AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Jenkins, Yonchu ^a   Sun, Tian Qiang ^a   Markovtsov, Vadim ^a   Foretz, Marc ^b,c,d   Li, Wei ^a   Nguyen, Henry ^a   Li, Yingwu ^a   Pan, Alison ^a   Uy, Gerald ^a   Gross, Lisa ^a   Baltgalvis, Kristen ^a   Yung, Stephanie L ^a   Gururaja, Tarikere ^a   Kinoshita, Taisei ^a   Owyang, Alexander ^a   Smith, Ira J ^a   McCaughey, Kelly ^a   White, Kathy ^a   Godinez, Guillermo ^a   Alcantara, Raniel ^a   Choy, Carmen ^a   Ren, Hong ^a   Basile, Rachel ^a   Sweeny, David J ^a   Xu, Xiang ^a   Issakani, Sarkiz D ^a   Carroll, David C ^a   Goff, Dane A ^a   Shaw, Simon J ^a   Singh, Rajinder ^a   Boros, Laszlo G ^e,f   Laplante, Marc André ^g   Marcotte, Bruno ^g   Kohen, Rita ^g   Viollet, Benoit ^b,c,d   Marette, André ^g   Payan, Donald G ^a   Kinsella, Todd M ^a   Hitoshi, Yasumichi ^a   more..

^a RIGEL PHARMACEUTICALS INC   (United States)

^b INSTITUT COCHIN   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e SIDMAP LLC   (United States)

^f HARBOR UCLA MEDICAL CENTER   (United States)

^g LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRANCHED CHAIN AMINO ACID; GLUCOSE; GLUCOSE C 13; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; METFORMIN; PALMITIC ACID C 13; R 419; RADIOPHARMACEUTICAL AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; FATTY ACID OXIDATION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID METABOLISM; LIPOGENESIS; LIVER; MALE; METABOLIC PARAMETERS; METABOLOMICS; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE CELL; NONHUMAN; NUTRIENT DYNAMICS; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

AMINO ACIDS, BRANCHED-CHAIN; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; FATTY ACIDS; GLUCOSE; HEP G2 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; MICE; MITOCHONDRIA, LIVER; MUSCLE CELLS; OXIDATION-REDUCTION; PALMITATES; PROTEIN KINASE INHIBITORS;

EID: 84891959705     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081870     Document Type: Article

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