Treg depletion attenuates irradiation-induced pulmonary fibrosis by reducing fibrocyte accumulation, inducing Th17 response, and shifting IFN-γ, IL-12/IL-4, IL-5 balance

Immunobiology

Volumn 220, Issue 11, 2015, Pages 1284-1291

  Xiong, Shanshan ^a   Guo, Renfeng ^b   Yang, Zhihua ^a   Xu, Long ^a   Du, Li ^a   Li, Ruoxi ^a   Xiao, Fengjun ^a   Wang, Qianjun ^a   Zhu, Maoxiang ^a   Pan, Xiujie ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Fibrocyte; Irradiation induced pulmonary fibrosis; Regulatory T cells; Th1 Th2 cytokines; Th17 cells

Indexed keywords

CD25 ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; CYTOKINE; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ FOXP3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DISEASE COURSE; FEMALE; FLOW CYTOMETRY; GAMMA RADIATION; IRRADIATION; LUNG FIBROSIS; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIOTHERAPY; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; TH1 TH2 BALANCE; TH17 CELL; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CD4 LYMPHOCYTE COUNT; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE DEPLETION; METABOLISM; PATHOLOGY; PHENOTYPE; PULMONARY FIBROSIS; T LYMPHOCYTE SUBPOPULATION; X RAY;

ANIMALS; ANTIBODIES, MONOCLONAL; CD4 LYMPHOCYTE COUNT; CYTOKINES; FEMALE; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-4; INTERLEUKIN-5; LYMPHOCYTE DEPLETION; MICE; PHENOTYPE; PULMONARY FIBROSIS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; X-RAYS;

EID: 84940449053     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2015.07.001     Document Type: Article

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