Fibrocytes: A unique cell population implicated in wound healing

Cellular and Molecular Life Sciences

Volumn 60, Issue 7, 2003, Pages 1342-1350

  Metz, C N ^a  

^a North Shore LIJ Research Institute ^*  (United States)

Author keywords

Angiogenesis; Antigen presentation; Fibrosis; TGF ; Tissue remodeling; Tissue repair

Indexed keywords

ALPHA CHEMOKINE; B7 ANTIGEN; BETA CHEMOKINE; CD11B ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CYTOKINE; FIBRONECTIN; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MICROSOMAL AMINOPEPTIDASE; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; VIMENTIN;

ANGIOGENESIS; ANTIGEN PRESENTATION; CELL; CELL ISOLATION; CELL POPULATION; CYTOKINE PRODUCTION; FIBROBLAST; FIBROCYTE; FIBROSIS; HUMAN; NONHUMAN; REVIEW; TISSUE REPAIR; WOUND HEALING;

ANIMALS; CHEMOKINES; FIBROBLASTS; FIBROSIS; HUMANS; MEMBRANE PROTEINS; WOUND HEALING;

EID: 0042368890     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-003-2328-0     Document Type: Review

References (45)

1. Dunphy J. E. The fibroblast: a ubiquitous ally for the surgeon. (1963) N. Engl. J. Med. 268: 1367-1371
2. Bucala R., Spiegel L. A., Chesney J., Hogan M. and Cerami A. (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol. Med. 1: 71-81
3. Chesney J., Bacher M., Bender A. and Bucala R. (1997) The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ. Proc. Natl. Acad. Sci. USA 94: 6307-6312
4. Abe R., Donnelly S. C., Peng T., Bucala R. and Metz C. N. (2001) Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J. Immunol. 166: 7556-7562
5. Harris D. L., King E., Ramsland P. A. and Edmundson A. B. (2000) Binding of nascent collagen by amyloidogenic light chains and amyloid fibrillogenesis in monolayers of human fibrocytes. J. Mol. Recognit.. 13: 198-212
6. Takahashi T. and Kimura R. S. (1970) The ultrastructure of the spiral ligament in the Rhesus monkey. Acta Otolaryngol. 69: 46-60
7. Ichimiya I., Yoshida K., Hirano T., Suzuki M. and Mogi G. (2000) Significance of spiral ligament fibrocytes with cochlear inflammation. Int. J. Pediatr. Otorhinolaryngol. 56: 45-51
8. Chesney J., Metz C., Stavitsky A. B., Bacher M. and Bucala R. (1998) Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes. J. Immunol. 160: 419-425
9. Shreedhar V., Moodycliffe A. M., Ullrich S. E., Bucana C., Kripke M. L. and Flores-Romo L. (1999) Dendritic cells require T cells for functional maturation in vivo. Immunity 11: 625-636
10. Barth P. J., Ebrahimsade S., Ramaswamy A. and Moll R. (2002) CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ and benign breast lesions. Virchows Arch. 440: 298-303
11. Saeki H., Moore A. M., Brown M. J. and Hwang S. T. (1999) Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162: 2472-2475
12. Hjelmstrom P., Fjell J., Nakagawa T., Sacca R., Cuff C. A. and Ruddle N. H. (2000) Lymphoid tissue homing chemokines are expressed in chronic inflammation. Am. J. Patrol. 156: 1133-1138
13. Schmitt D. (1999) Immune functions of the human skin. Models of in vitro studies using Langerhans cells. Cell Biol.Toxicol. 15: 41-45
14. Geppert T. D and Lipsky P. E. (1985) Antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression. J. Immunol. 135: 3750-3762
15. Schall T. J., Bacon K., Camp R. D., Kaspari J. W. and Goeddel D. V. (1993) Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes. J. Exp. Med. 177: 1821-1826
16. Zhu Y., Koo K., Bradshaw J. D., Sutton W. F., Kuller L. R., Bucala R. et al. (2000) Macaque blood-derived antigen-presenting cells elicit SIV-specific immune responses. J. Med. Primatol. 29: 182-192
17. Burger A., Loffler H., Bamberg M. and Rodemann H. P. (1998) Molecular and cellular basis of radiation fibrosis. Int. J. Radiat. Bol. 73: 401-408
18. + fibrocytes in neoplastic and inflammatory pancreatic lesions. Virchows Arch. 440: 128-133
19. Kirchmann T. T., Prieto V. G. and Smoller B. R. (1994) CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma. Arch. Dermatol. 130: 589-592
20. Kirchmann T. T., Prieto V. G. and Smoller B. R. (1995) Use of CD34 in assessing the relationship between stroma and tumor in desmoplastic keratinocytic neoplasms. J. Cutan. Pathol. 22: 422-426
21. Steere A. C. (2001) Lyme disease. N. Engl. J. Med. 345: 115-125
22. Steere A. C. (1995) Musculoskeletal manifestations of Lyme disease. Am. J. Med. 98: 44S-48S
23. Guo B. P., Brown E. L., Dorward D. W., Rosenberg L. C. and Hook M. (1998) Decorin-binding adhesins from Borrelia burgdorferi. Mol. Microbiol. 30: 711-723
24. Grab D. J., Lanners H., Martin L. N., Chesney J., Cai C., Adkisson H. D. et al. (1999) Interaction of Borrelia burgdorferi with peripheral blood fibrocytes, antigen-presenting cells with the potential for connective tissue targeting. Mol. Med. 5: 46-54
25. Grab D. J., Lanners H. N., Williams W. L. and Bucala R. (1999) Peripheral blood fibrocytes with foamy virus infection-like morphology. Hum. Pathol. 30: 1395-1396
26. Grab D., Salim M., Chesney J., Bucala R. and Lanners H. (2002) A role for peripheral blood fibrocytes in Lyme disease? Med. Hypotheses. 59: 1
27. Powell D. W., Mifflin R. C., Valentich J. D., Crowe S. E., Saada J. I. and West A. B. (1999) Myofibroblasts. I. Paracrine cells important in health and disease. Am. J Physiol. 277: C1-C9
28. Powell D. W., Mifflin R. C., Valentich J. D., Crowe S. E., Saada J. I. and West A. B. (1999) Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am. J. Physiol. 277: C183-C201
29. Davidson J. (1992) Wound repair. In: Inflammation: Basic Principles and Clinical Correlates, pp. 809-819, Gallin J. and Goldstein I. (eds), Raven Press, New York
30. Tonnesen M. G., Feng X. and Clark R. A. (2000) Angiogenesis in wound healing. J. Investig. Dermatol. Symp. Proc. 5: 40-46
31. Hartlapp I., Abe R., Saeed R. W., Peng T., Voelter W., Bucala R. et al. (2001) Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo. FASEB J. 15: 2215-2224
32. Agren M. S. (1994) Gelatinase activity during wound healing. Br. J. Dermatol. 131: 634-640
33. Agren M. S. (1999) Matrix metalloproteinases (MMPs) are required for re-epithelialization of cutaneous wounds. Arch. Dermatol. Res. 291: 583-590
34. Salo T., Makela M., Kylmaniemi M., Autio-Harmainen H. and Larjava H. (1994) Expression of matrix metalloproteinase-2 and -9 during early human wound healing. Lab. Invest. 70: 176-182
35. Ueda K., Furuya E., Yasuda Y., Oba S. and Tajima S. (1999) Keloids have continuous high metabolic activity. Plast. Reconstr. Surg. 104: 694-698
36. Abergel R. P., Pizzurro D., Meeker C. A., Lask G., Matsuoka L. Y., Minor R. R. et al. (1985) Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures. J. Invest. Dermatol. 84: 384-390
37. Narvaez D., Kanitakis J., Faure M. and Claudy A. (1996) Immunohistochemical study of CD34-positive dendritic cells of human dermis. Am. J. Dermatopathol. 18: 283-288
38. Yamazaki K. and Eyden B. P. (1995) Ultrastructural and immunohistochemical observations on intralobular fibroblasts of human breast, with observations on the CD34 antigen. J. Submicrosc. Cytol. Pathol. 27: 309-323
39. Humphreys T. R., Monteiro M. R. and Murphy G. F. (2000) Mast cells and dendritic cells in basal cell carcinoma stroma. Dermatol. Surg. 26: 200-203
40. Luttges J., Mentzel T., Hubner G. and Kloppel G. (1999) Solitary fibrous tumour of the pancreas: a new member of the small group of mesenchymal pancreatic tumours. Virchows Arch. 435: 37-42
41. Seidal T. and Edvardsson H. (2000) Diagnosis of gastrointestinal stromal tumor by fine-needle aspiration biopsy: a cytological and immunocytochemical study. Diagn. Cytopathol. 23: 397-401
42. Seidal T. and Edvardsson H. (1999) Expression of c-kit (CD117) and Ki67 provides information about the possible cell of origin and clinical course of gastrointestinal stromal tumours. Histopathology 34: 416-424
43. + dendrophages. Histopathology 29: 411-419
44. Sircar K., Hewlett B. R., Huizinga J. D., Chorneyko K., Berezin I. and Riddell R. H. (1999) Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am. J. Surg. Patrol. 23: 377-389
45. Suster S. and Fisher C. (1997) Immunoreactivity for the human hematopoietic progenitor cell antigen (CD34) in lipomatous tumors. Am. J. Surg. Pathol. 21: 195-200