Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats

Journal of Hepatology

Volumn 58, Issue 2, 2013, Pages 240-246

  Guillaume, Maeva ^a,b   Rodriguez Vilarrupla, Aina ^a,b   Gracia Sancho, Jorge ^a,b   Rosado, Eugenio ^a,b   Mancini, Aldo ^c   Bosch, Jaume ^a,b   Garcia Pagán, Joan Carles ^a,b  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

SMA; smooth muscle actin; acetylcholine; Ach; arbitrary units; AU; carbon tetrachloride; CCl4; DHE; dihydroethidium; hepatic stellate cells; horseradish peroxidase; HRP; HSC; intrahepatic vascular resistance; IVR; liver sinusoidal endothelial cells; LSEC; MAP; mean arterial pressure; methoxamine; Mtx; nitric oxide; NO; O 2 ; PBF; portal blood flow; portal pressure; PP; recombinant human manganese containing superoxide dismutase; rMnSOD; SOD; superoxide; superoxide dismutase

Indexed keywords

ACETYLCHOLINE; ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; MANGANESE SUPEROXIDE DISMUTASE; PROCOLLAGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; HISTOPATHOLOGY; LIVER CIRRHOSIS; LIVER FIBROSIS; MALE; NONHUMAN; OXIDATIVE STRESS; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STELLATE CELL; VASCULAR RESISTANCE; VASODILATATION;

ANIMALS; CARBON TETRACHLORIDE; DISEASE MODELS, ANIMAL; HYPERTENSION, PORTAL; LIVER CIRRHOSIS; MALE; OXIDATIVE STRESS; PORTAL PRESSURE; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SUPEROXIDE DISMUTASE; TREATMENT OUTCOME; VASCULAR RESISTANCE;

EID: 84872385637     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.09.010     Document Type: Article

References (28)

1. J. Bosch, and J.C. Garcia-Pagan Complications of cirrhosis. I. Portal hypertension J Hepatol 32 2000 141 156
2. Y. Iwakiri, and R.J. Groszmann Vascular endothelial dysfunction in cirrhosis J Hepatol 46 2007 927 934
3. Y. Iwakiri, and R.J. Groszmann The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule Hepatology 43 2006 S121 S131
4. D.C. Rockey, and J.J. Chung Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension Gastroenterology 114 1998 344 351
5. V. Shah, M. Toruner, F. Haddad, G. Cadelina, A. Papapetropoulos, and K. Choo Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat Gastroenterology 117 1999 1222 1228
6. T.K. Gupta, M. Toruner, M.K. Chung, and R.J. Groszmann Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats Hepatology 28 1998 926 931
7. J. Gracia-Sancho, B. Lavina, A. Rodriguez-Vilarrupla, H. Garcia-Caldero, M. Fernandez, and J. Bosch Increased oxidative stress in cirrhotic rat livers: a potential mechanism contributing to reduced nitric oxide bioavailability Hepatology 47 2008 1248 1256
8. M. Van de Casteele, J.F. Van Pelt, F. Nevens, J. Fevery, and J. Reichen Low NO bioavailability in CCl4 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: a comparison of two portal hypertensive rat models with healthy controls Comp Hepatol 2 2003 2
9. J. Bosch, J.G. Abraldes, M. Fernandez, and J.C. Garcia-Pagan Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension J Hepatol 53 2010 558 567
10. B. Lavina, J. Gracia-Sancho, A. Rodriguez-Vilarrupla, Y. Chu, D.D. Heistad, and J. Bosch Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension Gut 58 2009 118 125
11. H. Garcia-Caldero, A. Rodriguez-Vilarrupla, J. Gracia-Sancho, M. Divi, B. Lavina, and J. Bosch Tempol administration, a superoxide dismutase mimetic, reduces hepatic vascular resistance and portal pressure in cirrhotic rats J Hepatol 54 2010 660 665
12. A. Borrelli, A. Schiattarella, R. Mancini, F. Morelli, C. Capasso, and V. De Luca The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro Int J Cancer 128 2011 453 459
13. A. Mancini, A. Borrelli, A. Schiattarella, L. Aloj, M. Aurilio, and F. Morelli Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent Int J Cancer 123 2008 2684 2695
14. A. Mancini, A. Borrelli, A. Schiattarella, S. Fasano, A. Occhiello, and A. Pica Tumor suppressive activity of a variant isoform of manganese superoxide dismutase released by a human liposarcoma cell line Int J Cancer 119 2006 932 943
15. A. Borrelli, A. Schiattarella, R. Mancini, B. Morrica, V. Cerciello, and M. Mormile A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells Free Radic Biol Med 46 2009 110 116
16. N.A. Rahman, K. Mori, M. Mizukami, T. Suzuki, N. Takahashi, and C. Ohyama Role of peroxynitrite and recombinant human manganese superoxide dismutase in reducing ischemia-reperfusion renal tissue injury Transplant Proc 41 2009 3603 3610
17. M. Graupera, J.C. Garcia-Pagan, J.G. Abraldes, C. Peralta, M. Bragulat, and H. Corominola Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers Hepatology 37 2003 172 181
18. M. Graupera, J.C. Garcia-Pagan, E. Titos, J. Claria, A. Massaguer, and J. Bosch 5-Lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes Gastroenterology 122 2002 387 393
19. M. Mejias, E. Garcia-Pras, C. Tiani, R. Miquel, J. Bosch, and M. Fernandez Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats Hepatology 49 2009 1245 1256
20. B. Castaneda, W. Debernardi-Venon, J.C. Bandi, V. Andreu, S. Perez-del-Pulgar, and E. Moitinho The role of portal pressure in the severity of bleeding in portal hypertensive rats Hepatology 31 2000 581 586
21. J. Trebicka, M. Hennenberg, M. Odenthal, K. Shir, S. Klein, and M. Granzow Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells J Hepatol 53 2010 702 712
22. A. Rodriguez-Vilarrupla, B. Lavina, H. Garcia-Caldero, L. Russo, E. Rosado, and N. Roglans PPARalpha activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats J Hepatol 56 2012 1033 1039
23. M. Fernandez, M. Mejias, E. Garcia-Pras, R. Mendez, J.C. Garcia-Pagan, and J. Bosch Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats Hepatology 46 2007 1208 1217
24. L. Xu, A.Y. Hui, E. Albanis, M.J. Arthur, S.M. O'Byrne, and W.S. Blaner Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis Gut 54 2005 142 151
25. Y.Y. Yang, K.C. Lee, Y.T. Huang, Y.W. Wang, M.C. Hou, and F.Y. Lee Effects of N-acetylcysteine administration in hepatic microcirculation of rats with biliary cirrhosis J Hepatol 49 2008 25 33
26. Y.Y. Yang, T.Y. Lee, Y.T. Huang, C.C. Chan, Y.C. Yeh, and F.Y. Lee Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats Liver Int 32 2012 48 57
27. S. Nagula, D. Jain, R.J. Groszmann, and G. Garcia-Tsao Histological-hemodynamic correlation in cirrhosis- A histological classification of the severity of cirrhosis J Hepatol 44 2006 111 117
28. R. Bataller, and D.A. Brenner Liver fibrosis J Clin Invest 115 2005 209 218