-
1
-
-
84897954412
-
Autophagy paradox and ceramide
-
1:CAS:528:DC%2BC3sXhsFGqs7fN 24055889
-
Jiang W, Ogretmen B (2014) Autophagy paradox and ceramide. Biochim Biophys Acta 1841(5):783-792
-
(2014)
Biochim Biophys Acta
, vol.1841
, Issue.5
, pp. 783-792
-
-
Jiang, W.1
Ogretmen, B.2
-
2
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
1:CAS:528:DyaK28XjvVKnsro%3D 8657285
-
Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S (1996) Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381(6585):800-803
-
(1996)
Nature
, vol.381
, Issue.6585
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
Vanek, P.G.4
Coso, O.A.5
Gutkind, S.6
Spiegel, S.7
-
3
-
-
56249108080
-
Ceramide starves cells to death by down-regulating nutrient transporter proteins
-
2582319 1:CAS:528:DC%2BD1cXhsVWns7rP
-
Guenther GG, Peralta ER, Rosales KR, Wong SY, Siskind LJ, Edinger AL (2008) Ceramide starves cells to death by down-regulating nutrient transporter proteins. Proc Natl Acad Sci USA 105(45):17402-17407
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.45
, pp. 17402-17407
-
-
Guenther, G.G.1
Peralta, E.R.2
Rosales, K.R.3
Wong, S.Y.4
Siskind, L.J.5
Edinger, A.L.6
-
4
-
-
84868628424
-
Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes
-
3484448 1:CAS:528:DC%2BC38Xhs1Cis7fE 23023704
-
Russo SB, Baicu CF, Van Laer A, Geng T, Kasiganesan H, Zile MR, Cowart LA (2012) Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes. J Clin Invest 122(11):3919-3930
-
(2012)
J Clin Invest
, vol.122
, Issue.11
, pp. 3919-3930
-
-
Russo, S.B.1
Baicu, C.F.2
Van Laer, A.3
Geng, T.4
Kasiganesan, H.5
Zile, M.R.6
Cowart, L.A.7
-
5
-
-
10744225487
-
A unified nomenclature for yeast autophagy-related genes
-
1:CAS:528:DC%2BD3sXotlSqu7o%3D
-
Klionsky DJ, Cregg JM, Dunn WA Jr, Emr SD, Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M, Ohsumi Y (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-545
-
(2003)
Dev Cell
, vol.5
, Issue.4
, pp. 539-545
-
-
Klionsky, D.J.1
Cregg, J.M.2
Dunn, W.A.3
Emr, S.D.4
Sakai, Y.5
Sandoval, I.V.6
Sibirny, A.7
Subramani, S.8
Thumm, M.9
Veenhuis, M.10
Ohsumi, Y.11
-
6
-
-
0027936092
-
Isolation of autophagocytosis mutants of Saccharomyces cerevisiae
-
1:CAS:528:DyaK2cXmtVSks78%3D 8050581
-
Thumm M, Egner R, Koch B, Schlumpberger M, Straub M, Veenhuis M, Wolf DH (1994) Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett 349(2):275-280
-
(1994)
FEBS Lett
, vol.349
, Issue.2
, pp. 275-280
-
-
Thumm, M.1
Egner, R.2
Koch, B.3
Schlumpberger, M.4
Straub, M.5
Veenhuis, M.6
Wolf, D.H.7
-
7
-
-
50249103834
-
The cell biology of autophagy in metazoans: A developing story
-
2702844 1:CAS:528:DC%2BD1cXhtVehs7jI 18567846
-
Melendez A, Neufeld TP (2008) The cell biology of autophagy in metazoans: a developing story. Development 135(14):2347-2360
-
(2008)
Development
, vol.135
, Issue.14
, pp. 2347-2360
-
-
Melendez, A.1
Neufeld, T.P.2
-
8
-
-
53549113031
-
The role of TOR in autophagy regulation from yeast to plants and mammals
-
1:CAS:528:DC%2BD1cXht12rurvO 18670193
-
Diaz-Troya S, Perez-Perez ME, Florencio FJ, Crespo JL (2008) The role of TOR in autophagy regulation from yeast to plants and mammals. Autophagy 4(7):851-865
-
(2008)
Autophagy
, vol.4
, Issue.7
, pp. 851-865
-
-
Diaz-Troya, S.1
Perez-Perez, M.E.2
Florencio, F.J.3
Crespo, J.L.4
-
9
-
-
53849119118
-
Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism
-
1:CAS:528:DC%2BD1cXht1aisrfE 18651095
-
Liao XH, Majithia A, Huang X, Kimmel AR (2008) Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism. Amino Acids 35(4):761-770
-
(2008)
Amino Acids
, vol.35
, Issue.4
, pp. 761-770
-
-
Liao, X.H.1
Majithia, A.2
Huang, X.3
Kimmel, A.R.4
-
10
-
-
84880331368
-
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
-
1:CAS:528:DC%2BC3sXnvVSitb0%3D 23685627
-
Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL (2013) ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 15(7):741-750
-
(2013)
Nat Cell Biol
, vol.15
, Issue.7
, pp. 741-750
-
-
Russell, R.C.1
Tian, Y.2
Yuan, H.3
Park, H.W.4
Chang, Y.Y.5
Kim, J.6
Kim, H.7
Neufeld, T.P.8
Dillin, A.9
Guan, K.L.10
-
11
-
-
84856275868
-
PtdIns 3-kinase orchestrates autophagosome formation in yeast
-
3067060 21490802
-
Obara K, Ohsumi Y (2011) PtdIns 3-kinase orchestrates autophagosome formation in yeast. J Lipids. doi: 10.1155/2011/498768
-
(2011)
J Lipids
-
-
Obara, K.1
Ohsumi, Y.2
-
12
-
-
77956414236
-
The origin of the autophagosomal membrane
-
1:CAS:528:DC%2BC3cXhtFSju7zK 20811355
-
Tooze SA, Yoshimori T (2010) The origin of the autophagosomal membrane. Nat Cell Biol 12(9):831-835
-
(2010)
Nat Cell Biol
, vol.12
, Issue.9
, pp. 831-835
-
-
Tooze, S.A.1
Yoshimori, T.2
-
13
-
-
77955165003
-
The plasma membrane brings autophagosomes to life
-
1:CAS:528:DC%2BC3cXpsFWnsLs%3D 20680002
-
Cuervo AM (2010) The plasma membrane brings autophagosomes to life. Nat Cell Biol 12(8):735-737
-
(2010)
Nat Cell Biol
, vol.12
, Issue.8
, pp. 735-737
-
-
Cuervo, A.M.1
-
14
-
-
77957669416
-
The Golgi as a potential membrane source for autophagy
-
3359472 20729630
-
Geng J, Klionsky DJ (2010) The Golgi as a potential membrane source for autophagy. Autophagy 6(7):950-951
-
(2010)
Autophagy
, vol.6
, Issue.7
, pp. 950-951
-
-
Geng, J.1
Klionsky, D.J.2
-
15
-
-
84875365804
-
Autophagosomes form at ER-mitochondria contact sites
-
1:CAS:528:DC%2BC3sXktlGhtr4%3D 23455425
-
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T (2013) Autophagosomes form at ER-mitochondria contact sites. Nature 495(7441):389-393
-
(2013)
Nature
, vol.495
, Issue.7441
, pp. 389-393
-
-
Hamasaki, M.1
Furuta, N.2
Matsuda, A.3
Nezu, A.4
Yamamoto, A.5
Fujita, N.6
Oomori, H.7
Noda, T.8
Haraguchi, T.9
Hiraoka, Y.10
Amano, A.11
Yoshimori, T.12
-
16
-
-
84881506338
-
The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis
-
3736544 23930225
-
Ge L, Melville D, Zhang M, Schekman R (2013) The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. eLife 2:e00947
-
(2013)
ELife
, vol.2
, pp. e00947
-
-
Ge, L.1
Melville, D.2
Zhang, M.3
Schekman, R.4
-
17
-
-
77952495224
-
Mitochondria supply membranes for autophagosome biogenesis during starvation
-
3059894 1:CAS:528:DC%2BC3cXms1egsr8%3D 20478256
-
Hailey DW, Rambold AS, Satpute-Krishnan P, Mitra K, Sougrat R, Kim PK, Lippincott-Schwartz J (2010) Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 141(4):656-667
-
(2010)
Cell
, vol.141
, Issue.4
, pp. 656-667
-
-
Hailey, D.W.1
Rambold, A.S.2
Satpute-Krishnan, P.3
Mitra, K.4
Sougrat, R.5
Kim, P.K.6
Lippincott-Schwartz, J.7
-
18
-
-
84988422403
-
ATG16L1 meets ATG9 in recycling endosomes: Additional roles for the plasma membrane and endocytosis in autophagosome biogenesis
-
1:CAS:528:DC%2BC2cXht1Gns7jP 24257061
-
Puri C, Renna M, Bento CF, Moreau K, Rubinsztein DC (2014) ATG16L1 meets ATG9 in recycling endosomes: additional roles for the plasma membrane and endocytosis in autophagosome biogenesis. Autophagy 10(1):182-184
-
(2014)
Autophagy
, vol.10
, Issue.1
, pp. 182-184
-
-
Puri, C.1
Renna, M.2
Bento, C.F.3
Moreau, K.4
Rubinsztein, D.C.5
-
19
-
-
84896542255
-
Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis
-
4016984 1:CAS:528:DC%2BC2cXjvFWjtrw%3D 24613307
-
Dupont N, Chauhan S, Arko-Mensah J, Castillo EF, Masedunskas A, Weigert R, Robenek H, Proikas-Cezanne T, Deretic V (2014) neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Curr Biol 24(6):609-620
-
(2014)
Curr Biol
, vol.24
, Issue.6
, pp. 609-620
-
-
Dupont, N.1
Chauhan, S.2
Arko-Mensah, J.3
Castillo, E.F.4
Masedunskas, A.5
Weigert, R.6
Robenek, H.7
Proikas-Cezanne, T.8
Deretic, V.9
-
20
-
-
78149475088
-
Regulation of mammalian autophagy in physiology and pathophysiology
-
1:CAS:528:DC%2BC3cXhsFSqtbjO 20959619
-
Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC (2010) Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 90(4):1383-1435
-
(2010)
Physiol Rev
, vol.90
, Issue.4
, pp. 1383-1435
-
-
Ravikumar, B.1
Sarkar, S.2
Davies, J.E.3
Futter, M.4
Garcia-Arencibia, M.5
Green-Thompson, Z.W.6
Jimenez-Sanchez, M.7
Korolchuk, V.I.8
Lichtenberg, M.9
Luo, S.10
Massey, D.C.11
Menzies, F.M.12
Moreau, K.13
Narayanan, U.14
Renna, M.15
Siddiqi, F.H.16
Underwood, B.R.17
Winslow, A.R.18
Rubinsztein, D.C.19
-
21
-
-
7244255989
-
Role for Rab7 in maturation of late autophagic vacuoles
-
15340014
-
Jager S, Bucci C, Tanida I, Ueno T, Kominami E, Saftig P, Eskelinen EL (2004) Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci 117(Pt 20):4837-4848
-
(2004)
J Cell Sci
, vol.117
, pp. 4837-4848
-
-
Jager, S.1
Bucci, C.2
Tanida, I.3
Ueno, T.4
Kominami, E.5
Saftig, P.6
Eskelinen, E.L.7
-
22
-
-
84870880174
-
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
-
1:CAS:528:DC%2BC38XhvVaisrvK 23217709
-
Itakura E, Kishi-Itakura C, Mizushima N (2012) The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151(6):1256-1269
-
(2012)
Cell
, vol.151
, Issue.6
, pp. 1256-1269
-
-
Itakura, E.1
Kishi-Itakura, C.2
Mizushima, N.3
-
23
-
-
84901381389
-
The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17
-
3982997 24554770
-
Jiang P, Nishimura T, Sakamaki Y, Itakura E, Hatta T, Natsume T, Mizushima N (2014) The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell 25(8):1327-1337
-
(2014)
Mol Biol Cell
, vol.25
, Issue.8
, pp. 1327-1337
-
-
Jiang, P.1
Nishimura, T.2
Sakamaki, Y.3
Itakura, E.4
Hatta, T.5
Natsume, T.6
Mizushima, N.7
-
24
-
-
77951214016
-
Mammalian autophagy: Core molecular machinery and signaling regulation
-
2854249 1:CAS:528:DC%2BC3cXks1SrtL4%3D 20034776
-
Yang Z, Klionsky DJ (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22(2):124-131
-
(2010)
Curr Opin Cell Biol
, vol.22
, Issue.2
, pp. 124-131
-
-
Yang, Z.1
Klionsky, D.J.2
-
25
-
-
67650517556
-
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
-
1:CAS:528:DC%2BC3cXovFykuw%3D%3D 19502794
-
Lamark T, Kirkin V, Dikic I, Johansen T (2009) NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 8(13):1986-1990
-
(2009)
Cell Cycle
, vol.8
, Issue.13
, pp. 1986-1990
-
-
Lamark, T.1
Kirkin, V.2
Dikic, I.3
Johansen, T.4
-
26
-
-
78049498376
-
Ceramide synthases: Roles in cell physiology and signaling
-
1:CAS:528:DC%2BC3MXjsFGhtQ%3D%3D 20919646
-
Stiban J, Tidhar R, Futerman AH (2010) Ceramide synthases: roles in cell physiology and signaling. Adv Exp Med Biol 688:60-71
-
(2010)
Adv Exp Med Biol
, vol.688
, pp. 60-71
-
-
Stiban, J.1
Tidhar, R.2
Futerman, A.H.3
-
27
-
-
78049518892
-
An overview of sphingolipid metabolism: From synthesis to breakdown
-
3069696 1:CAS:528:DC%2BC3MXjsFGhtg%3D%3D 20919643
-
Gault CR, Obeid LM, Hannun YA (2010) An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol 688:1-23
-
(2010)
Adv Exp Med Biol
, vol.688
, pp. 1-23
-
-
Gault, C.R.1
Obeid, L.M.2
Hannun, Y.A.3
-
28
-
-
34250898152
-
Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy
-
17560117
-
Huwiler A, Zangemeister-Wittke U (2007) Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. Critical reviews in oncology/hematology 63(2):150-159
-
(2007)
Critical Reviews in Oncology/hematology
, vol.63
, Issue.2
, pp. 150-159
-
-
Huwiler, A.1
Zangemeister-Wittke, U.2
-
29
-
-
0031919157
-
Regulation of ceramide production and apoptosis
-
1:CAS:528:DyaK1cXitVOhsbg%3D 9558480
-
Kolesnick RN, Kronke M (1998) Regulation of ceramide production and apoptosis. Annu Rev Physiol 60:643-665
-
(1998)
Annu Rev Physiol
, vol.60
, pp. 643-665
-
-
Kolesnick, R.N.1
Kronke, M.2
-
30
-
-
77951887251
-
Glycosphingolipids in microdomain formation and their spatial organization
-
1:CAS:528:DC%2BC3cXkvFKqtb8%3D 19941856
-
Gupta G, Surolia A (2010) Glycosphingolipids in microdomain formation and their spatial organization. FEBS Lett 584(9):1634-1641
-
(2010)
FEBS Lett
, vol.584
, Issue.9
, pp. 1634-1641
-
-
Gupta, G.1
Surolia, A.2
-
31
-
-
77956277183
-
Lipid microdomains and the regulation of ion channel function
-
2976012 1:CAS:528:DC%2BC3cXhtF2rur7O 20519314
-
Dart C (2010) Lipid microdomains and the regulation of ion channel function. J Physiol 588(Pt 17):3169-3178
-
(2010)
J Physiol
, vol.588
, pp. 3169-3178
-
-
Dart, C.1
-
32
-
-
84875844779
-
Ripples in the pond-using a systems approach to decipher the cellular functions of membrane microdomains
-
1:CAS:528:DC%2BC3sXitVequ7s%3D 23322173
-
Inder KL, Davis M, Hill MM (2013) Ripples in the pond-using a systems approach to decipher the cellular functions of membrane microdomains. Mol Biosyst 9(3):330-338
-
(2013)
Mol Biosyst
, vol.9
, Issue.3
, pp. 330-338
-
-
Inder, K.L.1
Davis, M.2
Hill, M.M.3
-
33
-
-
84872959202
-
Caveolae as plasma membrane sensors, protectors and organizers
-
1:CAS:528:DC%2BC3sXhtFGrt74%3D 23340574
-
Parton RG, del Pozo MA (2013) Caveolae as plasma membrane sensors, protectors and organizers. Nat Rev Mol Cell Biol 14(2):98-112
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, Issue.2
, pp. 98-112
-
-
Parton, R.G.1
Del Pozo, M.A.2
-
34
-
-
84897954501
-
Sphingolipids as modulators of membrane proteins
-
1:CAS:528:DC%2BC3sXhsl2mu7bL 24201378
-
Ernst AM, Brugger B (2014) Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta 1841(5):665-670
-
(2014)
Biochim Biophys Acta
, vol.1841
, Issue.5
, pp. 665-670
-
-
Ernst, A.M.1
Brugger, B.2
-
35
-
-
0347611095
-
Molecular machinery for non-vesicular trafficking of ceramide
-
1:CAS:528:DC%2BD3sXpvVGmtL8%3D 14685229
-
Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M (2003) Molecular machinery for non-vesicular trafficking of ceramide. Nature 426(6968):803-809
-
(2003)
Nature
, vol.426
, Issue.6968
, pp. 803-809
-
-
Hanada, K.1
Kumagai, K.2
Yasuda, S.3
Miura, Y.4
Kawano, M.5
Fukasawa, M.6
Nishijima, M.7
-
36
-
-
34547096008
-
Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT
-
1:CAS:528:DC%2BD2sXmt1ersLo%3D 17442665
-
Kumagai K, Kawano M, Shinkai-Ouchi F, Nishijima M, Hanada K (2007) Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT. J Biol Chem 282(24):17758-17766
-
(2007)
J Biol Chem
, vol.282
, Issue.24
, pp. 17758-17766
-
-
Kumagai, K.1
Kawano, M.2
Shinkai-Ouchi, F.3
Nishijima, M.4
Hanada, K.5
-
37
-
-
38649131260
-
Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide
-
2206563 1:CAS:528:DC%2BD1cXpvV2mtA%3D%3D 18184806
-
Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R (2008) Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci USA 105(2):488-493
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.2
, pp. 488-493
-
-
Kudo, N.1
Kumagai, K.2
Tomishige, N.3
Yamaji, T.4
Wakatsuki, S.5
Nishijima, M.6
Hanada, K.7
Kato, R.8
-
38
-
-
34249820539
-
CERT and intracellular trafficking of ceramide
-
1:CAS:528:DC%2BD2sXmtlWgsbY%3D 17314061
-
Hanada K, Kumagai K, Tomishige N, Kawano M (2007) CERT and intracellular trafficking of ceramide. Biochim Biophys Acta 1771(6):644-653
-
(2007)
Biochim Biophys Acta
, vol.1771
, Issue.6
, pp. 644-653
-
-
Hanada, K.1
Kumagai, K.2
Tomishige, N.3
Kawano, M.4
-
39
-
-
20444402239
-
Molecular mechanisms and regulation of ceramide transport
-
1:CAS:528:DC%2BD2MXltVaquro%3D 15907394
-
Perry RJ, Ridgway ND (2005) Molecular mechanisms and regulation of ceramide transport. Biochim Biophys Acta 1734(3):220-234
-
(2005)
Biochim Biophys Acta
, vol.1734
, Issue.3
, pp. 220-234
-
-
Perry, R.J.1
Ridgway, N.D.2
-
40
-
-
14644393694
-
Lipid traffic: Floppy drives and a superhighway
-
1:CAS:528:DC%2BD2MXhslSlsLg%3D 15738987
-
Holthuis JC, Levine TP (2005) Lipid traffic: floppy drives and a superhighway. Nat Rev Mol Cell Biol 6(3):209-220
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, Issue.3
, pp. 209-220
-
-
Holthuis, J.C.1
Levine, T.P.2
-
41
-
-
84882924058
-
Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids
-
3951269 1:CAS:528:DC%2BC3sXhtFWku7nM 23863933
-
Simanshu DK, Kamlekar RK, Wijesinghe DS, Zou X, Zhai X, Mishra SK, Molotkovsky JG, Malinina L, Hinchcliffe EH, Chalfant CE, Brown RE, Patel DJ (2013) Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature 500(7463):463-467
-
(2013)
Nature
, vol.500
, Issue.7463
, pp. 463-467
-
-
Simanshu, D.K.1
Kamlekar, R.K.2
Wijesinghe, D.S.3
Zou, X.4
Zhai, X.5
Mishra, S.K.6
Molotkovsky, J.G.7
Malinina, L.8
Hinchcliffe, E.H.9
Chalfant, C.E.10
Brown, R.E.11
Patel, D.J.12
-
42
-
-
84893766895
-
Membranes and mammalian glycolipid transferring proteins
-
1:CAS:528:DC%2BC3sXhvVKgtrbF 24220498
-
Tuuf J, Mattjus P (2014) Membranes and mammalian glycolipid transferring proteins. Chem Phys Lipids 178:27-37
-
(2014)
Chem Phys Lipids
, vol.178
, pp. 27-37
-
-
Tuuf, J.1
Mattjus, P.2
-
43
-
-
0021869543
-
Specificity of the glycolipid transfer protein from pig brain
-
1:CAS:528:DyaL2MXhvF2ksbs%3D 3988728
-
Yamada K, Abe A, Sasaki T (1985) Specificity of the glycolipid transfer protein from pig brain. J Biol Chem 260(8):4615-4621
-
(1985)
J Biol Chem
, vol.260
, Issue.8
, pp. 4615-4621
-
-
Yamada, K.1
Abe, A.2
Sasaki, T.3
-
44
-
-
0022416514
-
Properties of a specific glycolipid transfer protein from bovine brain
-
1:CAS:528:DyaL2MXltlOns7s%3D 4064225
-
Brown RE, Stephenson FA, Markello T, Barenholz Y, Thompson TE (1985) Properties of a specific glycolipid transfer protein from bovine brain. Chem Phys Lipids 38(1-2):79-93
-
(1985)
Chem Phys Lipids
, vol.38
, Issue.1-2
, pp. 79-93
-
-
Brown, R.E.1
Stephenson, F.A.2
Markello, T.3
Barenholz, Y.4
Thompson, T.E.5
-
45
-
-
22544464453
-
Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex
-
1393170 1:CAS:528:DC%2BD2MXlvFymtb4%3D 15901739
-
Malakhova ML, Malinina L, Pike HM, Kanack AT, Patel DJ, Brown RE (2005) Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex. J Biol Chem 280(28):26312-26320
-
(2005)
J Biol Chem
, vol.280
, Issue.28
, pp. 26312-26320
-
-
Malakhova, M.L.1
Malinina, L.2
Pike, H.M.3
Kanack, A.T.4
Patel, D.J.5
Brown, R.E.6
-
46
-
-
2342556630
-
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P
-
1:CAS:528:DC%2BD2cXjsFSltrk%3D 15107860
-
Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi DR, Kular GS, Daniele T, Marra P, Lucocq JM, De Matteis MA (2004) FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol 6(5):393-404
-
(2004)
Nat Cell Biol
, vol.6
, Issue.5
, pp. 393-404
-
-
Godi, A.1
Di Campli, A.2
Konstantakopoulos, A.3
Di Tullio, G.4
Alessi, D.R.5
Kular, G.S.6
Daniele, T.7
Marra, P.8
Lucocq, J.M.9
De Matteis, M.A.10
-
47
-
-
34548498611
-
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide
-
17687330
-
D'Angelo G, Polishchuk E, Di Tullio G, Santoro M, Di Campli A, Godi A, West G, Bielawski J, Chuang CC, van der Spoel AC, Platt FM, Hannun YA, Polishchuk R, Mattjus P, De Matteis MA (2007) Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature 449(7158):62-67
-
(2007)
Nature
, vol.449
, Issue.7158
, pp. 62-67
-
-
D'Angelo, G.1
Polishchuk, E.2
Di Tullio, G.3
Santoro, M.4
Di Campli, A.5
Godi, A.6
West, G.7
Bielawski, J.8
Chuang, C.C.9
Van Der Spoel, A.C.10
Platt, F.M.11
Hannun, Y.A.12
Polishchuk, R.13
Mattjus, P.14
De Matteis, M.A.15
-
48
-
-
77955789211
-
Altered lipid content inhibits autophagic vesicular fusion
-
2909278 1:CAS:528:DC%2BC3cXhtVeitr%2FE 20375270
-
Koga H, Kaushik S, Cuervo AM (2010) Altered lipid content inhibits autophagic vesicular fusion. FASEB J 24(8):3052-3065
-
(2010)
FASEB J
, vol.24
, Issue.8
, pp. 3052-3065
-
-
Koga, H.1
Kaushik, S.2
Cuervo, A.M.3
-
49
-
-
79960294696
-
Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae
-
1:CAS:528:DC%2BC3MXptVyqt7s%3D 21703229
-
Yamagata M, Obara K, Kihara A (2011) Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae. Biochem Biophys Res Commun 410(4):786-791
-
(2011)
Biochem Biophys Res Commun
, vol.410
, Issue.4
, pp. 786-791
-
-
Yamagata, M.1
Obara, K.2
Kihara, A.3
-
50
-
-
0032509523
-
The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion
-
1:CAS:528:DyaK1MXmsA%3D%3D 9837889
-
Hinkovska-Galcheva VT, Boxer LA, Mansfield PJ, Harsh D, Blackwood A, Shayman JA (1998) The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion. J Biol Chem 273(50):33203-33209
-
(1998)
J Biol Chem
, vol.273
, Issue.50
, pp. 33203-33209
-
-
Hinkovska-Galcheva, V.T.1
Boxer, L.A.2
Mansfield, P.J.3
Harsh, D.4
Blackwood, A.5
Shayman, J.A.6
-
51
-
-
84903764947
-
Coupling between endocytosis and sphingosine kinase 1 recruitment
-
Shen H, Giordano F, Wu Y, Chan J, Zhu C, Milosevic I, Wu X, Yao K, Chen B, Baumgart T, Sieburth D, Camilli PD (2014) Coupling between endocytosis and sphingosine kinase 1 recruitment. Nat Cell Biol 510:552-555
-
(2014)
Nat Cell Biol
, vol.510
, pp. 552-555
-
-
Shen, H.1
Giordano, F.2
Wu, Y.3
Chan, J.4
Zhu, C.5
Milosevic, I.6
Wu, X.7
Yao, K.8
Chen, B.9
Baumgart, T.10
Sieburth, D.11
Camilli, P.D.12
-
52
-
-
84862611041
-
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes
-
3365497 1:CAS:528:DC%2BC38XotFWgur8%3D 22613832
-
Longatti A, Lamb CA, Razi M, Yoshimura S, Barr FA, Tooze SA (2012) TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J Cell Biol 197(5):659-675
-
(2012)
J Cell Biol
, vol.197
, Issue.5
, pp. 659-675
-
-
Longatti, A.1
Lamb, C.A.2
Razi, M.3
Yoshimura, S.4
Barr, F.A.5
Tooze, S.A.6
-
53
-
-
84894275180
-
Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization
-
3923643 24356450
-
Szatmari Z, Kis V, Lippai M, Hegedus K, Farago T, Lorincz P, Tanaka T, Juhasz G, Sass M (2014) Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization. Mol Biol Cell 25(4):522-531
-
(2014)
Mol Biol Cell
, vol.25
, Issue.4
, pp. 522-531
-
-
Szatmari, Z.1
Kis, V.2
Lippai, M.3
Hegedus, K.4
Farago, T.5
Lorincz, P.6
Tanaka, T.7
Juhasz, G.8
Sass, M.9
-
54
-
-
58149188064
-
Effects of ceramide and other simple sphingolipids on membrane lateral structure
-
1:CAS:528:DC%2BD1MXksVWmug%3D%3D 18848519
-
Goni FM, Alonso A (2009) Effects of ceramide and other simple sphingolipids on membrane lateral structure. Biochim Biophys Acta 1788(1):169-177
-
(2009)
Biochim Biophys Acta
, vol.1788
, Issue.1
, pp. 169-177
-
-
Goni, F.M.1
Alonso, A.2
-
55
-
-
38149085341
-
Sphingomyelinase generation of ceramide promotes clustering of nanoscale domains in supported bilayer membranes
-
1:STN:280:DC%2BD1c%2FltFalsg%3D%3D 17988649
-
Ira Johnston LJ (2008) Sphingomyelinase generation of ceramide promotes clustering of nanoscale domains in supported bilayer membranes. Biochim Biophys Acta 1778(1):185-197
-
(2008)
Biochim Biophys Acta
, vol.1778
, Issue.1
, pp. 185-197
-
-
Ira Johnston, L.J.1
-
56
-
-
0032535156
-
Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane
-
1:CAS:528:DyaK1cXnsVGgurY%3D 9860872
-
Holopainen JM, Subramanian M, Kinnunen PK (1998) Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. Biochemistry 37(50):17562-17570
-
(1998)
Biochemistry
, vol.37
, Issue.50
, pp. 17562-17570
-
-
Holopainen, J.M.1
Subramanian, M.2
Kinnunen, P.K.3
-
57
-
-
84880523313
-
Ceramide in plasma membrane repair
-
1:CAS:528:DC%2BC3sXhsFKls7vP 23563665
-
Draeger A, Babiychuk EB (2013) Ceramide in plasma membrane repair. Handb Exp Pharmacol 216:341-353
-
(2013)
Handb Exp Pharmacol
, vol.216
, pp. 341-353
-
-
Draeger, A.1
Babiychuk, E.B.2
-
58
-
-
3042781119
-
Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae
-
1224232 1:CAS:528:DC%2BD2cXltVagtL4%3D 15032750
-
Faergeman NJ, Feddersen S, Christiansen JK, Larsen MK, Schneiter R, Ungermann C, Mutenda K, Roepstorff P, Knudsen J (2004) Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae. Biochem J 380(Pt 3):907-918
-
(2004)
Biochem J
, vol.380
, pp. 907-918
-
-
Faergeman, N.J.1
Feddersen, S.2
Christiansen, J.K.3
Larsen, M.K.4
Schneiter, R.5
Ungermann, C.6
Mutenda, K.7
Roepstorff, P.8
Knudsen, J.9
-
59
-
-
77957020175
-
Membrane fusion: Five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuoles
-
1:CAS:528:DC%2BC3cXhsFCnur7J 20521906
-
Wickner W (2010) Membrane fusion: five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuoles. Annu Rev Cell Dev Biol 26:115-136
-
(2010)
Annu Rev Cell Dev Biol
, vol.26
, pp. 115-136
-
-
Wickner, W.1
-
60
-
-
0036892508
-
Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus
-
136663 1:CAS:528:DC%2BD38XptVygurY%3D 12438595
-
Samsonov AV, Chatterjee PK, Razinkov VI, Eng CH, Kielian M, Cohen FS (2002) Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus. J Virol 76(24):12691-12702
-
(2002)
J Virol
, vol.76
, Issue.24
, pp. 12691-12702
-
-
Samsonov, A.V.1
Chatterjee, P.K.2
Razinkov, V.I.3
Eng, C.H.4
Kielian, M.5
Cohen, F.S.6
-
61
-
-
0028199032
-
Membrane fusion of Semliki Forest virus requires sphingolipids in the target membrane
-
395159 1:CAS:528:DyaK2cXksl2qtr0%3D 8026464
-
Nieva JL, Bron R, Corver J, Wilschut J (1994) Membrane fusion of Semliki Forest virus requires sphingolipids in the target membrane. EMBO J 13(12):2797-2804
-
(1994)
EMBO J
, vol.13
, Issue.12
, pp. 2797-2804
-
-
Nieva, J.L.1
Bron, R.2
Corver, J.3
Wilschut, J.4
-
62
-
-
55549134611
-
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
-
1:CAS:528:DC%2BD1cXhtlCjtLrL 18953351
-
Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM (2008) Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med 14(11):1247-1255
-
(2008)
Nat Med
, vol.14
, Issue.11
, pp. 1247-1255
-
-
Lloyd-Evans, E.1
Morgan, A.J.2
He, X.3
Smith, D.A.4
Elliot-Smith, E.5
Sillence, D.J.6
Churchill, G.C.7
Schuchman, E.H.8
Galione, A.9
Platt, F.M.10
-
63
-
-
75749102680
-
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology
-
1:CAS:528:DC%2BC3cXht1Sksro%3D 20111001
-
Kirkegaard T, Roth AG, Petersen NH, Mahalka AK, Olsen OD, Moilanen I, Zylicz A, Knudsen J, Sandhoff K, Arenz C, Kinnunen PK, Nylandsted J, Jaattela M (2010) Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature 463(7280):549-553
-
(2010)
Nature
, vol.463
, Issue.7280
, pp. 549-553
-
-
Kirkegaard, T.1
Roth, A.G.2
Petersen, N.H.3
Mahalka, A.K.4
Olsen, O.D.5
Moilanen, I.6
Zylicz, A.7
Knudsen, J.8
Sandhoff, K.9
Arenz, C.10
Kinnunen, P.K.11
Nylandsted, J.12
Jaattela, M.13
-
64
-
-
84883627583
-
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase
-
1:CAS:528:DC%2BC3sXhsVahsL%2FM 24029234
-
Petersen NH, Olsen OD, Groth-Pedersen L, Ellegaard AM, Bilgin M, Redmer S, Ostenfeld MS, Ulanet D, Dovmark TH, Lonborg A, Vindelov SD, Hanahan D, Arenz C, Ejsing CS, Kirkegaard T, Rohde M, Nylandsted J, Jaattela M (2013) Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase. Cancer Cell 24(3):379-393
-
(2013)
Cancer Cell
, vol.24
, Issue.3
, pp. 379-393
-
-
Petersen, N.H.1
Olsen, O.D.2
Groth-Pedersen, L.3
Ellegaard, A.M.4
Bilgin, M.5
Redmer, S.6
Ostenfeld, M.S.7
Ulanet, D.8
Dovmark, T.H.9
Lonborg, A.10
Vindelov, S.D.11
Hanahan, D.12
Arenz, C.13
Ejsing, C.S.14
Kirkegaard, T.15
Rohde, M.16
Nylandsted, J.17
Jaattela, M.18
-
65
-
-
84899957348
-
High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A
-
1:CAS:528:DC%2BC2cXhsl2ns7Y%3D 24488099
-
Gabande-Rodriguez E, Boya P, Labrador V, Dotti CG, Ledesma MD (2014) High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A. Cell Death Differ 21(6):864-875
-
(2014)
Cell Death Differ
, vol.21
, Issue.6
, pp. 864-875
-
-
Gabande-Rodriguez, E.1
Boya, P.2
Labrador, V.3
Dotti, C.G.4
Ledesma, M.D.5
-
66
-
-
2442485884
-
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
-
1:CAS:528:DC%2BD2cXjsVKnur4%3D 14970205
-
Scarlatti F, Bauvy C, Ventruti A, Sala G, Cluzeaud F, Vandewalle A, Ghidoni R, Codogno P (2004) Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem 279(18):18384-18391
-
(2004)
J Biol Chem
, vol.279
, Issue.18
, pp. 18384-18391
-
-
Scarlatti, F.1
Bauvy, C.2
Ventruti, A.3
Sala, G.4
Cluzeaud, F.5
Vandewalle, A.6
Ghidoni, R.7
Codogno, P.8
-
67
-
-
84869208878
-
Regulation of autophagy and its associated cell death by "sphingolipid rheostat": Reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway
-
3501064 1:CAS:528:DC%2BC38Xhs12ksb%2FN 23035115
-
Taniguchi M, Kitatani K, Kondo T, Hashimoto-Nishimura M, Asano S, Hayashi A, Mitsutake S, Igarashi Y, Umehara H, Takeya H, Kigawa J, Okazaki T (2012) Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. J Biol Chem 287(47):39898-39910
-
(2012)
J Biol Chem
, vol.287
, Issue.47
, pp. 39898-39910
-
-
Taniguchi, M.1
Kitatani, K.2
Kondo, T.3
Hashimoto-Nishimura, M.4
Asano, S.5
Hayashi, A.6
Mitsutake, S.7
Igarashi, Y.8
Umehara, H.9
Takeya, H.10
Kigawa, J.11
Okazaki, T.12
-
68
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
1:CAS:528:DC%2BD28XivVCgurc%3D 16415355
-
Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R, Botti J, Codogno P (2006) Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 281(13):8518-8527
-
(2006)
J Biol Chem
, vol.281
, Issue.13
, pp. 8518-8527
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Carpentier, S.4
Levade, T.5
Ghidoni, R.6
Botti, J.7
Codogno, P.8
-
69
-
-
0037119991
-
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
-
2173216 12235122
-
Le Stunff H, Galve-Roperh I, Peterson C, Milstien S, Spiegel S (2002) Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol 158(6):1039-1049
-
(2002)
J Cell Biol
, vol.158
, Issue.6
, pp. 1039-1049
-
-
Le Stunff, H.1
Galve-Roperh, I.2
Peterson, C.3
Milstien, S.4
Spiegel, S.5
-
70
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
1:CAS:528:DC%2BD2cXmtVOhsb4%3D 15286740
-
Ogretmen B, Hannun YA (2004) Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 4(8):604-616
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.8
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
71
-
-
0034733910
-
Sphingosine-1-phosphate: Signaling inside and out
-
1:CAS:528:DC%2BD3cXktlKqsbs%3D 10878250
-
Spiegel S, Milstien S (2000) Sphingosine-1-phosphate: signaling inside and out. FEBS Lett 476(1-2):55-57
-
(2000)
FEBS Lett
, vol.476
, Issue.1-2
, pp. 55-57
-
-
Spiegel, S.1
Milstien, S.2
-
72
-
-
78651265495
-
Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy
-
3131882 1:CAS:528:DC%2BC3MXjs1Cnuw%3D%3D 20798685
-
Lepine S, Allegood JC, Park M, Dent P, Milstien S, Spiegel S (2011) Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell Death Differ 18(2):350-361
-
(2011)
Cell Death Differ
, vol.18
, Issue.2
, pp. 350-361
-
-
Lepine, S.1
Allegood, J.C.2
Park, M.3
Dent, P.4
Milstien, S.5
Spiegel, S.6
-
73
-
-
0032508706
-
Molecular cloning and functional characterization of murine sphingosine kinase
-
1:CAS:528:DyaK1cXmtFOkur4%3D 9726979
-
Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S (1998) Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem 273(37):23722-23728
-
(1998)
J Biol Chem
, vol.273
, Issue.37
, pp. 23722-23728
-
-
Kohama, T.1
Olivera, A.2
Edsall, L.3
Nagiec, M.M.4
Dickson, R.5
Spiegel, S.6
-
74
-
-
0034733556
-
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
-
1:CAS:528:DC%2BD3cXkslahsLs%3D 10751414
-
Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S (2000) Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem 275(26):19513-19520
-
(2000)
J Biol Chem
, vol.275
, Issue.26
, pp. 19513-19520
-
-
Liu, H.1
Sugiura, M.2
Nava, V.E.3
Edsall, L.C.4
Kono, K.5
Poulton, S.6
Milstien, S.7
Kohama, T.8
Spiegel, S.9
-
75
-
-
0032103445
-
Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants
-
1219509 1:CAS:528:DyaK1cXkt1Sqtr4%3D 9601083
-
Lanterman MM, Saba JD (1998) Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. Biochem J 332(Pt 2):525-531
-
(1998)
Biochem J
, vol.332
, pp. 525-531
-
-
Lanterman, M.M.1
Saba, J.D.2
-
76
-
-
0033230364
-
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
-
2151183 1:CAS:528:DC%2BD3cXislyru7s%3D 10545499
-
Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S, Spiegel S (1999) Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 147(3):545-558
-
(1999)
J Cell Biol
, vol.147
, Issue.3
, pp. 545-558
-
-
Olivera, A.1
Kohama, T.2
Edsall, L.3
Nava, V.4
Cuvillier, O.5
Poulton, S.6
Spiegel, S.7
-
77
-
-
0034610743
-
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
-
1:CAS:528:DC%2BD3cXlvVSqsg%3D%3D 10638761
-
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403(6765):98-103
-
(2000)
Nature
, vol.403
, Issue.6765
, pp. 98-103
-
-
Nakagawa, T.1
Zhu, H.2
Morishima, N.3
Li, E.4
Xu, J.5
Yankner, B.A.6
Yuan, J.7
-
78
-
-
77952937151
-
Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation
-
1:CAS:528:DC%2BC3cXmsVOmsrY%3D 20502006
-
Potteck H, Nieuwenhuis B, Luth A, van der Giet M, Kleuser B (2010) Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation. Cell Physiol Biochem 26(1):67-78
-
(2010)
Cell Physiol Biochem
, vol.26
, Issue.1
, pp. 67-78
-
-
Potteck, H.1
Nieuwenhuis, B.2
Luth, A.3
Van Der Giet, M.4
Kleuser, B.5
-
79
-
-
57749196164
-
Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM
-
1:CAS:528:DC%2BD1cXhsFamtb7L 19000755
-
Maeurer C, Holland S, Pierre S, Potstada W, Scholich K (2009) Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. Cell Signal 21(2):293-300
-
(2009)
Cell Signal
, vol.21
, Issue.2
, pp. 293-300
-
-
Maeurer, C.1
Holland, S.2
Pierre, S.3
Potstada, W.4
Scholich, K.5
-
80
-
-
0035860831
-
Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration
-
1:CAS:528:DC%2BD3MXntFGitbg%3D 11557736
-
Kluk MJ, Hla T (2001) Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res 89(6):496-502
-
(2001)
Circ Res
, vol.89
, Issue.6
, pp. 496-502
-
-
Kluk, M.J.1
Hla, T.2
-
81
-
-
0027991078
-
Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway
-
1:CAS:528:DyaK2cXhsF2ltr0%3D 8106352
-
Mattie M, Brooker G, Spiegel S (1994) Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J Biol Chem 269(5):3181-3188
-
(1994)
J Biol Chem
, vol.269
, Issue.5
, pp. 3181-3188
-
-
Mattie, M.1
Brooker, G.2
Spiegel, S.3
-
82
-
-
0029079324
-
Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism
-
1:CAS:528:DyaK2MXls1eisL8%3D 7744787
-
Wu J, Spiegel S, Sturgill TW (1995) Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. J Biol Chem 270(19):11484-11488
-
(1995)
J Biol Chem
, vol.270
, Issue.19
, pp. 11484-11488
-
-
Wu, J.1
Spiegel, S.2
Sturgill, T.W.3
-
83
-
-
0142091073
-
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
-
1:CAS:528:DC%2BD3sXovFKksLk%3D 12954646
-
Igarashi N, Okada T, Hayashi S, Fujita T, Jahangeer S, Nakamura S (2003) Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J Biol Chem 278(47):46832-46839
-
(2003)
J Biol Chem
, vol.278
, Issue.47
, pp. 46832-46839
-
-
Igarashi, N.1
Okada, T.2
Hayashi, S.3
Fujita, T.4
Jahangeer, S.5
Nakamura, S.6
-
84
-
-
34848867249
-
Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2
-
1:CAS:528:DC%2BD2sXhtVWjsb%2FF 17635916
-
Ding G, Sonoda H, Yu H, Kajimoto T, Goparaju SK, Jahangeer S, Okada T, Nakamura S (2007) Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2. J Biol Chem 282(37):27493-27502
-
(2007)
J Biol Chem
, vol.282
, Issue.37
, pp. 27493-27502
-
-
Ding, G.1
Sonoda, H.2
Yu, H.3
Kajimoto, T.4
Goparaju, S.K.5
Jahangeer, S.6
Okada, T.7
Nakamura, S.8
-
85
-
-
27744547965
-
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
-
1:CAS:528:DC%2BD2MXhtFKhtLvM 16118219
-
Maceyka M, Sankala H, Hait NC, Le Stunff H, Liu H, Toman R, Collier C, Zhang M, Satin LS, Merrill AH Jr, Milstien S, Spiegel S (2005) SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem 280(44):37118-37129
-
(2005)
J Biol Chem
, vol.280
, Issue.44
, pp. 37118-37129
-
-
Maceyka, M.1
Sankala, H.2
Hait, N.C.3
Le Stunff, H.4
Liu, H.5
Toman, R.6
Collier, C.7
Zhang, M.8
Satin, L.S.9
Merrill, A.H.10
Milstien, S.11
Spiegel, S.12
-
86
-
-
34250894388
-
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
-
1:CAS:528:DC%2BD2sXhtVGrtLfJ 17438366
-
Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, Geneste O, Kroemer G (2007) BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 3(4):374-376
-
(2007)
Autophagy
, vol.3
, Issue.4
, pp. 374-376
-
-
Maiuri, M.C.1
Criollo, A.2
Tasdemir, E.3
Vicencio, J.M.4
Tajeddine, N.5
Hickman, J.A.6
Geneste, O.7
Kroemer, G.8
-
87
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
2682037 1:CAS:528:DC%2BD1MXlvFSqu70%3D 19273585
-
Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J, Mazure NM (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 29(10):2570-2581
-
(2009)
Mol Cell Biol
, vol.29
, Issue.10
, pp. 2570-2581
-
-
Bellot, G.1
Garcia-Medina, R.2
Gounon, P.3
Chiche, J.4
Roux, D.5
Pouyssegur, J.6
Mazure, N.M.7
-
88
-
-
84905392495
-
Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons
-
1:CAS:528:DC%2BC2cXht1SksLfO 24928515
-
Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C (2014) Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem 289(30):20845-20857
-
(2014)
J Biol Chem
, vol.289
, Issue.30
, pp. 20845-20857
-
-
Sheng, R.1
Zhang, T.T.2
Felice, V.D.3
Qin, T.4
Qin, Z.H.5
Smith, C.D.6
Sapp, E.7
Difiglia, M.8
Waeber, C.9
-
89
-
-
0141924852
-
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis
-
1:CAS:528:DC%2BD3sXnvFamt7s%3D 12835323
-
Liu H, Toman RE, Goparaju SK, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S (2003) Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem 278(41):40330-40336
-
(2003)
J Biol Chem
, vol.278
, Issue.41
, pp. 40330-40336
-
-
Liu, H.1
Toman, R.E.2
Goparaju, S.K.3
Maceyka, M.4
Nava, V.E.5
Sankala, H.6
Payne, S.G.7
Bektas, M.8
Ishii, I.9
Chun, J.10
Milstien, S.11
Spiegel, S.12
-
90
-
-
0032514918
-
BAD enables ceramide to signal apoptosis via Ras and Raf-1
-
1:CAS:528:DyaK1cXnsVyrurs%3D 9804808
-
Basu S, Bayoumy S, Zhang Y, Lozano J, Kolesnick R (1998) BAD enables ceramide to signal apoptosis via Ras and Raf-1. J Biol Chem 273(46):30419-30426
-
(1998)
J Biol Chem
, vol.273
, Issue.46
, pp. 30419-30426
-
-
Basu, S.1
Bayoumy, S.2
Zhang, Y.3
Lozano, J.4
Kolesnick, R.5
-
91
-
-
0029951162
-
Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase
-
38916 1:CAS:528:DyaK28Xkt1Whs78%3D 8692926
-
Huwiler A, Brunner J, Hummel R, Vervoordeldonk M, Stabel S, van den Bosch H, Pfeilschifter J (1996) Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc Natl Acad Sci USA 93(14):6959-6963
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.14
, pp. 6959-6963
-
-
Huwiler, A.1
Brunner, J.2
Hummel, R.3
Vervoordeldonk, M.4
Stabel, S.5
Van Den Bosch, H.6
Pfeilschifter, J.7
-
92
-
-
0033575320
-
Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
-
1:CAS:528:DyaK1MXks1OjsL0%3D 10400650
-
Ruvolo PP, Deng X, Ito T, Carr BK, May WS (1999) Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J Biol Chem 274(29):20296-20300
-
(1999)
J Biol Chem
, vol.274
, Issue.29
, pp. 20296-20300
-
-
Ruvolo, P.P.1
Deng, X.2
Ito, T.3
Carr, B.K.4
May, W.S.5
-
93
-
-
0032566717
-
A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis
-
1:CAS:528:DyaK1cXmsVGlsr8%3D 9738012
-
Ruvolo PP, Deng X, Carr BK, May WS (1998) A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem 273(39):25436-25442
-
(1998)
J Biol Chem
, vol.273
, Issue.39
, pp. 25436-25442
-
-
Ruvolo, P.P.1
Deng, X.2
Carr, B.K.3
May, W.S.4
-
94
-
-
0028934811
-
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
-
42516 1:CAS:528:DyaK2MXktFWktr0%3D 7877980
-
Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA (1995) Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci USA 92(5):1347-1351
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.5
, pp. 1347-1351
-
-
Dbaibo, G.S.1
Pushkareva, M.Y.2
Jayadev, S.3
Schwarz, J.K.4
Horowitz, J.M.5
Obeid, L.M.6
Hannun, Y.A.7
-
95
-
-
0037203342
-
Ceramide in apoptosis: An overview and current perspectives
-
1:CAS:528:DC%2BD3sXivVOqtg%3D%3D 12531544
-
Pettus BJ, Chalfant CE, Hannun YA (2002) Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 1585(2-3):114-125
-
(2002)
Biochim Biophys Acta
, vol.1585
, Issue.2-3
, pp. 114-125
-
-
Pettus, B.J.1
Chalfant, C.E.2
Hannun, Y.A.3
-
96
-
-
84860507660
-
Ceramide and apoptosis: Exploring the enigmatic connections between sphingolipid metabolism and programmed cell death
-
1:CAS:528:DC%2BC38XmsF2nsrc%3D 21707511
-
Mullen TD, Obeid LM (2012) Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death. Anticancer Agents Med Chem 12(4):340-363
-
(2012)
Anticancer Agents Med Chem
, vol.12
, Issue.4
, pp. 340-363
-
-
Mullen, T.D.1
Obeid, L.M.2
-
97
-
-
33747603712
-
Sphingosine and ceramide signalling in apoptosis
-
1:CAS:528:DC%2BD28XhtVWnurjE 16916783
-
Woodcock J (2006) Sphingosine and ceramide signalling in apoptosis. IUBMB Life 58(8):462-466
-
(2006)
IUBMB Life
, vol.58
, Issue.8
, pp. 462-466
-
-
Woodcock, J.1
-
98
-
-
3042562282
-
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
-
1:CAS:528:DC%2BD2cXkvFWlsb0%3D 15205343
-
Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S (2004) Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 64(12):4286-4293
-
(2004)
Cancer Res
, vol.64
, Issue.12
, pp. 4286-4293
-
-
Daido, S.1
Kanzawa, T.2
Yamamoto, A.3
Takeuchi, H.4
Kondo, Y.5
Kondo, S.6
-
99
-
-
7744235672
-
Death by design: Apoptosis, necrosis and autophagy
-
1:CAS:528:DC%2BD2cXpsVOrtbk%3D 15530778
-
Edinger AL, Thompson CB (2004) Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16(6):663-669
-
(2004)
Curr Opin Cell Biol
, vol.16
, Issue.6
, pp. 663-669
-
-
Edinger, A.L.1
Thompson, C.B.2
-
100
-
-
25144506835
-
Autophagy in cell death: An innocent convict?
-
1236698 1:CAS:528:DC%2BD2MXhtVygt7jJ 16200202
-
Levine B, Yuan J (2005) Autophagy in cell death: an innocent convict? J Clin Investig 115(10):2679-2688
-
(2005)
J Clin Investig
, vol.115
, Issue.10
, pp. 2679-2688
-
-
Levine, B.1
Yuan, J.2
-
101
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
-
1:CAS:528:DC%2BD2cXksVGmsbg%3D 15131264
-
Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ (2004) Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304(5676):1500-1502
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
Welsh, S.6
Baehrecke, E.H.7
Lenardo, M.J.8
-
102
-
-
10344262564
-
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
-
1:CAS:528:DC%2BD2cXhtVarsL%2FJ 15558033
-
Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y (2004) Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6(12):1221-1228
-
(2004)
Nat Cell Biol
, vol.6
, Issue.12
, pp. 1221-1228
-
-
Shimizu, S.1
Kanaseki, T.2
Mizushima, N.3
Mizuta, T.4
Arakawa-Kobayashi, S.5
Thompson, C.B.6
Tsujimoto, Y.7
-
103
-
-
84863009089
-
The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death
-
22613819
-
Van Brocklyn JR, Williams JB (2012) The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death. Comp Biochem Physiol B 163(1):26-36
-
(2012)
Comp Biochem Physiol B
, vol.163
, Issue.1
, pp. 26-36
-
-
Van Brocklyn, J.R.1
Williams, J.B.2
-
104
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
1:CAS:528:DC%2BD2MXhtVOrurbP 16179260
-
Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122(6):927-939
-
(2005)
Cell
, vol.122
, Issue.6
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
105
-
-
38749136302
-
Regulation of macroautophagy by mTOR and Beclin 1 complexes
-
1:CAS:528:DC%2BD1cXhsVGktLY%3D 17928127
-
Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P (2008) Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 90(2):313-323
-
(2008)
Biochimie
, vol.90
, Issue.2
, pp. 313-323
-
-
Pattingre, S.1
Espert, L.2
Biard-Piechaczyk, M.3
Codogno, P.4
-
106
-
-
18644386792
-
Ceramide triggers an NF-kappaB-dependent survival pathway through calpain
-
1:CAS:528:DC%2BD2MXkvVSrtLo%3D 15933726
-
Demarchi F, Bertoli C, Greer PA, Schneider C (2005) Ceramide triggers an NF-kappaB-dependent survival pathway through calpain. Cell Death Differ 12(5):512-522
-
(2005)
Cell Death Differ
, vol.12
, Issue.5
, pp. 512-522
-
-
Demarchi, F.1
Bertoli, C.2
Greer, P.A.3
Schneider, C.4
-
107
-
-
21744460556
-
Multiple death pathways in retina-derived 661 W cells following growth factor deprivation: Crosstalk between caspases and calpains
-
1:CAS:528:DC%2BD2MXltFKjsb4%3D 15846377
-
Gomez-Vicente V, Donovan M, Cotter TG (2005) Multiple death pathways in retina-derived 661 W cells following growth factor deprivation: crosstalk between caspases and calpains. Cell Death Differ 12(7):796-804
-
(2005)
Cell Death Differ
, vol.12
, Issue.7
, pp. 796-804
-
-
Gomez-Vicente, V.1
Donovan, M.2
Cotter, T.G.3
-
108
-
-
0001110114
-
Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
-
1:CAS:528:DC%2BD3cXhsVymtrk%3D 10671558
-
Chua BT, Guo K, Li P (2000) Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases. J Biol Chem 275(7):5131-5135
-
(2000)
J Biol Chem
, vol.275
, Issue.7
, pp. 5131-5135
-
-
Chua, B.T.1
Guo, K.2
Li, P.3
-
109
-
-
33751244535
-
Calpain is required for macroautophagy in mammalian cells
-
2064596 1:CAS:528:DC%2BD28Xht1GksbjO 17101693
-
Demarchi F, Bertoli C, Copetti T, Tanida I, Brancolini C, Eskelinen EL, Schneider C (2006) Calpain is required for macroautophagy in mammalian cells. J Cell Biol 175(4):595-605
-
(2006)
J Cell Biol
, vol.175
, Issue.4
, pp. 595-605
-
-
Demarchi, F.1
Bertoli, C.2
Copetti, T.3
Tanida, I.4
Brancolini, C.5
Eskelinen, E.L.6
Schneider, C.7
-
110
-
-
38649105202
-
Regulation of ceramide biosynthesis by TOR complex 2
-
1:CAS:528:DC%2BD1cXitVWhtLk%3D
-
Aronova S, Wedaman K, Aronov PA, Fontes K, Ramos K, Hammock BD, Powers T (2008) Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab 7(2):148-158
-
(2008)
Cell Metab
, vol.7
, Issue.2
, pp. 148-158
-
-
Aronova, S.1
Wedaman, K.2
Aronov, P.A.3
Fontes, K.4
Ramos, K.5
Hammock, B.D.6
Powers, T.7
-
111
-
-
0027527545
-
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide
-
1:CAS:528:DyaK3sXmsVKmu7k%3D 8253743
-
Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA (1993) Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem 268(35):26226-26232
-
(1993)
J Biol Chem
, vol.268
, Issue.35
, pp. 26226-26232
-
-
Bielawska, A.1
Crane, H.M.2
Liotta, D.3
Obeid, L.M.4
Hannun, Y.A.5
-
112
-
-
84866517745
-
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy
-
1:CAS:528:DC%2BC38Xhs1KjtrjO 22960157
-
Gagliostro V, Casas J, Caretti A, Abad JL, Tagliavacca L, Ghidoni R, Fabrias G, Signorelli P (2012) Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy. Int J Biochem Cell Biol 44(12):2135-2143
-
(2012)
Int J Biochem Cell Biol
, vol.44
, Issue.12
, pp. 2135-2143
-
-
Gagliostro, V.1
Casas, J.2
Caretti, A.3
Abad, J.L.4
Tagliavacca, L.5
Ghidoni, R.6
Fabrias, G.7
Signorelli, P.8
-
113
-
-
80053259864
-
Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins
-
1:CAS:528:DC%2BC3MXht1yku77I 21767261
-
Romero Rosales K, Singh G, Wu K, Chen J, Janes MR, Lilly MB, Peralta ER, Siskind LJ, Bennett MJ, Fruman DA, Edinger AL (2011) Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. Biochem J 439(2):299-311
-
(2011)
Biochem J
, vol.439
, Issue.2
, pp. 299-311
-
-
Romero Rosales, K.1
Singh, G.2
Wu, K.3
Chen, J.4
Janes, M.R.5
Lilly, M.B.6
Peralta, E.R.7
Siskind, L.J.8
Bennett, M.J.9
Fruman, D.A.10
Edinger, A.L.11
-
114
-
-
84875170467
-
TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis
-
3596256 1:CAS:528:DC%2BC3sXkslSksr0%3D 23363605
-
Shimobayashi M, Oppliger W, Moes S, Jeno P, Hall MN (2013) TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Mol Biol Cell 24(6):870-881
-
(2013)
Mol Biol Cell
, vol.24
, Issue.6
, pp. 870-881
-
-
Shimobayashi, M.1
Oppliger, W.2
Moes, S.3
Jeno, P.4
Hall, M.N.5
-
115
-
-
84857131380
-
Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
-
3277121 1:CAS:528:DC%2BC38XitlKlsLw%3D
-
Niles BJ, Mogri H, Hill A, Vlahakis A, Powers T (2012) Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2. Proc Natl Acad Sci USA 109(5):1536-1541
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.5
, pp. 1536-1541
-
-
Niles, B.J.1
Mogri, H.2
Hill, A.3
Vlahakis, A.4
Powers, T.5
-
116
-
-
84860501617
-
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
-
1:CAS:528:DC%2BC38XlsFSqu7s%3D 22504275
-
Berchtold D, Piccolis M, Chiaruttini N, Riezman I, Riezman H, Roux A, Walther TC, Loewith R (2012) Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol 14(5):542-547
-
(2012)
Nat Cell Biol
, vol.14
, Issue.5
, pp. 542-547
-
-
Berchtold, D.1
Piccolis, M.2
Chiaruttini, N.3
Riezman, I.4
Riezman, H.5
Roux, A.6
Walther, T.C.7
Loewith, R.8
-
117
-
-
82755163564
-
Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae
-
3228448 1:CAS:528:DC%2BC3MXhs1eitLnF 22080611
-
Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J (2011) Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 108(48):19222-19227
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.48
, pp. 19222-19227
-
-
Roelants, F.M.1
Breslow, D.K.2
Muir, A.3
Weissman, J.S.4
Thorner, J.5
-
118
-
-
77649121162
-
Orm family proteins mediate sphingolipid homeostasis
-
2877384 1:CAS:528:DC%2BC3cXitl2gs7k%3D 20182505
-
Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS (2010) Orm family proteins mediate sphingolipid homeostasis. Nature 463(7284):1048-1053
-
(2010)
Nature
, vol.463
, Issue.7284
, pp. 1048-1053
-
-
Breslow, D.K.1
Collins, S.R.2
Bodenmiller, B.3
Aebersold, R.4
Simons, K.5
Shevchenko, A.6
Ejsing, C.S.7
Weissman, J.S.8
-
119
-
-
84888433996
-
TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy
-
1:CAS:528:DC%2BC3sXhslyqtbjL 24239358
-
Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rodkaer SV, Clay L, Bjoras M, Barral Y, Chang A, Faergeman NJ, Dunn TM, Riezman H, Enserink JM (2013) TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy. Cell Rep 5(4):1036-1046
-
(2013)
Cell Rep
, vol.5
, Issue.4
, pp. 1036-1046
-
-
Zimmermann, C.1
Santos, A.2
Gable, K.3
Epstein, S.4
Gururaj, C.5
Chymkowitch, P.6
Pultz, D.7
Rodkaer, S.V.8
Clay, L.9
Bjoras, M.10
Barral, Y.11
Chang, A.12
Faergeman, N.J.13
Dunn, T.M.14
Riezman, H.15
Enserink, J.M.16
-
120
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
-
2242811 18282106
-
Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4(2):e24
-
(2008)
PLoS Genet
, vol.4
, Issue.2
, pp. e24
-
-
Hansen, M.1
Chandra, A.2
Mitic, L.L.3
Onken, B.4
Driscoll, M.5
Kenyon, C.6
-
121
-
-
77950656808
-
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
-
2815753 1:CAS:528:DC%2BC3cXpvVentA%3D%3D 20157579
-
Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Tavernarakis N, Madeo F, Kroemer G (2009) Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging 1(12):961-970
-
(2009)
Aging
, vol.1
, Issue.12
, pp. 961-970
-
-
Morselli, E.1
Galluzzi, L.2
Kepp, O.3
Criollo, A.4
Maiuri, M.C.5
Tavernarakis, N.6
Madeo, F.7
Kroemer, G.8
-
122
-
-
35848937781
-
Autophagy is required for dietary restriction-mediated life span extension in C. elegans
-
17912023
-
Jia K, Levine B (2007) Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3(6):597-599
-
(2007)
Autophagy
, vol.3
, Issue.6
, pp. 597-599
-
-
Jia, K.1
Levine, B.2
-
123
-
-
63549108476
-
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
-
2680339 1:CAS:528:DC%2BD1MXks1SrsLY%3D 19239417
-
Greer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8(2):113-127
-
(2009)
Aging Cell
, vol.8
, Issue.2
, pp. 113-127
-
-
Greer, E.L.1
Brunet, A.2
-
124
-
-
84883765669
-
Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan
-
3773046 1:CAS:528:DC%2BC3sXhsVektrjN 23725375
-
Liu J, Huang X, Withers BR, Blalock E, Liu K, Dickson RC (2013) Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan. Aging Cell 12(5):833-841
-
(2013)
Aging Cell
, vol.12
, Issue.5
, pp. 833-841
-
-
Liu, J.1
Huang, X.2
Withers, B.R.3
Blalock, E.4
Liu, K.5
Dickson, R.C.6
-
125
-
-
84859166169
-
Down-regulating sphingolipid synthesis increases yeast lifespan
-
3271065 1:CAS:528:DC%2BC38XisFeqs74%3D
-
Huang X, Liu J, Dickson RC (2012) Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet 8(2):e1002493
-
(2012)
PLoS Genet
, vol.8
, Issue.2
, pp. e1002493
-
-
Huang, X.1
Liu, J.2
Dickson, R.C.3
-
126
-
-
84919392954
-
Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans
-
25437839
-
Cutler RG, Thompson KW, Camandola S, Mack KT, Mattson MP (2014) Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans. Mech Ageing Dev 143-144:9-18
-
(2014)
Mech Ageing Dev
, vol.143-144
, pp. 9-18
-
-
Cutler, R.G.1
Thompson, K.W.2
Camandola, S.3
Mack, K.T.4
Mattson, M.P.5
-
127
-
-
84880478801
-
Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans
-
3716707 1:CAS:528:DC%2BC3sXht1aju7jJ
-
Mosbech MB, Kruse R, Harvald EB, Olsen AS, Gallego SF, Hannibal-Bach HK, Ejsing CS, Faergeman NJ (2013) Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans. PLoS One 8(7):e70087
-
(2013)
PLoS One
, vol.8
, Issue.7
, pp. e70087
-
-
Mosbech, M.B.1
Kruse, R.2
Harvald, E.B.3
Olsen, A.S.4
Gallego, S.F.5
Hannibal-Bach, H.K.6
Ejsing, C.S.7
Faergeman, N.J.8
-
128
-
-
66949135852
-
Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells
-
2714426 1:CAS:528:DC%2BD1MXksFWqsrY%3D 19240113
-
Marza E, Simonsen KT, Faergeman NJ, Lesa GM (2009) Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells. J Cell Sci 122(Pt 6):822-833
-
(2009)
J Cell Sci
, vol.122
, pp. 822-833
-
-
Marza, E.1
Simonsen, K.T.2
Faergeman, N.J.3
Lesa, G.M.4
-
129
-
-
0037423225
-
The uracil transporter Fur4p associates with lipid rafts
-
1:CAS:528:DC%2BD3sXot1KrtQ%3D%3D 12446707
-
Hearn JD, Lester RL, Dickson RC (2003) The uracil transporter Fur4p associates with lipid rafts. J Biol Chem 278(6):3679-3686
-
(2003)
J Biol Chem
, vol.278
, Issue.6
, pp. 3679-3686
-
-
Hearn, J.D.1
Lester, R.L.2
Dickson, R.C.3
-
130
-
-
34547752909
-
Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: Essential role in transport activity and normal control by ubiquitination
-
1949357 1:CAS:528:DC%2BD2sXovFaksr0%3D 17553927
-
Lauwers E, Grossmann G, Andre B (2007) Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitination. Mol Biol Cell 18(8):3068-3080
-
(2007)
Mol Biol Cell
, vol.18
, Issue.8
, pp. 3068-3080
-
-
Lauwers, E.1
Grossmann, G.2
Andre, B.3
-
131
-
-
79953227034
-
A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae
-
3063671 1:CAS:528:DC%2BC3MXmsVSgs7g%3D 21196517
-
Finnigan GC, Ryan M, Stevens TH (2011) A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Genetics 187(3):771-783
-
(2011)
Genetics
, vol.187
, Issue.3
, pp. 771-783
-
-
Finnigan, G.C.1
Ryan, M.2
Stevens, T.H.3
-
132
-
-
75149176725
-
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
-
2797032 19723703
-
Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B (2010) Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J 24(1):296-308
-
(2010)
FASEB J
, vol.24
, Issue.1
, pp. 296-308
-
-
Senkal, C.E.1
Ponnusamy, S.2
Bielawski, J.3
Hannun, Y.A.4
Ogretmen, B.5
-
133
-
-
28144431972
-
Acyl chain length affects ceramide action on sterol/sphingomyelin-rich domains
-
1:CAS:528:DC%2BD2MXht1OltLjP 16321609
-
Nybond S, Bjorkqvist YJ, Ramstedt B, Slotte JP (2005) Acyl chain length affects ceramide action on sterol/sphingomyelin-rich domains. Biochim Biophys Acta 1718(1-2):61-66
-
(2005)
Biochim Biophys Acta
, vol.1718
, Issue.1-2
, pp. 61-66
-
-
Nybond, S.1
Bjorkqvist, Y.J.2
Ramstedt, B.3
Slotte, J.P.4
-
134
-
-
84919781522
-
Autophagy regulates sphingolipid levels in the liver
-
1:CAS:528:DC%2BC2cXhvF2rsb7I 25332431
-
Alexaki A, Gupta SD, Majumder S, Kono M, Tuymetova G, Harmon JM, Dunn TM, Proia RL (2014) Autophagy regulates sphingolipid levels in the liver. J Lipid Res 55(12):2521-2531
-
(2014)
J Lipid Res
, vol.55
, Issue.12
, pp. 2521-2531
-
-
Alexaki, A.1
Gupta, S.D.2
Majumder, S.3
Kono, M.4
Tuymetova, G.5
Harmon, J.M.6
Dunn, T.M.7
Proia, R.L.8
-
135
-
-
84870995648
-
Regulation of lipid stores and metabolism by lipophagy
-
3524634 22595754
-
Liu K, Czaja MJ (2012) Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ 20:3-11
-
(2012)
Cell Death Differ
, vol.20
, pp. 3-11
-
-
Liu, K.1
Czaja, M.J.2
-
136
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
2676208 1:CAS:528:DC%2BD1MXjvV2ks7s%3D 19339967
-
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ (2009) Autophagy regulates lipid metabolism. Nature 458(7242):1131-1135
-
(2009)
Nature
, vol.458
, Issue.7242
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
Xiang, Y.4
Novak, I.5
Komatsu, M.6
Tanaka, K.7
Cuervo, A.M.8
Czaja, M.J.9
|