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Volumn 21, Issue 4, 2015, Pages 373-382

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ACIPIMOX; AMPK ALPHA2 SUBUNIT, MOUSE; ANTILIPEMIC AGENT; DUSP1 PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; NICOTINE; PRKAA2 PROTEIN, HUMAN; PYRAZINE DERIVATIVE; SERINE;

EID: 84940002527     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3826     Document Type: Article
Times cited : (136)

References (66)
  • 1
    • 79954632229 scopus 로고    scopus 로고
    • Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide
    • Dubé, J.J. et al. Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. Diabetologia 54, 1147-1156 (2011).
    • (2011) Diabetologia , vol.54 , pp. 1147-1156
    • Dubé, J.J.1
  • 2
    • 0033542401 scopus 로고    scopus 로고
    • Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men
    • Iribarren, C., Tekawa, I.S., Sidney, S. & Friedman, G.D. Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men. N. Engl. J. Med. 340, 1773-1780 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1773-1780
    • Iribarren, C.1    Tekawa, I.S.2    Sidney, S.3    Friedman, G.D.4
  • 3
    • 0029787156 scopus 로고    scopus 로고
    • Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance
    • Eliasson, B., Taskinen, M.R. & Smith, U. Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance. Circulation 94, 878-881 (1996).
    • (1996) Circulation , vol.94 , pp. 878-881
    • Eliasson, B.1    Taskinen, M.R.2    Smith, U.3
  • 4
    • 0020093041 scopus 로고
    • Smoking and its effects on body weight and the systems of caloric regulation
    • Wack, J.T. & Rodin, J. Smoking and its effects on body weight and the systems of caloric regulation. Am. J. Clin. Nutr. 35, 366-380 (1982).
    • (1982) Am. J. Clin. Nutr. , vol.35 , pp. 366-380
    • Wack, J.T.1    Rodin, J.2
  • 5
    • 0028851975 scopus 로고
    • The infuence of smoking cessation on the prevalence of overweight in the United-States
    • Flegal, K.M., Troiano, R.P., Pamuk, E.R., Kuczmarski, R.J. & Campbell, S.M. The infuence of smoking cessation on the prevalence of overweight in the United-States. N. Engl. J. Med. 333, 1165-1170 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1165-1170
    • Flegal, K.M.1    Troiano, R.P.2    Pamuk, E.R.3    Kuczmarski, R.J.4    Campbell, S.M.5
  • 6
    • 0026034372 scopus 로고
    • Smoking cessation and severity of weight-gain in a national cohort
    • Williamson, D.F. et al. Smoking cessation and severity of weight-gain in a national cohort. N. Engl. J. Med. 324, 739-745 (1991).
    • (1991) N. Engl. J. Med. , vol.324 , pp. 739-745
    • Williamson, D.F.1
  • 7
    • 84885418407 scopus 로고    scopus 로고
    • The prevalence, predictors and associated health outcomes of high nicotine dependence using three measures among US smokers
    • Schnoll, R.A., Goren, A., Annunziata, K. & Suaya, J.A. The prevalence, predictors and associated health outcomes of high nicotine dependence using three measures among US smokers. Addiction 108, 1989-2000 (2013).
    • (2013) Addiction , vol.108 , pp. 1989-2000
    • Schnoll, R.A.1    Goren, A.2    Annunziata, K.3    Suaya, J.A.4
  • 8
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson, G.L. & Lapadat, R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911-1912 (2002).
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 9
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter, V., Nagaev, I. & Smith, U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J. Biol. Chem. 278, 45777-45784 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 10
    • 23944475571 scopus 로고    scopus 로고
    • Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1
    • Hiratani, K. et al. Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1. Biochem. Biophys. Res. Commun. 335, 836-842 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.335 , pp. 836-842
    • Hiratani, K.1
  • 11
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi, J. et al. A central role for JNK in obesity and insulin resistance. Nature 420, 333-336 (2002).
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1
  • 14
    • 0031817225 scopus 로고    scopus 로고
    • Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells
    • Heusch, W.L. & Maneckjee, R. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis 19, 551-556 (1998).
    • (1998) Carcinogenesis , vol.19 , pp. 551-556
    • Heusch, W.L.1    Maneckjee, R.2
  • 15
    • 79952671534 scopus 로고    scopus 로고
    • Nicotine induces upregulated expression of beta defensin-2 via the p38MAPK pathway in the HaCaT human keratinocyte cell line
    • Nakamura, S. et al. Nicotine induces upregulated expression of beta defensin-2 via the p38MAPK pathway in the HaCaT human keratinocyte cell line. Med. Mol. Morphol. 43, 204-210 (2010).
    • (2010) Med. Mol. Morphol. , vol.43 , pp. 204-210
    • Nakamura, S.1
  • 16
    • 9144246960 scopus 로고    scopus 로고
    • Nicotine enhances angiotensin II-induced mitogenic response in vascular smooth muscle cells and fbroblasts
    • Li, J.M. et al. Nicotine enhances angiotensin II-induced mitogenic response in vascular smooth muscle cells and fbroblasts. Arterioscler. Thromb. Vasc. Biol. 24, 80-84 (2004).
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 80-84
    • Li, J.M.1
  • 17
    • 79959956336 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits NF-kappaB signaling and infammation: Impact on healthspan and lifespan
    • Salminen, A., Hyttinen, J.M. & Kaarniranta, K. AMP-activated protein kinase inhibits NF-kappaB signaling and infammation: impact on healthspan and lifespan. J. Mol. Med. 89, 667-676 (2011).
    • (2011) J. Mol. Med. , vol.89 , pp. 667-676
    • Salminen, A.1    Hyttinen, J.M.2    Kaarniranta, K.3
  • 18
    • 67650914230 scopus 로고    scopus 로고
    • AMPK in health and disease
    • Steinberg, G.R. & Kemp, B.E. AMPK in health and disease. Physiol. Rev. 89, 1025-1078 (2009).
    • (2009) Physiol. Rev. , vol.89 , pp. 1025-1078
    • Steinberg, G.R.1    Kemp, B.E.2
  • 19
    • 34848880141 scopus 로고    scopus 로고
    • Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes-A role for oxidant stress
    • An, Z.B. et al. Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes-a role for oxidant stress. J. Biol. Chem. 282, 26793-26801 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 26793-26801
    • An, Z.B.1
  • 20
    • 84862007631 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo
    • Wang, S. et al. Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat. Med. 18, 902-910 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 902-910
    • Wang, S.1
  • 21
    • 84859557325 scopus 로고    scopus 로고
    • Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
    • Martínez de Morentin, P.B. et al. Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes 61, 807-817 (2012).
    • (2012) Diabetes , vol.61 , pp. 807-817
    • Martínez De Morentin, P.B.1
  • 22
    • 0041967223 scopus 로고    scopus 로고
    • Cigarette smoking and cardiovascular disease: Pathophysiology and implications for treatment
    • Benowitz, N.L. Cigarette smoking and cardiovascular disease: pathophysiology and implications for treatment. Prog. Cardiovasc. Dis. 46, 91-111 (2003).
    • (2003) Prog. Cardiovasc. Dis. , vol.46 , pp. 91-111
    • Benowitz, N.L.1
  • 24
    • 84890120647 scopus 로고    scopus 로고
    • Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance
    • Jocken, J.W. et al. Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance. Diabetologia 56, 2255-2265 (2013).
    • (2013) Diabetologia , vol.56 , pp. 2255-2265
    • Jocken, J.W.1
  • 25
    • 79958702575 scopus 로고    scopus 로고
    • Nicotine decreases food intake through activation of POMC neurons
    • Mineur, Y.S. et al. Nicotine decreases food intake through activation of POMC neurons. Science 332, 1330-1332 (2011).
    • (2011) Science , vol.332 , pp. 1330-1332
    • Mineur, Y.S.1
  • 26
    • 84864657351 scopus 로고    scopus 로고
    • Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
    • Pal, D. et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med. 18, 1279-1285 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1279-1285
    • Pal, D.1
  • 27
    • 84873570184 scopus 로고    scopus 로고
    • Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
    • Liew, C.W. et al. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat. Med. 19, 217-226 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 217-226
    • Liew, C.W.1
  • 28
    • 73849144666 scopus 로고    scopus 로고
    • Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir
    • Guo, W. et al. Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir. Arterioscler. Thromb. Vasc. Biol. 29, 2028-2032 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , pp. 2028-2032
    • Guo, W.1
  • 29
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie, D.G., Ross, F.A. & Hawley, S.A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13, 251-262 (2012).
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 30
    • 84889887123 scopus 로고    scopus 로고
    • Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
    • Fullerton, M.D. et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat. Med. 19, 1649-1654 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1649-1654
    • Fullerton, M.D.1
  • 32
    • 0035039274 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise
    • Musi, N. et al. AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes 50, 921-927 (2001).
    • (2001) Diabetes , vol.50 , pp. 921-927
    • Musi, N.1
  • 33
    • 0024516569 scopus 로고
    • Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism
    • Garton, A.J. et al. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. Eur. J Biochemistry 179, 249-254 (1989).
    • (1989) Eur. J Biochemistry , vol.179 , pp. 249-254
    • Garton, A.J.1
  • 34
    • 21644455008 scopus 로고    scopus 로고
    • Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
    • Daval, M. et al. Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J. Biol. Chem. 280, 25250-25257 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 25250-25257
    • Daval, M.1
  • 35
    • 77949268951 scopus 로고    scopus 로고
    • Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase
    • Bourron, O. et al. Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase. Diabetologia 53, 768-778 (2010).
    • (2010) Diabetologia , vol.53 , pp. 768-778
    • Bourron, O.1
  • 36
    • 75049085233 scopus 로고    scopus 로고
    • PKA phosphorylates and inactivates AMPKalpha to promote effcient lipolysis
    • Djouder, N. et al. PKA phosphorylates and inactivates AMPKalpha to promote effcient lipolysis. EMBO J. 29, 469-481 (2010).
    • (2010) EMBO J. , vol.29 , pp. 469-481
    • Djouder, N.1
  • 37
    • 79958047295 scopus 로고    scopus 로고
    • Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
    • Ahmadian, M. et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab. 13, 739-748 (2011).
    • (2011) Cell Metab. , vol.13 , pp. 739-748
    • Ahmadian, M.1
  • 38
    • 84862567849 scopus 로고    scopus 로고
    • Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of infammatory cytokine gene expression and ROS production
    • Lin, L. et al. Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of infammatory cytokine gene expression and ROS production. Am. J. Physiol. Endocrinol. Metab. 302, E1550-E1559 (2012).
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.302 , pp. E1550-E1559
    • Lin, L.1
  • 39
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity
    • Um, S.H. et al. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature 431, 200-205 (2004).
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1
  • 40
    • 0038043252 scopus 로고    scopus 로고
    • Adipose-specifc expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2
    • Horike, N. et al. Adipose-specifc expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J. Biol. Chem. 278, 18440-18447 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 18440-18447
    • Horike, N.1
  • 41
    • 34250367531 scopus 로고    scopus 로고
    • JNK1 is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation
    • Sánchez-Tillo, E. et al. JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation. J. Biol. Chem. 282, 12566-12573 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 12566-12573
    • Sánchez-Tillo, E.1
  • 42
    • 0038832564 scopus 로고    scopus 로고
    • Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
    • Brondello, J.M., Pouyssegur, J. & McKenzie, F.R. Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286, 2514-2517 (1999).
    • (1999) Science , vol.286 , pp. 2514-2517
    • Brondello, J.M.1    Pouyssegur, J.2    McKenzie, F.R.3
  • 43
    • 33745353794 scopus 로고    scopus 로고
    • Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity
    • Wu, J.J. et al. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab. 4, 61-73 (2006).
    • (2006) Cell Metab. , vol.4 , pp. 61-73
    • Wu, J.J.1
  • 44
    • 84891929605 scopus 로고    scopus 로고
    • Nicotine elicits prolonged calcium signaling along ventral hippocampal axons
    • Zhong, C., Talmage, D.A. & Role, L.W. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. PLoS ONE 8, e82719 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e82719
    • Zhong, C.1    Talmage, D.A.2    Role, L.W.3
  • 45
    • 8344237497 scopus 로고    scopus 로고
    • Neuroscience. What genes tell us about nicotine addiction
    • Hogg, R.C. & Bertrand, D. Neuroscience. What genes tell us about nicotine addiction. Science 306, 983-985 (2004).
    • (2004) Science , vol.306 , pp. 983-985
    • Hogg, R.C.1    Bertrand, D.2
  • 46
    • 84870155127 scopus 로고    scopus 로고
    • Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice
    • Friedman, T.C. et al. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology 153, 5809-5820 (2012).
    • (2012) Endocrinology , vol.153 , pp. 5809-5820
    • Friedman, T.C.1
  • 47
    • 84899442593 scopus 로고    scopus 로고
    • Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats
    • Seoane-Collazo, P. et al. Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats. Endocrinology 155, 1679-1689 (2014).
    • (2014) Endocrinology , vol.155 , pp. 1679-1689
    • Seoane-Collazo, P.1
  • 48
    • 84871253591 scopus 로고    scopus 로고
    • Chronic exposure to nicotine enhances insulin sensitivity through alpha 7 nicotinic acetylcholine receptor-STAT3 pathway
    • Xu, T.Y. et al. Chronic exposure to nicotine enhances insulin sensitivity through alpha 7 nicotinic acetylcholine receptor-STAT3 pathway. PLoS ONE 7, e51217 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e51217
    • Xu, T.Y.1
  • 49
    • 33750578279 scopus 로고    scopus 로고
    • Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha
    • Yoon, M.J. et al. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 55, 2562-2570 (2006).
    • (2006) Diabetes , vol.55 , pp. 2562-2570
    • Yoon, M.J.1
  • 50
    • 33644863486 scopus 로고    scopus 로고
    • Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling
    • Lin, Y.W. & Yang, J.L. Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. J. Biol. Chem. 281, 915-926 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 915-926
    • Lin, Y.W.1    Yang, J.L.2
  • 51
    • 77957832253 scopus 로고    scopus 로고
    • Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway
    • Choi, S.M. et al. Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Mol. Cell. Biol. 30, 5009-5020 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 5009-5020
    • Choi, S.M.1
  • 52
    • 4344714725 scopus 로고    scopus 로고
    • Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit
    • Villena, J.A. et al. Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit. Diabetes 53, 2242-2249 (2004).
    • (2004) Diabetes , vol.53 , pp. 2242-2249
    • Villena, J.A.1
  • 53
    • 0029945325 scopus 로고    scopus 로고
    • Stimulation of adipose tissue lipolysis following insulin-induced hypoglycaemia: Evidence of increased beta-adrenoceptor-mediated lipolytic response in IDDM
    • Bolinder, J., Sjoberg, S. & Arner, P. Stimulation of adipose tissue lipolysis following insulin-induced hypoglycaemia: evidence of increased beta-adrenoceptor-mediated lipolytic response in IDDM. Diabetologia 39, 845-853 (1996).
    • (1996) Diabetologia , vol.39 , pp. 845-853
    • Bolinder, J.1    Sjoberg, S.2    Arner, P.3
  • 54
    • 0024335705 scopus 로고
    • A randomized crossover study of sulphonylurea and insulin treatment in patients with type 2 diabetes poorly controlled on dietary therapy
    • Wolffenbuttel, B.H., Weber, R.F., van Koetsveld, P.M., Weeks, L. & Verschoor, L. A randomized crossover study of sulphonylurea and insulin treatment in patients with type 2 diabetes poorly controlled on dietary therapy. Diabet. Med. 6, 520-525 (1989).
    • (1989) Diabet. Med. , vol.6 , pp. 520-525
    • Wolffenbuttel, B.H.1    Weber, R.F.2    Van Koetsveld, P.M.3    Weeks, L.4    Verschoor, L.5
  • 55
    • 0023625723 scopus 로고
    • Constant-rate infusion of nicotine and cotinine. I. A physiological pharmacokinetic analysis of the cotinine disposition, and effects on clearance and distribution in the rat
    • Gabrielsson, J. & Bondesson, U. Constant-rate infusion of nicotine and cotinine. I. A physiological pharmacokinetic analysis of the cotinine disposition, and effects on clearance and distribution in the rat. J. Pharmacokinet. Biopharm. 15, 583-599 (1987).
    • (1987) J. Pharmacokinet. Biopharm. , vol.15 , pp. 583-599
    • Gabrielsson, J.1    Bondesson, U.2
  • 56
    • 84888197890 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase-alpha2 defciency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation
    • Song, P. et al. Adenosine monophosphate-activated protein kinase-alpha2 defciency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation. Arterioscler. Thromb. Vasc. Biol. 33, 2800-2809 (2013).
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , pp. 2800-2809
    • Song, P.1
  • 57
    • 0029757347 scopus 로고    scopus 로고
    • Disruption of the erp/mkp-1 gene does not affect mouse development: Normal MAP kinase activity in ERP/MKP-1-defcient fbroblasts
    • Dorfman, K. et al. Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-defcient fbroblasts. Oncogene 13, 925-931 (1996).
    • (1996) Oncogene , vol.13 , pp. 925-931
    • Dorfman, K.1
  • 58
    • 84859452677 scopus 로고    scopus 로고
    • Yin Yang 1 defciency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling
    • Blättler, S.M. et al. Yin Yang 1 defciency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metab. 15, 505-517 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 505-517
    • Blättler, S.M.1
  • 59
    • 84878871217 scopus 로고    scopus 로고
    • Distinct patterns of tissue-specifc lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
    • Turner, N. et al. Distinct patterns of tissue-specifc lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia 56, 1638-1648 (2013).
    • (2013) Diabetologia , vol.56 , pp. 1638-1648
    • Turner, N.1
  • 60
    • 81055144760 scopus 로고    scopus 로고
    • Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity
    • Li, P. et al. Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 147, 815-826 (2011).
    • (2011) Cell , vol.147 , pp. 815-826
    • Li, P.1
  • 61
    • 84883692803 scopus 로고    scopus 로고
    • Liver kinase b1 is required for white adipose tissue growth and differentiation
    • Zhang, W., Wang, Q., Song, P. & Zou, M.H. Liver kinase b1 is required for white adipose tissue growth and differentiation. Diabetes 62, 2347-2358 (2013).
    • (2013) Diabetes , vol.62 , pp. 2347-2358
    • Zhang, W.1    Wang, Q.2    Song, P.3    Zou, M.H.4
  • 62
    • 0030698379 scopus 로고    scopus 로고
    • Cigarette smoking and insulin resistance in patients with noninsulin-dependent diabetes mellitus
    • Targher, G. et al. Cigarette smoking and insulin resistance in patients with noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 82, 3619-3624 (1997).
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 3619-3624
    • Targher, G.1
  • 63
    • 0034693232 scopus 로고    scopus 로고
    • Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    • Coburn, C.T. et al. Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J. Biol. Chem. 275, 32523-32529 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 32523-32529
    • Coburn, C.T.1
  • 64
    • 0035824678 scopus 로고    scopus 로고
    • Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective defciency of brown adipose tissue, obesity, and insulin resistance
    • Siri, P. et al. Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective defciency of brown adipose tissue, obesity, and insulin resistance. J. Biol. Chem. 276, 46064-46072 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 46064-46072
    • Siri, P.1
  • 65
    • 84863281299 scopus 로고    scopus 로고
    • Inhibition of AMP-activated protein kinase alpha (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fbroblasts and cardiomyocytes: Role of p53 and SIRT1
    • Wang, S., Song, P. & Zou, M.H. Inhibition of AMP-activated protein kinase alpha (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fbroblasts and cardiomyocytes: role of p53 and SIRT1. J. Biol. Chem. 287, 8001-8012 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 8001-8012
    • Wang, S.1    Song, P.2    Zou, M.H.3
  • 66
    • 67650083087 scopus 로고    scopus 로고
    • Identifcation of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis
    • Xie, Z.L. et al. Identifcation of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. Mol. Cell. Biol. 29, 3582-3596 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3582-3596
    • Xie, Z.L.1


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