The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

Molecular Metabolism

Volumn 4, Issue 9, 2015, Pages 643-651

  Marcinko, Katarina ^a   Bujak, Adam L ^a   Lally, James S V ^a   Ford, Rebecca J ^a   Wong, Tammy H ^a   Smith, Brennan K ^a   Kemp, Bruce E ^b   Jenkins, Yonchu ^c   Li, Wei ^c   Kinsella, Todd M ^c   Hitoshi, Yasumichi ^c   Steinberg, Gregory R ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c RIGEL PHARMACEUTICALS INC   (United States)

Author keywords

AMPK; Complex I; Diabetes; Exercise mimetic; Mitochondrial; Obesity; R419

Indexed keywords

DEOXYGLUCOSE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; N [1 (4 CYANOBENZYL)PIPERIDIN 4 YL] 6 [4 (4 METHOXYBENZOYL)PIPERIDINE 1 CARBONYL]NICOTINAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY MASS; CELL FUNCTION; CONTROLLED STUDY; DRUG MECHANISM; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXERCISE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; MALE; MITOCHONDRION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE; TREADMILL EXERCISE; UPREGULATION; WEIGHT GAIN;

MUS;

EID: 84940439443     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2015.06.002     Document Type: Article

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