Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease

Bioorganic Chemistry

Volumn 62, Issue , 2015, Pages 106-116

  Rahim, Fazal ^a   Javed, Muhammad Tariq ^a   Ullah, Hayat ^a   Wadood, Abdul ^b   Taha, Muhammad ^c,d   Ashraf, Muhammad ^e   Qurat Ul Ain, ^e   Khan, Muhammad Anas ^f   Khan, Fahad ^a   Mirza, Salma ^g   Khan, Khalid M ^g  

^a HAZARA UNIVERSITY   (Pakistan)

^b ABDUL WALI KHAN UNIVERSITY   (Pakistan)

^c UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^d Faculty of Applied Science UiTM ^*  (Malaysia)

^e THE ISLAMIA UNIVERSITY OF BAHAWALPUR   (Pakistan)

^f UNIVERSITY OF PESHAWAR   (Pakistan)

^g UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Acetylcholinesterase inhibition; Alzheimer's disease; Butyrylcholinesterase Inhibition; Molecular docking; Synthesis; Thiazole

Indexed keywords

1 [[[2 [4 (4 CHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL] 3 [2 [4 (4 CHLORO PHENYL)THIAZOL 2 YL]HYDRAZANO]METHYL]BENZENE; 2 [2 (2,4 DICHLOROBENZYLIDENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [2 (ANTHRACEN 9 YL METHYLENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [2 (ANTHRACEN 9 YLMETHYLENE)HYDRAZINYL] 4 (4 CLOROPHENYL)THIAZOLE; 2 [2 [1 (2 BROMO 4 NITROPHENYL)ETHYLIDENE]HYDRAZINYL] 4 (4 CHLOROPHENYL)THIAZOLE; 2 [2 [4 (BENZYLOXY)BENZYLIDENE]HYDRAINYL] 4 (4 METHOXYPHENYL)THIAZOLE; 2 [2 [4 (BENZYLOXY)BENZYLIDENE]HYDRAZINYL] 4 (4 CHLOROPHENYL)THIAZOLE; 2,6 DI TERT BUTYL 4 [[2 [4 (4 CHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL]PHENOL; 4 (4 CHLOROPHENYL) 2 [2 (2 NITROBENZYLIDENE)HYDRAZINYL]THIAZOLE; 4 (4 CHLOROPHENYL) 2 [2 (2,4 DICHLOROHENZYLIDENE)HYDRAZINYL]THIAZOLE; 4 (4 CHLOROPHENYL) 2 [2 (NAPHTHALEN 2 YL METHYLENE)HYDRAZINYL]THIAZOLE; 4 (4 CHLOROPHENYL) 2 [2 [(3-NITROPHENYL)ETHYLIDENE]HYDRAIZNYL]THIAZOLE; 4 (4 CHLOROPHENYL) 2 [2 [1 (4 METHOXYPHENYL)ETHYLIDENE]HYDRAZINYL]THIAZOLE; 4 (4 CHLOROPHENYL) 2 [2 [1 [4 (PIPERIDIN 1 YL)PHENYL]ETHYLIDENE]HYDRAZINYL]THIAZOLE; 4 (4 CHLOROPHENYL) 2 [2 [2 (4 NITROPHENYL)ETHYLIDENE]HYDRAZINYL]THIAZOLE; 4 (4 METHOXYPHENYL) 2 [2 (3 NITROBENZYLIDENE)HYDRAZINYL]THIAZOLE; 4 (4 METHOXYPHENYL) 2 [2 (4 NITROBENZYLIDENE)HYDRAZINYL]THIAZOLE; 4 (4 METHOXYPHENYL) 2 [2 (NAPHTHALEN 2 YL METHYLENE)HYDRAZINYL]THIAZOLE; 4 (4 METHOXYPHENYL) 2 [2 [1 (3 NITRO PHENYL)ETHYLIDENE]HYDRAZINYL]THAIZOL; 4 (4 METHOXYPHENYL) 2 [2 [1 (4-METHOXYPHENYL)ETHYLIDENE]HYDRAZINYL]THIAZOL; 4 [[2 [4 (4 CHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL] N,N DIMETHYL ANILINE; 4 [[2 [4 (4 CHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL]BENZENE 1,2 DIOL; 4 [[2 [4 (4 METHOXYPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL] N,N DIMETHYLANILINE; 5 [[2 [4 (4 CHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL] 2 METHOXYPHENOL; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; PHYSOSTIGMINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHOLINESTERASE INHIBITION; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HYDROGEN BOND; IC50; IN VITRO STUDY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ENZYME ACTIVE SITE;

ALZHEIMER DISEASE; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; MOLECULAR DOCKING SIMULATION; THIAZOLES;

EID: 84940020718     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2015.08.002     Document Type: Article

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