
5. Whitesell L., Lindquist S. Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opinion on Therapeutic Targets 2009, 13:469-478.
6. Reinke H., Saini C., Fleury-Olela F., Dibner C., Benjamin I.J., Schibler U. Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes & Development 2008, 22:331-345.
7. Buhr E.D., Yoo S.H., Takahashi J.S. Temperature as a universal resetting cue for mammalian circadian oscillators. Science 2010, 330:379-385.
8. Matz J.M., Blake M.J., Tatelman H.M., Lavoi K.P., Holbrook N.J. Characterization and regulation of cold-induced heat shock protein expression in mouse brown adipose tissue. American Journal of Physiology 1995, 269:R38-47.
9. Tamaru T., Hattori M., Honda K., Benjamin I., Ozawa T., Takamatsu K. Synchronization of circadian Per2 rhythms and HSF1-BMAL1:CLOCK interaction in mouse fibroblasts after short-term heat shock pulse. PLoS One 2011, 6:e24521.
10. Lowell B.B., Spiegelman B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 2000, 404:652-660.
11. Davis T.R., Johnston D.R., Bell F.C., Cremer B.J. Regulation of shivering and non-shivering heat production during acclimation of rats. American Journal of Physiology 1960, 198:471-475.
12. Klingenberg M., Huang S.G. Structure and function of the uncoupling protein from brown adipose tissue. Biochimica et Biophysica Acta 1999, 1415:271-296.
13. Daan S., Spoelstra K., Albrecht U., Schmutz I., Daan M., Daan B., et al. Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele. Journal of Biological Rhythms 2011, 26:118-129.
14. Ripperger J.A., Schibler U. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nature Genetics 2006, 38:369-374.
15. Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U. The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes & Development 2010, 24:345-357.
16. Langmesser S., Tallone T., Bordon A., Rusconi S., Albrecht U. Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Molecular Biology 2008, 9:41.
17. Zheng B., Larkin D.W., Albrecht U., Sun Z.S., Sage M., Eichele G., et al. The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 1999, 400:169-173.
18. Yang X., Downes M., Yu R.T., Bookout A.L., He W., Straume M., et al. Nuclear receptor expression links the circadian clock to metabolism. Cell 2006, 126:801-810.
19. Cullen K.E., Sarge K.D. Characterization of hypothermia-induced cellular stress response in mouse tissues. Journal of Biological Chemistry 1997, 272:1742-1746.
20. Albrecht U., Bordon A., Schmutz I., Ripperger J. The multiple facets of Per2. Cold Spring Harbor Symposia on Quantitative Biology 2007, 72:95-104.
21. Cannon B., Nedergaard J. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). International Journal of Obestetrics (London) 2010, 34(1):S7-16.
22. Enerback S., Jacobsson A., Simpson E.M., Guerra C., Yamashita H., Harper M.E., et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 1997, 387:90-94.
23. Barbera M.J., Schluter A., Pedraza N., Iglesias R., Villarroya F., Giralt M. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. Journal of Biological Chemistry 2001, 276:1486-1493.
24. Rabelo R., Schifman A., Rubio A., Sheng X., Silva J.E. Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene. Endocrinology 1995, 136:1003-1013.
25. Lee S.S., Pineau T., Drago J., Lee E.J., Owens J.W., Kroetz D.L., et al. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Molecular and Cellular Biology 1995, 15:3012-3022.
26. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92:829-839.
27. Guerra C., Koza R.A., Walsh K., Kurtz D.M., Wood P.A., Kozak L.P. Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation. Journal of Clinical Investigation 1998, 102:1724-1731.
28. Grimaldi B., Bellet M.M., Katada S., Astarita G., Hirayama J., Amin R.H., et al. PER2 controls lipid metabolism by direct regulation of PPARgamma. Cell Metabolism 2010, 12:509-520.
29. Furuhashi M., Hotamisligil G.S. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nature Reviews Drug Discovery 2008, 7:489-503.
30. Vergnes L., Chin R., Young S.G., Reue K. Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. Journal of Biological Chemistry 2011, 286:380-390.
31. Morf J., Rey G., Schneider K., Stratmann M., Fujita J., Naef F., et al. Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally. Science 2012, 338:379-383.
32. Viswambharan H., Carvas J.M., Antic V., Marecic A., Jud C., Zaugg C.E., et al. Mutation of the circadian clock gene Per2 alters vascular endothelial function. Circulation 2007, 115:2188-2195.
33. Bae K., Lee K., Seo Y., Lee H., Kim D., Choi I. Differential effects of two period genes on the physiology and proteomic profiles of mouse anterior tibialis muscles. Molecules and Cells 2006, 22:275-284.
34. Kalsbeek A., Yi C.X., Cailotto C., la Fleur S.E., Fliers E., Buijs R.M. Mammalian clock output mechanisms. Essays in Biochemistry 2011, 49:137-151.
35. Guilding C., Piggins H.D. Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?. European Journal of Neuroscience 2007, 25:3195-3216.