Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production

American Journal of Physiology - Endocrinology and Metabolism

Volumn 302, Issue 12, 2012, Pages

  Lin, Ligen ^a   Pang, Weijun ^a,c   Chen, Keyun ^a   Wang, Fei ^a   Gengler, Jon ^a,b   Sun, Yuxiang ^a   Tong, Qiang ^a,b  

^a CHILDREN S NUTRITION RESEARCH CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c NORTHWEST A F UNIVERSITY   (China)

Author keywords

c Jun NH 2 terminal kinase; Interleukin 1 ; Lipolysis; Nicotinamide adenine dinucleotide phosphate oxidase; Reactive oxygen species; Tumor necrosis factor

Indexed keywords

HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR PU 1; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL FUNCTION; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPOLYSIS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SUBCUTANEOUS FAT; UPREGULATION; WHITE ADIPOSE TISSUE;

3T3 CELLS; ADIPOCYTES; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CYTOKINES; DEOXYGLUCOSE; GENE SILENCING; INSULIN; INSULIN RESISTANCE; INTERFERON REGULATORY FACTORS; LIPOLYSIS; MICE; MICE, INBRED C57BL; NADPH OXIDASE; OBESITY; PLASMIDS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84862567849     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00462.2011     Document Type: Article

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