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Volumn 43, Issue 3, 2006, Pages 485-491

Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; NITRIC OXIDE; SUPEROXIDE;

EID: 33645240442     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21080     Document Type: Article
Times cited : (104)

References (50)
  • 1
    • 0034053015 scopus 로고    scopus 로고
    • Complications of cirrhosis. I. Portal hypertension
    • Bosch J, Garcia-Pagan JC. Complications of cirrhosis. I. Portal hypertension. J Hepatol 2000;32(1 Suppl):141-156.
    • (2000) J Hepatol , vol.32 , Issue.1 SUPPL. , pp. 141-156
    • Bosch, J.1    Garcia-Pagan, J.C.2
  • 2
    • 15444362095 scopus 로고    scopus 로고
    • Increased hepatic resistance: A new target in the pharmacologic therapy of portal hypertension
    • Hernandez-Guerra M, Garcia-Pagan JC, Bosch J. Increased hepatic resistance: a new target in the pharmacologic therapy of portal hypertension. J Clin Gastroenterol 2005;39(4 Suppl 2):S131-S137.
    • (2005) J Clin Gastroenterol , vol.39 , Issue.4 SUPPL. 2
    • Hernandez-Guerra, M.1    Garcia-Pagan, J.C.2    Bosch, J.3
  • 3
    • 0021927396 scopus 로고
    • Increased portal venous resistance hinders portal pressure reduction during the administration of beta-adrenergic blocking agents in a portal hypertensive model
    • Kroeger RJ, Groszmann RJ. Increased portal venous resistance hinders portal pressure reduction during the administration of beta-adrenergic blocking agents in a portal hypertensive model. HEPATOLOGY 1985;5:97-101.
    • (1985) Hepatology , vol.5 , pp. 97-101
    • Kroeger, R.J.1    Groszmann, R.J.2
  • 4
    • 0021816284 scopus 로고
    • Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators
    • Bhathal PS, Grossman HJ. Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators. J Hepatol 1985;1:325-337.
    • (1985) J Hepatol , vol.1 , pp. 325-337
    • Bhathal, P.S.1    Grossman, H.J.2
  • 5
    • 0031682956 scopus 로고    scopus 로고
    • Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats
    • Gupta TK, Toruner M, Chung MK, Groszmann RJ. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. HEPATOLOGY 1998;28:926-931.
    • (1998) Hepatology , vol.28 , pp. 926-931
    • Gupta, T.K.1    Toruner, M.2    Chung, M.K.3    Groszmann, R.J.4
  • 6
    • 0031941122 scopus 로고    scopus 로고
    • Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension
    • Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998;114:344-351.
    • (1998) Gastroenterology , vol.114 , pp. 344-351
    • Rockey, D.C.1    Chung, J.J.2
  • 7
    • 0032738990 scopus 로고    scopus 로고
    • Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the Rat
    • Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, et al. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the Rat. Gastroenterology 1999;117:1222-1228.
    • (1999) Gastroenterology , vol.117 , pp. 1222-1228
    • Shah, V.1    Toruner, M.2    Haddad, F.3    Cadelina, G.4    Papapetropoulos, A.5    Choo, K.6
  • 8
    • 0037308223 scopus 로고    scopus 로고
    • Low doses of isosorbide mononitrate attenuate the postprandial increase in portal pressure in patients with cirrhosis
    • Bellis L, Berzigotti A, Abraldes JG, Moitinho E, Garcia-Pagan JC, Bosch J, et al. Low doses of isosorbide mononitrate attenuate the postprandial increase in portal pressure in patients with cirrhosis. HEPATOLOGY 2003;37:378-384.
    • (2003) Hepatology , vol.37 , pp. 378-384
    • Bellis, L.1    Berzigotti, A.2    Abraldes, J.G.3    Moitinho, E.4    Garcia-Pagan, J.C.5    Bosch, J.6
  • 9
    • 1542317594 scopus 로고    scopus 로고
    • Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis
    • Zafra C, Abraldes JG, Turnes J, Berzigotti A, Fernandez M, Garca-Pagan JC, et al. Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis. Gastroenterology 2004;126:749-755.
    • (2004) Gastroenterology , vol.126 , pp. 749-755
    • Zafra, C.1    Abraldes, J.G.2    Turnes, J.3    Berzigotti, A.4    Fernandez, M.5    Garca-Pagan, J.C.6
  • 10
    • 0036719232 scopus 로고    scopus 로고
    • In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats
    • Van de Casteele M., Omasta A, Janssens S, Roskams T, Desmet V, Nevens F, et al. In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats. Gut 2002;51:440-445.
    • (2002) Gut , vol.51 , pp. 440-445
    • Van De Casteele, M.1    Omasta, A.2    Janssens, S.3    Roskams, T.4    Desmet, V.5    Nevens, F.6
  • 11
    • 0031941122 scopus 로고    scopus 로고
    • Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension
    • Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998;114:344-351.
    • (1998) Gastroenterology , vol.114 , pp. 344-351
    • Rockey, D.C.1    Chung, J.J.2
  • 12
    • 0031577442 scopus 로고    scopus 로고
    • Tetrahydrobiopterin regulates Superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase
    • Wever RM, van DT, van Rijn HJ, de GF, Rabelink TJ. Tetrahydrobiopterin regulates Superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase. Biochem Biophys Res Commun 1997;237:340-344.
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 340-344
    • Wever, R.M.1    Van, D.T.2    Van Rijn, H.J.3    De, G.F.4    Rabelink, T.J.5
  • 13
    • 2942519830 scopus 로고    scopus 로고
    • Low NO bioavailability in CC14 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: A comparison of two portal hypertensive rat models with healthy controls
    • Van de Casteele M, Van Pelt JF, Nevens F, Fevery J, Reichen J. Low NO bioavailability in CC14 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: a comparison of two portal hypertensive rat models with healthy controls. Comp Hepatol 2003;2:2.
    • (2003) Comp Hepatol , vol.2 , pp. 2
    • Van De Casteele, M.1    Van Pelt, J.F.2    Nevens, F.3    Fevery, J.4    Reichen, J.5
  • 14
    • 0036023302 scopus 로고    scopus 로고
    • Oxidative stress EPR measurement in human liver by radical-probe technique: Correlation with etiology, histology and cell proliferation
    • Valgimigli M, Valgimigli L, Trere D, Gaiani S, Pedulli GF, Gramantieri L, et al. Oxidative stress EPR measurement in human liver by radical-probe technique: correlation with etiology, histology and cell proliferation. Free Radic Res 2002;36:939-948.
    • (2002) Free Radic Res , vol.36 , pp. 939-948
    • Valgimigli, M.1    Valgimigli, L.2    Trere, D.3    Gaiani, S.4    Pedulli, G.F.5    Gramantieri, L.6
  • 15
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001;35:297-306.
    • (2001) J Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 16
    • 0037218573 scopus 로고    scopus 로고
    • Oxidative stress in viral and alcoholic hepatitis
    • Loguercio C, Federico A. Oxidative stress in viral and alcoholic hepatitis. Free Radic Biol Med 2003;34:1-10.
    • (2003) Free Radic Biol Med , vol.34 , pp. 1-10
    • Loguercio, C.1    Federico, A.2
  • 17
    • 0032499667 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension
    • Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998;97:2222-2229.
    • (1998) Circulation , vol.97 , pp. 2222-2229
    • Taddei, S.1    Virdis, A.2    Ghiadoni, L.3    Magagna, A.4    Salvetti, A.5
  • 18
    • 0030034465 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1996;97:22-28.
    • (1996) J Clin Invest , vol.97 , pp. 22-28
    • Ting, H.H.1    Timimi, F.K.2    Boles, K.S.3    Creager, S.J.4    Ganz, P.5    Ma, C.6
  • 19
    • 0030997880 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia
    • Ting HH, Timimi FK, Haley EA, Roddy MA, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Circulation 1997;95:2617-2622.
    • (1997) Circulation , vol.95 , pp. 2617-2622
    • Ting, H.H.1    Timimi, F.K.2    Haley, E.A.3    Roddy, M.A.4    Ganz, P.5    Creager, M.A.6
  • 20
    • 0030782969 scopus 로고    scopus 로고
    • Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients
    • Solzbach U, Hornig B, Jeserich M, Just H. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation 1997;96:1513-1519.
    • (1997) Circulation , vol.96 , pp. 1513-1519
    • Solzbach, U.1    Hornig, B.2    Jeserich, M.3    Just, H.4
  • 21
    • 0035873316 scopus 로고    scopus 로고
    • Impaired endothelium-dependent vasodilation in the brachial artery in variant angina pectoris and the effect of intravenous administration of vitamin C
    • Hamabe A, Takase B, Uehata A, Kurita A, Ohsuzu F, Tamai S. Impaired endothelium-dependent vasodilation in the brachial artery in variant angina pectoris and the effect of intravenous administration of vitamin C. Am J Cardiol 2001;87:1154-1159.
    • (2001) Am J Cardiol , vol.87 , pp. 1154-1159
    • Hamabe, A.1    Takase, B.2    Uehata, A.3    Kurita, A.4    Ohsuzu, F.5    Tamai, S.6
  • 22
    • 0035498943 scopus 로고    scopus 로고
    • Reversibility of coronary endothelial vasomotor dysfunction in idiopathic dilated cardiomyopathy: Acute effects of vitamin C
    • Richartz BM, Werner GS, Ferrari M, Figulla HR. Reversibility of coronary endothelial vasomotor dysfunction in idiopathic dilated cardiomyopathy: acute effects of vitamin C. Am J Cardiol 2001;88:1001-1005.
    • (2001) Am J Cardiol , vol.88 , pp. 1001-1005
    • Richartz, B.M.1    Werner, G.S.2    Ferrari, M.3    Figulla, H.R.4
  • 23
    • 0032476697 scopus 로고    scopus 로고
    • Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations
    • Jackson TS, Xu A, Vita JA, Keaney JF Jr. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 1998;83:916-922.
    • (1998) Circ Res , vol.83 , pp. 916-922
    • Jackson, T.S.1    Xu, A.2    Vita, J.A.3    Keaney Jr., J.F.4
  • 24
    • 0034033581 scopus 로고    scopus 로고
    • Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension
    • Sherman DL, Keaney JF Jr., Biegelsen ES, Duffy SJ, Coffman JD, Vita JA. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension 2000;35:936-941.
    • (2000) Hypertension , vol.35 , pp. 936-941
    • Sherman, D.L.1    Keaney Jr., J.F.2    Biegelsen, E.S.3    Duffy, S.J.4    Coffman, J.D.5    Vita, J.A.6
  • 25
    • 0024603813 scopus 로고
    • Reduction of portal pressure by isosorbide-5-mononitrate in patients with cirrhosis: Effects on splanchnic and systemic hemodynamics and liver function
    • Navasa M, Chesta J, Bosch J, Rodes J. Reduction of portal pressure by isosorbide-5-mononitrate in patients with cirrhosis: effects on splanchnic and systemic hemodynamics and liver function. Gastroenterology 1989;96:1110-1118.
    • (1989) Gastroenterology , vol.96 , pp. 1110-1118
    • Navasa, M.1    Chesta, J.2    Bosch, J.3    Rodes, J.4
  • 26
    • 0025904709 scopus 로고
    • Measurement of hepatic blood-flow, hepatic extraction and intrinsic clearance of indocyanine green in patients with cirrhosis-Comparison of a noninvasive pharmacokinetic method with measurements using hepatic vein catheterization
    • Navasa M, Bosch J, Mastai R, Bruix J, Rodes J. Measurement of hepatic blood-flow, hepatic extraction and intrinsic clearance of indocyanine green in patients with cirrhosis-Comparison of a noninvasive pharmacokinetic method with measurements using hepatic vein catheterization. Eur J Gastroenterol Hepatol 1991:305-312.
    • (1991) Eur J Gastroenterol Hepatol , pp. 305-312
    • Navasa, M.1    Bosch, J.2    Mastai, R.3    Bruix, J.4    Rodes, J.5
  • 27
    • 0025243723 scopus 로고
    • The effect of non-protein liquid meals on the hepatic venous pressure gradient in patients with cirrhosis
    • McCormick PA, Dick R, Graffeo M, Wagstaff D, Madden A, McIntyre N, et al. The effect of non-protein liquid meals on the hepatic venous pressure gradient in patients with cirrhosis. J Hepatol 1990;11:221-225.
    • (1990) J Hepatol , vol.11 , pp. 221-225
    • McCormick, P.A.1    Dick, R.2    Graffeo, M.3    Wagstaff, D.4    Madden, A.5    McIntyre, N.6
  • 29
    • 0027932941 scopus 로고
    • Octreotide prevents postprandial splanchnic hyperemia in patients with portal hypertension
    • Albillos A, Rossi I, Iborra J, Lledo JL, Calleja JL, Barrios C, et al. Octreotide prevents postprandial splanchnic hyperemia in patients with portal hypertension. J Hepatol 1994;21:88-94.
    • (1994) J Hepatol , vol.21 , pp. 88-94
    • Albillos, A.1    Rossi, I.2    Iborra, J.3    Lledo, J.L.4    Calleja, J.L.5    Barrios, C.6
  • 32
    • 0029891589 scopus 로고    scopus 로고
    • Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: Implications for regulation of portal pressure and resistance
    • Rockey DC, Weisiger RA. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. HEPATOLOGY 1996;24:233-240.
    • (1996) Hepatology , vol.24 , pp. 233-240
    • Rockey, D.C.1    Weisiger, R.A.2
  • 33
    • 0033852479 scopus 로고    scopus 로고
    • Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis
    • Titos E, Claria J, Bataller R, Bosch-Marce M, Gines P, Jimenez W, et al. Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. Gastroenterology 2000;119:794-805.
    • (2000) Gastroenterology , vol.119 , pp. 794-805
    • Titos, E.1    Claria, J.2    Bataller, R.3    Bosch-Marce, M.4    Gines, P.5    Jimenez, W.6
  • 34
    • 0036163806 scopus 로고    scopus 로고
    • 5-Lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: A possible role of cysteinyl-leukotrienes
    • Graupera M, Garcia-Pagan JC, Titos E, Claria J, Massaguer A, Bosch J, et al. 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes. Gastroenterology 2002;122:387-393.
    • (2002) Gastroenterology , vol.122 , pp. 387-393
    • Graupera, M.1    Garcia-Pagan, J.C.2    Titos, E.3    Claria, J.4    Massaguer, A.5    Bosch, J.6
  • 35
    • 0037221217 scopus 로고    scopus 로고
    • Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers
    • Graupera M, Garcia-Pagan JC, Abraldes JG, Peralta C, Bragulat M, Corominola H, et al. Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. HEPATOLOGY 2003;37:172-181.
    • (2003) Hepatology , vol.37 , pp. 172-181
    • Graupera, M.1    Garcia-Pagan, J.C.2    Abraldes, J.G.3    Peralta, C.4    Bragulat, M.5    Corominola, H.6
  • 36
    • 2442671360 scopus 로고    scopus 로고
    • The resistance of the cirrhotic liver: A new target for the treatment of portal hypertension. 1985
    • Garcia-Pagan JC, Bosch J. The resistance of the cirrhotic liver: a new target for the treatment of portal hypertension. 1985. J Hepatol 2004;40:887-890.
    • (2004) J Hepatol , vol.40 , pp. 887-890
    • Garcia-Pagan, J.C.1    Bosch, J.2
  • 38
    • 0034121518 scopus 로고    scopus 로고
    • Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension
    • Yu Q, Shao R, Qian HS, George SE, Rockey DC. Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. J Clin Invest 2000;105:741-748.
    • (2000) J Clin Invest , vol.105 , pp. 741-748
    • Yu, Q.1    Shao, R.2    Qian, H.S.3    George, S.E.4    Rockey, D.C.5
  • 39
    • 0035902558 scopus 로고    scopus 로고
    • NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension
    • Fiorucci S, Antonelli E, Morelli O, Mencarelli A, Casini A, Mello T, et al. NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. Proc Natl Acad Sci U S A 2001;98:8897-8902.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8897-8902
    • Fiorucci, S.1    Antonelli, E.2    Morelli, O.3    Mencarelli, A.4    Casini, A.5    Mello, T.6
  • 40
    • 0347906012 scopus 로고    scopus 로고
    • A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats
    • Loureiro-Silva MR, Cadelina GW, Iwakiri Y, Groszmann RJ. A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats. J Hepatol 2003;39:940-946.
    • (2003) J Hepatol , vol.39 , pp. 940-946
    • Loureiro-Silva, M.R.1    Cadelina, G.W.2    Iwakiri, Y.3    Groszmann, R.J.4
  • 41
    • 0022640297 scopus 로고
    • Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
    • Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986;320:454-456.
    • (1986) Nature , vol.320 , pp. 454-456
    • Gryglewski, R.J.1    Palmer, R.M.2    Moncada, S.3
  • 43
    • 0036790718 scopus 로고    scopus 로고
    • Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C
    • Yadav D, Hertan HI, Schweitzer P, Norkus EP, Pitchumoni CS. Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C. Am J Gastroenterol 2002;97:2634-2639.
    • (2002) Am J Gastroenterol , vol.97 , pp. 2634-2639
    • Yadav, D.1    Hertan, H.I.2    Schweitzer, P.3    Norkus, E.P.4    Pitchumoni, C.S.5
  • 45
    • 0036234599 scopus 로고    scopus 로고
    • Blood antioxidant levels in patients with alcoholic liver disease correlate with the degree of liver impairment and are not specific to alcoholic liver injury itself
    • Van de Casteele M, Zaman Z, Zeegers M, Servaes R, Fevery J, Nevens F. Blood antioxidant levels in patients with alcoholic liver disease correlate with the degree of liver impairment and are not specific to alcoholic liver injury itself. Aliment Pharmacol Ther 2002;16:985-992.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 985-992
    • Van De Casteele, M.1    Zaman, Z.2    Zeegers, M.3    Servaes, R.4    Fevery, J.5    Nevens, F.6
  • 48
    • 0035808310 scopus 로고    scopus 로고
    • L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin
    • Heller R, Unbehaun A, Schellenberg B, Mayer B, Werner-Felmayer G, Werner ER. L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. J Biol Chem 2001;276:40-47.
    • (2001) J Biol Chem , vol.276 , pp. 40-47
    • Heller, R.1    Unbehaun, A.2    Schellenberg, B.3    Mayer, B.4    Werner-Felmayer, G.5    Werner, E.R.6
  • 49
    • 0037428209 scopus 로고    scopus 로고
    • Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity
    • d'Uscio LV, Milstien S, Richardson D, Smith L, Katusic ZS. Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res 2003;92:88-95.
    • (2003) Circ Res , vol.92 , pp. 88-95
    • D'Uscio, L.V.1    Milstien, S.2    Richardson, D.3    Smith, L.4    Katusic, Z.S.5
  • 50
    • 0036916881 scopus 로고    scopus 로고
    • Indexes of NO bioavailability in human blood
    • Lauer T, Kleinbongard P, Keim M. Indexes of NO bioavailability in human blood. News Physiol Sci 2002;17:251-5:251-255.
    • (2002) News Physiol Sci , vol.17 , pp. 251-255
    • Lauer, T.1    Kleinbongard, P.2    Keim, M.3


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