Crocus sativus L. (saffron) for cancer chemoprevention: A mini review

Journal of Traditional and Complementary Medicine

Volumn 5, Issue 2, 2015, Pages 81-87

  Bhandari, Prasan R ^a  

^a SDM COLLEGE OF MEDICAL SCIENCES AND HOSPITAL   (India)

Author keywords

Anticancer; Cancer; Chemoprevention; Crocus sativus; Pharmacology; Saffron

Indexed keywords

EID: 84940164645     PISSN: None     EISSN: 22254110     Source Type: Journal    
DOI: 10.1016/j.jtcme.2014.10.009     Document Type: Review

References (56)

1. Goss PE, Strasser-Weippl K, Lee-Bychkovsky BL, et al. Challenges to effective cancer control in China, India, and Russia. Lancet Oncol. 2014;15:489-538.
2. Mallath MK, Taylor DG, Badwe RA, et al. The growing burden of cancer in India: epidemiology and social context. Lancet Oncol. 2014;15:e205ee212.
3. Vineis P, Wild CP. Global cancer patterns: causes and prevention. Lancet. 2014;383:549-557.
4. Schottenfeld D, Beebe-Dimmer JL, Buffler PA, Omenn GS. Current perspective on the global and United States cancer burden attributable to lifestyle and environmental risk factors. Annu Rev Public Health. 2013;34:97-117.
5. D'Souza ND, Murthy NS, Aras RY. Projection of burden of cancer mortality for India, 2011-2026. Asian Pac J Cancer Prev. 2013;14:4387-4392.
6. D'Souza ND, Murthy NS, Aras RY. Projection of cancer incident cases for India-till 2026. Asian Pac J Cancer Prev. 2013;14:4379-4386.
7. Gutheil WG, Reed G, Ray A, Anant S, Dhar A. Crocetin: an agent derived from saffron for prevention and therapy for cancer. Curr Pharm Biotechnol. 2012;13: 173-179.
8. Mohan A, Narayanan S, Sethuraman S, Krishnan UM. Combinations of plant polyphenols and anticancer molecules: a novel treatment strategy for cancer chemotherapy. Anticancer Agents Med Chem. 2013;13:281-295.
9. Das I, Chakrabarty RN, Das S. Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev. 2004;5:70-76.
10. Champalal KD, Nilakshi N, Gadiya RV, Abhyankar MM. Detailed profile of Crocus sativus. Int J Pharm Biol Sci. 2011;2:530-540.
11. Kumar V, Bhat ZA, Kumar D, Khan NA, Shah MY. Pharmacological profile of Crocus sativus e a comprehensive review. Pharmacologyonline. 2011;3: 799-811.
12. Rezaee R, Hosseinzadeh H. Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iran J Basic Med Sci. 2013;16:12-26.
13. Samarghandian S, Borji A. Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients. Pharmacognosy Res. 2014;6:99-107.
14. Williams CD. Antioxidants and prevention of gastrointestinal cancers. Curr Opin Gastroenterol. 2013;29:195-200.
15. Bathaie SZ, Miri H, Mohagheghi MA, Mokhtari-Dizaji M, Shahbazfar AA, Hasanzadeh H. Saffron aqueous extract inhibits the chemically-induced gastric cancer progression in the Wistar albino rat. Iran J Basic Med Sci. 2013;16: 27-38.
16. Bathaie SZ, Hoshyar R, Miri H, Sadeghizadeh M. Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochem Cell Biol. 2013;91:397-403.
17. Hoshyar R, Bathaie SZ, Sadeghizadeh M. Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells. DNA Cell Biol. 2013;32:50-57.
18. Haraldsdottir S, Einarsdottir HM, Smaradottir A, Gunnlaugsson A, Halfdanarson TR. Colorectal cancer e review. Laeknabladid. 2014;100:75-82.
19. N1 Arber, Levin B. Chemoprevention of colorectal cancer: ready for routine use? Recent Res Cancer. 2005;166:213-230.
20. Aung HH, Wang CZ, Ni M, et al. Crocin from Crocus sativus possesses significant antiproliferation effects on human colorectal cancer cells. Exp Oncol. 2007;29: 175-180.
21. Bajbouj K, Schulze-Luehrmann J, Diermeier S, Amin A, Schneider-Stock R. The anticancer effect of saffron in two p53 isogenic colorectal cancer cell lines. BMC Complement Altern Med. 2012;12:69.
22. Lim EJ, Torresi J. Prevention of hepatitis C virus infection and liver cancer. Recent Res Cancer. 2014;193:113-133.
23. Rasool M, Rashid S, Arooj M, et al. New possibilities in hepatocellular carcinoma treatment. Anticancer Res. 2014;34:1563-1571.
24. Costantini S, Colonna G, Castello G. A holistic approach to study the effects of natural antioxidants on inflammation and liver cancer. Cancer Treat Res. 2014;159:311-323.
25. Amin A, Hamza AA, Bajbouj K, Ashraf SS, Daoud S. Saffron: a potential candidate for a novel anticancer drug against hepatocellular carcinoma. Hepatology. 2011;54:857-867.
26. Noureini SK, Wink M. Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT downregulation. Asian Pac J Cancer Prev. 2012;13:2305-2309.
27. Iovanna J, Mallmann MC, Goncąlves A, Turrini O, Dagorn JC. Current knowledge on pancreatic cancer. Front Oncol. 2012;2:6.
28. Ling S, Feng T, Jia K, Tian Y, Li Y. Inflammation to cancer: the molecular biology in the pancreas (Review). Oncol Lett. 2014;7:1747-1754.
29. Fendrich V. Chemoprevention of pancreatic cancer-one step closer. Langenbecks Arch Surg. 2012;397:495-505.
30. Boreddy SR, Srivastava SK. Pancreatic cancer chemoprevention by phytochemicals. Cancer Lett. 2013;334:86-94.
31. Mascari~nas E, Eibl G, Grippo PJ. Evaluating dietary compounds in pancreatic cancer modeling systems. Methods Mol Biol. 2013;980:225-248.
32. Dhar A, Mehta S, Dhar G, et al. Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther. 2009;8:315-323.
33. Bakshi H, Sam S, Rozati R, et al. DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from kashmiri saffron in a human pancreatic cancer cell line. Asian Pac J Cancer Prev. 2010;11:675-679.
34. Schmitz-Drager BJ, Schoffski O, Marberger M, Sahin S, Schmid HP. Risk adapted chemoprevention for prostate cancer: an option? Recent Res Cancer. 2014;202: 79-91.
35. Eisinger F, Cancel-Tassin G, Azzouzi AR, Gravis G, Rossi D, Cussenot O. Pharmaco and diet based prostate cancer prevention. Bull Cancer. 2013;100: 497-507.
36. D'Alessandro AM, Mancini A, Lizzi AR, et al. Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer. Nutr Cancer. 2013;65:930-942.
37. Samarghandian S, Shabestari MM. DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. Indian J Urol. 2013;29: 177-183.
38. Sasieni P. Chemoprevention of cervical cancer. Best Pract Res Clin Obstet Gynaecol. 2006;20:295-305.
39. Zhong YJ, Shi F, Zheng XL, et al. Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and-independent mechanisms. Acta Pharmacol Sin. 2011;32:1529-1536.
40. Sinha D, Biswas J, Sung B, Aggarwal BB, Bishayee A. Chemopreventive and chemotherapeutic potential of curcumin in breast cancer. Curr Drug Targets. 2012;13:1799-1819.
41. Advani P, Moreno-Aspitia A. Current strategies for the prevention of breast cancer. Breast Cancer (Dove Med Press). 2014;6:59-71.
42. Singh AA. India can do more for breast and cervical cancer control. Asian Pac J Cancer Prev. 2009;10:527-530.
43. Chryssanthi DG, Dedes PG, Karamanos NK, Cordopatis P, Lamari FN. Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases. Planta Med. 2011;77:146-151.
44. Chun KS, Kundu J, Kundu JK, Surh YJ. Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals. Toxicol Lett. 2014. S0378-4274(14)00223-9.
45. Singh M, Suman S, Shukla Y. New enlightenment of skin cancer chemoprevention through phytochemicals: in vitro and in vivo studies and the underlying mechanisms. Biomed Res Int. 2014;2014:243452.
46. Das I, Das S, Saha T. Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: a histopathological study. Acta Histochem. 2010;112:317-327.
47. Magesh V, Singh JP, Selvendiran K, Ekambaram G, Sakthisekaran D. Antitumor activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes, and histopathological studies. Mol Cell Biochem. 2006;287:127-135.
48. Samarghandian S, Borji A, Farahmand SK, Afshari R, Davoodi S. Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. Biomed Res Int. 2013;2013:417928.
49. Samarghandian S, Tavakkol Afshari J, Davoodi S. Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction. Appl Biochem Biotechnol. 2011;164:238-247.
50. Samarghandian S, Boskabady MH, Davoodi S. Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line. Pharmacogn Mag. 2010;6:309-314.
51. Sun Y, Xu HJ, Zhao YX, et al. Crocin exhibits antitumor effects on human leukemia HL-60 cells in vitro and in vivo. Evid Based Complement Alternat Med. 2013;2013:690164.
52. Geromichalos GD, Papadopoulos T, Sahpazidou D, Sinakos Z. Safranal, a Crocus sativus L constituent suppresses the growth of K-562 cells of chronic myelogenous leukemia. In silico and in vitro study. Food Chem Toxicol. 2014 Sep 17;74C:45-50.
53. Rezaee R, Mahmoudi M, Abnous K, et al. Cytotoxic effects of crocin on MOLT-4 human leukemia cells. J Complement Integr Med. 2013:10. http://dx.doi.org/10.1515/jcim-2013-0011.
54. Chahine N, Hanna J, Makhlouf H, Duca L, Martiny L, Chahine R. Protective effect of saffron extract against doxorubicin cardiotoxicity in isolated rabbit heart. Pharm Biol. 2013;51:1564-1571.
55. Alavizadeh SH, Hosseinzadeh H. Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol. 2014;64:65-80.
56. Hosseinzadeh H, Sadeghi Shakib S, Khadem Sameni A, Taghiabadi E. Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. Iran J Pharm Res. 2013;12:93-99.