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Volumn 130, Issue 3, 2006, Pages 838-854

Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; METHOXAMINE; MOESIN; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 33644870801     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.11.029     Document Type: Article
Times cited : (98)

References (61)
  • 1
    • 0000929032 scopus 로고
    • Circulatory changes in chronic liver disease
    • J.F. Murray, A.M. Dawson, S. Sherlock Circulatory changes in chronic liver disease Am J Med 24 1958 358 367
    • (1958) Am J Med , vol.24 , pp. 358-367
    • Murray, J.F.1    Dawson, A.M.2    Sherlock, S.3
  • 2
    • 0027938229 scopus 로고
    • Hyperdynamic circulation of liver disease 40 years later: Pathophysiology and clinical consequences
    • R.J. Groszmann Hyperdynamic circulation of liver disease 40 years later pathophysiology and clinical consequences Hepatology 20 1994 1359 1363
    • (1994) Hepatology , vol.20 , pp. 1359-1363
    • Groszmann, R.J.1
  • 3
    • 0020677377 scopus 로고
    • Hyperdynamic circulation in portal hypertensive rat model: A primary factor for maintenance of chronic portal hypertension
    • J. Vorobioff, J. Bredfeldt, R. Groszmann Hyperdynamic circulation in portal hypertensive rat model a primary factor for maintenance of chronic portal hypertension Am J Physiol 244 1983 G52 G57
    • (1983) Am J Physiol , vol.244
    • Vorobioff, J.1    Bredfeldt, J.2    Groszmann, R.3
  • 4
    • 0026737603 scopus 로고
    • The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats
    • F.Y. Lee, A. Albillos, L.A. Colombato, R.J. Groszmann The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats Hepatology 16 1992 1043 1048
    • (1992) Hepatology , vol.16 , pp. 1043-1048
    • Lee, F.Y.1    Albillos, A.2    Colombato, L.A.3    Groszmann, R.J.4
  • 5
    • 0027392508 scopus 로고
    • G-nitro-L-arginine administration corrects peripheral vasodilation and systemic capillary hypotension and ameliorates plasma volume expansion and sodium retention in portal hypertensive rats
    • G-nitro-L-arginine administration corrects peripheral vasodilation and systemic capillary hypotension and ameliorates plasma volume expansion and sodium retention in portal hypertensive rats Hepatology 17 1993 84 90
    • (1993) Hepatology , vol.17 , pp. 84-90
    • Lee, F.Y.1    Colombato, L.A.2    Lbillos, A.3    Groszmann, R.J.4
  • 6
    • 0026708176 scopus 로고
    • In vitro hyporeactivity to methoxamine in portal hypertensive rats: Reversal by nitric oxide blockade
    • C.C. Sieber, R.J. Groszmann In vitro hyporeactivity to methoxamine in portal hypertensive rats reversal by nitric oxide blockade Am J Physiol Gastrointest Liver Physiol 262 1992 G996 G1001
    • (1992) Am J Physiol Gastrointest Liver Physiol , vol.262
    • Sieber, C.C.1    Groszmann, R.J.2
  • 7
    • 0026749847 scopus 로고
    • Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats
    • C.C. Sieber, R.J. Groszmann Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats Gastroenterology 103 1992 235 239
    • (1992) Gastroenterology , vol.103 , pp. 235-239
    • Sieber, C.C.1    Groszmann, R.J.2
  • 8
    • 0027236198 scopus 로고
    • Role of nitric oxide in the in vitro splanchnic hyporeactivity in ascitic cirrhotic rats
    • C.C. Sieber, J.C. Lopez-Talavera, R.J. Groszmann Role of nitric oxide in the in vitro splanchnic hyporeactivity in ascitic cirrhotic rats Gastroenterology 104 1993 1750 1754
    • (1993) Gastroenterology , vol.104 , pp. 1750-1754
    • Sieber, C.C.1    Lopez-Talavera, J.C.2    Groszmann, R.J.3
  • 9
    • 0032944047 scopus 로고    scopus 로고
    • Altered adrenergic responsiveness of endothelium denuded hepatic arteries and portal veins in patients with cirrhosis
    • J. Heller, M. Schepke, N. Gehnen, G. Molderings, A. Müller, J. Erhard Altered adrenergic responsiveness of endothelium denuded hepatic arteries and portal veins in patients with cirrhosis Gastroenterology 116 1999 387 393
    • (1999) Gastroenterology , vol.116 , pp. 387-393
    • Heller, J.1    Schepke, M.2    Gehnen, N.3    Molderings, G.4    Müller, A.5    Erhard, J.6
  • 10
    • 0034767966 scopus 로고    scopus 로고
    • Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: Evidence for a receptor-specific mechanism
    • M. Schepke, J. Heller, S. Paschke, J. Thomas, M. Wolff, M. Neef Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis evidence for a receptor-specific mechanism Hepatology 34 2001 884 888
    • (2001) Hepatology , vol.34 , pp. 884-888
    • Schepke, M.1    Heller, J.2    Paschke, S.3    Thomas, J.4    Wolff, M.5    Neef, M.6
  • 11
    • 0029154015 scopus 로고
    • The role of increased nitric oxide in the vascular hyporeactivity to noradrenaline in long-term portal vein ligated rats
    • P.P. Michielsen, G.E. Boeckxstaens, S.U. Sys, A.G. Herman, P.A. Pelckmans The role of increased nitric oxide in the vascular hyporeactivity to noradrenaline in long-term portal vein ligated rats J Hepatol 23 1995 341 347
    • (1995) J Hepatol , vol.23 , pp. 341-347
    • Michielsen, P.P.1    Boeckxstaens, G.E.2    Sys, S.U.3    Herman, A.G.4    Pelckmans, P.A.5
  • 12
    • 0036841301 scopus 로고    scopus 로고
    • Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension
    • Y. Iwakiri, G. Cadelina, W.C. Sessa, R.J. Groszmann Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension Am J Physiol Gastrointest Liver Physiol 283 2002 G1074 G1081
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Iwakiri, Y.1    Cadelina, G.2    Sessa, W.C.3    Groszmann, R.J.4
  • 13
    • 0032620047 scopus 로고    scopus 로고
    • Pharmacomechanical coupling: The role of calcium, G-proteins, kinases and phosphatases
    • A.P. Somlyo, X. Wu, L.A. Walker, A.V. Somlyo Pharmacomechanical coupling the role of calcium, G-proteins, kinases and phosphatases Rev Physiol Biochem Pharmacol 134 1999 201 234
    • (1999) Rev Physiol Biochem Pharmacol , vol.134 , pp. 201-234
    • Somlyo, A.P.1    Wu, X.2    Walker, L.A.3    Somlyo, A.V.4
  • 14
    • 0034650714 scopus 로고    scopus 로고
    • Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    • A.P. Somlyo, A.V. Somlyo Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II J Physiol 522 2000 177 185
    • (2000) J Physiol , vol.522 , pp. 177-185
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 15
    • 0034213327 scopus 로고    scopus 로고
    • Rho GTPases and their effector proteins
    • A.L. Bishop, A. Hall Rho GTPases and their effector proteins Biochem J 348 2000 241 255
    • (2000) Biochem J , vol.348 , pp. 241-255
    • Bishop, A.L.1    Hall, A.2
  • 16
    • 0030656619 scopus 로고    scopus 로고
    • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    • M. Uehata, T. Ishizaki, H. Satoh, T. Ono, T. Kawahara T Morishita Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension Nature 389 1997 990 994
    • (1997) Nature , vol.389 , pp. 990-994
    • Uehata, M.1    Ishizaki, T.2    Satoh, H.3    Ono, T.4    Kawahara Morishita, T.T.5
  • 17
    • 0141751697 scopus 로고    scopus 로고
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II modulated by G proteins, kinases, and myosin phosphatase Physiol Rev 83 2003 1325 1358
    • (2003) Physiol Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 19
    • 0038024241 scopus 로고    scopus 로고
    • Rocks: Multifunctional kinases in cell behaviour
    • K. Riento, A.J. Ridley Rocks multifunctional kinases in cell behaviour Nature Rev Mol Cell Biol 4 2003 446 456
    • (2003) Nature Rev Mol Cell Biol , vol.4 , pp. 446-456
    • Riento, K.1    Ridley, A.J.2
  • 20
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • S. Etienne-Manneville, A. Hall Rho GTPases in cell biology Nature 420 2002 629 635
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 22
    • 12444332012 scopus 로고    scopus 로고
    • Portal hypertension is associated with increased mRNA levels of vasopressor G-protein-coupled receptors in human hepatic arteries
    • M. Neef, E. Biecker, J. Heller, M. Schepke, H.D. Nischalke, M. Wolff Portal hypertension is associated with increased mRNA levels of vasopressor G-protein-coupled receptors in human hepatic arteries Eur J Clin Invest 33 2003 249 255
    • (2003) Eur J Clin Invest , vol.33 , pp. 249-255
    • Neef, M.1    Biecker, E.2    Heller, J.3    Schepke, M.4    Nischalke, H.D.5    Wolff, M.6
  • 23
    • 0033777071 scopus 로고    scopus 로고
    • Determination of GTP loading on Rho
    • X.D. Ren, M.A. Schwartz Determination of GTP loading on Rho Methods Enzymol 325 2000 264 272
    • (2000) Methods Enzymol , vol.325 , pp. 264-272
    • Ren, X.D.1    Schwartz, M.A.2
  • 24
    • 0033552677 scopus 로고    scopus 로고
    • Activation of moesin and adducin by Rho-kinase downstream of Rho
    • Y. Fukuta, N. Oshiro, K. Kaibuchi Activation of moesin and adducin by Rho-kinase downstream of Rho Biophys Chem 82 1999 139 147
    • (1999) Biophys Chem , vol.82 , pp. 139-147
    • Fukuta, Y.1    Oshiro, N.2    Kaibuchi, K.3
  • 25
    • 0032567361 scopus 로고    scopus 로고
    • Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures
    • N. Oshiro, Y. Fukata, K. Kaibuchi Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures J Biol Chem 273 1998 34663 34666
    • (1998) J Biol Chem , vol.273 , pp. 34663-34666
    • Oshiro, N.1    Fukata, Y.2    Kaibuchi, K.3
  • 26
    • 0032550225 scopus 로고    scopus 로고
    • Association of the myosin-binding subunit of myosin phosphatase and moesin: Dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatases
    • Y. Fukuta, K. Kimura, N. Oshiro, H. Saya, Y. Matsuura, K. Kaibuchi Association of the myosin-binding subunit of myosin phosphatase and moesin dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatases J Cell Biol 141 1998 409 418
    • (1998) J Cell Biol , vol.141 , pp. 409-418
    • Fukuta, Y.1    Kimura, K.2    Oshiro, N.3    Saya, H.4    Matsuura, Y.5    Kaibuchi, K.6
  • 27
    • 0033749211 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced platelet shape change proceeds via Rho/Rho kinase-mediated myosin light-chain and moesin phosphorylation
    • M. Retzer, M. Essler Lysophosphatidic acid-induced platelet shape change proceeds via Rho/Rho kinase-mediated myosin light-chain and moesin phosphorylation Cell Signal 12 2000 645 648
    • (2000) Cell Signal , vol.12 , pp. 645-648
    • Retzer, M.1    Essler, M.2
  • 28
    • 0031907484 scopus 로고    scopus 로고
    • RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts
    • R.J. Shaw, M. Henry, F. Solomon, T. Jacks RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts Mol Biol Cell 9 1998 403 419
    • (1998) Mol Biol Cell , vol.9 , pp. 403-419
    • Shaw, R.J.1    Henry, M.2    Solomon, F.3    Jacks, T.4
  • 29
    • 0032498528 scopus 로고    scopus 로고
    • Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
    • T. Matsui, M. Maeda, Y. Doi, S. Yonemura, M. Amano, K. Kaibuchi, S. Tsukita, S. Tsukita Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association J Cell Biol 140 1998 647 657
    • (1998) J Cell Biol , vol.140 , pp. 647-657
    • Matsui, T.1    Maeda, M.2    Doi, Y.3    Yonemura, S.4    Amano, M.5    Kaibuchi, K.6    Tsukita, S.7    Tsukita, S.8
  • 30
    • 0021686283 scopus 로고
    • Anesthetic influence on regional hemodynamics in normal and hemorrhaged rats
    • W.C. Seyde, D.E. Longnecker Anesthetic influence on regional hemodynamics in normal and hemorrhaged rats Anesthesiology 61 1984 686 698
    • (1984) Anesthesiology , vol.61 , pp. 686-698
    • Seyde, W.C.1    Longnecker, D.E.2
  • 31
    • 0034929805 scopus 로고    scopus 로고
    • Characterization of portal hypertension models by microspheres in anaesthetised rats: A comparison of liver flow
    • M. Van de Casteele, H. Sägesser, H. Zimmermann, J. Reichen Characterization of portal hypertension models by microspheres in anaesthetised rats a comparison of liver flow Pharmacol Ther 90 2001 35 43
    • (2001) Pharmacol Ther , vol.90 , pp. 35-43
    • Van De Casteele, M.1    Sägesser, H.2    Zimmermann, H.3    Reichen, J.4
  • 32
    • 0033971485 scopus 로고    scopus 로고
    • Mixed endothelin receptor antagonist, SB209670, decreases portal pressure in biliary cirrhotic rats in vivo by reducing portal venous system resistance
    • H. Kojima, J. Yamao, T. Tsujimoto, M. Uemura, A. Takaya, H. Fukui Mixed endothelin receptor antagonist, SB209670, decreases portal pressure in biliary cirrhotic rats in vivo by reducing portal venous system resistance J Hepatol 32 2000 43 50
    • (2000) J Hepatol , vol.32 , pp. 43-50
    • Kojima, H.1    Yamao, J.2    Tsujimoto, T.3    Uemura, M.4    Takaya, A.5    Fukui, H.6
  • 33
    • 0028835313 scopus 로고
    • Measurement of organ blood flow with coloured microspheres in the rat
    • J.P. Hakkinen, M.W. Miller, A.H. Smith, D.R. Knight Measurement of organ blood flow with coloured microspheres in the rat Cardiovasc Res 29 1995 74 79
    • (1995) Cardiovasc Res , vol.29 , pp. 74-79
    • Hakkinen, J.P.1    Miller, M.W.2    Smith, A.H.3    Knight, D.R.4
  • 34
    • 0032833217 scopus 로고    scopus 로고
    • Relationship between vascular reactivity in vitro and blood flows in rats with cirrhosis
    • D. Pateron, F. Oberti, P. Lefilliatre, N. Veal, K.A. Tazi, P. Sogni Relationship between vascular reactivity in vitro and blood flows in rats with cirrhosis Clin Sci 97 1999 313 318
    • (1999) Clin Sci , vol.97 , pp. 313-318
    • Pateron, D.1    Oberti, F.2    Lefilliatre, P.3    Veal, N.4    Tazi, K.A.5    Sogni, P.6
  • 35
    • 0027178984 scopus 로고
    • Impaired responsiveness to angiotensin II in experimental cirrhosis: Role of nitric oxide
    • A. Castro, W. Jimenez, J. Claria, J. Ros, J. Martinez, M. Bosch Impaired responsiveness to angiotensin II in experimental cirrhosis role of nitric oxide Hepatology 18 1993 367 372
    • (1993) Hepatology , vol.18 , pp. 367-372
    • Castro, A.1    Jimenez, W.2    Claria, J.3    Ros, J.4    Martinez, J.5    Bosch, M.6
  • 36
    • 0027151849 scopus 로고
    • Cardiovascular hyporesponsiveness to norepinephrine, propranolol, and nitroglycerin in portal-hypertensive and aged rats
    • J. Polio, C.C. Sieber, E. Lerner, R.J. Groszmann Cardiovascular hyporesponsiveness to norepinephrine, propranolol, and nitroglycerin in portal-hypertensive and aged rats Hepatology 18 1993 128 136
    • (1993) Hepatology , vol.18 , pp. 128-136
    • Polio, J.1    Sieber, C.C.2    Lerner, E.3    Groszmann, R.J.4
  • 37
    • 0023157190 scopus 로고
    • Vascular reactivity in experimental portal hypertension
    • A. Bomzon, L.M. Blendis Vascular reactivity in experimental portal hypertension Am J Physiol 257 1987 G158 G162
    • (1987) Am J Physiol , vol.257
    • Bomzon, A.1    Blendis, L.M.2
  • 38
    • 0029985846 scopus 로고    scopus 로고
    • Hyporeactivity of mesenteric resistance arteries in portal hypertensive rats
    • P. Sogni, S. Sabry, R. Moreau, A. Gadano, D. Lebrec, A.T. Dinh-Xuan Hyporeactivity of mesenteric resistance arteries in portal hypertensive rats J Hepatol 25 1996 487 490
    • (1996) J Hepatol , vol.25 , pp. 487-490
    • Sogni, P.1    Sabry, S.2    Moreau, R.3    Gadano, A.4    Lebrec, D.5    Dinh-Xuan, A.T.6
  • 39
    • 0030434265 scopus 로고    scopus 로고
    • Vascular hyporesponsiveness in aorta from portal hypertensive rats: Possible sites of involvement
    • Y.T. Huang, G.F. Wang, M.C.M. Yang, S.P. Chang, H.C. Lin, C.Y. Hong Vascular hyporesponsiveness in aorta from portal hypertensive rats possible sites of involvement J Pharmacol Exp Ther 278 1996 535 541
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 535-541
    • Huang, Y.T.1    Wang, G.F.2    Yang, M.C.M.3    Chang, S.P.4    Lin, H.C.5    Hong, C.Y.6
  • 41
    • 0034021173 scopus 로고    scopus 로고
    • Selective alteration of agonist-mediated contraction in hepatic arteries isolated from patients with cirrhosis
    • M. Islam, B. Williams, K. Madhavan, P. Hayes, P. Hadoke Selective alteration of agonist-mediated contraction in hepatic arteries isolated from patients with cirrhosis Gastroenterology 118 2000 765 771
    • (2000) Gastroenterology , vol.118 , pp. 765-771
    • Islam, M.1    Williams, B.2    Madhavan, K.3    Hayes, P.4    Hadoke, P.5
  • 42
    • 0030825621 scopus 로고    scopus 로고
    • In vitro evidence for vascular hyporesponsiveness in clinical and experimental cirrhosis
    • P.W.F. Hadoke, P.C. Hayes In vitro evidence for vascular hyporesponsiveness in clinical and experimental cirrhosis Pharmacol Ther 75 1997 51 68
    • (1997) Pharmacol Ther , vol.75 , pp. 51-68
    • Hadoke, P.W.F.1    Hayes, P.C.2
  • 43
    • 0036154951 scopus 로고    scopus 로고
    • The paradox of nitric oxide in cirrhosis and portal hypertension: Too much, not enough
    • R. Wiest, R.J. Groszmann The paradox of nitric oxide in cirrhosis and portal hypertension too much, not enough Hepatology 35 2002 478 491
    • (2002) Hepatology , vol.35 , pp. 478-491
    • Wiest, R.1    Groszmann, R.J.2
  • 44
    • 0026068870 scopus 로고
    • Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo
    • S. Moncada, D.D. Rees, R. Schulz, R.M. Palmer Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo Proc Natl Acad Sci U S A 88 1991 2166 2170
    • (1991) Proc Natl Acad Sci U S a , vol.88 , pp. 2166-2170
    • Moncada, S.1    Rees, D.D.2    Schulz, R.3    Palmer, R.M.4
  • 45
    • 0025930555 scopus 로고
    • Participation of endothelium-derived relaxing factor and role of cyclic GMP in inhibitory effects of endothelium on contractile responses elicited by α-adrenoceptor agonists in rat aorta
    • S. Topouzis, C. Schott, J.C. Stoclet Participation of endothelium-derived relaxing factor and role of cyclic GMP in inhibitory effects of endothelium on contractile responses elicited by α-adrenoceptor agonists in rat aorta J Cardiovasc Pharmacol 18 1991 670 678
    • (1991) J Cardiovasc Pharmacol , vol.18 , pp. 670-678
    • Topouzis, S.1    Schott, C.2    Stoclet, J.C.3
  • 46
    • 0025195176 scopus 로고
    • NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein
    • M.E. Gold, K.S. Wood, R.E. Byrns, J. Fukuto, L.J. Ignarro NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein Proc Natl Acad Sci U S A 87 1990 4430 4434
    • (1990) Proc Natl Acad Sci U S a , vol.87 , pp. 4430-4434
    • Gold, M.E.1    Wood, K.S.2    Byrns, R.E.3    Fukuto, J.4    Ignarro, L.J.5
  • 47
    • 0027140442 scopus 로고
    • Selective inhibition of basal but not agonist-stimulated activity of nitric oxide in rat aorta by NG-monomethyl-L-arginine
    • J.D. Frew, K. Paisley, W. Martin Selective inhibition of basal but not agonist-stimulated activity of nitric oxide in rat aorta by NG-monomethyl-L- arginine Br J Pharmacol 110 1993 1003 1008
    • (1993) Br J Pharmacol , vol.110 , pp. 1003-1008
    • Frew, J.D.1    Paisley, K.2    Martin, W.3
  • 48
    • 0036460051 scopus 로고    scopus 로고
    • Rho/Rho-kinase mediated signaling in physiology and pathophysiology
    • N. Wettschureck, S. Offermanns Rho/Rho-kinase mediated signaling in physiology and pathophysiology J Mol Med 80 2002 629 638
    • (2002) J Mol Med , vol.80 , pp. 629-638
    • Wettschureck, N.1    Offermanns, S.2
  • 49
    • 0036156469 scopus 로고    scopus 로고
    • Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts
    • G. Pawlak, D.M. Helfman Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts Mol Biol Cell 13 2002 336 347
    • (2002) Mol Biol Cell , vol.13 , pp. 336-347
    • Pawlak, G.1    Helfman, D.M.2
  • 50
    • 0033635110 scopus 로고    scopus 로고
    • Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
    • R.M. Touyz, E.L. Schiffrin Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells Pharmacol Rev 52 2000 639 672
    • (2000) Pharmacol Rev , vol.52 , pp. 639-672
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 51
    • 0034725603 scopus 로고    scopus 로고
    • Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase
    • S. Eguchi, T. Inagami Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase Regul Pept 91 2000 13 20
    • (2000) Regul Pept , vol.91 , pp. 13-20
    • Eguchi, S.1    Inagami, T.2
  • 52
    • 0035313703 scopus 로고    scopus 로고
    • Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking
    • W.E. Miller, R.J. Lefkowitz Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking Curr Opin Cell Biol 13 2001 139 145
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 139-145
    • Miller, W.E.1    Lefkowitz, R.J.2
  • 53
    • 9544251247 scopus 로고
    • Discrepant regulation among α and β adrenoceptors in vascular walls of cirrhotic rats
    • C. Gaudin, J.M. Launay, R. Moreau, S. Cailmail, D. Lebrec Discrepant regulation among α and β adrenoceptors in vascular walls of cirrhotic rats (abstr) J Hepatol 21 1994 S43
    • (1994) J Hepatol , vol.21 , pp. 43
    • Gaudin, C.1    Launay, J.M.2    Moreau, R.3    Cailmail, S.4    Lebrec, D.5
  • 55
    • 0032875356 scopus 로고    scopus 로고
    • Physiologic regulation of G protein-linked signaling
    • A.J. Morris, C.C. Malbon Physiologic regulation of G protein-linked signaling Physiol Rev 79 1999 1373 1430
    • (1999) Physiol Rev , vol.79 , pp. 1373-1430
    • Morris, A.J.1    Malbon, C.C.2
  • 56
    • 0141651600 scopus 로고    scopus 로고
    • Receptor-independent activation of Rho-kinase-mediated calcium sensitisation in smooth muscle
    • S. Ayman, P. Wallace, C.P. Wayman, A. Gibson, I. McFadzean Receptor-independent activation of Rho-kinase-mediated calcium sensitisation in smooth muscle Br J Pharmacol 139 2003 1532 1538
    • (2003) Br J Pharmacol , vol.139 , pp. 1532-1538
    • Ayman, S.1    Wallace, P.2    Wayman, C.P.3    Gibson, A.4    McFadzean, I.5
  • 57
    • 0141794500 scopus 로고    scopus 로고
    • 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction
    • 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction Circ Res 93 2003 548 556
    • (2003) Circ Res , vol.93 , pp. 548-556
    • Sakurada, S.1    Takuwa, N.2    Sugimoto, N.3    Wang, Y.4    Seto, M.5    Sasaki, Y.6    Takuwa, Y.7
  • 58
    • 0036606183 scopus 로고    scopus 로고
    • Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase
    • M. Mita, H. Yanagihara, S. Hishinuma, M. Saito, M.P. Walsh Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase Biochem J 364 2002 431 440
    • (2002) Biochem J , vol.364 , pp. 431-440
    • Mita, M.1    Yanagihara, H.2    Hishinuma, S.3    Saito, M.4    Walsh, M.P.5
  • 60
    • 0037704150 scopus 로고    scopus 로고
    • +-induced contraction by the ROCKs inhibitor Y-27632 in vascular smooth muscle: Possible involvement of ROCKs in a signal transduction pathway
    • +-induced contraction by the ROCKs inhibitor Y-27632 in vascular smooth muscle possible involvement of ROCKs in a signal transduction pathway J Pharmacol Sci 92 2003 56 69
    • (2003) J Pharmacol Sci , vol.92 , pp. 56-69
    • Sakamoto, K.1    Hori, M.2    Izumi, M.3    Oka, T.4    Kohama, K.5    Ozaki, H.6    Karaki, H.7
  • 61
    • 15444368647 scopus 로고    scopus 로고
    • Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus
    • P.H. Ratz, K.M. Berg, N.H. Urban, A.S. Miner Regulation of smooth muscle calcium sensitivity KCl as a calcium-sensitizing stimulus Am J Physiol Cell Physiol 288 2005 C769 C783
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Ratz, P.H.1    Berg, K.M.2    Urban, N.H.3    Miner, A.S.4


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