Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver

Gut

Volumn 60, Issue 4, 2011, Pages 517-524

  Gracia Sancho, Jorge ^a,b   Russo, Lucia ^a   García Calderó, Héctor ^a   García Pagán, Joan Carles ^a   García Cardeña, Guillermo ^b   Bosch, Jaime ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; KRUPPEL LIKE FACTOR 2; NATRIURETIC PEPTIDE TYPE C; SIMVASTATIN; THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM CELL; GENE TARGETING; HEMODYNAMIC PARAMETERS; LIVER CELL; LIVER CIRRHOSIS; LIVER FIBROSIS; MALE; NONHUMAN; PHENOTYPIC VARIATION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CARBON TETRACHLORIDE; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HEMODYNAMICS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; PORTAL PRESSURE; RATS; RATS, WISTAR; SIMVASTATIN;

EID: 79952538496     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.220913     Document Type: Article

References (38)

1. Bieker JJ. Kruppel-like factors: three fingers in many pies. J Biol Chem 2001;276:34355-8. (Pubitemid 37384419)
2. Anderson KP, Kern CB, Crable SC, et al. Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family. Mol Cell Biol 1995;15:5957-65.
3. Kuo CT, Veselits ML, Barton KP, et al. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev 1997;11:2996-3006. (Pubitemid 27508510)
4. SenBanerjee S, Lin Z, Atkins GB, et al. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med 2004;199:1305-15. (Pubitemid 38685723)
5. Parmar KM, Larman HB, Dai G, et al. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J Clin Invest 2006;116:49-58. (Pubitemid 43121790)
6. Lin Z, Kumar A, SenBanerjee S, et al. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res 2005;96:e48-57.
7. Gracia-Sancho J, Villarreal G Jr, Zhang Y, et al. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res 2010;85:514-19.
8. Dekker RJ, van Soest S, Fontijn RD, et al. Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2). Blood 2002;100:1689-98. (Pubitemid 34925146)
9. Dekker RJ, van Thienen JV, Rohlena J, et al. Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. Am J Pathol 2005;167:609-18. (Pubitemid 43026114)
10. Bosch J, Garcia-Pagan JC. Complications of cirrhosis. I. Portal hypertension. J Hepatol 2000;32(1 Suppl):141-56.
11. Graupera M, Garcia-Pagan JC, Abraldes JG, et al. Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. Hepatology 2003;37:172-81. (Pubitemid 36042158)
12. Gracia-Sancho J, Lavina B, Rodriguez-Vilarrupla A, et al. Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers. J Hepatol 2007;47:220-7. (Pubitemid 47028585)
13. Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998;114:344-51. (Pubitemid 28093543)
14. Gracia-Sancho J, Lavina B, Rodriguez-Vilarrupla A, et al. Increased oxidative stress in cirrhotic rat livers: a potential mechanism contributing to reduced nitric oxide bioavailability. Hepatology 2008;47:1248-56. (Pubitemid 351547911)
15. Shah V, Haddad FG, Garcia-Cardena G, et al. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest 1997;100:2923-30. (Pubitemid 28007564)
16. Abraldes JG, Rodriguez-Vilarrupla A, Graupera M, et al. Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl(4) cirrhotic rats. J Hepatol 2007;46:1040-6. (Pubitemid 46680358)
17. Gracia-Sancho J, Laviña B, Rodriguez-Vilarrupla A, et al. Evidence against NADPH oxidase modulating hepatic vascular tone in cirrhosis. Gastroenterology 2007;133:959-66. (Pubitemid 47381358)
18. Wang N, Miao H, Li YS, et al. Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun 2006;341:1244-51. (Pubitemid 43221798)
19. Gimbrone MA Jr, Topper JN, Nagel T, et al. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann NY Acad Sci 2000;902:230-9; discussion 239-40.
20. Zhang JX, Pegoli W, Clemens MG. Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 1994;266:G624-32.
21. Rockey DC, Housset CN, Friedman SL. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J Clin Invest 1993;92:1795-804. (Pubitemid 23304545)
22. Gupta TK, Toruner M, Chung MK, et al. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. Hepatology 1998;28:926-31. (Pubitemid 28450251)
23. Iwakiri Y, Groszmann RJ. Vascular endothelial dysfunction in cirrhosis. J Hepatol 2007;46:927-34. (Pubitemid 46529052)
24. Shah V. Cellular and molecular basis of portal hypertension. Clin Liver Dis 2001;5:629-44. (Pubitemid 32847053)
25. Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 1997;100:2153-7. (Pubitemid 27500136)
26. Dai G, Kaazempur-Mofrad MR, Natarajan S, et al. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A 2004;101:14871-6. (Pubitemid 39410767)
27. Qi K, Qiu H, Rutherford J, et al. Direct visualization of nitric oxide release by liver cells after the arrest of metastatic tumor cells in the hepatic microvasculature. J Surg Res 2004;119:29-35. (Pubitemid 38581981)
28. Kawanami D, Mahabeleshwar GH, Lin Z, et al. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J Biol Chem 2009;284:20522-30.
29. Sako K, Fukuhara S, Minami T, et al. Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem 2009;284:5592-601.
30. Dach K, Zovko J, Hogardt M, et al. Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1. Infect Immun 2009;77:5583-92.
31. Wanless IR, Wong F, Blendis LM, et al. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology 1995;21:1238-47.
32. Tanaka M, Wanless IR. Pathology of the liver in Budd-Chiari syndrome: portal vein thrombosis and the histogenesis of veno-centric cirrhosis, veno-portal cirrhosis, and large regenerative nodules. Hepatology 1998;27:488-96. (Pubitemid 28081064)
33. Shah V, Garcia-Cardena G, Sessa WC, et al. The hepatic circulation in health and disease: report of a single-topic symposium. Hepatology 1998;27:279-88. (Pubitemid 28041565)
34. Parmar KM, Nambudiri V, Dai G, et al. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem 2005;280:26714-19. (Pubitemid 41040703)
35. Sen-Banerjee S, Mir S, Lin Z, et al. Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation 2005;112:720-6. (Pubitemid 41099052)
36. Trebicka J, Hennenberg M, Laleman W, et al. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology 2007;46:242-53. (Pubitemid 47171941)
37. Zafra C, Abraldes JG, Turnes J, et al. Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis. Gastroenterology 2004;126:749-55. (Pubitemid 38298323)
38. Abraldes JG, Albillos A, Banares R, et al. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology 2009;136:1651-8.