Fibroblasts stimulated via HLA-II molecules produce prostaglandin E 2 and regulate cytokine production from helper T cells

Laboratory Investigation

Volumn 90, Issue 12, 2010, Pages 1747-1756

  Kato Kogoe, Nahoko ^a   Ohyama, Hideki ^a   Nishimura, Fusanori ^b   Meguro, Michio ^c   Yoshizawa, Sayuri ^c   Okada, Yuka ^c   Nakasho, Keiji ^a   Yamanegi, Koji ^a   Yamada, Naoko ^a   Hata, Masaki ^a   Higashi, Takehiro ^d   Terada, Nobuyuki ^a   Matsushita, Sho ^d  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

collagen synthesis; fibroblast; HLA II; IL 13; Th cells

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; CYTOKINE; GAMMA INTERFERON; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; INDOMETACIN; INTERLEUKIN 13; INTERLEUKIN 5; PROSTAGLANDIN E2;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL STIMULATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FIBROBLAST; GENE EXPRESSION; GINGIVA; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; MALE; MIXED LYMPHOCYTE CULTURE; MIXED LYMPHOCYTE REACTION; NORMAL HUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SUPERNATANT; T LYMPHOCYTE; TH2 CELL;

EID: 78649676447     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2010.128     Document Type: Article

References (57)

1. Strieter RM, Phan SH, Showell HJ, et al. Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts. J Biol Chem 1989;264:10621-10626.
2. Larsen CG, Anderson AO, Oppenheim JJ, et al. Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor. Immunology 1989;68:31-36.
3. Xing Z, Jordana M, Braciak T, et al. Lipopolysaccharide induces expression of granulocyte/macrophage colony-stimulating factor, interleukin-8, and interleukin-6 in human nasal, but not lung, fibroblasts: evidence for heterogeneity within the respiratory tract. Am J Respir Cell Mol Biol 1993;9:255-263.
4. Tamura M, Tokuda M, Nagaoka S, et al. Lipopolysaccharides of Bacteroides intermedius (Prevotella intermedia) and Bacteroides (Porphyromonas) gingivalis induce interleukin-8 gene expression in human gingival fibroblast cultures. Infect Immun 1992;60:4932-4937.
5. Tran CN, Lundy SK, White PT, et al. Molecular interactions between T cells and fibroblast-like synoviocytes: role of membrane tumor necrosis factor-alpha on cytokine-activated T cells. Am J Pathol 2007;171:1588-1598.
6. Ohta K, Shigeishi H, Taki M, et al. Regulation of CXCL9/10/11 in oral keratinocytes and fibroblasts. J Dent Res 2008;87:1160-1165.
7. Zhang Y, Cao HJ, Graf B, et al. CD40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts. J Immunol 1998;160:1053-1057. (Pubitemid 28093397)
8. Pober JS, Collins T, Gimbrone Jr MA, et al. Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature 1983;305:726-729.
9. Matsuoka T, Kohrogi H, Ando M, et al. Altered TCR ligands affect antigen-presenting cell responses: up-regulation of IL-12 by an analogue peptide. J Immunol 1996;157:4837-4843.
10. Matsuoka T, Tabata H, Matsushita S. Monocytes are differentially activated through HLA-DR, -DQ, and -DP molecules via mitogen-activated protein kinases. J Immunol 2001;166:2202-2208.
11. Ohyama H, Nishimura F, Meguro M, et al. Counter-antigen presentation: fibroblasts produce cytokines by signalling through HLA class II molecules without inducing T-cell proliferation. Cytokine 2002;17:175-181.
12. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;19:392:245-392:252.
13. Luft T, Jefford M, Luetjens P, et al. Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood 2002;100:1362-1372.
14. Lee JJ, Takei M, Hori S, et al. The role of PGE(2) in the differentiation of dendritic cells: how do dendritic cells influence T-cell polarization and chemokine receptor expression? Stem Cells 2002;20:448-459.
15. de Jong EC, Vieira PL, Kalinski P, et al. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J Immunol 2002;168:1704-1709.
16. Nishimura F, Terranova VP. Comparative study of the chemotactic responses of periodontal ligament cells and gingival fibroblasts to polypeptide growth factors. J Dent Res 1996;75:986-992.
17. Maurer DH, Hanke JH, Mickelson E, et al. Differential presentation of HLA-DR, DQ, and DP restriction elements by interferon-gamma-treated dermal fibroblasts. J Immunol 1987;139:715-723.
18. Okada Y, Meguro M, Ohyama H, et al. Human leukocyte histocompatibility antigen class II-induced cytokines from human gingival fibroblasts promote proliferation of human umbilical vein endothelial cells: potential association with enhanced angiogenesis in chronic periodontal inflammation. J Periodontal Res 2009;44:103-109.
19. Kapsenberg ML. Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 2003;3:984-993.
20. Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nat Immunol 2000;1:199-205.
21. Feili-Hariri M, Falkner DH, Morel PA. Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy. J Leukoc Biol 2005;78: 656-664.
22. Harris SG, Padilla J, Koumas L, et al. Prostaglandins as modulators of immunity. Trends Immunol 2002;23:144-150.
23. Kaliń ski P, Vieira PL, Schuitemaker JH, et al Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood 2001, 97, 3466-3469.
24. Sempowski GD, Derdak S, Phipps RP. Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets. J Cell Physiol 1996;167:290-296.
25. Liu X, Kohyama T, Wang H, et al. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am J Physiol Lung Cell Mol Physiol 2002;282:L1049-L1056.
26. Kimura T, Ishii Y, Yoh K, et al. Overexpression of the transcription factor GATA-3 enhances the development of pulmonary fibrosis. Am J Pathol 2006;169:96-104.
27. Clark RA, Yamanaka K, Bai M, et al. Human skin cells support thymus-independent T cell development. J Clin Invest 2005;115:3239-3249.
28. Clark RA, Kupper TS. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 2007;109:194-202.
29. Aschenbrenner K, D'Cruz LM, Vollmann EH, et al. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol 2007;8:351-358.
30. Black AP, Ardern-Jones MR, Kasprowicz V, et al. Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells. Eur J Immunol 2007;37:1485-1493.
31. Ardern-Jones MR, Black AP, Bateman EA, et al. Bacterial superantigen facilitates epithelial presentation of allergen to T helper 2 cells. Proc Natl Acad Sci USA 2007;104:5557-5562.
32. Saalbach A, Klein C, Sleeman J, et al. Dermal fibroblasts induce maturation of dendritic cells. J Immunol 2007;178:4966-4974.
33. Svensson M, Maroof A, Ato M, et al. Stromal cells direct local differentiation of regulatory dendritic cells. Immunity 2004;21:805-816.
34. Zhang M, Tang H, Guo Z, et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol 2004;5:1124-1133.
35. Mollah ZU, Aiba S, Manome H, et al. Cord blood CD34+ cells differentiate into dermal dendritic cells in co-culture with cutaneous fibroblasts or stromal cells. J Invest Dermatol 2002;118:450-460.
36. Liu YJ, Soumelis V, Watanabe N, et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol 2007;25:193-219.
37. Gold KN, Weyand CM, Goronzy JJ. Modulation of helper T cell function by prostaglandins. Arthritis Rheum 1994;37:925-933.
38. 2. J Immunol 1990;145:2616-2625.
39. 2 primes naive T cells for the production of anti-inflammatory cytokines. Eur J Immunol 1997;27:3526-3531.
40. Kubo S, Takahashi HK, Takei M, et al. E-prostanoid (EP)2/EP4 receptor-dependent maturation of human monocyte-derived dendritic cells and induction of helper T2 polarization. J Pharmacol Exp Ther 2004;309: 1213-1220.
41. 2 induces IL-23 production in bone marrow-derived dendritic cells. FASEB J 2004;18:1318-1320. (Pubitemid 39561589)
42. 2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells. J Immunol 2008;181:721-735.
43. 2 synergistically with interleukin-23 favors human Th17 expansion. Blood 2008;112:3696-3703.
44. 2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med 2009;206:535-548.
45. 2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells. Eur J Immunol 2009;39:1301-1312.
46. Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 2002;3:673-680.
47. Wang YH, Ito T, Wang YH, et al. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 2006;24:827-838.
48. Koyama K, Ozawa T, Hatsushika K, et al. A possible role for TSLP in inflammatory arthritis. Biochem Biophys Res Commun 2007;357: 99-104.
49. Hirayama K, Matsushita S, Kikuchi I, et al. HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. Nature 1987;327:426-430.
50. Wynn TA. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol 2004;4:583-594.
51. Chiaramonte MG, Donaldson DD, Cheever AW, et al. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 1999;104:777-785.
52. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005;115:209-218.
53. Zhu Z, Homer RJ, Wang Z, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999;103:779-788.
54. Jakubzick C, Choi ES, Joshi BH, et al. Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4- and IL-13-responsive cells. J Immunol 2003;171:2684-2693.
55. Zurawski SM, Vega Jr F, Huyghe B, et al. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 1993;12:2663-2670.
56. Jinnin M, Ihn H, Yamane K, et al. Interleukin-13 stimulates the transcription of the human alpha2 (I) collagen gene in human dermal fibroblasts. J Biol Chem 2004;279:41783-41791.
57. Fichtner-Feigl S, Strober W, Kawakami K, et al. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med 2006;12:99-106.