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Volumn 7, Issue 12, 2012, Pages

Chronic Exposure to Nicotine Enhances Insulin Sensitivity through α7 Nicotinic Acetylcholine Receptor-STAT3 Pathway

Author keywords

[No Author keywords available]

Indexed keywords

4 [[(4 METHYLPHENYL)SULFONYLOXY]ACETAMIDO]SALICYLIC ACID; 4 CHLORO N (3 QUINUCLIDINYL)BENZAMIDE; BUNGAROTOXIN RECEPTOR; GLUCOSE; HEXAMETHONIUM; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA2; INSULIN; NICOTINE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 84871253591     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051217     Document Type: Article
Times cited : (45)

References (58)
  • 1
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, et al. (2007) Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab 5: 167-179.
    • (2007) Cell Metab , vol.5 , pp. 167-179
    • Holland, W.L.1    Brozinick, J.T.2    Wang, L.P.3    Hawkins, E.D.4    Sargent, K.M.5
  • 2
    • 77955657267 scopus 로고    scopus 로고
    • Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
    • DeFronzo RA, (2010) Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009. Diabetologia 53: 1270-1287.
    • (2010) Diabetologia , vol.53 , pp. 1270-1287
    • DeFronzo, R.A.1
  • 3
    • 77953539812 scopus 로고    scopus 로고
    • Long-term metformin use is associated with decreased risk of breast cancer
    • Bodmer M, Meier C, Krahenbuhl S, Jick SS, Meier CR, (2010) Long-term metformin use is associated with decreased risk of breast cancer. Diabetes Care 33: 1304-1308.
    • (2010) Diabetes Care , vol.33 , pp. 1304-1308
    • Bodmer, M.1    Meier, C.2    Krahenbuhl, S.3    Jick, S.S.4    Meier, C.R.5
  • 5
    • 75149140978 scopus 로고    scopus 로고
    • Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis
    • Jiang M, Jerome WG, Hayward SW, (2010) Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis. Autophagy 6: 175-176.
    • (2010) Autophagy , vol.6 , pp. 175-176
    • Jiang, M.1    Jerome, W.G.2    Hayward, S.W.3
  • 6
    • 34250178250 scopus 로고    scopus 로고
    • Rosiglitazone and cardiovascular risk
    • Psaty BM, Furberg CD, (2007) Rosiglitazone and cardiovascular risk. N Engl J Med 356: 2522-2524.
    • (2007) N Engl J Med , vol.356 , pp. 2522-2524
    • Psaty, B.M.1    Furberg, C.D.2
  • 7
    • 77955907527 scopus 로고    scopus 로고
    • Clinical consequences of disseminating the rosiglitazone FDA safety warning
    • Orrico KB, Lin JK, Wei A, Yue H, (2010) Clinical consequences of disseminating the rosiglitazone FDA safety warning. Am J Manag Care 16: e111-116.
    • (2010) Am J Manag Care , vol.16
    • Orrico, K.B.1    Lin, J.K.2    Wei, A.3    Yue, H.4
  • 8
    • 77954988618 scopus 로고    scopus 로고
    • Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone
    • Graham DJ, Ouellet-Hellstrom R, MaCurdy TE, Ali F, Sholley C, et al. (2010) Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. Jama 304: 411-418.
    • (2010) Jama , vol.304 , pp. 411-418
    • Graham, D.J.1    Ouellet-Hellstrom, R.2    MaCurdy, T.E.3    Ali, F.4    Sholley, C.5
  • 9
    • 37149034177 scopus 로고    scopus 로고
    • Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis
    • Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J, (2007) Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. Jama 298: 2654-2664.
    • (2007) Jama , vol.298 , pp. 2654-2664
    • Willi, C.1    Bodenmann, P.2    Ghali, W.A.3    Faris, P.D.4    Cornuz, J.5
  • 10
    • 0034847114 scopus 로고    scopus 로고
    • Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjects
    • Axelsson T, Jansson PA, Smith U, Eliasson B, (2001) Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjects. J Intern Med 249: 539-544.
    • (2001) J Intern Med , vol.249 , pp. 539-544
    • Axelsson, T.1    Jansson, P.A.2    Smith, U.3    Eliasson, B.4
  • 11
    • 2342578804 scopus 로고    scopus 로고
    • Acute effects of nicotine on serum glucose insulin growth hormone and cortisol in healthy smokers
    • Morgan TM, Crawford L, Stoller A, Toth D, Yeo KT, et al. (2004) Acute effects of nicotine on serum glucose insulin growth hormone and cortisol in healthy smokers. Metabolism 53: 578-582.
    • (2004) Metabolism , vol.53 , pp. 578-582
    • Morgan, T.M.1    Crawford, L.2    Stoller, A.3    Toth, D.4    Yeo, K.T.5
  • 12
    • 0029787156 scopus 로고    scopus 로고
    • Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance
    • Eliasson B, Taskinen MR, Smith U, (1996) Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance. Circulation 94: 878-881.
    • (1996) Circulation , vol.94 , pp. 878-881
    • Eliasson, B.1    Taskinen, M.R.2    Smith, U.3
  • 13
    • 0032912931 scopus 로고    scopus 로고
    • Weight gain and insulin resistance during nicotine replacement therapy
    • Assali AR, Beigel Y, Schreibman R, Shafer Z, Fainaru M, (1999) Weight gain and insulin resistance during nicotine replacement therapy. Clin Cardiol 22: 357-360.
    • (1999) Clin Cardiol , vol.22 , pp. 357-360
    • Assali, A.R.1    Beigel, Y.2    Schreibman, R.3    Shafer, Z.4    Fainaru, M.5
  • 14
    • 0037223501 scopus 로고    scopus 로고
    • Long-term oral nicotine administration reduces insulin resistance in obese rats
    • Liu RH, Mizuta M, Matsukura S, (2003) Long-term oral nicotine administration reduces insulin resistance in obese rats. Eur J Pharmacol 458: 227-234.
    • (2003) Eur J Pharmacol , vol.458 , pp. 227-234
    • Liu, R.H.1    Mizuta, M.2    Matsukura, S.3
  • 15
    • 3042548823 scopus 로고    scopus 로고
    • The expression and functional role of nicotinic acetylcholine receptors in rat adipocytes
    • Liu RH, Mizuta M, Matsukura S, (2004) The expression and functional role of nicotinic acetylcholine receptors in rat adipocytes. J Pharmacol Exp Ther 310: 52-58.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 52-58
    • Liu, R.H.1    Mizuta, M.2    Matsukura, S.3
  • 16
    • 39849101345 scopus 로고    scopus 로고
    • Establishment and evaluation of a nicotine-treatment and- withdrawal rat model
    • Lan XH, Xu TY, Miao CY, (2008) Establishment and evaluation of a nicotine-treatment and- withdrawal rat model. AJSMMU 29: 156-161.
    • (2008) AJSMMU , vol.29 , pp. 156-161
    • Lan, X.H.1    Xu, T.Y.2    Miao, C.Y.3
  • 17
    • 67650398292 scopus 로고    scopus 로고
    • Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor
    • Liu C, Shen FM, Le YY, Kong Y, Liu X, et al. (2009) Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med 37: 634-641.
    • (2009) Crit Care Med , vol.37 , pp. 634-641
    • Liu, C.1    Shen, F.M.2    Le, Y.Y.3    Kong, Y.4    Liu, X.5
  • 18
    • 79952537492 scopus 로고    scopus 로고
    • Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway
    • Wang P, Xu TY, Guan YF, Tian WW, Viollet B, et al. (2011) Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol 69: 360-374.
    • (2011) Ann Neurol , vol.69 , pp. 360-374
    • Wang, P.1    Xu, T.Y.2    Guan, Y.F.3    Tian, W.W.4    Viollet, B.5
  • 19
    • 84860561281 scopus 로고    scopus 로고
    • Loss of AMP-activated protein kinase-alpha2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle
    • Wang P, Zhang RY, Song J, Guan YF, Xu TY, et al. (2012) Loss of AMP-activated protein kinase-alpha2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle. Diabetes 61: 1051-1061.
    • (2012) Diabetes , vol.61 , pp. 1051-1061
    • Wang, P.1    Zhang, R.Y.2    Song, J.3    Guan, Y.F.4    Xu, T.Y.5
  • 20
    • 79551498431 scopus 로고    scopus 로고
    • Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension
    • Li DJ, Evans RG, Yang ZW, Song SW, Wang P, et al. (2011) Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension. Hypertension 57: 298-307.
    • (2011) Hypertension , vol.57 , pp. 298-307
    • Li, D.J.1    Evans, R.G.2    Yang, Z.W.3    Song, S.W.4    Wang, P.5
  • 21
    • 40649099564 scopus 로고    scopus 로고
    • Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist
    • Waring JF, Abel S, Li J, Bitner RS, Nikkel AL, et al. (2008) Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist. Neurosci Res 60: 266-274.
    • (2008) Neurosci Res , vol.60 , pp. 266-274
    • Waring, J.F.1    Abel, S.2    Li, J.3    Bitner, R.S.4    Nikkel, A.L.5
  • 22
    • 70349886560 scopus 로고    scopus 로고
    • Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity
    • Beck Jorgensen S, O'Neill HM, Hewitt K, Kemp BE, Steinberg GR, (2009) Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity. Diabetologia 52: 2395-2404.
    • (2009) Diabetologia , vol.52 , pp. 2395-2404
    • Beck Jorgensen, S.1    O'Neill, H.M.2    Hewitt, K.3    Kemp, B.E.4    Steinberg, G.R.5
  • 23
    • 77953203933 scopus 로고    scopus 로고
    • The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice
    • Sassmann A, Gier B, Grone HJ, Drews G, Offermanns S, et al. (2010) The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. J Clin Invest 120: 2184-2193.
    • (2010) J Clin Invest , vol.120 , pp. 2184-2193
    • Sassmann, A.1    Gier, B.2    Grone, H.J.3    Drews, G.4    Offermanns, S.5
  • 24
    • 12144258579 scopus 로고    scopus 로고
    • Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats
    • Strader AD, Vahl TP, Jandacek RJ, Woods SC, D'Alessio DA, et al. (2005) Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab 288: E447-453.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Strader, A.D.1    Vahl, T.P.2    Jandacek, R.J.3    Woods, S.C.4    D'Alessio, D.A.5
  • 25
    • 0142125315 scopus 로고    scopus 로고
    • Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in Rattus norvegicus
    • Gasparetti AL, de Souza CT, Pereira-da-Silva M, Oliveira RL, Saad MJ, et al. (2003) Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in Rattus norvegicus. J Physiol 552: 149-162.
    • (2003) J Physiol , vol.552 , pp. 149-162
    • Gasparetti, A.L.1    de Souza, C.T.2    Pereira-da-Silva, M.3    Oliveira, R.L.4    Saad, M.J.5
  • 27
    • 74549142287 scopus 로고    scopus 로고
    • The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
    • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, et al. (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140: 280-293.
    • (2010) Cell , vol.140 , pp. 280-293
    • Zhong, L.1    D'Urso, A.2    Toiber, D.3    Sebastian, C.4    Henry, R.E.5
  • 28
    • 75149126171 scopus 로고    scopus 로고
    • Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling
    • Yan J, Yang H, Wang G, Sun L, Zhou Y, et al. (2010) Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling. Autophagy 6: 67-73.
    • (2010) Autophagy , vol.6 , pp. 67-73
    • Yan, J.1    Yang, H.2    Wang, G.3    Sun, L.4    Zhou, Y.5
  • 29
    • 84863012215 scopus 로고    scopus 로고
    • Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia
    • Wang P, Guan YF, Du H, Zhai QW, Su DF, et al. (2012) Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy 8: 77-87.
    • (2012) Autophagy , vol.8 , pp. 77-87
    • Wang, P.1    Guan, Y.F.2    Du, H.3    Zhai, Q.W.4    Su, D.F.5
  • 30
    • 33847644592 scopus 로고    scopus 로고
    • A novel platform for accelerated pharmacodynamic profiling for lead optimization of anticancer drug candidates
    • Szwaya J, Bruseo C, Nakuci E, McSweeney D, Xiang X, et al. (2007) A novel platform for accelerated pharmacodynamic profiling for lead optimization of anticancer drug candidates. J Biomol Screen 12: 159-166.
    • (2007) J Biomol Screen , vol.12 , pp. 159-166
    • Szwaya, J.1    Bruseo, C.2    Nakuci, E.3    McSweeney, D.4    Xiang, X.5
  • 31
    • 77949902607 scopus 로고    scopus 로고
    • 4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes
    • Xu TY, Chen RH, Wang P, Zhang RY, Ke SF, et al. (2010) 4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes. Clin Exp Pharmacol Physiol 37: 441-446.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 441-446
    • Xu, T.Y.1    Chen, R.H.2    Wang, P.3    Zhang, R.Y.4    Ke, S.F.5
  • 32
    • 77955982990 scopus 로고    scopus 로고
    • Circulating and local visfatin/Nampt/PBEF levels in spontaneously hypertensive rats, stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats
    • Wang P, Du H, Zhang RY, Guan YF, Xu TY, et al. (2010) Circulating and local visfatin/Nampt/PBEF levels in spontaneously hypertensive rats, stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. J Physiol Sci 60: 317-324.
    • (2010) J Physiol Sci , vol.60 , pp. 317-324
    • Wang, P.1    Du, H.2    Zhang, R.Y.3    Guan, Y.F.4    Xu, T.Y.5
  • 33
    • 57049134614 scopus 로고    scopus 로고
    • Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats
    • Cacho J, Sevillano J, de Castro J, Herrera E, Ramos MP, (2008) Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats. Am J Physiol Endocrinol Metab 295: E1269-1276.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Cacho, J.1    Sevillano, J.2    de Castro, J.3    Herrera, E.4    Ramos, M.P.5
  • 34
    • 33846470636 scopus 로고    scopus 로고
    • Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells
    • Wada T, Naito M, Kenmochi H, Tsuneki H, Sasaoka T, (2007) Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells. Endocrinology 148: 790-799.
    • (2007) Endocrinology , vol.148 , pp. 790-799
    • Wada, T.1    Naito, M.2    Kenmochi, H.3    Tsuneki, H.4    Sasaoka, T.5
  • 35
    • 0026450951 scopus 로고
    • Pharmacological properties of the homomeric alpha 7 receptor
    • Bertrand D, Bertrand S, Ballivet M, (1992) Pharmacological properties of the homomeric alpha 7 receptor. Neurosci Lett 146: 87-90.
    • (1992) Neurosci Lett , vol.146 , pp. 87-90
    • Bertrand, D.1    Bertrand, S.2    Ballivet, M.3
  • 36
    • 52949136021 scopus 로고
    • The physiological disposition of hexamethonium and related compounds
    • Levine RR, (1960) The physiological disposition of hexamethonium and related compounds. J Pharmacol Exp Ther 129: 296-304.
    • (1960) J Pharmacol Exp Ther , vol.129 , pp. 296-304
    • Levine, R.R.1
  • 38
    • 51249095379 scopus 로고    scopus 로고
    • Can patients with type 2 diabetes be treated with 5′-AMP-activated protein kinase activators?
    • Winder WW, (2008) Can patients with type 2 diabetes be treated with 5′-AMP-activated protein kinase activators? Diabetologia 51: 1761-1764.
    • (2008) Diabetologia , vol.51 , pp. 1761-1764
    • Winder, W.W.1
  • 39
    • 48449095742 scopus 로고    scopus 로고
    • STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3 beta
    • Moh A, Zhang W, Yu S, Wang J, Xu X, et al. (2008) STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3 beta. Diabetes 57: 1227-1235.
    • (2008) Diabetes , vol.57 , pp. 1227-1235
    • Moh, A.1    Zhang, W.2    Yu, S.3    Wang, J.4    Xu, X.5
  • 40
    • 45749158925 scopus 로고    scopus 로고
    • Central insulin action regulates peripheral glucose and fat metabolism in mice
    • Koch L, Wunderlich FT, Seibler J, Konner AC, Hampel B, et al. (2008) Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest 118: 2132-2147.
    • (2008) J Clin Invest , vol.118 , pp. 2132-2147
    • Koch, L.1    Wunderlich, F.T.2    Seibler, J.3    Konner, A.C.4    Hampel, B.5
  • 42
    • 0037251455 scopus 로고    scopus 로고
    • The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
    • Viollet B, Andreelli F, Jorgensen SB, Perrin C, Geloen A, et al. (2003) The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest 111: 91-98.
    • (2003) J Clin Invest , vol.111 , pp. 91-98
    • Viollet, B.1    Andreelli, F.2    Jorgensen, S.B.3    Perrin, C.4    Geloen, A.5
  • 43
    • 0037326307 scopus 로고    scopus 로고
    • Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models
    • Viollet B, Andreelli F, Jorgensen SB, Perrin C, Flamez D, et al. (2003) Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem Soc Trans 31: 216-219.
    • (2003) Biochem Soc Trans , vol.31 , pp. 216-219
    • Viollet, B.1    Andreelli, F.2    Jorgensen, S.B.3    Perrin, C.4    Flamez, D.5
  • 44
    • 79951875569 scopus 로고    scopus 로고
    • Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance
    • Wang X, Yang Z, Xue B, Shi H, (2011) Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance. Endocrinology 152: 836-846.
    • (2011) Endocrinology , vol.152 , pp. 836-846
    • Wang, X.1    Yang, Z.2    Xue, B.3    Shi, H.4
  • 45
    • 0037271732 scopus 로고    scopus 로고
    • Smokeless nicotine administration does not result in hypertension or a deterioration in glucose tolerance or insulin sensitivity in juvenile rats
    • Swislocki AL, (2003) Smokeless nicotine administration does not result in hypertension or a deterioration in glucose tolerance or insulin sensitivity in juvenile rats. Metabolism 52: 67-72.
    • (2003) Metabolism , vol.52 , pp. 67-72
    • Swislocki, A.L.1
  • 46
    • 0030866203 scopus 로고    scopus 로고
    • Smokeless nicotine administration is associated with hypertension but not with a deterioration in glucose tolerance in rats
    • Swislocki AL, Tsuzuki A, Tait M, Khuu D, Fann K, (1997) Smokeless nicotine administration is associated with hypertension but not with a deterioration in glucose tolerance in rats. Metabolism 46: 1008-1012.
    • (1997) Metabolism , vol.46 , pp. 1008-1012
    • Swislocki, A.L.1    Tsuzuki, A.2    Tait, M.3    Khuu, D.4    Fann, K.5
  • 47
    • 0028232207 scopus 로고
    • Establishing a nicotine threshold for addiction. The implications for tobacco regulation
    • Benowitz NL, Henningfield JE, (1994) Establishing a nicotine threshold for addiction. The implications for tobacco regulation. N Engl J Med 331: 123-125.
    • (1994) N Engl J Med , vol.331 , pp. 123-125
    • Benowitz, N.L.1    Henningfield, J.E.2
  • 48
    • 33747125503 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells
    • Gahring LC, Rogers SW, (2006) Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells. Aaps J 7: E885-894.
    • (2006) Aaps J , vol.7
    • Gahring, L.C.1    Rogers, S.W.2
  • 49
    • 79958702575 scopus 로고    scopus 로고
    • Nicotine decreases food intake through activation of POMC neurons
    • Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, et al. (2011) Nicotine decreases food intake through activation of POMC neurons. Science 332: 1330-1332.
    • (2011) Science , vol.332 , pp. 1330-1332
    • Mineur, Y.S.1    Abizaid, A.2    Rao, Y.3    Salas, R.4    DiLeone, R.J.5
  • 50
    • 79957945033 scopus 로고    scopus 로고
    • Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction
    • Wang P, Yang FJ, Du H, Guan YF, Xu TY, et al. (2011) Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction. Mol Med 17: 523-532.
    • (2011) Mol Med , vol.17 , pp. 523-532
    • Wang, P.1    Yang, F.J.2    Du, H.3    Guan, Y.F.4    Xu, T.Y.5
  • 53
    • 73949111377 scopus 로고    scopus 로고
    • An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes
    • Marrero MB, Lucas R, Salet C, Hauser TA, Mazurov A, et al. (2010) An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes. J Pharmacol Exp Ther 332: 173-180.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 173-180
    • Marrero, M.B.1    Lucas, R.2    Salet, C.3    Hauser, T.A.4    Mazurov, A.5
  • 54
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR, (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7: 85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 55
    • 67649579590 scopus 로고    scopus 로고
    • Cholinergic modulation of inflammation
    • Pavlov VA, (2008) Cholinergic modulation of inflammation. Int J Clin Exp Med 1: 203-212.
    • (2008) Int J Clin Exp Med , vol.1 , pp. 203-212
    • Pavlov, V.A.1
  • 56
    • 80053198167 scopus 로고    scopus 로고
    • From hypertension to stroke: mechanisms and potential prevention strategies
    • Yu JG, Zhou RR, Cai GJ, (2011) From hypertension to stroke: mechanisms and potential prevention strategies. CNS Neurosci Ther 17: 577-584.
    • (2011) CNS Neurosci Ther , vol.17 , pp. 577-584
    • Yu, J.G.1    Zhou, R.R.2    Cai, G.J.3
  • 57
    • 84863534359 scopus 로고    scopus 로고
    • Cotinine: a potential new therapeutic agent against Alzheimer's disease
    • Echeverria V, Zeitlin R, (2012) Cotinine: a potential new therapeutic agent against Alzheimer's disease. CNS Neurosci Ther 18: 517-523.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 517-523
    • Echeverria, V.1    Zeitlin, R.2
  • 58
    • 80053198889 scopus 로고    scopus 로고
    • Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats
    • Wang P, Tian WW, Song J, Guan YF, Miao CY, (2011) Deficiency of NG2+ cells contributes to the susceptibility of stroke-prone spontaneously hypertensive rats. CNS Neurosci Ther 17: 327-332.
    • (2011) CNS Neurosci Ther , vol.17 , pp. 327-332
    • Wang, P.1    Tian, W.W.2    Song, J.3    Guan, Y.F.4    Miao, C.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.