A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: Comparison with effects of contraction and other AMPK activators

Biochemical Journal

Volumn 460, Issue 3, 2014, Pages 363-375

  Lai, Yu Chiang ^a   Kviklyte, Samanta ^a   Vertommen, Didier ^a   Lantier, Louise ^b,c   Foretz, Marc ^b,c   Viollet, Benoît ^b,c   Hallén, Stefan ^d   Rider, Mark H ^a  

^a DE DUVE INSTITUTE   (Belgium)

^b INSTITUT COCHIN   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

Acetyl CoA carboxylase (ACC); AMP activated protein kinase activator (AMPK activator); Fatty acid oxidation; Glycogen; Protein synthesis

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ACETYL COENZYME A CARBOXYLASE; BENZIMIDAZOLE DERIVATIVE; GLYCOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE BETA1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE BETA2; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; EXTENSOR DIGITORUM LONGUS MUSCLE; FATTY ACID OXIDATION; GLUCOSE TRANSPORT; GLYCOGEN ANALYSIS; GLYCOGEN MUSCLE LEVEL; MALE; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SOLEUS MUSCLE;

ACETYL-COA CARBOXYLASE; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BENZIMIDAZOLES; ENZYME ACTIVATION; FATTY ACIDS; GLUCOSE; GLYCOGEN; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PYRONES; RATS; RIBONUCLEOTIDES; THIOPHENES;

EID: 84901725138     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131673     Document Type: Article

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