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Volumn 9, Issue 2, 2015, Pages 183-191

New cellular and molecular targets for the treatment of portal hypertension

Author keywords

Cirrhosis; Endothelium; Hepatic stellate cells; Liver; Liver sinusoidal endothelial cells; LSEC; Simvastatin

Indexed keywords

6-ETHYLCHENODEOXYCHOLIC ACID; ACETIC ACID DERIVATIVE; ANTIOXIDANT; BIOPTERIN; CHENODEOXYCHOLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; NAPHTHALENE DERIVATIVE; PROPIONIC ACID DERIVATIVE; QUINOLINE DERIVATIVE; SAPROPTERIN; TERUTROBAN;

EID: 84939974360     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-015-9613-5     Document Type: Review
Times cited : (51)

References (80)
  • 3
    • 33644553509 scopus 로고    scopus 로고
    • The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule
    • COI: 1:CAS:528:DC%2BD28XhvVSktLY%3D, PID: 16447289
    • Iwakiri Y, Groszmann RJ. The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. Hepatology 2006;43:S121–S131
    • (2006) Hepatology , vol.43 , pp. S121-S131
    • Iwakiri, Y.1    Groszmann, R.J.2
  • 4
    • 84863981483 scopus 로고    scopus 로고
    • Functional aspects on the pathophysiology of portal hypertension in cirrhosis
    • PID: 22504334
    • Garcia-Pagan JC, Gracia-Sancho J, Bosch J. Functional aspects on the pathophysiology of portal hypertension in cirrhosis. J Hepatol 2012;57:458–461
    • (2012) J Hepatol , vol.57 , pp. 458-461
    • Garcia-Pagan, J.C.1    Gracia-Sancho, J.2    Bosch, J.3
  • 5
    • 0036096420 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: diagnosis and treatment
    • PID: 12016426
    • Befeler AS, Di Bisceglie AM. Hepatocellular carcinoma: diagnosis and treatment. Gastroenterology 2002;122:1609–1619
    • (2002) Gastroenterology , vol.122 , pp. 1609-1619
    • Befeler, A.S.1    Di Bisceglie, A.M.2
  • 7
    • 0021816284 scopus 로고
    • Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators
    • Bathal PS, Grossmann HJ. Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators. J Hepatol 1985;1:325–329
    • (1985) J Hepatol , vol.1 , pp. 325-329
    • Bathal, P.S.1    Grossmann, H.J.2
  • 8
    • 35948931882 scopus 로고    scopus 로고
    • Hepatic microvasculature in liver injury
    • COI: 1:CAS:528:DC%2BD2sXhtl2gsrvO, PID: 17979075
    • DeLeve LD. Hepatic microvasculature in liver injury. Semin Liver Dis 2007;27:390–400
    • (2007) Semin Liver Dis , vol.27 , pp. 390-400
    • DeLeve, L.D.1
  • 9
    • 0033450924 scopus 로고    scopus 로고
    • Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis
    • COI: 1:CAS:528:DC%2BD3cXlt1OhtA%3D%3D, PID: 10643625
    • Pinzani M, Gentilini P. Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis. Semin Liver Dis 1999;19:397–410
    • (1999) Semin Liver Dis , vol.19 , pp. 397-410
    • Pinzani, M.1    Gentilini, P.2
  • 10
    • 62749148283 scopus 로고    scopus 로고
    • Hepatic sinusoidal cells in health and disease: update from the 14th international symposium
    • PID: 19210626
    • Smedsrod B, Le CD, Ikejima K, Jaeschke H, Kawada N, Naito M, et al. Hepatic sinusoidal cells in health and disease: update from the 14th international symposium. Liver Int 2009;29:490–501
    • (2009) Liver Int , vol.29 , pp. 490-501
    • Smedsrod, B.1    Le, C.D.2    Ikejima, K.3    Jaeschke, H.4    Kawada, N.5    Naito, M.6
  • 11
    • 34447102726 scopus 로고    scopus 로고
    • Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers
    • COI: 1:CAS:528:DC%2BD2sXnsFKgtb0%3D, PID: 17459512
    • Gracia-Sancho J, Lavina B, Rodriguez-Vilarrupla A, Garcia-Caldero H, Bosch J, Garcia-Pagan JC. Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers. J Hepatol 2007;47:220–227
    • (2007) J Hepatol , vol.47 , pp. 220-227
    • Gracia-Sancho, J.1    Lavina, B.2    Rodriguez-Vilarrupla, A.3    Garcia-Caldero, H.4    Bosch, J.5    Garcia-Pagan, J.C.6
  • 12
    • 34347397134 scopus 로고    scopus 로고
    • Kupffer cell activation in normal and fibrotic livers increases portal pressure via thromboxane A(2)
    • Steib CJ, Gerbes AL, Bystron M, op den Winkel M, Hartl J, Roggel F et al. Kupffer cell activation in normal and fibrotic livers increases portal pressure via thromboxane A(2). J Hepatol 2007; 47:228–238
    • (2007) J Hepatol , vol.47 , pp. 228-238
    • Steib, C.J.1    Gerbes, A.L.2    Bystron, M.3    op den Winkel, M.4    Hartl, J.5    Roggel, F.6
  • 13
    • 0029011135 scopus 로고
    • Hepatic stellate (Ito) cells—expanding roles for A liver-specific pericyte
    • COI: 1:STN:280:DyaK28%2FjsFWntA%3D%3D, PID: 7560865
    • Pinzani M. Hepatic stellate (Ito) cells—expanding roles for A liver-specific pericyte. J Hepatol 1995;22:700–706
    • (1995) J Hepatol , vol.22 , pp. 700-706
    • Pinzani, M.1
  • 14
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis—from bench to bedside
    • Friedman SL. Liver fibrosis—from bench to bedside. J Hepatol 2003;38 Suppl 1:S38–S53
    • J Hepatol 2003;38 Suppl , vol.1 , pp. S38-S53
    • Friedman, S.L.1
  • 15
    • 51349168307 scopus 로고    scopus 로고
    • Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence
    • COI: 1:CAS:528:DC%2BD1cXhtFKrsLfJ, PID: 18613151
    • DeLeve LD, Wang X, Guo Y. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology 2008;48:920–930
    • (2008) Hepatology , vol.48 , pp. 920-930
    • DeLeve, L.D.1    Wang, X.2    Guo, Y.3
  • 16
    • 33845642594 scopus 로고    scopus 로고
    • Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells
    • COI: 1:CAS:528:DC%2BD2sXislKksg%3D%3D, PID: 17133487
    • Nieto N. Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells. Hepatology 2006;44:1487–1501
    • (2006) Hepatology , vol.44 , pp. 1487-1501
    • Nieto, N.1
  • 17
  • 18
    • 0015308917 scopus 로고
    • An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells
    • COI: 1:STN:280:DyaE387js1Cnsg%3D%3D, PID: 4335119
    • Wisse E. An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells. J Ultrastruct Res 1972;38:528–562
    • (1972) J Ultrastruct Res , vol.38 , pp. 528-562
    • Wisse, E.1
  • 19
    • 0025273599 scopus 로고
    • Scavenger functions of the liver endothelial cell
    • COI: 1:STN:280:DyaK3c7pslKjtg%3D%3D, PID: 2156492
    • Smedsrod B, Pertoft H, Gustafson S, Laurent TC. Scavenger functions of the liver endothelial cell. Biochem J 1990;266:313–327
    • (1990) Biochem J , vol.266 , pp. 313-327
    • Smedsrod, B.1    Pertoft, H.2    Gustafson, S.3    Laurent, T.C.4
  • 20
    • 13844275253 scopus 로고    scopus 로고
    • Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen
    • COI: 1:CAS:528:DC%2BD2MXhtlens78%3D, PID: 15710220
    • McCuskey RS, Bethea NW, Wong J, McCuskey MK, Abril ER, Wang X, et al. Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J Hepatol 2005;42:371–377
    • (2005) J Hepatol , vol.42 , pp. 371-377
    • McCuskey, R.S.1    Bethea, N.W.2    Wong, J.3    McCuskey, M.K.4    Abril, E.R.5    Wang, X.6
  • 21
    • 70349229378 scopus 로고    scopus 로고
    • Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro
    • COI: 1:CAS:528:DC%2BD1MXhtFKntLzE, PID: 19585615
    • March S, Hui EE, Underhill GH, Khetani S, Bhatia SN. Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology 2009;50:920–928
    • (2009) Hepatology , vol.50 , pp. 920-928
    • March, S.1    Hui, E.E.2    Underhill, G.H.3    Khetani, S.4    Bhatia, S.N.5
  • 22
    • 15244353838 scopus 로고    scopus 로고
    • Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers
    • COI: 1:CAS:528:DC%2BD2MXjtlyjtrw%3D, PID: 15550559
    • Graupera M, March S, Engel P, Rodes J, Bosch J, Garcia-Pagan JC. Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers. Am J Physiol Gastrointest Liver Physiol 2005;288:G763–G770
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288 , pp. G763-G770
    • Graupera, M.1    March, S.2    Engel, P.3    Rodes, J.4    Bosch, J.5    Garcia-Pagan, J.C.6
  • 23
    • 0031916189 scopus 로고    scopus 로고
    • Cellular localization of endothelin-1 and increased production in liver injury in the rat: potential for autocrine and paracrine effects on stellate cells
    • COI: 1:CAS:528:DyaK1cXhtVGgtLk%3D, PID: 9462646
    • Rockey DC, Fouassier L, Chung JJ, Carayon A, Vallee P, Rey C, et al. Cellular localization of endothelin-1 and increased production in liver injury in the rat: potential for autocrine and paracrine effects on stellate cells. Hepatology 1998;27:472–480
    • (1998) Hepatology , vol.27 , pp. 472-480
    • Rockey, D.C.1    Fouassier, L.2    Chung, J.J.3    Carayon, A.4    Vallee, P.5    Rey, C.6
  • 24
    • 0031941122 scopus 로고    scopus 로고
    • Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension
    • COI: 1:CAS:528:DyaK1cXpt1KjtA%3D%3D, PID: 9453496
    • Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998;114:344–351
    • (1998) Gastroenterology , vol.114 , pp. 344-351
    • Rockey, D.C.1    Chung, J.J.2
  • 25
    • 0026775513 scopus 로고
    • Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients
    • COI: 1:CAS:528:DyaK38XlsVyju78%3D, PID: 1644929
    • Pinzani M, Failli P, Ruocco C, Casini A, Milani S, Baldi E, et al. Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J Clin Invest 1992;90:642–646
    • (1992) J Clin Invest , vol.90 , pp. 642-646
    • Pinzani, M.1    Failli, P.2    Ruocco, C.3    Casini, A.4    Milani, S.5    Baldi, E.6
  • 26
    • 0036051963 scopus 로고    scopus 로고
    • Role of hepatic stellate cells in the pathogenesis of portal hypertension
    • Marra F, Pinzani M. Role of hepatic stellate cells in the pathogenesis of portal hypertension. Nefrologia 2002; 22 Suppl 5:34–40
    • Nefrologia 2002; 22 Suppl , vol.5 , pp. 34-40
    • Marra, F.1    Pinzani, M.2
  • 27
    • 0020379865 scopus 로고
    • Relation between localization and function of rat liver Kupffer cells
    • COI: 1:STN:280:DyaL3s%2FjsFWltw%3D%3D, PID: 6182391
    • Sleyster EC, Knook DL. Relation between localization and function of rat liver Kupffer cells. Lab Invest 1982;47:484–490
    • (1982) Lab Invest , vol.47 , pp. 484-490
    • Sleyster, E.C.1    Knook, D.L.2
  • 28
    • 77952732092 scopus 로고    scopus 로고
    • Treatment with the leukotriene inhibitor montelukast for 10 days attenuates portal hypertension in rat liver cirrhosis
    • Steib CJ, Bilzer M, op den Winkel M, Pfeiler S, Hartmann AC, Hennenberg M, et al. Treatment with the leukotriene inhibitor montelukast for 10 days attenuates portal hypertension in rat liver cirrhosis. Hepatology 2010; 51:2086–2096
    • (2010) Hepatology , vol.51 , pp. 2086-2096
    • Steib, C.J.1    Bilzer, M.2    op den Winkel, M.3    Pfeiler, S.4    Hartmann, A.C.5    Hennenberg, M.6
  • 29
    • 0029891589 scopus 로고    scopus 로고
    • Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance
    • COI: 1:CAS:528:DyaK28XkvFSju7s%3D, PID: 8707268
    • Rockey DC, Weisiger RA. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Hepatology 1996;24:233–240
    • (1996) Hepatology , vol.24 , pp. 233-240
    • Rockey, D.C.1    Weisiger, R.A.2
  • 30
    • 0018915843 scopus 로고
    • Hepatic hemodynamics and the renin-angiotensin-aldosterone system in cirrhosis
    • COI: 1:STN:280:DyaL3c%2FntVWnug%3D%3D, PID: 7350041
    • Bosch J, Arroyo V, Betriu A, Mas A, Carrilho F, Rivera F, et al. Hepatic hemodynamics and the renin-angiotensin-aldosterone system in cirrhosis. Gastroenterology 1980;78:92–99
    • (1980) Gastroenterology , vol.78 , pp. 92-99
    • Bosch, J.1    Arroyo, V.2    Betriu, A.3    Mas, A.4    Carrilho, F.5    Rivera, F.6
  • 31
    • 0034120267 scopus 로고    scopus 로고
    • Angiotensin II induces contraction and proliferation of human hepatic stellate cells
    • COI: 1:CAS:528:DC%2BD3cXktlaiu7w%3D, PID: 10833490
    • Bataller R, Gines P, Nicolas JM, Gorbig MN, Garcia-Ramallo E, Gasull X, et al. Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology 2000;118:1149–1156
    • (2000) Gastroenterology , vol.118 , pp. 1149-1156
    • Bataller, R.1    Gines, P.2    Nicolas, J.M.3    Gorbig, M.N.4    Garcia-Ramallo, E.5    Gasull, X.6
  • 32
    • 0037221217 scopus 로고    scopus 로고
    • Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers
    • COI: 1:CAS:528:DC%2BD3sXovVWhtQ%3D%3D, PID: 12500202
    • Graupera M, Garcia-Pagan JC, Abraldes JG, Peralta C, Bragulat M, Corominola H, et al. Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. Hepatology 2003;37:172–181
    • (2003) Hepatology , vol.37 , pp. 172-181
    • Graupera, M.1    Garcia-Pagan, J.C.2    Abraldes, J.G.3    Peralta, C.4    Bragulat, M.5    Corominola, H.6
  • 33
    • 42249111199 scopus 로고    scopus 로고
    • Increased oxidative stress in cirrhotic rat livers: a potential mechanism contributing to reduced nitric oxide bioavailability
    • COI: 1:CAS:528:DC%2BD1cXkslOjs7g%3D, PID: 18273863
    • Gracia-Sancho J, Lavina B, Rodriguez-Vilarupla A, Garcia-Caldero H, Fernandez M, Bosch J, et al. Increased oxidative stress in cirrhotic rat livers: a potential mechanism contributing to reduced nitric oxide bioavailability. Hepatology 2008;47:1248–1256
    • (2008) Hepatology , vol.47 , pp. 1248-1256
    • Gracia-Sancho, J.1    Lavina, B.2    Rodriguez-Vilarupla, A.3    Garcia-Caldero, H.4    Fernandez, M.5    Bosch, J.6
  • 36
    • 79952538496 scopus 로고    scopus 로고
    • Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver
    • COI: 1:CAS:528:DC%2BC3MXltVKgurY%3D, PID: 21112949
    • Gracia-Sancho J, Russo L, Garcia-Caldero H, Garcia-Pagan JC, Garcia-Cardena G, Bosch J. Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver. Gut 2011;60:517–524
    • (2011) Gut , vol.60 , pp. 517-524
    • Gracia-Sancho, J.1    Russo, L.2    Garcia-Caldero, H.3    Garcia-Pagan, J.C.4    Garcia-Cardena, G.5    Bosch, J.6
  • 37
    • 0032738990 scopus 로고    scopus 로고
    • Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat
    • COI: 1:CAS:528:DyaK1MXnsVCqtrY%3D, PID: 10535886
    • Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, et al. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 1999;117:1222–1228
    • (1999) Gastroenterology , vol.117 , pp. 1222-1228
    • Shah, V.1    Toruner, M.2    Haddad, F.3    Cadelina, G.4    Papapetropoulos, A.5    Choo, K.6
  • 38
    • 0032883956 scopus 로고    scopus 로고
    • Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension
    • COI: 1:CAS:528:DyaK1MXls1agt7c%3D, PID: 10444461
    • Shah V, Wiest R, Garcia-Cardena G, Cadelina G, Groszmann RJ, Sessa WC. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. Am J Physiol 1999;277:G463–G468
    • (1999) Am J Physiol , vol.277 , pp. G463-G468
    • Shah, V.1    Wiest, R.2    Garcia-Cardena, G.3    Cadelina, G.4    Groszmann, R.J.5    Sessa, W.C.6
  • 39
    • 0034973581 scopus 로고    scopus 로고
    • Regulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats
    • COI: 1:CAS:528:DC%2BD3MXksFKmt78%3D, PID: 11352814
    • Shah V, Cao S, Hendrickson H, Yao J, Katusic ZS. Regulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats. Am J Physiol Gastrointest Liver Physiol 2001;280:G1209–G1216
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280 , pp. G1209-G1216
    • Shah, V.1    Cao, S.2    Hendrickson, H.3    Yao, J.4    Katusic, Z.S.5
  • 40
    • 32944479991 scopus 로고    scopus 로고
    • A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis
    • COI: 1:CAS:528:DC%2BD2MXhtlGns7vM, PID: 16317694
    • Laleman W, Omasta A, Van de CM, Zeegers M, Vander EI, Van LL, et al. A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis. Hepatology 2005;42:1382–1390
    • (2005) Hepatology , vol.42 , pp. 1382-1390
    • Laleman, W.1    Omasta, A.2    Van de, C.M.3    Zeegers, M.4    Vander, E.I.5    Van, L.L.6
  • 41
    • 24744444714 scopus 로고    scopus 로고
    • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
    • COI: 1:CAS:528:DC%2BD2MXpslelurs%3D, PID: 16142243
    • Liu SL, Premont RT, Kontos CD, Zhu SK, Rockey DC. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 2005;11:952–958
    • (2005) Nat Med , vol.11 , pp. 952-958
    • Liu, S.L.1    Premont, R.T.2    Kontos, C.D.3    Zhu, S.K.4    Rockey, D.C.5
  • 42
    • 33745941120 scopus 로고    scopus 로고
    • The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis
    • COI: 1:CAS:528:DC%2BD28XnsFWjt74%3D, PID: 16799985
    • Matei V, Rodriguez-Vilarrupla A, Deulofeu R, Colomer D, Fernandez M, Bosch J, et al. The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis. Hepatology 2006;44:44–52
    • (2006) Hepatology , vol.44 , pp. 44-52
    • Matei, V.1    Rodriguez-Vilarrupla, A.2    Deulofeu, R.3    Colomer, D.4    Fernandez, M.5    Bosch, J.6
  • 44
    • 84866751112 scopus 로고    scopus 로고
    • Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats
    • COI: 1:CAS:528:DC%2BC38XhvVOis7bE, PID: 22436078
    • Rosado E, Rodriguez-Vilarrupla A, Gracia-Sancho J, Monclus M, Bosch J, Garcia-Pagan JC. Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats. J Cell Mol Med 2012;16:2461–2470
    • (2012) J Cell Mol Med , vol.16 , pp. 2461-2470
    • Rosado, E.1    Rodriguez-Vilarrupla, A.2    Gracia-Sancho, J.3    Monclus, M.4    Bosch, J.5    Garcia-Pagan, J.C.6
  • 45
    • 0027938229 scopus 로고
    • Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences
    • COI: 1:STN:280:DyaK2M%2Fht1WmtQ%3D%3D, PID: 7927273
    • Groszmann RJ. Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences. Hepatology 1994;20:1359–1363
    • (1994) Hepatology , vol.20 , pp. 1359-1363
    • Groszmann, R.J.1
  • 46
    • 0032938259 scopus 로고    scopus 로고
    • NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats
    • COI: 1:CAS:528:DyaK1MXislCrsro%3D, PID: 10198349
    • Wiest R, Shah V, Sessa WC, Groszmann RJ. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am J Physiol 1999;276:G1043–G1051
    • (1999) Am J Physiol , vol.276 , pp. G1043-G1051
    • Wiest, R.1    Shah, V.2    Sessa, W.C.3    Groszmann, R.J.4
  • 47
    • 79960950729 scopus 로고    scopus 로고
    • Physiopathology of splanchnic vasodilation in portal hypertension
    • PID: 21160999
    • Martell M, Coll M, Ezkurdia N, Raurell I, Genesca J. Physiopathology of splanchnic vasodilation in portal hypertension. World J Hepatol 2010;2:208–220
    • (2010) World J Hepatol , vol.2 , pp. 208-220
    • Martell, M.1    Coll, M.2    Ezkurdia, N.3    Raurell, I.4    Genesca, J.5
  • 48
    • 33644870801 scopus 로고    scopus 로고
    • Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats
    • COI: 1:CAS:528:DC%2BD28XjsVyltrg%3D, PID: 16530523
    • Hennenberg M, Biecker E, Trebicka J, Jochem K, Zhou Q, Schmidt M, et al. Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Gastroenterology 2006;130:838–854
    • (2006) Gastroenterology , vol.130 , pp. 838-854
    • Hennenberg, M.1    Biecker, E.2    Trebicka, J.3    Jochem, K.4    Zhou, Q.5    Schmidt, M.6
  • 49
    • 20444367984 scopus 로고    scopus 로고
    • Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats
    • COI: 1:CAS:528:DC%2BD2MXlt1Ghsb8%3D, PID: 15893841
    • Fernandez M, Mejias M, Angermayr B, Garcia-Pagan JC, Rodes J, Bosch J. Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats. J Hepatol 2005;43:98–103
    • (2005) J Hepatol , vol.43 , pp. 98-103
    • Fernandez, M.1    Mejias, M.2    Angermayr, B.3    Garcia-Pagan, J.C.4    Rodes, J.5    Bosch, J.6
  • 50
    • 36348935694 scopus 로고    scopus 로고
    • Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats
    • COI: 1:CAS:528:DC%2BD2sXht1aksrvM, PID: 17654489
    • Fernandez M, Mejias M, Garcia-Pras E, Mendez R, Garcia-Pagan JC, Bosch J. Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats. Hepatology 2007;46:1208–1217
    • (2007) Hepatology , vol.46 , pp. 1208-1217
    • Fernandez, M.1    Mejias, M.2    Garcia-Pras, E.3    Mendez, R.4    Garcia-Pagan, J.C.5    Bosch, J.6
  • 51
    • 65449130742 scopus 로고    scopus 로고
    • Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats
    • COI: 1:CAS:528:DC%2BD1MXkslWjsrs%3D, PID: 19137587
    • Mejias M, Garcia-Pras E, Tiani C, Miquel R, Bosch J, Fernandez M. Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats. Hepatology 2009;49:1245–1256
    • (2009) Hepatology , vol.49 , pp. 1245-1256
    • Mejias, M.1    Garcia-Pras, E.2    Tiani, C.3    Miquel, R.4    Bosch, J.5    Fernandez, M.6
  • 52
    • 77956268976 scopus 로고    scopus 로고
    • Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells
    • COI: 1:CAS:528:DC%2BC3cXhtV2gtbnL, PID: 20633948
    • Trebicka J, Hennenberg M, Odenthal M, Shir K, Klein S, Granzow M, et al. Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J Hepatol 2010;53:702–712
    • (2010) J Hepatol , vol.53 , pp. 702-712
    • Trebicka, J.1    Hennenberg, M.2    Odenthal, M.3    Shir, K.4    Klein, S.5    Granzow, M.6
  • 53
    • 84941281919 scopus 로고    scopus 로고
    • KLF2 exerts anti-fibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins
    • Marrone G, Maeso-Díaz R, Garcia-Cardena G, Garcia-Pagan JC, Bosch J, Gracia-Sancho J. KLF2 exerts anti-fibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins. Gut 2014; doi:10.1136/gutjnl-2014-308338
    • (2014) Gut
    • Marrone, G.1    Maeso-Díaz, R.2    Garcia-Cardena, G.3    Garcia-Pagan, J.C.4    Bosch, J.5    Gracia-Sancho, J.6
  • 54
    • 84871211218 scopus 로고    scopus 로고
    • The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins
    • COI: 1:CAS:528:DC%2BC3sXhvVKksQ%3D%3D, PID: 22989565
    • Marrone G, Russo L, Rosado E, Hide D, Garcia-Cardena G, Garcia-Pagan JC, et al. The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins. J Hepatol 2013;58:98–103
    • (2013) J Hepatol , vol.58 , pp. 98-103
    • Marrone, G.1    Russo, L.2    Rosado, E.3    Hide, D.4    Garcia-Cardena, G.5    Garcia-Pagan, J.C.6
  • 55
    • 84876286546 scopus 로고    scopus 로고
    • Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats
    • PID: 23262250
    • Di Pascoli M, Divi M, Rodriguez-Vilarrupla A, Rosado E, Gracia-Sancho J, Vilaseca M, et al. Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. J Hepatol 2013;58:904–910
    • (2013) J Hepatol , vol.58 , pp. 904-910
    • Di Pascoli, M.1    Divi, M.2    Rodriguez-Vilarrupla, A.3    Rosado, E.4    Gracia-Sancho, J.5    Vilaseca, M.6
  • 56
    • 84872385637 scopus 로고    scopus 로고
    • Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats
    • COI: 1:CAS:528:DC%2BC3sXovFWnug%3D%3D, PID: 22989570
    • Guillaume M, Rodriguez-Vilarrupla A, Gracia-Sancho J, Rosado E, Mancini A, Bosch J, et al. Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats. J Hepatol 2013;58:240–246
    • (2013) J Hepatol , vol.58 , pp. 240-246
    • Guillaume, M.1    Rodriguez-Vilarrupla, A.2    Gracia-Sancho, J.3    Rosado, E.4    Mancini, A.5    Bosch, J.6
  • 57
    • 84893901321 scopus 로고    scopus 로고
    • Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis
    • COI: 1:CAS:528:DC%2BC2cXhtVOitL0%3D
    • Hsu SJ, Wang SS, Hsin IF, Lee FY, Huang HC, Huo TI, et al. Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis. Clin Sci (Lond) 2014;126:633–644
    • (2014) Clin Sci (Lond) , vol.126 , pp. 633-644
    • Hsu, S.J.1    Wang, S.S.2    Hsin, I.F.3    Lee, F.Y.4    Huang, H.C.5    Huo, T.I.6
  • 58
    • 84901605121 scopus 로고    scopus 로고
    • Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats
    • COI: 1:CAS:528:DC%2BC2cXovFahurc%3D, PID: 24259407
    • Verbeke L, Farre R, Trebicka J, Komuta M, Roskams T, Klein S, et al. Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats. Hepatology 2014;59:2286–2298
    • (2014) Hepatology , vol.59 , pp. 2286-2298
    • Verbeke, L.1    Farre, R.2    Trebicka, J.3    Komuta, M.4    Roskams, T.5    Klein, S.6
  • 59
    • 84869222173 scopus 로고    scopus 로고
    • HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects
    • COI: 1:CAS:528:DC%2BC38XhslWqsb%2FM, PID: 22878469
    • Klein S, Van Beuge MM, Granzow M, Beljaars L, Schierwagen R, Kilic S, et al. HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects. J Hepatol 2012;57:1220–1227
    • (2012) J Hepatol , vol.57 , pp. 1220-1227
    • Klein, S.1    Van Beuge, M.M.2    Granzow, M.3    Beljaars, L.4    Schierwagen, R.5    Kilic, S.6
  • 60
    • 84896493187 scopus 로고    scopus 로고
    • Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo
    • COI: 1:CAS:528:DC%2BC2cXkvVGlsrY%3D, PID: 23873655
    • Fallowfield JA, Hayden AL, Snowdon VK, Aucott RL, Stutchfield BM, Mole DJ, et al. Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo. Hepatology 2014;59:1492–1504
    • (2014) Hepatology , vol.59 , pp. 1492-1504
    • Fallowfield, J.A.1    Hayden, A.L.2    Snowdon, V.K.3    Aucott, R.L.4    Stutchfield, B.M.5    Mole, D.J.6
  • 61
    • 46349096789 scopus 로고    scopus 로고
    • Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl4 cirrhotic rats
    • COI: 1:CAS:528:DC%2BD1cXotlWqsbk%3D, PID: 18534709
    • Matei V, Rodriguez-Vilarrupla A, Deulofeu R, Garcia-Caldero H, Fernandez M, Bosch J, et al. Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl4 cirrhotic rats. J Hepatol 2008;49:192–197
    • (2008) J Hepatol , vol.49 , pp. 192-197
    • Matei, V.1    Rodriguez-Vilarrupla, A.2    Deulofeu, R.3    Garcia-Caldero, H.4    Fernandez, M.5    Bosch, J.6
  • 62
    • 85006962090 scopus 로고    scopus 로고
    • Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension
    • Mookerjee RP, Mehta G, Balasubramaniyan V, Mohamed F, Davies N, Sharma V, et al. Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension. J Hepatol 2014;10
    • (2014) J Hepatol , pp. 10
    • Mookerjee, R.P.1    Mehta, G.2    Balasubramaniyan, V.3    Mohamed, F.4    Davies, N.5    Sharma, V.6
  • 63
    • 33645240442 scopus 로고    scopus 로고
    • Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension
    • COI: 1:CAS:528:DC%2BD28XjtVKqsbs%3D, PID: 16496307
    • Hernandez-Guerra M, Garcia-Pagan JC, Turnes J, Bellot P, Deulofeu R, Abraldes JG, et al. Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension. Hepatology 2006;43:485–491
    • (2006) Hepatology , vol.43 , pp. 485-491
    • Hernandez-Guerra, M.1    Garcia-Pagan, J.C.2    Turnes, J.3    Bellot, P.4    Deulofeu, R.5    Abraldes, J.G.6
  • 64
    • 83255164277 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats
    • PID: 22098317
    • Yang YY, Lee TY, Huang YT, Chan CC, Yeh YC, Lee FY, et al. Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats. Liver Int 2012;32:48–57
    • (2012) Liver Int , vol.32 , pp. 48-57
    • Yang, Y.Y.1    Lee, T.Y.2    Huang, Y.T.3    Chan, C.C.4    Yeh, Y.C.5    Lee, F.Y.6
  • 65
    • 84865324219 scopus 로고    scopus 로고
    • Postprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: results of a phase 2, double-blind, randomized controlled trial
    • PID: 22811444
    • De Gottardi A, Berzigotti A, Seijo S, D’Amico M, Thormann W, Abraldes JG, et al. Postprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: results of a phase 2, double-blind, randomized controlled trial. Am J Clin Nutr 2012;96:584–590
    • (2012) Am J Clin Nutr , vol.96 , pp. 584-590
    • De Gottardi, A.1    Berzigotti, A.2    Seijo, S.3    D’Amico, M.4    Thormann, W.5    Abraldes, J.G.6
  • 66
    • 34247568377 scopus 로고    scopus 로고
    • Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl(4) cirrhotic rats
    • COI: 1:CAS:528:DC%2BD2sXkvFGjsb8%3D, PID: 17335931
    • Abraldes JG, Rodriguez-Vilarrupla A, Graupera M, Zafra C, Garcia-Caldero H, Garcia-Pagan JC, et al. Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl(4) cirrhotic rats. J Hepatol 2007;46:1040–1046
    • (2007) J Hepatol , vol.46 , pp. 1040-1046
    • Abraldes, J.G.1    Rodriguez-Vilarrupla, A.2    Graupera, M.3    Zafra, C.4    Garcia-Caldero, H.5    Garcia-Pagan, J.C.6
  • 67
    • 34547469050 scopus 로고    scopus 로고
    • Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    • COI: 1:CAS:528:DC%2BD2sXosVyltLk%3D, PID: 17596891
    • Trebicka J, Hennenberg M, Laleman W, Shelest N, Biecker E, Schepke M, et al. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology 2007;46:242–253
    • (2007) Hepatology , vol.46 , pp. 242-253
    • Trebicka, J.1    Hennenberg, M.2    Laleman, W.3    Shelest, N.4    Biecker, E.5    Schepke, M.6
  • 68
    • 65349094504 scopus 로고    scopus 로고
    • Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BD1MXmtFWqu7o%3D, PID: 19208350
    • Abraldes JG, Albillos A, Banares R, Turnes J, Gonzalez R, Garcia-Pagan JC, et al. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology 2009;136:1651–1658
    • (2009) Gastroenterology , vol.136 , pp. 1651-1658
    • Abraldes, J.G.1    Albillos, A.2    Banares, R.3    Turnes, J.4    Gonzalez, R.5    Garcia-Pagan, J.C.6
  • 69
    • 84930475918 scopus 로고    scopus 로고
    • Addition of simvastatin to standard treatment improves survival after variceal bleeding in patients with cirrhosis. A double-blind randomized trial (NCT01095185)
    • Abraldes JG, Villanueva C, Aracil C, Turnes J, Hernandez-Guerra M, Genesca J, et al. Addition of simvastatin to standard treatment improves survival after variceal bleeding in patients with cirrhosis. A double-blind randomized trial (NCT01095185). J Hepatol 2014;60:S525
    • (2014) J Hepatol , vol.60 , pp. S525
    • Abraldes, J.G.1    Villanueva, C.2    Aracil, C.3    Turnes, J.4    Hernandez-Guerra, M.5    Genesca, J.6
  • 70
    • 77955853856 scopus 로고    scopus 로고
    • Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension
    • COI: 1:CAS:528:DC%2BC3cXhtVelurvI, PID: 20561700
    • Bosch J, Abraldes JG, Fernandez M, Garcia-Pagan JC. Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension. J Hepatol 2010;53:558–567
    • (2010) J Hepatol , vol.53 , pp. 558-567
    • Bosch, J.1    Abraldes, J.G.2    Fernandez, M.3    Garcia-Pagan, J.C.4
  • 71
    • 84924420610 scopus 로고    scopus 로고
    • Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats
    • PID: 24848263
    • Mejias M, Coch L, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, et al. Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats. Gut 2014. doi:10.1136/gutjnl-2014-307138
    • (2014) Gut
    • Mejias, M.1    Coch, L.2    Berzigotti, A.3    Garcia-Pras, E.4    Gallego, J.5    Bosch, J.6
  • 72
    • 84898987733 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes fibrosis resolution and repair in mice
    • COI: 1:CAS:528:DC%2BC2cXmtlWiur8%3D, PID: 24503129
    • Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, et al. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology 2014;146:1339–1350
    • (2014) Gastroenterology , vol.146 , pp. 1339-1350
    • Yang, L.1    Kwon, J.2    Popov, Y.3    Gajdos, G.B.4    Ordog, T.5    Brekken, R.A.6
  • 73
    • 84904724134 scopus 로고    scopus 로고
    • Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats
    • COI: 1:CAS:528:DC%2BC2cXht1WmsL7I, PID: 24390792
    • Coch L, Mejias M, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, et al. Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats. Hepatology 2014;60:633–647
    • (2014) Hepatology , vol.60 , pp. 633-647
    • Coch, L.1    Mejias, M.2    Berzigotti, A.3    Garcia-Pras, E.4    Gallego, J.5    Bosch, J.6
  • 75
    • 44649155781 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine administration in hepatic microcirculation of rats with biliary cirrhosis
    • COI: 1:CAS:528:DC%2BD1cXmvFels7o%3D, PID: 18490076
    • Yang YY, Lee KC, Huang YT, Wang YW, Hou MC, Lee FY, et al. Effects of N-acetylcysteine administration in hepatic microcirculation of rats with biliary cirrhosis. J Hepatol 2008;49:25–33
    • (2008) J Hepatol , vol.49 , pp. 25-33
    • Yang, Y.Y.1    Lee, K.C.2    Huang, Y.T.3    Wang, Y.W.4    Hou, M.C.5    Lee, F.Y.6
  • 76
    • 84884969414 scopus 로고    scopus 로고
    • Leptin receptor blockade reduces intrahepatic vascular resistance and portal pressure in an experimental model of rat liver cirrhosis
    • COI: 1:CAS:528:DC%2BC3sXhslejur7M, PID: 23886859
    • Delgado MG, Gracia-Sancho J, Marrone G, Rodriguez-Vilarupla A, Deulofeu R, Abraldes JG, et al. Leptin receptor blockade reduces intrahepatic vascular resistance and portal pressure in an experimental model of rat liver cirrhosis. Am J Physiol Gastrointest Liver Physiol 2013;305:G496–G502
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.305 , pp. G496-G502
    • Delgado, M.G.1    Gracia-Sancho, J.2    Marrone, G.3    Rodriguez-Vilarupla, A.4    Deulofeu, R.5    Abraldes, J.G.6
  • 78
    • 33847060977 scopus 로고    scopus 로고
    • Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats
    • COI: 1:CAS:528:DC%2BD2sXjtlKis74%3D, PID: 17258737
    • Laleman W, Van Landeghem L, Van der Elst I, Zeegers M, Fevery J, Nevens F. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats. Gastroenterology 2007;132:709–719
    • (2007) Gastroenterology , vol.132 , pp. 709-719
    • Laleman, W.1    Van Landeghem, L.2    Van der Elst, I.3    Zeegers, M.4    Fevery, J.5    Nevens, F.6
  • 79
    • 84859121214 scopus 로고    scopus 로고
    • Spironolactone lowers portal hypertension by inhibiting liver fibrosis, ROCK-2 activity and activating NO/PKG pathway in the bile-duct-ligated rat
    • COI: 1:CAS:528:DC%2BC38Xlslehtbc%3D, PID: 22479572
    • Luo W, Meng Y, Ji HL, Pan CQ, Huang S, Yu CH, et al. Spironolactone lowers portal hypertension by inhibiting liver fibrosis, ROCK-2 activity and activating NO/PKG pathway in the bile-duct-ligated rat. PLoS ONE 2012;7:e34230
    • (2012) PLoS ONE , vol.7 , pp. e34230
    • Luo, W.1    Meng, Y.2    Ji, H.L.3    Pan, C.Q.4    Huang, S.5    Yu, C.H.6
  • 80
    • 84866858655 scopus 로고    scopus 로고
    • Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats
    • COI: 1:CAS:528:DC%2BC38XhsVars7fJ, PID: 22890553
    • Klein S, Klosel J, Schierwagen R, Korner C, Granzow M, Huss S, et al. Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats. Lab Invest 2012;92:1440–1450
    • (2012) Lab Invest , vol.92 , pp. 1440-1450
    • Klein, S.1    Klosel, J.2    Schierwagen, R.3    Korner, C.4    Granzow, M.5    Huss, S.6


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