Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 245-252

  Khan, Khalid Mohammed ^a   Rahim, Fazal ^b   Wadood, Abdul ^c   Kosar, Naveen ^b   Taha, Muhammad ^d   Lalani, Salima ^a   Khan, Aisha ^b   Fakhri, Muhammad Imran ^a   Junaid, Muhammad ^c   Rehman, Wajid ^b   Khan, Momin ^c   Perveen, Shahnaz ^e   Sajid, Muhammad ^b   Choudhary, M Iqbal ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b HAZARA UNIVERSITY   (Pakistan)

^c ABDUL WALI KHAN UNIVERSITY   (Pakistan)

^d UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^e PCSIR LABORATORIES COMPLEX   (Pakistan)

Author keywords

Biscoumarin; Molecular docking; Glucosidase inhibition

Indexed keywords

3,3 ((3 HYDROXYPHENYL) METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE); 3,3 ((3,4,5 TRIMETHOXYPHENYL)METHYLENE)BIS(6 METHYL 4 HYDROXY 2H CHROMEN 2 ONE; 3,3' ((2 4 DICHLOROPHENYL)METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE); 3,3' ((2 NITROPHENYL)METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE); 3,3' ((2 NITROPHENYL)METHYLENE)BIS(6 METHYL 4 HYDROXY 2H CHROMEN 2 ONE); 3,3' ((3 ETHOXY 4 HYDROXYPHENYL)METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE; 3,3' ((3 ETHOXY 4 HYDROXYPHENYL)METHYLENE)BIS(6 METHYL 2 HYDROXY 2H CHROMEN 2 ONE; 3,3' ((3 HYDROXY 4 METHOXYPHENYL)METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE; 3,3' ((3 HYDROXYPHENYL)METHYLENE)BIS(6 METHYL 4 HYDROXY 2H CHROMEN 2 ONE); 3,3' ((3 METHOXY,4 HYDROXYPHENYL)METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE; 3,3' ((3 NITROPHENYL) METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE); 3,3' ((3 NITROPHENYL)METHYLENE)BIS(4 HYDROXY 6 METHYL 2H CHROMEN 2 ONE); 3,3' ((3,4 DIMETHOXYPHENYL)METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE); 3,3' ((3,4,5 TRIMETHOXYPHENYL)METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE; 3,3' ((4 (METHYLTHIO)PHENYL)METHYL)(6 METHYL 2H CHROMEN 2 ONE); 3,3' ((4 METHOXYPHENYL)METHYLENE)BIS(4 HYDROXY 6 METHYL 2H CHROMEN 2 ONE); 3,3' ((4 METHOXYPHENYL)METHYLENE)BIS(6 CHLORO 4 HYDROXY 2H CHROMEN 2 ONE); 3,3' ((4 NITROPHENYL)METHYLENE)BIS(4 HYDROXY 6 METHYL 2H CHROMEN 2 ONE); ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; COUMARIN DERIVATIVE; UNCLASSIFIED DRUG; ALPHA GLUCOSIDASE; GLYCOSIDASE INHIBITOR;

ARTICLE; DIABETES MELLITUS; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; MOLECULAR DOCKING; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALPHA-GLUCOSIDASES; COUMARINS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDE HYDROLASE INHIBITORS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901047505     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.010     Document Type: Article

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