Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 12, 2012, Pages 2135-2143

  Gagliostro, Vincenzo ^a   Casas, Josefina ^b   Caretti, Anna ^a   Abad, Jose L ^b   Tagliavacca, Luigina ^a   Ghidoni, Riccardo ^a   Fabrias, Gemma ^b   Signorelli, Paola ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

Author keywords

Autophagy; Desaturase; Dihydroceramide; Dihydrosphingomyelin; ER stress; Sphingolipids

Indexed keywords

3 METHYLADENINE; ANTINEOPLASTIC AGENT; CERAMIDE DERIVATIVE; CYCLIN D1; DIHYDROCERAMIDE DESATURASE INHIBITOR; ENZYME INHIBITOR; ETOPOSIDE; INITIATION FACTOR 2ALPHA; SPHINGOLIPID; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; XM 462; XM 642;

ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PROCESSING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CERAMIDES; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM STRESS; ETOPOSIDE; EUKARYOTIC INITIATION FACTOR-2; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NOCODAZOLE; OXIDOREDUCTASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA SPLICING; SPHINGOLIPIDS; SULFIDES; TRANSCRIPTION FACTORS;

EID: 84866517745     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.08.025     Document Type: Article

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