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Volumn 20, Issue 5, 2015, Pages 658-670

Autophagy in the light of sphingolipid metabolism

Author keywords

Apoptosis; Autophagy; Ceramide; Sphingolipids; Sphingosine 1 phosphate; TOR

Indexed keywords

SPHINGOLIPID;

EID: 84939979972     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1108-2     Document Type: Review
Times cited : (72)

References (136)
  • 1
    • 84897954412 scopus 로고    scopus 로고
    • Autophagy paradox and ceramide
    • 1:CAS:528:DC%2BC3sXhsFGqs7fN 24055889
    • Jiang W, Ogretmen B (2014) Autophagy paradox and ceramide. Biochim Biophys Acta 1841(5):783-792
    • (2014) Biochim Biophys Acta , vol.1841 , Issue.5 , pp. 783-792
    • Jiang, W.1    Ogretmen, B.2
  • 2
    • 0029948396 scopus 로고    scopus 로고
    • Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
    • 1:CAS:528:DyaK28XjvVKnsro%3D 8657285
    • Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S (1996) Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381(6585):800-803
    • (1996) Nature , vol.381 , Issue.6585 , pp. 800-803
    • Cuvillier, O.1    Pirianov, G.2    Kleuser, B.3    Vanek, P.G.4    Coso, O.A.5    Gutkind, S.6    Spiegel, S.7
  • 4
    • 84868628424 scopus 로고    scopus 로고
    • Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes
    • 3484448 1:CAS:528:DC%2BC38Xhs1Cis7fE 23023704
    • Russo SB, Baicu CF, Van Laer A, Geng T, Kasiganesan H, Zile MR, Cowart LA (2012) Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes. J Clin Invest 122(11):3919-3930
    • (2012) J Clin Invest , vol.122 , Issue.11 , pp. 3919-3930
    • Russo, S.B.1    Baicu, C.F.2    Van Laer, A.3    Geng, T.4    Kasiganesan, H.5    Zile, M.R.6    Cowart, L.A.7
  • 7
    • 50249103834 scopus 로고    scopus 로고
    • The cell biology of autophagy in metazoans: A developing story
    • 2702844 1:CAS:528:DC%2BD1cXhtVehs7jI 18567846
    • Melendez A, Neufeld TP (2008) The cell biology of autophagy in metazoans: a developing story. Development 135(14):2347-2360
    • (2008) Development , vol.135 , Issue.14 , pp. 2347-2360
    • Melendez, A.1    Neufeld, T.P.2
  • 8
    • 53549113031 scopus 로고    scopus 로고
    • The role of TOR in autophagy regulation from yeast to plants and mammals
    • 1:CAS:528:DC%2BD1cXht12rurvO 18670193
    • Diaz-Troya S, Perez-Perez ME, Florencio FJ, Crespo JL (2008) The role of TOR in autophagy regulation from yeast to plants and mammals. Autophagy 4(7):851-865
    • (2008) Autophagy , vol.4 , Issue.7 , pp. 851-865
    • Diaz-Troya, S.1    Perez-Perez, M.E.2    Florencio, F.J.3    Crespo, J.L.4
  • 9
    • 53849119118 scopus 로고    scopus 로고
    • Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism
    • 1:CAS:528:DC%2BD1cXht1aisrfE 18651095
    • Liao XH, Majithia A, Huang X, Kimmel AR (2008) Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism. Amino Acids 35(4):761-770
    • (2008) Amino Acids , vol.35 , Issue.4 , pp. 761-770
    • Liao, X.H.1    Majithia, A.2    Huang, X.3    Kimmel, A.R.4
  • 11
    • 84856275868 scopus 로고    scopus 로고
    • PtdIns 3-kinase orchestrates autophagosome formation in yeast
    • 3067060 21490802
    • Obara K, Ohsumi Y (2011) PtdIns 3-kinase orchestrates autophagosome formation in yeast. J Lipids. doi: 10.1155/2011/498768
    • (2011) J Lipids
    • Obara, K.1    Ohsumi, Y.2
  • 12
    • 77956414236 scopus 로고    scopus 로고
    • The origin of the autophagosomal membrane
    • 1:CAS:528:DC%2BC3cXhtFSju7zK 20811355
    • Tooze SA, Yoshimori T (2010) The origin of the autophagosomal membrane. Nat Cell Biol 12(9):831-835
    • (2010) Nat Cell Biol , vol.12 , Issue.9 , pp. 831-835
    • Tooze, S.A.1    Yoshimori, T.2
  • 13
    • 77955165003 scopus 로고    scopus 로고
    • The plasma membrane brings autophagosomes to life
    • 1:CAS:528:DC%2BC3cXpsFWnsLs%3D 20680002
    • Cuervo AM (2010) The plasma membrane brings autophagosomes to life. Nat Cell Biol 12(8):735-737
    • (2010) Nat Cell Biol , vol.12 , Issue.8 , pp. 735-737
    • Cuervo, A.M.1
  • 14
    • 77957669416 scopus 로고    scopus 로고
    • The Golgi as a potential membrane source for autophagy
    • 3359472 20729630
    • Geng J, Klionsky DJ (2010) The Golgi as a potential membrane source for autophagy. Autophagy 6(7):950-951
    • (2010) Autophagy , vol.6 , Issue.7 , pp. 950-951
    • Geng, J.1    Klionsky, D.J.2
  • 16
    • 84881506338 scopus 로고    scopus 로고
    • The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis
    • 3736544 23930225
    • Ge L, Melville D, Zhang M, Schekman R (2013) The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. eLife 2:e00947
    • (2013) ELife , vol.2 , pp. e00947
    • Ge, L.1    Melville, D.2    Zhang, M.3    Schekman, R.4
  • 18
    • 84988422403 scopus 로고    scopus 로고
    • ATG16L1 meets ATG9 in recycling endosomes: Additional roles for the plasma membrane and endocytosis in autophagosome biogenesis
    • 1:CAS:528:DC%2BC2cXht1Gns7jP 24257061
    • Puri C, Renna M, Bento CF, Moreau K, Rubinsztein DC (2014) ATG16L1 meets ATG9 in recycling endosomes: additional roles for the plasma membrane and endocytosis in autophagosome biogenesis. Autophagy 10(1):182-184
    • (2014) Autophagy , vol.10 , Issue.1 , pp. 182-184
    • Puri, C.1    Renna, M.2    Bento, C.F.3    Moreau, K.4    Rubinsztein, D.C.5
  • 22
    • 84870880174 scopus 로고    scopus 로고
    • The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
    • 1:CAS:528:DC%2BC38XhvVaisrvK 23217709
    • Itakura E, Kishi-Itakura C, Mizushima N (2012) The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151(6):1256-1269
    • (2012) Cell , vol.151 , Issue.6 , pp. 1256-1269
    • Itakura, E.1    Kishi-Itakura, C.2    Mizushima, N.3
  • 23
    • 84901381389 scopus 로고    scopus 로고
    • The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17
    • 3982997 24554770
    • Jiang P, Nishimura T, Sakamaki Y, Itakura E, Hatta T, Natsume T, Mizushima N (2014) The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell 25(8):1327-1337
    • (2014) Mol Biol Cell , vol.25 , Issue.8 , pp. 1327-1337
    • Jiang, P.1    Nishimura, T.2    Sakamaki, Y.3    Itakura, E.4    Hatta, T.5    Natsume, T.6    Mizushima, N.7
  • 24
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • 2854249 1:CAS:528:DC%2BC3cXks1SrtL4%3D 20034776
    • Yang Z, Klionsky DJ (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22(2):124-131
    • (2010) Curr Opin Cell Biol , vol.22 , Issue.2 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 25
    • 67650517556 scopus 로고    scopus 로고
    • NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
    • 1:CAS:528:DC%2BC3cXovFykuw%3D%3D 19502794
    • Lamark T, Kirkin V, Dikic I, Johansen T (2009) NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 8(13):1986-1990
    • (2009) Cell Cycle , vol.8 , Issue.13 , pp. 1986-1990
    • Lamark, T.1    Kirkin, V.2    Dikic, I.3    Johansen, T.4
  • 26
    • 78049498376 scopus 로고    scopus 로고
    • Ceramide synthases: Roles in cell physiology and signaling
    • 1:CAS:528:DC%2BC3MXjsFGhtQ%3D%3D 20919646
    • Stiban J, Tidhar R, Futerman AH (2010) Ceramide synthases: roles in cell physiology and signaling. Adv Exp Med Biol 688:60-71
    • (2010) Adv Exp Med Biol , vol.688 , pp. 60-71
    • Stiban, J.1    Tidhar, R.2    Futerman, A.H.3
  • 27
    • 78049518892 scopus 로고    scopus 로고
    • An overview of sphingolipid metabolism: From synthesis to breakdown
    • 3069696 1:CAS:528:DC%2BC3MXjsFGhtg%3D%3D 20919643
    • Gault CR, Obeid LM, Hannun YA (2010) An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol 688:1-23
    • (2010) Adv Exp Med Biol , vol.688 , pp. 1-23
    • Gault, C.R.1    Obeid, L.M.2    Hannun, Y.A.3
  • 28
    • 34250898152 scopus 로고    scopus 로고
    • Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy
    • 17560117
    • Huwiler A, Zangemeister-Wittke U (2007) Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. Critical reviews in oncology/hematology 63(2):150-159
    • (2007) Critical Reviews in Oncology/hematology , vol.63 , Issue.2 , pp. 150-159
    • Huwiler, A.1    Zangemeister-Wittke, U.2
  • 29
    • 0031919157 scopus 로고    scopus 로고
    • Regulation of ceramide production and apoptosis
    • 1:CAS:528:DyaK1cXitVOhsbg%3D 9558480
    • Kolesnick RN, Kronke M (1998) Regulation of ceramide production and apoptosis. Annu Rev Physiol 60:643-665
    • (1998) Annu Rev Physiol , vol.60 , pp. 643-665
    • Kolesnick, R.N.1    Kronke, M.2
  • 30
    • 77951887251 scopus 로고    scopus 로고
    • Glycosphingolipids in microdomain formation and their spatial organization
    • 1:CAS:528:DC%2BC3cXkvFKqtb8%3D 19941856
    • Gupta G, Surolia A (2010) Glycosphingolipids in microdomain formation and their spatial organization. FEBS Lett 584(9):1634-1641
    • (2010) FEBS Lett , vol.584 , Issue.9 , pp. 1634-1641
    • Gupta, G.1    Surolia, A.2
  • 31
    • 77956277183 scopus 로고    scopus 로고
    • Lipid microdomains and the regulation of ion channel function
    • 2976012 1:CAS:528:DC%2BC3cXhtF2rur7O 20519314
    • Dart C (2010) Lipid microdomains and the regulation of ion channel function. J Physiol 588(Pt 17):3169-3178
    • (2010) J Physiol , vol.588 , pp. 3169-3178
    • Dart, C.1
  • 32
    • 84875844779 scopus 로고    scopus 로고
    • Ripples in the pond-using a systems approach to decipher the cellular functions of membrane microdomains
    • 1:CAS:528:DC%2BC3sXitVequ7s%3D 23322173
    • Inder KL, Davis M, Hill MM (2013) Ripples in the pond-using a systems approach to decipher the cellular functions of membrane microdomains. Mol Biosyst 9(3):330-338
    • (2013) Mol Biosyst , vol.9 , Issue.3 , pp. 330-338
    • Inder, K.L.1    Davis, M.2    Hill, M.M.3
  • 33
    • 84872959202 scopus 로고    scopus 로고
    • Caveolae as plasma membrane sensors, protectors and organizers
    • 1:CAS:528:DC%2BC3sXhtFGrt74%3D 23340574
    • Parton RG, del Pozo MA (2013) Caveolae as plasma membrane sensors, protectors and organizers. Nat Rev Mol Cell Biol 14(2):98-112
    • (2013) Nat Rev Mol Cell Biol , vol.14 , Issue.2 , pp. 98-112
    • Parton, R.G.1    Del Pozo, M.A.2
  • 34
    • 84897954501 scopus 로고    scopus 로고
    • Sphingolipids as modulators of membrane proteins
    • 1:CAS:528:DC%2BC3sXhsl2mu7bL 24201378
    • Ernst AM, Brugger B (2014) Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta 1841(5):665-670
    • (2014) Biochim Biophys Acta , vol.1841 , Issue.5 , pp. 665-670
    • Ernst, A.M.1    Brugger, B.2
  • 35
    • 0347611095 scopus 로고    scopus 로고
    • Molecular machinery for non-vesicular trafficking of ceramide
    • 1:CAS:528:DC%2BD3sXpvVGmtL8%3D 14685229
    • Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M (2003) Molecular machinery for non-vesicular trafficking of ceramide. Nature 426(6968):803-809
    • (2003) Nature , vol.426 , Issue.6968 , pp. 803-809
    • Hanada, K.1    Kumagai, K.2    Yasuda, S.3    Miura, Y.4    Kawano, M.5    Fukasawa, M.6    Nishijima, M.7
  • 36
    • 34547096008 scopus 로고    scopus 로고
    • Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT
    • 1:CAS:528:DC%2BD2sXmt1ersLo%3D 17442665
    • Kumagai K, Kawano M, Shinkai-Ouchi F, Nishijima M, Hanada K (2007) Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT. J Biol Chem 282(24):17758-17766
    • (2007) J Biol Chem , vol.282 , Issue.24 , pp. 17758-17766
    • Kumagai, K.1    Kawano, M.2    Shinkai-Ouchi, F.3    Nishijima, M.4    Hanada, K.5
  • 37
    • 38649131260 scopus 로고    scopus 로고
    • Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide
    • 2206563 1:CAS:528:DC%2BD1cXpvV2mtA%3D%3D 18184806
    • Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R (2008) Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci USA 105(2):488-493
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.2 , pp. 488-493
    • Kudo, N.1    Kumagai, K.2    Tomishige, N.3    Yamaji, T.4    Wakatsuki, S.5    Nishijima, M.6    Hanada, K.7    Kato, R.8
  • 38
    • 34249820539 scopus 로고    scopus 로고
    • CERT and intracellular trafficking of ceramide
    • 1:CAS:528:DC%2BD2sXmtlWgsbY%3D 17314061
    • Hanada K, Kumagai K, Tomishige N, Kawano M (2007) CERT and intracellular trafficking of ceramide. Biochim Biophys Acta 1771(6):644-653
    • (2007) Biochim Biophys Acta , vol.1771 , Issue.6 , pp. 644-653
    • Hanada, K.1    Kumagai, K.2    Tomishige, N.3    Kawano, M.4
  • 39
    • 20444402239 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of ceramide transport
    • 1:CAS:528:DC%2BD2MXltVaquro%3D 15907394
    • Perry RJ, Ridgway ND (2005) Molecular mechanisms and regulation of ceramide transport. Biochim Biophys Acta 1734(3):220-234
    • (2005) Biochim Biophys Acta , vol.1734 , Issue.3 , pp. 220-234
    • Perry, R.J.1    Ridgway, N.D.2
  • 40
    • 14644393694 scopus 로고    scopus 로고
    • Lipid traffic: Floppy drives and a superhighway
    • 1:CAS:528:DC%2BD2MXhslSlsLg%3D 15738987
    • Holthuis JC, Levine TP (2005) Lipid traffic: floppy drives and a superhighway. Nat Rev Mol Cell Biol 6(3):209-220
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.3 , pp. 209-220
    • Holthuis, J.C.1    Levine, T.P.2
  • 42
    • 84893766895 scopus 로고    scopus 로고
    • Membranes and mammalian glycolipid transferring proteins
    • 1:CAS:528:DC%2BC3sXhvVKgtrbF 24220498
    • Tuuf J, Mattjus P (2014) Membranes and mammalian glycolipid transferring proteins. Chem Phys Lipids 178:27-37
    • (2014) Chem Phys Lipids , vol.178 , pp. 27-37
    • Tuuf, J.1    Mattjus, P.2
  • 43
    • 0021869543 scopus 로고
    • Specificity of the glycolipid transfer protein from pig brain
    • 1:CAS:528:DyaL2MXhvF2ksbs%3D 3988728
    • Yamada K, Abe A, Sasaki T (1985) Specificity of the glycolipid transfer protein from pig brain. J Biol Chem 260(8):4615-4621
    • (1985) J Biol Chem , vol.260 , Issue.8 , pp. 4615-4621
    • Yamada, K.1    Abe, A.2    Sasaki, T.3
  • 44
    • 0022416514 scopus 로고
    • Properties of a specific glycolipid transfer protein from bovine brain
    • 1:CAS:528:DyaL2MXltlOns7s%3D 4064225
    • Brown RE, Stephenson FA, Markello T, Barenholz Y, Thompson TE (1985) Properties of a specific glycolipid transfer protein from bovine brain. Chem Phys Lipids 38(1-2):79-93
    • (1985) Chem Phys Lipids , vol.38 , Issue.1-2 , pp. 79-93
    • Brown, R.E.1    Stephenson, F.A.2    Markello, T.3    Barenholz, Y.4    Thompson, T.E.5
  • 45
    • 22544464453 scopus 로고    scopus 로고
    • Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex
    • 1393170 1:CAS:528:DC%2BD2MXlvFymtb4%3D 15901739
    • Malakhova ML, Malinina L, Pike HM, Kanack AT, Patel DJ, Brown RE (2005) Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex. J Biol Chem 280(28):26312-26320
    • (2005) J Biol Chem , vol.280 , Issue.28 , pp. 26312-26320
    • Malakhova, M.L.1    Malinina, L.2    Pike, H.M.3    Kanack, A.T.4    Patel, D.J.5    Brown, R.E.6
  • 48
    • 77955789211 scopus 로고    scopus 로고
    • Altered lipid content inhibits autophagic vesicular fusion
    • 2909278 1:CAS:528:DC%2BC3cXhtVeitr%2FE 20375270
    • Koga H, Kaushik S, Cuervo AM (2010) Altered lipid content inhibits autophagic vesicular fusion. FASEB J 24(8):3052-3065
    • (2010) FASEB J , vol.24 , Issue.8 , pp. 3052-3065
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 49
    • 79960294696 scopus 로고    scopus 로고
    • Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae
    • 1:CAS:528:DC%2BC3MXptVyqt7s%3D 21703229
    • Yamagata M, Obara K, Kihara A (2011) Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae. Biochem Biophys Res Commun 410(4):786-791
    • (2011) Biochem Biophys Res Commun , vol.410 , Issue.4 , pp. 786-791
    • Yamagata, M.1    Obara, K.2    Kihara, A.3
  • 50
    • 0032509523 scopus 로고    scopus 로고
    • The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion
    • 1:CAS:528:DyaK1MXmsA%3D%3D 9837889
    • Hinkovska-Galcheva VT, Boxer LA, Mansfield PJ, Harsh D, Blackwood A, Shayman JA (1998) The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion. J Biol Chem 273(50):33203-33209
    • (1998) J Biol Chem , vol.273 , Issue.50 , pp. 33203-33209
    • Hinkovska-Galcheva, V.T.1    Boxer, L.A.2    Mansfield, P.J.3    Harsh, D.4    Blackwood, A.5    Shayman, J.A.6
  • 52
    • 84862611041 scopus 로고    scopus 로고
    • TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes
    • 3365497 1:CAS:528:DC%2BC38XotFWgur8%3D 22613832
    • Longatti A, Lamb CA, Razi M, Yoshimura S, Barr FA, Tooze SA (2012) TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes. J Cell Biol 197(5):659-675
    • (2012) J Cell Biol , vol.197 , Issue.5 , pp. 659-675
    • Longatti, A.1    Lamb, C.A.2    Razi, M.3    Yoshimura, S.4    Barr, F.A.5    Tooze, S.A.6
  • 53
    • 84894275180 scopus 로고    scopus 로고
    • Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization
    • 3923643 24356450
    • Szatmari Z, Kis V, Lippai M, Hegedus K, Farago T, Lorincz P, Tanaka T, Juhasz G, Sass M (2014) Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization. Mol Biol Cell 25(4):522-531
    • (2014) Mol Biol Cell , vol.25 , Issue.4 , pp. 522-531
    • Szatmari, Z.1    Kis, V.2    Lippai, M.3    Hegedus, K.4    Farago, T.5    Lorincz, P.6    Tanaka, T.7    Juhasz, G.8    Sass, M.9
  • 54
    • 58149188064 scopus 로고    scopus 로고
    • Effects of ceramide and other simple sphingolipids on membrane lateral structure
    • 1:CAS:528:DC%2BD1MXksVWmug%3D%3D 18848519
    • Goni FM, Alonso A (2009) Effects of ceramide and other simple sphingolipids on membrane lateral structure. Biochim Biophys Acta 1788(1):169-177
    • (2009) Biochim Biophys Acta , vol.1788 , Issue.1 , pp. 169-177
    • Goni, F.M.1    Alonso, A.2
  • 55
    • 38149085341 scopus 로고    scopus 로고
    • Sphingomyelinase generation of ceramide promotes clustering of nanoscale domains in supported bilayer membranes
    • 1:STN:280:DC%2BD1c%2FltFalsg%3D%3D 17988649
    • Ira Johnston LJ (2008) Sphingomyelinase generation of ceramide promotes clustering of nanoscale domains in supported bilayer membranes. Biochim Biophys Acta 1778(1):185-197
    • (2008) Biochim Biophys Acta , vol.1778 , Issue.1 , pp. 185-197
    • Ira Johnston, L.J.1
  • 56
    • 0032535156 scopus 로고    scopus 로고
    • Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane
    • 1:CAS:528:DyaK1cXnsVGgurY%3D 9860872
    • Holopainen JM, Subramanian M, Kinnunen PK (1998) Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. Biochemistry 37(50):17562-17570
    • (1998) Biochemistry , vol.37 , Issue.50 , pp. 17562-17570
    • Holopainen, J.M.1    Subramanian, M.2    Kinnunen, P.K.3
  • 57
    • 84880523313 scopus 로고    scopus 로고
    • Ceramide in plasma membrane repair
    • 1:CAS:528:DC%2BC3sXhsFKls7vP 23563665
    • Draeger A, Babiychuk EB (2013) Ceramide in plasma membrane repair. Handb Exp Pharmacol 216:341-353
    • (2013) Handb Exp Pharmacol , vol.216 , pp. 341-353
    • Draeger, A.1    Babiychuk, E.B.2
  • 59
    • 77957020175 scopus 로고    scopus 로고
    • Membrane fusion: Five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuoles
    • 1:CAS:528:DC%2BC3cXhsFCnur7J 20521906
    • Wickner W (2010) Membrane fusion: five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuoles. Annu Rev Cell Dev Biol 26:115-136
    • (2010) Annu Rev Cell Dev Biol , vol.26 , pp. 115-136
    • Wickner, W.1
  • 60
    • 0036892508 scopus 로고    scopus 로고
    • Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus
    • 136663 1:CAS:528:DC%2BD38XptVygurY%3D 12438595
    • Samsonov AV, Chatterjee PK, Razinkov VI, Eng CH, Kielian M, Cohen FS (2002) Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus. J Virol 76(24):12691-12702
    • (2002) J Virol , vol.76 , Issue.24 , pp. 12691-12702
    • Samsonov, A.V.1    Chatterjee, P.K.2    Razinkov, V.I.3    Eng, C.H.4    Kielian, M.5    Cohen, F.S.6
  • 61
    • 0028199032 scopus 로고
    • Membrane fusion of Semliki Forest virus requires sphingolipids in the target membrane
    • 395159 1:CAS:528:DyaK2cXksl2qtr0%3D 8026464
    • Nieva JL, Bron R, Corver J, Wilschut J (1994) Membrane fusion of Semliki Forest virus requires sphingolipids in the target membrane. EMBO J 13(12):2797-2804
    • (1994) EMBO J , vol.13 , Issue.12 , pp. 2797-2804
    • Nieva, J.L.1    Bron, R.2    Corver, J.3    Wilschut, J.4
  • 65
    • 84899957348 scopus 로고    scopus 로고
    • High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A
    • 1:CAS:528:DC%2BC2cXhsl2ns7Y%3D 24488099
    • Gabande-Rodriguez E, Boya P, Labrador V, Dotti CG, Ledesma MD (2014) High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A. Cell Death Differ 21(6):864-875
    • (2014) Cell Death Differ , vol.21 , Issue.6 , pp. 864-875
    • Gabande-Rodriguez, E.1    Boya, P.2    Labrador, V.3    Dotti, C.G.4    Ledesma, M.D.5
  • 66
    • 2442485884 scopus 로고    scopus 로고
    • Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
    • 1:CAS:528:DC%2BD2cXjsVKnur4%3D 14970205
    • Scarlatti F, Bauvy C, Ventruti A, Sala G, Cluzeaud F, Vandewalle A, Ghidoni R, Codogno P (2004) Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem 279(18):18384-18391
    • (2004) J Biol Chem , vol.279 , Issue.18 , pp. 18384-18391
    • Scarlatti, F.1    Bauvy, C.2    Ventruti, A.3    Sala, G.4    Cluzeaud, F.5    Vandewalle, A.6    Ghidoni, R.7    Codogno, P.8
  • 67
    • 84869208878 scopus 로고    scopus 로고
    • Regulation of autophagy and its associated cell death by "sphingolipid rheostat": Reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway
    • 3501064 1:CAS:528:DC%2BC38Xhs12ksb%2FN 23035115
    • Taniguchi M, Kitatani K, Kondo T, Hashimoto-Nishimura M, Asano S, Hayashi A, Mitsutake S, Igarashi Y, Umehara H, Takeya H, Kigawa J, Okazaki T (2012) Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. J Biol Chem 287(47):39898-39910
    • (2012) J Biol Chem , vol.287 , Issue.47 , pp. 39898-39910
    • Taniguchi, M.1    Kitatani, K.2    Kondo, T.3    Hashimoto-Nishimura, M.4    Asano, S.5    Hayashi, A.6    Mitsutake, S.7    Igarashi, Y.8    Umehara, H.9    Takeya, H.10    Kigawa, J.11    Okazaki, T.12
  • 68
    • 33646831810 scopus 로고    scopus 로고
    • Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
    • 1:CAS:528:DC%2BD28XivVCgurc%3D 16415355
    • Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R, Botti J, Codogno P (2006) Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 281(13):8518-8527
    • (2006) J Biol Chem , vol.281 , Issue.13 , pp. 8518-8527
    • Lavieu, G.1    Scarlatti, F.2    Sala, G.3    Carpentier, S.4    Levade, T.5    Ghidoni, R.6    Botti, J.7    Codogno, P.8
  • 69
    • 0037119991 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
    • 2173216 12235122
    • Le Stunff H, Galve-Roperh I, Peterson C, Milstien S, Spiegel S (2002) Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol 158(6):1039-1049
    • (2002) J Cell Biol , vol.158 , Issue.6 , pp. 1039-1049
    • Le Stunff, H.1    Galve-Roperh, I.2    Peterson, C.3    Milstien, S.4    Spiegel, S.5
  • 70
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active sphingolipids in cancer pathogenesis and treatment
    • 1:CAS:528:DC%2BD2cXmtVOhsb4%3D 15286740
    • Ogretmen B, Hannun YA (2004) Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 4(8):604-616
    • (2004) Nat Rev Cancer , vol.4 , Issue.8 , pp. 604-616
    • Ogretmen, B.1    Hannun, Y.A.2
  • 71
    • 0034733910 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: Signaling inside and out
    • 1:CAS:528:DC%2BD3cXktlKqsbs%3D 10878250
    • Spiegel S, Milstien S (2000) Sphingosine-1-phosphate: signaling inside and out. FEBS Lett 476(1-2):55-57
    • (2000) FEBS Lett , vol.476 , Issue.1-2 , pp. 55-57
    • Spiegel, S.1    Milstien, S.2
  • 72
    • 78651265495 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy
    • 3131882 1:CAS:528:DC%2BC3MXjs1Cnuw%3D%3D 20798685
    • Lepine S, Allegood JC, Park M, Dent P, Milstien S, Spiegel S (2011) Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell Death Differ 18(2):350-361
    • (2011) Cell Death Differ , vol.18 , Issue.2 , pp. 350-361
    • Lepine, S.1    Allegood, J.C.2    Park, M.3    Dent, P.4    Milstien, S.5    Spiegel, S.6
  • 73
    • 0032508706 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of murine sphingosine kinase
    • 1:CAS:528:DyaK1cXmtFOkur4%3D 9726979
    • Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S (1998) Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem 273(37):23722-23728
    • (1998) J Biol Chem , vol.273 , Issue.37 , pp. 23722-23728
    • Kohama, T.1    Olivera, A.2    Edsall, L.3    Nagiec, M.M.4    Dickson, R.5    Spiegel, S.6
  • 74
    • 0034733556 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
    • 1:CAS:528:DC%2BD3cXkslahsLs%3D 10751414
    • Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S (2000) Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem 275(26):19513-19520
    • (2000) J Biol Chem , vol.275 , Issue.26 , pp. 19513-19520
    • Liu, H.1    Sugiura, M.2    Nava, V.E.3    Edsall, L.C.4    Kono, K.5    Poulton, S.6    Milstien, S.7    Kohama, T.8    Spiegel, S.9
  • 75
    • 0032103445 scopus 로고    scopus 로고
    • Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants
    • 1219509 1:CAS:528:DyaK1cXkt1Sqtr4%3D 9601083
    • Lanterman MM, Saba JD (1998) Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. Biochem J 332(Pt 2):525-531
    • (1998) Biochem J , vol.332 , pp. 525-531
    • Lanterman, M.M.1    Saba, J.D.2
  • 76
    • 0033230364 scopus 로고    scopus 로고
    • Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
    • 2151183 1:CAS:528:DC%2BD3cXislyru7s%3D 10545499
    • Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S, Spiegel S (1999) Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 147(3):545-558
    • (1999) J Cell Biol , vol.147 , Issue.3 , pp. 545-558
    • Olivera, A.1    Kohama, T.2    Edsall, L.3    Nava, V.4    Cuvillier, O.5    Poulton, S.6    Spiegel, S.7
  • 77
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    • 1:CAS:528:DC%2BD3cXlvVSqsg%3D%3D 10638761
    • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403(6765):98-103
    • (2000) Nature , vol.403 , Issue.6765 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 78
    • 77952937151 scopus 로고    scopus 로고
    • Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation
    • 1:CAS:528:DC%2BC3cXmsVOmsrY%3D 20502006
    • Potteck H, Nieuwenhuis B, Luth A, van der Giet M, Kleuser B (2010) Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation. Cell Physiol Biochem 26(1):67-78
    • (2010) Cell Physiol Biochem , vol.26 , Issue.1 , pp. 67-78
    • Potteck, H.1    Nieuwenhuis, B.2    Luth, A.3    Van Der Giet, M.4    Kleuser, B.5
  • 79
    • 57749196164 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM
    • 1:CAS:528:DC%2BD1cXhsFamtb7L 19000755
    • Maeurer C, Holland S, Pierre S, Potstada W, Scholich K (2009) Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. Cell Signal 21(2):293-300
    • (2009) Cell Signal , vol.21 , Issue.2 , pp. 293-300
    • Maeurer, C.1    Holland, S.2    Pierre, S.3    Potstada, W.4    Scholich, K.5
  • 80
    • 0035860831 scopus 로고    scopus 로고
    • Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration
    • 1:CAS:528:DC%2BD3MXntFGitbg%3D 11557736
    • Kluk MJ, Hla T (2001) Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res 89(6):496-502
    • (2001) Circ Res , vol.89 , Issue.6 , pp. 496-502
    • Kluk, M.J.1    Hla, T.2
  • 81
    • 0027991078 scopus 로고
    • Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway
    • 1:CAS:528:DyaK2cXhsF2ltr0%3D 8106352
    • Mattie M, Brooker G, Spiegel S (1994) Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J Biol Chem 269(5):3181-3188
    • (1994) J Biol Chem , vol.269 , Issue.5 , pp. 3181-3188
    • Mattie, M.1    Brooker, G.2    Spiegel, S.3
  • 82
    • 0029079324 scopus 로고
    • Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism
    • 1:CAS:528:DyaK2MXls1eisL8%3D 7744787
    • Wu J, Spiegel S, Sturgill TW (1995) Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. J Biol Chem 270(19):11484-11488
    • (1995) J Biol Chem , vol.270 , Issue.19 , pp. 11484-11488
    • Wu, J.1    Spiegel, S.2    Sturgill, T.W.3
  • 83
    • 0142091073 scopus 로고    scopus 로고
    • Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
    • 1:CAS:528:DC%2BD3sXovFKksLk%3D 12954646
    • Igarashi N, Okada T, Hayashi S, Fujita T, Jahangeer S, Nakamura S (2003) Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J Biol Chem 278(47):46832-46839
    • (2003) J Biol Chem , vol.278 , Issue.47 , pp. 46832-46839
    • Igarashi, N.1    Okada, T.2    Hayashi, S.3    Fujita, T.4    Jahangeer, S.5    Nakamura, S.6
  • 84
    • 34848867249 scopus 로고    scopus 로고
    • Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2
    • 1:CAS:528:DC%2BD2sXhtVWjsb%2FF 17635916
    • Ding G, Sonoda H, Yu H, Kajimoto T, Goparaju SK, Jahangeer S, Okada T, Nakamura S (2007) Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2. J Biol Chem 282(37):27493-27502
    • (2007) J Biol Chem , vol.282 , Issue.37 , pp. 27493-27502
    • Ding, G.1    Sonoda, H.2    Yu, H.3    Kajimoto, T.4    Goparaju, S.K.5    Jahangeer, S.6    Okada, T.7    Nakamura, S.8
  • 86
    • 34250894388 scopus 로고    scopus 로고
    • BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
    • 1:CAS:528:DC%2BD2sXhtVGrtLfJ 17438366
    • Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, Geneste O, Kroemer G (2007) BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 3(4):374-376
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 374-376
    • Maiuri, M.C.1    Criollo, A.2    Tasdemir, E.3    Vicencio, J.M.4    Tajeddine, N.5    Hickman, J.A.6    Geneste, O.7    Kroemer, G.8
  • 87
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
    • 2682037 1:CAS:528:DC%2BD1MXlvFSqu70%3D 19273585
    • Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J, Mazure NM (2009) Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 29(10):2570-2581
    • (2009) Mol Cell Biol , vol.29 , Issue.10 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouyssegur, J.6    Mazure, N.M.7
  • 88
    • 84905392495 scopus 로고    scopus 로고
    • Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons
    • 1:CAS:528:DC%2BC2cXht1SksLfO 24928515
    • Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C (2014) Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem 289(30):20845-20857
    • (2014) J Biol Chem , vol.289 , Issue.30 , pp. 20845-20857
    • Sheng, R.1    Zhang, T.T.2    Felice, V.D.3    Qin, T.4    Qin, Z.H.5    Smith, C.D.6    Sapp, E.7    Difiglia, M.8    Waeber, C.9
  • 90
    • 0032514918 scopus 로고    scopus 로고
    • BAD enables ceramide to signal apoptosis via Ras and Raf-1
    • 1:CAS:528:DyaK1cXnsVyrurs%3D 9804808
    • Basu S, Bayoumy S, Zhang Y, Lozano J, Kolesnick R (1998) BAD enables ceramide to signal apoptosis via Ras and Raf-1. J Biol Chem 273(46):30419-30426
    • (1998) J Biol Chem , vol.273 , Issue.46 , pp. 30419-30426
    • Basu, S.1    Bayoumy, S.2    Zhang, Y.3    Lozano, J.4    Kolesnick, R.5
  • 92
    • 0033575320 scopus 로고    scopus 로고
    • Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
    • 1:CAS:528:DyaK1MXks1OjsL0%3D 10400650
    • Ruvolo PP, Deng X, Ito T, Carr BK, May WS (1999) Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J Biol Chem 274(29):20296-20300
    • (1999) J Biol Chem , vol.274 , Issue.29 , pp. 20296-20300
    • Ruvolo, P.P.1    Deng, X.2    Ito, T.3    Carr, B.K.4    May, W.S.5
  • 93
    • 0032566717 scopus 로고    scopus 로고
    • A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis
    • 1:CAS:528:DyaK1cXmsVGlsr8%3D 9738012
    • Ruvolo PP, Deng X, Carr BK, May WS (1998) A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem 273(39):25436-25442
    • (1998) J Biol Chem , vol.273 , Issue.39 , pp. 25436-25442
    • Ruvolo, P.P.1    Deng, X.2    Carr, B.K.3    May, W.S.4
  • 95
    • 0037203342 scopus 로고    scopus 로고
    • Ceramide in apoptosis: An overview and current perspectives
    • 1:CAS:528:DC%2BD3sXivVOqtg%3D%3D 12531544
    • Pettus BJ, Chalfant CE, Hannun YA (2002) Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 1585(2-3):114-125
    • (2002) Biochim Biophys Acta , vol.1585 , Issue.2-3 , pp. 114-125
    • Pettus, B.J.1    Chalfant, C.E.2    Hannun, Y.A.3
  • 96
    • 84860507660 scopus 로고    scopus 로고
    • Ceramide and apoptosis: Exploring the enigmatic connections between sphingolipid metabolism and programmed cell death
    • 1:CAS:528:DC%2BC38XmsF2nsrc%3D 21707511
    • Mullen TD, Obeid LM (2012) Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death. Anticancer Agents Med Chem 12(4):340-363
    • (2012) Anticancer Agents Med Chem , vol.12 , Issue.4 , pp. 340-363
    • Mullen, T.D.1    Obeid, L.M.2
  • 97
    • 33747603712 scopus 로고    scopus 로고
    • Sphingosine and ceramide signalling in apoptosis
    • 1:CAS:528:DC%2BD28XhtVWnurjE 16916783
    • Woodcock J (2006) Sphingosine and ceramide signalling in apoptosis. IUBMB Life 58(8):462-466
    • (2006) IUBMB Life , vol.58 , Issue.8 , pp. 462-466
    • Woodcock, J.1
  • 98
    • 3042562282 scopus 로고    scopus 로고
    • Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
    • 1:CAS:528:DC%2BD2cXkvFWlsb0%3D 15205343
    • Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S (2004) Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 64(12):4286-4293
    • (2004) Cancer Res , vol.64 , Issue.12 , pp. 4286-4293
    • Daido, S.1    Kanzawa, T.2    Yamamoto, A.3    Takeuchi, H.4    Kondo, Y.5    Kondo, S.6
  • 99
    • 7744235672 scopus 로고    scopus 로고
    • Death by design: Apoptosis, necrosis and autophagy
    • 1:CAS:528:DC%2BD2cXpsVOrtbk%3D 15530778
    • Edinger AL, Thompson CB (2004) Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16(6):663-669
    • (2004) Curr Opin Cell Biol , vol.16 , Issue.6 , pp. 663-669
    • Edinger, A.L.1    Thompson, C.B.2
  • 100
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • 1236698 1:CAS:528:DC%2BD2MXhtVygt7jJ 16200202
    • Levine B, Yuan J (2005) Autophagy in cell death: an innocent convict? J Clin Investig 115(10):2679-2688
    • (2005) J Clin Investig , vol.115 , Issue.10 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 101
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • 1:CAS:528:DC%2BD2cXksVGmsbg%3D 15131264
    • Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ (2004) Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304(5676):1500-1502
    • (2004) Science , vol.304 , Issue.5676 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3    Dutt, P.4    Freundt, E.5    Welsh, S.6    Baehrecke, E.H.7    Lenardo, M.J.8
  • 102
    • 10344262564 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
    • 1:CAS:528:DC%2BD2cXhtVarsL%2FJ 15558033
    • Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y (2004) Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6(12):1221-1228
    • (2004) Nat Cell Biol , vol.6 , Issue.12 , pp. 1221-1228
    • Shimizu, S.1    Kanaseki, T.2    Mizushima, N.3    Mizuta, T.4    Arakawa-Kobayashi, S.5    Thompson, C.B.6    Tsujimoto, Y.7
  • 103
    • 84863009089 scopus 로고    scopus 로고
    • The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death
    • 22613819
    • Van Brocklyn JR, Williams JB (2012) The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death. Comp Biochem Physiol B 163(1):26-36
    • (2012) Comp Biochem Physiol B , vol.163 , Issue.1 , pp. 26-36
    • Van Brocklyn, J.R.1    Williams, J.B.2
  • 105
    • 38749136302 scopus 로고    scopus 로고
    • Regulation of macroautophagy by mTOR and Beclin 1 complexes
    • 1:CAS:528:DC%2BD1cXhsVGktLY%3D 17928127
    • Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P (2008) Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 90(2):313-323
    • (2008) Biochimie , vol.90 , Issue.2 , pp. 313-323
    • Pattingre, S.1    Espert, L.2    Biard-Piechaczyk, M.3    Codogno, P.4
  • 106
    • 18644386792 scopus 로고    scopus 로고
    • Ceramide triggers an NF-kappaB-dependent survival pathway through calpain
    • 1:CAS:528:DC%2BD2MXkvVSrtLo%3D 15933726
    • Demarchi F, Bertoli C, Greer PA, Schneider C (2005) Ceramide triggers an NF-kappaB-dependent survival pathway through calpain. Cell Death Differ 12(5):512-522
    • (2005) Cell Death Differ , vol.12 , Issue.5 , pp. 512-522
    • Demarchi, F.1    Bertoli, C.2    Greer, P.A.3    Schneider, C.4
  • 107
    • 21744460556 scopus 로고    scopus 로고
    • Multiple death pathways in retina-derived 661 W cells following growth factor deprivation: Crosstalk between caspases and calpains
    • 1:CAS:528:DC%2BD2MXltFKjsb4%3D 15846377
    • Gomez-Vicente V, Donovan M, Cotter TG (2005) Multiple death pathways in retina-derived 661 W cells following growth factor deprivation: crosstalk between caspases and calpains. Cell Death Differ 12(7):796-804
    • (2005) Cell Death Differ , vol.12 , Issue.7 , pp. 796-804
    • Gomez-Vicente, V.1    Donovan, M.2    Cotter, T.G.3
  • 108
    • 0001110114 scopus 로고    scopus 로고
    • Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
    • 1:CAS:528:DC%2BD3cXhsVymtrk%3D 10671558
    • Chua BT, Guo K, Li P (2000) Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases. J Biol Chem 275(7):5131-5135
    • (2000) J Biol Chem , vol.275 , Issue.7 , pp. 5131-5135
    • Chua, B.T.1    Guo, K.2    Li, P.3
  • 111
    • 0027527545 scopus 로고
    • Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide
    • 1:CAS:528:DyaK3sXmsVKmu7k%3D 8253743
    • Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA (1993) Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem 268(35):26226-26232
    • (1993) J Biol Chem , vol.268 , Issue.35 , pp. 26226-26232
    • Bielawska, A.1    Crane, H.M.2    Liotta, D.3    Obeid, L.M.4    Hannun, Y.A.5
  • 114
    • 84875170467 scopus 로고    scopus 로고
    • TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis
    • 3596256 1:CAS:528:DC%2BC3sXkslSksr0%3D 23363605
    • Shimobayashi M, Oppliger W, Moes S, Jeno P, Hall MN (2013) TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Mol Biol Cell 24(6):870-881
    • (2013) Mol Biol Cell , vol.24 , Issue.6 , pp. 870-881
    • Shimobayashi, M.1    Oppliger, W.2    Moes, S.3    Jeno, P.4    Hall, M.N.5
  • 115
    • 84857131380 scopus 로고    scopus 로고
    • Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
    • 3277121 1:CAS:528:DC%2BC38XitlKlsLw%3D
    • Niles BJ, Mogri H, Hill A, Vlahakis A, Powers T (2012) Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2. Proc Natl Acad Sci USA 109(5):1536-1541
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.5 , pp. 1536-1541
    • Niles, B.J.1    Mogri, H.2    Hill, A.3    Vlahakis, A.4    Powers, T.5
  • 116
    • 84860501617 scopus 로고    scopus 로고
    • Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
    • 1:CAS:528:DC%2BC38XlsFSqu7s%3D 22504275
    • Berchtold D, Piccolis M, Chiaruttini N, Riezman I, Riezman H, Roux A, Walther TC, Loewith R (2012) Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol 14(5):542-547
    • (2012) Nat Cell Biol , vol.14 , Issue.5 , pp. 542-547
    • Berchtold, D.1    Piccolis, M.2    Chiaruttini, N.3    Riezman, I.4    Riezman, H.5    Roux, A.6    Walther, T.C.7    Loewith, R.8
  • 117
    • 82755163564 scopus 로고    scopus 로고
    • Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae
    • 3228448 1:CAS:528:DC%2BC3MXhs1eitLnF 22080611
    • Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J (2011) Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 108(48):19222-19227
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.48 , pp. 19222-19227
    • Roelants, F.M.1    Breslow, D.K.2    Muir, A.3    Weissman, J.S.4    Thorner, J.5
  • 120
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    • 2242811 18282106
    • Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4(2):e24
    • (2008) PLoS Genet , vol.4 , Issue.2 , pp. e24
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 121
    • 77950656808 scopus 로고    scopus 로고
    • Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
    • 2815753 1:CAS:528:DC%2BC3cXpvVentA%3D%3D 20157579
    • Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Tavernarakis N, Madeo F, Kroemer G (2009) Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging 1(12):961-970
    • (2009) Aging , vol.1 , Issue.12 , pp. 961-970
    • Morselli, E.1    Galluzzi, L.2    Kepp, O.3    Criollo, A.4    Maiuri, M.C.5    Tavernarakis, N.6    Madeo, F.7    Kroemer, G.8
  • 122
    • 35848937781 scopus 로고    scopus 로고
    • Autophagy is required for dietary restriction-mediated life span extension in C. elegans
    • 17912023
    • Jia K, Levine B (2007) Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3(6):597-599
    • (2007) Autophagy , vol.3 , Issue.6 , pp. 597-599
    • Jia, K.1    Levine, B.2
  • 123
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • 2680339 1:CAS:528:DC%2BD1MXks1SrsLY%3D 19239417
    • Greer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8(2):113-127
    • (2009) Aging Cell , vol.8 , Issue.2 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 124
    • 84883765669 scopus 로고    scopus 로고
    • Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan
    • 3773046 1:CAS:528:DC%2BC3sXhsVektrjN 23725375
    • Liu J, Huang X, Withers BR, Blalock E, Liu K, Dickson RC (2013) Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan. Aging Cell 12(5):833-841
    • (2013) Aging Cell , vol.12 , Issue.5 , pp. 833-841
    • Liu, J.1    Huang, X.2    Withers, B.R.3    Blalock, E.4    Liu, K.5    Dickson, R.C.6
  • 125
    • 84859166169 scopus 로고    scopus 로고
    • Down-regulating sphingolipid synthesis increases yeast lifespan
    • 3271065 1:CAS:528:DC%2BC38XisFeqs74%3D
    • Huang X, Liu J, Dickson RC (2012) Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet 8(2):e1002493
    • (2012) PLoS Genet , vol.8 , Issue.2 , pp. e1002493
    • Huang, X.1    Liu, J.2    Dickson, R.C.3
  • 126
    • 84919392954 scopus 로고    scopus 로고
    • Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans
    • 25437839
    • Cutler RG, Thompson KW, Camandola S, Mack KT, Mattson MP (2014) Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans. Mech Ageing Dev 143-144:9-18
    • (2014) Mech Ageing Dev , vol.143-144 , pp. 9-18
    • Cutler, R.G.1    Thompson, K.W.2    Camandola, S.3    Mack, K.T.4    Mattson, M.P.5
  • 128
    • 66949135852 scopus 로고    scopus 로고
    • Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells
    • 2714426 1:CAS:528:DC%2BD1MXksFWqsrY%3D 19240113
    • Marza E, Simonsen KT, Faergeman NJ, Lesa GM (2009) Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells. J Cell Sci 122(Pt 6):822-833
    • (2009) J Cell Sci , vol.122 , pp. 822-833
    • Marza, E.1    Simonsen, K.T.2    Faergeman, N.J.3    Lesa, G.M.4
  • 129
    • 0037423225 scopus 로고    scopus 로고
    • The uracil transporter Fur4p associates with lipid rafts
    • 1:CAS:528:DC%2BD3sXot1KrtQ%3D%3D 12446707
    • Hearn JD, Lester RL, Dickson RC (2003) The uracil transporter Fur4p associates with lipid rafts. J Biol Chem 278(6):3679-3686
    • (2003) J Biol Chem , vol.278 , Issue.6 , pp. 3679-3686
    • Hearn, J.D.1    Lester, R.L.2    Dickson, R.C.3
  • 130
    • 34547752909 scopus 로고    scopus 로고
    • Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: Essential role in transport activity and normal control by ubiquitination
    • 1949357 1:CAS:528:DC%2BD2sXovFaksr0%3D 17553927
    • Lauwers E, Grossmann G, Andre B (2007) Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitination. Mol Biol Cell 18(8):3068-3080
    • (2007) Mol Biol Cell , vol.18 , Issue.8 , pp. 3068-3080
    • Lauwers, E.1    Grossmann, G.2    Andre, B.3
  • 131
    • 79953227034 scopus 로고    scopus 로고
    • A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae
    • 3063671 1:CAS:528:DC%2BC3MXmsVSgs7g%3D 21196517
    • Finnigan GC, Ryan M, Stevens TH (2011) A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae. Genetics 187(3):771-783
    • (2011) Genetics , vol.187 , Issue.3 , pp. 771-783
    • Finnigan, G.C.1    Ryan, M.2    Stevens, T.H.3
  • 132
    • 75149176725 scopus 로고    scopus 로고
    • Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
    • 2797032 19723703
    • Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B (2010) Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J 24(1):296-308
    • (2010) FASEB J , vol.24 , Issue.1 , pp. 296-308
    • Senkal, C.E.1    Ponnusamy, S.2    Bielawski, J.3    Hannun, Y.A.4    Ogretmen, B.5
  • 133
    • 28144431972 scopus 로고    scopus 로고
    • Acyl chain length affects ceramide action on sterol/sphingomyelin-rich domains
    • 1:CAS:528:DC%2BD2MXht1OltLjP 16321609
    • Nybond S, Bjorkqvist YJ, Ramstedt B, Slotte JP (2005) Acyl chain length affects ceramide action on sterol/sphingomyelin-rich domains. Biochim Biophys Acta 1718(1-2):61-66
    • (2005) Biochim Biophys Acta , vol.1718 , Issue.1-2 , pp. 61-66
    • Nybond, S.1    Bjorkqvist, Y.J.2    Ramstedt, B.3    Slotte, J.P.4
  • 135
    • 84870995648 scopus 로고    scopus 로고
    • Regulation of lipid stores and metabolism by lipophagy
    • 3524634 22595754
    • Liu K, Czaja MJ (2012) Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ 20:3-11
    • (2012) Cell Death Differ , vol.20 , pp. 3-11
    • Liu, K.1    Czaja, M.J.2


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